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Keywords: p53 mutation
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Biochem Soc Trans (2014) 42 (4): 752–757.
Published: 11 August 2014
... MDM2 inhibitors are currently under investigation in clinical trials. As for other targeted anti-cancer therapy approaches, relatively rapid resistance acquisition may limit the clinical efficacy of MDM2 inhibitors. In particular, MDM2 inhibitors were shown to induce p53 mutations in experimental...