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Keywords: p110δ
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Biochem Soc Trans (2007) 35 (2): 167–171.
Published: 20 March 2007
...D.T. Patton; F. Garçon; K. Okkenhaug PI3Ks (phosphoinositide 3-kinases) regulate diverse cellular functions such as metabolism, growth, gene expression and migration. The p110δ isoform of PI3K is mainly expressed in cells of the immune system and contributes to cellular and humoral immunity...
Biochem Soc Trans (2007) 35 (2): 183–185.
Published: 20 March 2007
... are not fully understood. General inhibitors of PI3K (phosphoinositide 3-kinase) suppress cytotoxicity in human and mouse NK cells. However, which isoforms and how they regulate NK cell activation is unknown, and no data have been published on mice carrying PI3K mutations. p110δ expression is restricted...