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Keywords: p110
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Biochem Soc Trans (2009) 37 (4): 615–626.
Published: 22 July 2009
...-specific LY294002 and PI3Kγ-selective AS-604850 occupy this region ( Table 1 a and Figure 2 ). This region has also been referred to as the ‘affinity pocket’ in the PI3Kγ–inhibitor complexes [ 5 ]. Table 1 Definitions of functionally important regions in the p110 subunit of the four isotypes...
Biochem Soc Trans (2007) 35 (2): 245–249.
Published: 20 March 2007
... mammalian target of rapamycin (mTOR) p110 phosphatidylinositol phosphoinositide 3-kinase (PI3K) PI3K (phosphoinositide 3-kinase) is activated by receptor tyrosine kinases and other cell-surface receptors to synthesize the lipid second messenger PIP 3 (phosphatidylinositol-3,4,5-trisphosphate...
Biochem Soc Trans (2004) 32 (2): 320–325.
Published: 01 April 2004
... consist of a cata- lytic subunit (p110 , p110 , p110 ) and a regulatory subunit (p85 , p55 , p50 , p85 , p55 ). The regulatory subunits are encoded by at least three genes: the p85 , p55 and p50 proteins are derived from a single gene by alternative splicing mechanisms, while distinct genes encode p85...