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Keywords: oxygenase
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Biochem Soc Trans (2020) 48 (5): 1843–1858.
Published: 28 September 2020
...Sally C. Fletcher; Mathew L. Coleman Fe(II)/2-oxoglutarate (2OG)-dependent oxygenases are a conserved enzyme class that catalyse diverse oxidative reactions across nature. In humans, these enzymes hydroxylate a broad range of biological substrates including DNA, RNA, proteins and some metabolic...
Biochem Soc Trans (2007) 35 (5): 870–875.
Published: 25 October 2007
..., which is then oxidized by β-oxidation. PhyH (phytanoyl-CoA 2-hydroxylase, also known as PAHX), an Fe(II) and 2OG (2-oxoglutarate) oxygenase, catalyses hydroxylation of phytanoyl-CoA. Mutations of PhyH ablate its role in α-oxidation, resulting in PA accumulation and ARD (adult Refsum's disease...
Biochem Soc Trans (2007) 35 (5): 881–886.
Published: 25 October 2007
... of phytanic acid have led to the clarification of the pathophysiology of Refsum's disease, rhizomelic chondrodysplasia and AMACR (α-methylacyl-CoA racemase) deficiency. This has highlighted the role of an Fe(II)- and 2-oxoglutarate-dependent oxygenases [PhyH (phytanoyl-CoA 2-hydroxylase), also known as PAHX...
Biochem Soc Trans (2004) 32 (6): 943–945.
Published: 26 October 2004
... (EGF β-hydroxylase) and putative asparagine/asparaginyl hydroxylases. Sequence analyses imply that EGFH does not contain the HXD/E iron-binding motif characteristic of most of the 2-oxoglutarate oxygenases. 1 Correspondence may be addressed to either of these authors (email...