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Keywords: oxidative stress
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Articles
Biochem Soc Trans (2022) BST20220593.
Published: 16 November 2022
... of the late sodium current (INaL), which impairs the action potential waveform and can cause severe cardiac arrhythmias. Moreover, long-term, low-dose exposure to PY displays oxidative stress in the heart, which could induce tissue remodeling and impairment. Isolated and preliminary evidence supports...
Articles
Biochem Soc Trans (2021) 49 (5): 2189–2198.
Published: 19 October 2021
.... These results point to a complementary co-regulation between NO and itaconate to orchestrate the response to damage and infection, which could play an important role in in the treatment of CVDs where both oxidative stress and inflammation can lead to further vascular damage. NO is also produced by endothelial...
Articles
Biochem Soc Trans (2017) 45 (6): 1295–1303.
Published: 17 November 2017
... and oxidative stress are implicated in many disorders. That these pathological processes can influence each other both up- and downstream makes for a complicated picture, but means that successfully targeting one area may have an effect on others. This targeting requires an understanding of the mechanisms...
Articles
Biochem Soc Trans (2015) 43 (5): 943–951.
Published: 09 October 2015
... of the mitochondria, whereas ABCB10 is involved in haem biosynthesis. They also play a role in preventing oxidative stress. Mutations in ABCB6 and ABCB7 have been linked to human disease. Recent crystal structures of yeast Atm1 and human ABCB10 have been key to identifying substrate-binding sites and transport...
Articles
Biochem Soc Trans (2015) 43 (4): 632–638.
Published: 03 August 2015
... (reduction-oxidation) homoeostasis using a previously unrecognized NADPH-independent source of reducing power fuelled by dietary methionine. The NADPH-dependent systems are robustly redundant in liver, such that disruption of either TrxR1 or GR alone does not cause oxidative stress. However, disruption...
Articles
Biochem Soc Trans (2015) 43 (4): 669–673.
Published: 03 August 2015
... observations difficult to account for the Nrf2 protein stabilization hypothesis. antioxidant response element chemoprotection oxidative stress oscillation Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the cellular expression of a battery of protective genes countering oxidative...
Articles
Biochem Soc Trans (2015) 43 (4): 663–668.
Published: 03 August 2015
... be addressed (email mpsoares@igc.gulbenkian.pt ) . 19 2 2015 © 2015 Authors 2015 This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution License 3.0 . disease tolerance infection Nrf2 oxidative stress tissue damage...
Articles
Biochem Soc Trans (2015) 43 (4): 627–631.
Published: 03 August 2015
... in the tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...
Articles
Biochem Soc Trans (2015) 43 (4): 645–649.
Published: 03 August 2015
... will describe the mechanisms leading to increased Nrf2 activity in cancer with a focus on the information achieved from large-scale multi-omics projects across various cancer types. Oxidative stress, an imbalance between the production and disposal of reactive oxygen species (ROS), has an important role...
Articles
Biochem Soc Trans (2014) 42 (4): 989–995.
Published: 11 August 2014
... © The Authors Journal compilation © 2014 Biochemical Society 2014 antioxidant glutathione oxidative stress peroxiredoxin protein oxidation reactive oxygen species Traditional endurance exercise is usually defined as activity that is sustained for between 30 min and 4 h [ 1...
Articles
Biochem Soc Trans (2014) 42 (4): 928–933.
Published: 11 August 2014
..., is rapidly deactivated by superoxide radicals. 1 To whom correspondence should be addressed (email ian.megson@uhi.ac.uk ). 30 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cardiovascular disease diabetes endothelial cell glucose oxidative stress...
Articles
Biochem Soc Trans (2014) 42 (4): 1001–1005.
Published: 11 August 2014
..., during oxidative stress, plasma oxycholesterols could have damaging effects on BBB (blood–brain barrier) function and consequently on neuronal cells. Cholesterol-lowering drugs such as statins may prevent the modifications to LDL in mid-life and might show beneficial effects in later life. The brain...
Articles
Biochem Soc Trans (2014) 42 (4): 1006–1011.
Published: 11 August 2014
... thrombosis and impair fibrinolysis, accelerate the development of atherosclerosis, increase the extent of myocardial ischaemia, and increase susceptibility to myocardial infarction. The pathways underlying these effects are complex and poorly understood; however, particulate-induced oxidative stress...
Articles
Biochem Soc Trans (2014) 42 (4): 917–921.
Published: 11 August 2014
... with the central goal to develop more effective antioxidant strategies and more powerful antimicrobial agents. aging chaperone host defence oxidative stress protein unfolding Living an aerobic lifestyle is treacherous. ROS (reactive oxygen species), including peroxide, superoxide and hydroxyl...
Articles
Biochem Soc Trans (2014) 42 (4): 959–964.
Published: 11 August 2014
... antioxidant autism spectrum disorder mitochondrial disease oxidative stress reactive oxygen species (ROS) redox imaging RTT (Rett syndrome) was initially described in 1966 as an “unusual brain atrophy syndrome” [ 1 , 2 ]. It primarily affects girls with a prevalence of 1:10000–15000...
Articles
Biochem Soc Trans (2014) 42 (2): 593–599.
Published: 20 March 2014
... intolerance in an oral glucose tolerance test, a clear correlation was found between glucose intolerance and the development of AD in people with elevated 2-h post-load glucose levels [ 10 ]. memory neurodegeneration oxidative stress synaptic plasticity © The Authors Journal compilation © 2014...
Articles
Biochem Soc Trans (2014) 42 (2): 433–438.
Published: 20 March 2014
... be proposed as predictive markers and/or therapeutic targets in new strategies for improving reproductive counselling and infertility therapies. advanced glycation end-product (AGE) female fertility oocyte aging ovarian aging oxidative stress polycystic ovarian syndrome (PCOS...
Articles
Biochem Soc Trans (2014) 42 (2): 511–517.
Published: 20 March 2014
... © The Authors Journal compilation © 2014 Biochemical Society 2014 dicarbonyl stress glycation mass spectrometry methylglyoxal 3-nitrotyrosine oxidative stress 8-oxodeoxyguanosine Proteins in physiological systems undergo continual spontaneous modification by glycating agents...
Articles
Biochem Soc Trans (2014) 42 (1): 42–46.
Published: 23 January 2014
...Rachel E. Martin; Zhenbo Cao; Neil J. Bulleid Hydrogen peroxide (H 2 O 2 ) can act as a signalling molecule affecting the cell cycle as well as contributing towards the oxidative stress response. The primary target of this molecule is oxidation-sensitive cysteine residues in proteins...
Articles
Biochem Soc Trans (2013) 41 (6): 1541–1545.
Published: 20 November 2013
...Karen F.S. Bell Neurons are more vulnerable to oxidative stress than astrocytes, the reasons for which have yet to be fully elucidated. Understanding the cellular and molecular mechanisms which contribute to this enhanced vulnerability is key to efforts aimed at ameliorating neuronal health...
Articles
Biochem Soc Trans (2011) 39 (6): 1795–1798.
Published: 21 November 2011
... that they play an important role [ 9 , 10 ]. We have reported previously that lamin B1 is important for cellular response to oxidative stress. Cells lacking a fully functional lamin B1 were found to harbour elevated levels of ROS (reactive oxygen species) and to be more susceptible to oxidative stress...
Articles
Biochem Soc Trans (2011) 39 (5): 1279–1287.
Published: 21 September 2011
... protected against oxidation than intracellular sites in terms of the presence of both antioxidants (low molecular mass and enzymatic) and repair enzymes. The extracellular compartment may therefore be subject to greater oxidative stress, marked alterations in redox balance and an accumulation of damage due...
Articles
Biochem Soc Trans (2011) 39 (5): 1247–1253.
Published: 21 September 2011
... Biochemical Society 2011 cysteine oxidative stress redox signalling S-thiolation thiolstat Among the various intracellular signalling networks operational within the living cell, the ones based on phosphorylation and dephosphorylation may be the best known and understood. Nonetheless, other...
Articles
Biochem Soc Trans (2011) 39 (5): 1299–1304.
Published: 21 September 2011
...James E. Turner; Jos A. Bosch; Sarah Aldred Vigorous exercise is associated with oxidative stress, a state that involves modifications to bodily molecules due to release of pro-oxidant species. Assessment of such modifications provides non-specific measures of oxidative stress in human tissues...
Articles
Biochem Soc Trans (2011) 39 (5): 1305–1309.
Published: 21 September 2011
... correspondence should be addressed (email irina.shabalina@wgi.su.se ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...
Articles
Biochem Soc Trans (2011) 39 (4): 1102–1106.
Published: 20 July 2011
...Marisa Iborra; Inés Moret; Francisco Rausell; Guillermo Bastida; Mariam Aguas; Elena Cerrillo; Pilar Nos; Belén Beltrán There is increasing interest in oxidative stress being a potential aetiological factor and/or a triggering factor in Crohn's disease, rather than a concomitant occurrence during...
Articles
Biochem Soc Trans (2011) 39 (1): 216–218.
Published: 19 January 2011
...) nitrosative stress oxidative stress Synechocystis sp. PCC6803 The FDPs (flavodi-iron proteins), previously named A-type flavoproteins, are a family of soluble and modular enzymes with a two-domain conserved core constituted by a metallo-β-lactamase-like domain, at the N-terminus, linked...
Articles
Biochem Soc Trans (2009) 37 (6): 1147–1160.
Published: 19 November 2009
... the neuroprotective and neurodestructive effects of NMDA receptor activity, as well as the factors that determine whether an episode of NMDA receptor activity is harmful or beneficial. It is becoming apparent that oxidative stress plays a role in promoting neuronal death in response to both hyper- and hypo-activity...
Articles
Biochem Soc Trans (2009) 37 (6): 1385–1388.
Published: 19 November 2009
...David G. Nicholls Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. Mitochondria play a central role in the survival or death of the exposed neuron. Calcium, oxidative stress...
Articles
Biochem Soc Trans (2009) 37 (4): 819–823.
Published: 22 July 2009
... in the lungs, and COPD is also associated with features of accelerated aging in other organs, such as the cardiovascular and musculoskeletal systems. Cigarette smoke and other oxidative stresses result in cellular senescence and accelerate lung aging. There is also evidence that anti-aging molecules...
Articles
Biochem Soc Trans (2008) 36 (6): 1309–1312.
Published: 19 November 2008
...Ilaria Pelizzoni; Romina Macco; Daniele Zacchetti; Fabio Grohovaz; Franca Codazzi Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage...
Articles
Biochem Soc Trans (2008) 36 (6): 1282–1287.
Published: 19 November 2008
... is cleaved in a non-amyloidogenic pathway within its Aβ domain to release the neuroprotective APP ectodomain, APP(s). To adapt and counteract metal-catalysed oxidative stress, as during reperfusion from stroke, iron and cytokines induce the translation of both APP and ferritin (an iron storage protein...
Articles
Biochem Soc Trans (2008) 36 (6): 1322–1328.
Published: 19 November 2008
... dismutase (SOD1) oxidative stress protein aggregation transition metal With an incidence of 1–2 per 100000 individuals per year, ALS (amyotrophic lateral sclerosis) (OMIM #105400), also referred to as Lou Gehrig's disease, is one of the most common motor neurodegenerative disorders...
Articles
Biochem Soc Trans (2008) 36 (6): 1293–1298.
Published: 19 November 2008
... correspondence should be addressed (email d.allsop@lancaster.ac.uk ). 17 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 amyloid hydrogen peroxide metal neurodegeneration oxidative stress reactive oxygen species The formation of extracellular deposits...
Articles
Biochem Soc Trans (2008) 36 (6): 1304–1308.
Published: 19 November 2008
...Robert C. Hider; Yongmin Ma; Francisco Molina-Holgado; Alessandra Gaeta; Sourav Roy Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated...
Articles
Biochem Soc Trans (2008) 36 (5): 1066–1070.
Published: 19 September 2008
... to monitor vitamin E status and its interactions, including the use of stable-isotope-labelled vitamin E and metabonomics, are highlighted. Specifically, stable-isotope studies have been used to monitor vitamin E absorption, hepatic processing and lipoprotein transport. As oxidative stress may influence...
Articles
Biochem Soc Trans (2008) 36 (5): 976–980.
Published: 19 September 2008
...Judy Hirst; Martin S. King; Kenneth R. Pryde ROS (reactive oxygen species) are considered to be a major cause of cellular oxidative stress, linked to neuromuscular diseases and aging. Complex I (NADH:ubiquinone oxidoreductase) is one of the main contributors to superoxide production by mitochondria...
Articles
Biochem Soc Trans (2008) 36 (5): 1037–1044.
Published: 19 September 2008
... proteases to break the protein into smaller peptide pieces, the amino acid residue(s) where the oxidative modification has occurred can be determined. The changes in mass for peptides containing specific modifications are shown in Table 1 . Two models of oxidative stress for PTM analysis by MS...
Articles
Biochem Soc Trans (2008) 36 (5): 1077–1082.
Published: 19 September 2008
... and offers potential for development of novel biomarkers of inflammatory diseases. In the present paper, we review some of the progress that has been made towards this goal. biomarker chlorohydrin chlorotyrosine free radical oxidative stress precursor-ion scanning HOCl is an oxidizing...
Articles
Biochem Soc Trans (2008) 36 (5): 930–934.
Published: 19 September 2008
... are currently envisaged. Among them, lipids and oxidative stress are considered as toxic candidates for the β-cell. The cellular link between fatty acids and ROS (reactive oxygen species) is essentially the mitochondrion, a key organelle for the control of insulin secretion. Mitochondria are the main source...
Articles
Biochem Soc Trans (2008) 36 (5): 1045–1050.
Published: 19 September 2008
... and produce life extension in the nematode Caenorhabditis elegans . This suggests that dicarbonyl glycation damage to the mitochondrial proteome may be a preceding event to mitochondrial dysfunction leading to oxidative stress. Future research will address the functional charges in mitochondrial proteins...
Articles
Biochem Soc Trans (2008) 36 (5): 1060–1065.
Published: 19 September 2008
...Jaffar Nourooz-Zadeh A large body of evidence indicates that measurement of F 2 -isoprostanes, specific prostaglandin F 2 -like compounds derived from the non-enzymatic peroxidation of arachidonic acid, is a reliable biomarker of oxidant stress in the human body. Since the discovery of F 2...
Articles
Biochem Soc Trans (2008) 36 (3): 343–347.
Published: 21 May 2008
..., 30623 Hannover, Germany. 13 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 diabetes free radical oxidative stress pancreatic β-cell death reactive nitrogen species reactive oxygen species The pancreatic β-cell is in an extraordinary situation...
Articles
Biochem Soc Trans (2007) 35 (5): 1232–1235.
Published: 25 October 2007
... the accumulation of high levels of mtDNA mutations and neurodegeneration both in normal aging and in neurodegenerative disease. mitochondrial DNA (mtDNA) mitochondrial DNA mutation mitochondrial dysfunction neurodegenerative disease oxidative stress Parkinson's disease The vast majority...
Articles
Biochem Soc Trans (2007) 35 (5): 1147–1150.
Published: 25 October 2007
...B. Halliwell The terms ‘antioxidant’, ‘oxidative stress’ and ‘oxidative damage’ are widely used but rarely defined. This brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using...
Articles
Biochem Soc Trans (2007) 35 (3): 466–469.
Published: 22 May 2007
... m.castrocabezas@sfg.nl ). © 2007 Biochemical Society 2007 chylomicron complement inflammation leucocyte lipaemia oxidative stress C3/ASP C3/acylation-stimulating protein CAD coronary artery disease CHD coronary heart disease CRP C-reactive protein FCHL familial...
Articles
Biochem Soc Trans (2007) 35 (2): 405–409.
Published: 20 March 2007
... be addressed (email stina.oredsson@cob.lu.se ). 2 10 2006 © 2007 The Biochemical Society 2007 apoptosis breast cancer cell cycle neuroblastoma oxidative stress polyamine analogue Tables 1 and 2 show the polyamine pools in a normal-like breast epithelial (MCF-10A), breast...
Articles
Biochem Soc Trans (2007) 35 (2): 284–287.
Published: 20 March 2007
...P. Kirkham The suppression of pro-inflammatory gene expression along with the clearance of apoptotic cells by phagocytosis can play an important role in resolving the inflammatory response. Any impairment of these processes can therefore lead to a chronic inflammatory state. Oxidative stress can...
Articles
Biochem Soc Trans (2006) 34 (5): 806–810.
Published: 25 October 2006
... are impaired. 24 7 2006 © 2006 The Biochemical Society 2006 β-cell glucose metabolism nicotinamide nucleotide transhydrogenase (Nnt) oxidative stress reactive oxygen species Type 2 diabetes 1 To whom correspondence should be addressed (email frances.ashcroft@physiol.ox.ac.uk...
Articles
Biochem Soc Trans (2006) 34 (5): 824–827.
Published: 25 October 2006
... are known to be the main source and target of ROS and the imbalance between excessive formation of ROS and limited antioxidant defences leads to oxidative stress [ 32 ]. β-Cells are particularly susceptible to oxidative stress [ 33 ] due to the weak expression of natural enzymatic defences, e.g. catalase...