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Keywords: oxidative stress
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1377–1385.
Published: 30 May 2023
...Yeping Wu; Ye-Wheen Lim; Robert G. Parton Oxidative stress is a feature of many disease conditions. Oxidative stress can activate a number of cellular pathways leading to cell death, including a distinct iron-dependent pathway involving lipid peroxidation, termed ferroptosis, but cells have evolved...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (3): 1169–1177.
Published: 04 May 2023
...Kathrin Ulrich Proteostasis and redox homeostasis are tightly interconnected and most protein quality control pathways are under direct redox regulation which allow cells to immediately respond to oxidative stress conditions. The activation of ATP-independent chaperones serves as a first line...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (6): 1737–1751.
Published: 16 November 2022
... of the late sodium current (INaL), which impairs the action potential waveform and can cause severe cardiac arrhythmias. Moreover, long-term, low-dose exposure to PY displays oxidative stress in the heart, which could induce tissue remodeling and impairment. Isolated and preliminary evidence supports...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (5): 2189–2198.
Published: 19 October 2021
... reprogramming oxidative stress In 1836, Samuel Baup discovered an unknown product following the thermal decomposition of citric acid [ 1 ]. Four years later, Gustav Crasso synthesised the same compound by decarboxylation of cis -aconitate naming it itaconate — an anagram of aconitate [ 2 ]. Remarked...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (6): 1295–1303.
Published: 17 November 2017
... and oxidative stress are implicated in many disorders. That these pathological processes can influence each other both up- and downstream makes for a complicated picture, but means that successfully targeting one area may have an effect on others. This targeting requires an understanding of the mechanisms...
Articles
Theresia A. Schaedler, Belinda Faust, Chitra A. Shintre, Elisabeth P. Carpenter, Vasundara Srinivasan, Hendrik W. van Veen, Janneke Balk
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 943–951.
Published: 09 October 2015
... of the mitochondria, whereas ABCB10 is involved in haem biosynthesis. They also play a role in preventing oxidative stress. Mutations in ABCB6 and ABCB7 have been linked to human disease. Recent crystal structures of yeast Atm1 and human ABCB10 have been key to identifying substrate-binding sites and transport...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 663–668.
Published: 03 August 2015
... be addressed (email mpsoares@igc.gulbenkian.pt ) . 19 2 2015 © 2015 Authors 2015 This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution License 3.0 . disease tolerance infection Nrf2 oxidative stress tissue damage...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 627–631.
Published: 03 August 2015
... in the tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 645–649.
Published: 03 August 2015
... Authors; published by Portland Press Limited 2015 cancer genome Kelch-like ECH-associated protein 1 (Keap1) nuclear factor E2-related factor 2 (Nrf2) oxidative stress The Cancer Genome Atlas (TCGA) Oxidative stress, an imbalance between the production and disposal of reactive oxygen...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 669–673.
Published: 03 August 2015
... chemoprotection oxidative stress oscillation Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the cellular expression of a battery of protective genes countering oxidative stress, toxic substances, lipid peroxidation, inflammation, metabolic dysfunction and aging [ 1 – 3 ]. It senses...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 632–638.
Published: 03 August 2015
... (reduction-oxidation) homoeostasis using a previously unrecognized NADPH-independent source of reducing power fuelled by dietary methionine. The NADPH-dependent systems are robustly redundant in liver, such that disruption of either TrxR1 or GR alone does not cause oxidative stress. However, disruption...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 928–933.
Published: 11 August 2014
..., is rapidly deactivated by superoxide radicals. 1 To whom correspondence should be addressed (email ian.megson@uhi.ac.uk ). 30 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cardiovascular disease diabetes endothelial cell glucose oxidative stress...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 989–995.
Published: 11 August 2014
... © The Authors Journal compilation © 2014 Biochemical Society 2014 antioxidant glutathione oxidative stress peroxiredoxin protein oxidation reactive oxygen species Traditional endurance exercise is usually defined as activity that is sustained for between 30 min and 4 h [ 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1001–1005.
Published: 11 August 2014
..., during oxidative stress, plasma oxycholesterols could have damaging effects on BBB (blood–brain barrier) function and consequently on neuronal cells. Cholesterol-lowering drugs such as statins may prevent the modifications to LDL in mid-life and might show beneficial effects in later life. 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1006–1011.
Published: 11 August 2014
... thrombosis and impair fibrinolysis, accelerate the development of atherosclerosis, increase the extent of myocardial ischaemia, and increase susceptibility to myocardial infarction. The pathways underlying these effects are complex and poorly understood; however, particulate-induced oxidative stress...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 959–964.
Published: 11 August 2014
... the associated cellular redox imbalance. 1 To whom correspondence should be addressed (email mmuelle7@gwdg.de ). 26 3 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 antioxidant autism spectrum disorder mitochondrial disease oxidative stress reactive...
Articles
Daniela Knoefler, Lars I.O. Leichert, Maike Thamsen, Claudia M. Cremers, Dana Reichmann, Michael J. Gray, Wei-Yun Wholey, Ursula Jakob
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 917–921.
Published: 11 August 2014
... To whom correspondence should be addressed (email ujakob@umich.edu ). 25 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 aging chaperone host defence oxidative stress protein unfolding Living an aerobic lifestyle is treacherous. ROS (reactive oxygen...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 433–438.
Published: 20 March 2014
... Society 2014 advanced glycation end-product (AGE) female fertility oocyte aging ovarian aging oxidative stress polycystic ovarian syndrome (PCOS) Although reproductive success is related to positive outcome of intrauterine fetal growth, it begins in the ovary with the production...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 593–599.
Published: 20 March 2014
... oxidative stress synaptic plasticity The majority of AD (Alzheimer's disease) and PD (Parkinson's disease) cases are ‘sporadic’, which means that there is no clear genetic pathway that causes the onset of the disease. This makes it more difficult to identify which factors trigger...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 511–517.
Published: 20 March 2014
... glycation, oxidation and nitration and DNA glycation and oxidation represent imperfections of physiological systems, and these processes increase in hyperglycaemia and metabolic stress conditions, e.g. dicarbonyl stress, oxidative stress and nitrosative stress. These abnormal metabolic states are widely...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (1): 42–46.
Published: 23 January 2014
...Rachel E. Martin; Zhenbo Cao; Neil J. Bulleid Hydrogen peroxide (H 2 O 2 ) can act as a signalling molecule affecting the cell cycle as well as contributing towards the oxidative stress response. The primary target of this molecule is oxidation-sensitive cysteine residues in proteins...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1541–1545.
Published: 20 November 2013
...Karen F.S. Bell Neurons are more vulnerable to oxidative stress than astrocytes, the reasons for which have yet to be fully elucidated. Understanding the cellular and molecular mechanisms which contribute to this enhanced vulnerability is key to efforts aimed at ameliorating neuronal health...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (6): 1795–1798.
Published: 21 November 2011
... Journal compilation © 2011 Biochemical Society 2011 cellular stress DNA damage heat shock nuclear envelope oxidative stress The NE (nuclear envelope) is a structure composed of the outer and inner nuclear membranes, an inter-membrane space bridged by protein complexes, and an underlying...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1247–1253.
Published: 21 September 2011
... Biochemical Society 2011 cysteine oxidative stress redox signalling S-thiolation thiolstat Among the various intracellular signalling networks operational within the living cell, the ones based on phosphorylation and dephosphorylation may be the best known and understood. Nonetheless, other...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1279–1287.
Published: 21 September 2011
... protected against oxidation than intracellular sites in terms of the presence of both antioxidants (low molecular mass and enzymatic) and repair enzymes. The extracellular compartment may therefore be subject to greater oxidative stress, marked alterations in redox balance and an accumulation of damage due...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1299–1304.
Published: 21 September 2011
...James E. Turner; Jos A. Bosch; Sarah Aldred Vigorous exercise is associated with oxidative stress, a state that involves modifications to bodily molecules due to release of pro-oxidant species. Assessment of such modifications provides non-specific measures of oxidative stress in human tissues...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1305–1309.
Published: 21 September 2011
... correspondence should be addressed (email irina.shabalina@wgi.su.se ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...
Articles
Marisa Iborra, Inés Moret, Francisco Rausell, Guillermo Bastida, Mariam Aguas, Elena Cerrillo, Pilar Nos, Belén Beltrán
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 1102–1106.
Published: 20 July 2011
...Marisa Iborra; Inés Moret; Francisco Rausell; Guillermo Bastida; Mariam Aguas; Elena Cerrillo; Pilar Nos; Belén Beltrán There is increasing interest in oxidative stress being a potential aetiological factor and/or a triggering factor in Crohn's disease, rather than a concomitant occurrence during...
Articles
Gene expression study of the flavodi-iron proteins from the cyanobacterium Synechocystis sp. PCC6803
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 216–218.
Published: 19 January 2011
...) nitrosative stress oxidative stress Synechocystis sp. PCC6803 The FDPs (flavodi-iron proteins), previously named A-type flavoproteins, are a family of soluble and modular enzymes with a two-domain conserved core constituted by a metallo-β-lactamase-like domain, at the N-terminus, linked...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1147–1160.
Published: 19 November 2009
... the neuroprotective and neurodestructive effects of NMDA receptor activity, as well as the factors that determine whether an episode of NMDA receptor activity is harmful or beneficial. It is becoming apparent that oxidative stress plays a role in promoting neuronal death in response to both hyper- and hypo-activity...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1385–1388.
Published: 19 November 2009
...David G. Nicholls Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. Mitochondria play a central role in the survival or death of the exposed neuron. Calcium, oxidative stress...
Articles
Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD)
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (4): 819–823.
Published: 22 July 2009
... in the lungs, and COPD is also associated with features of accelerated aging in other organs, such as the cardiovascular and musculoskeletal systems. Cigarette smoke and other oxidative stresses result in cellular senescence and accelerate lung aging. There is also evidence that anti-aging molecules...
Articles
Jack T. Rogers, Ashley I. Bush, Hyan-Hee Cho, Deborah H. Smith, Andrew M. Thomson, Avi L. Friedlich, Debomoy K. Lahiri, Peter J. Leedman, Xudong Huang, Catherine M. Cahill
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1282–1287.
Published: 19 November 2008
... is cleaved in a non-amyloidogenic pathway within its Aβ domain to release the neuroprotective APP ectodomain, APP(s). To adapt and counteract metal-catalysed oxidative stress, as during reperfusion from stroke, iron and cytokines induce the translation of both APP and ferritin (an iron storage protein...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1322–1328.
Published: 19 November 2008
... dismutase (SOD1) oxidative stress protein aggregation transition metal With an incidence of 1–2 per 100000 individuals per year, ALS (amyotrophic lateral sclerosis) (OMIM #105400), also referred to as Lou Gehrig's disease, is one of the most common motor neurodegenerative disorders...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1309–1312.
Published: 19 November 2008
...Ilaria Pelizzoni; Romina Macco; Daniele Zacchetti; Fabio Grohovaz; Franca Codazzi Iron and calcium are required for general cellular functions, as well as for specific neuronal-related activities. However, a pathological increase in their levels favours oxidative stress and mitochondrial damage...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1304–1308.
Published: 19 November 2008
...Robert C. Hider; Yongmin Ma; Francisco Molina-Holgado; Alessandra Gaeta; Sourav Roy Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (6): 1293–1298.
Published: 19 November 2008
... correspondence should be addressed (email d.allsop@lancaster.ac.uk ). 17 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 amyloid hydrogen peroxide metal neurodegeneration oxidative stress reactive oxygen species The formation of extracellular deposits...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1060–1065.
Published: 19 September 2008
...Jaffar Nourooz-Zadeh A large body of evidence indicates that measurement of F 2 -isoprostanes, specific prostaglandin F 2 -like compounds derived from the non-enzymatic peroxidation of arachidonic acid, is a reliable biomarker of oxidant stress in the human body. Since the discovery of F 2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1066–1070.
Published: 19 September 2008
... to monitor vitamin E status and its interactions, including the use of stable-isotope-labelled vitamin E and metabonomics, are highlighted. Specifically, stable-isotope studies have been used to monitor vitamin E absorption, hepatic processing and lipoprotein transport. As oxidative stress may influence...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 930–934.
Published: 19 September 2008
... are currently envisaged. Among them, lipids and oxidative stress are considered as toxic candidates for the β-cell. The cellular link between fatty acids and ROS (reactive oxygen species) is essentially the mitochondrion, a key organelle for the control of insulin secretion. Mitochondria are the main source...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 976–980.
Published: 19 September 2008
...Judy Hirst; Martin S. King; Kenneth R. Pryde ROS (reactive oxygen species) are considered to be a major cause of cellular oxidative stress, linked to neuromuscular diseases and aging. Complex I (NADH:ubiquinone oxidoreductase) is one of the main contributors to superoxide production by mitochondria...
Articles
Stephen Barnes, Erin M. Shonsey, Shannon M. Eliuk, David Stella, Kerri Barrett, Om P. Srivastava, Helen Kim, Matthew B. Renfrow
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1037–1044.
Published: 19 September 2008
... Society 2008 high-resolution mass spectrometry 4-hydroxynonenal (4HNE) lipoprotein oxidative stress post-translational modification protein oxidation PTMs (post-translational modifications) of proteins occur extensively throughout their lifetime in a cell. For certain proteins, rather...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1077–1082.
Published: 19 September 2008
... compilation © 2008 Biochemical Society 2008 biomarker chlorohydrin chlorotyrosine free radical oxidative stress precursor-ion scanning HOCl is an oxidizing and chlorinating compound that can be generated by activated phagocytes as an antimicrobial agent. The enzyme responsible is MPO...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1045–1050.
Published: 19 September 2008
... and produce life extension in the nematode Caenorhabditis elegans . This suggests that dicarbonyl glycation damage to the mitochondrial proteome may be a preceding event to mitochondrial dysfunction leading to oxidative stress. Future research will address the functional charges in mitochondrial proteins...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 343–347.
Published: 21 May 2008
..., 30623 Hannover, Germany. 13 11 2007 © The Authors Journal compilation © 2008 Biochemical Society 2008 diabetes free radical oxidative stress pancreatic β-cell death reactive nitrogen species reactive oxygen species The pancreatic β-cell is in an extraordinary situation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1147–1150.
Published: 25 October 2007
...B. Halliwell The terms ‘antioxidant’, ‘oxidative stress’ and ‘oxidative damage’ are widely used but rarely defined. This brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1232–1235.
Published: 25 October 2007
... compilation © 2007 Biochemical Society 2007 mitochondrial DNA (mtDNA) mitochondrial DNA mutation mitochondrial dysfunction neurodegenerative disease oxidative stress Parkinson's disease The vast majority of a cell's energy is produced by mitochondria in a process of OXPHOS (oxidative...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (3): 466–469.
Published: 22 May 2007
... TAG and glucose rise, neutrophil counts increase, with concomitant production of pro-inflammatory cytokines and oxidative stress, and that these changes may contribute to endothelial dysfunction [ 31 , 32 ]. Furthermore, TAG and glucose are able to induce leucocyte activation, as has been shown...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 405–409.
Published: 20 March 2007
... be addressed (email stina.oredsson@cob.lu.se ). 2 10 2006 © 2007 The Biochemical Society 2007 apoptosis breast cancer cell cycle neuroblastoma oxidative stress polyamine analogue Another observation is the DENSPM-induced lengthening of the S-phase observed in all cell lines...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 284–287.
Published: 20 March 2007
...P. Kirkham The suppression of pro-inflammatory gene expression along with the clearance of apoptotic cells by phagocytosis can play an important role in resolving the inflammatory response. Any impairment of these processes can therefore lead to a chronic inflammatory state. Oxidative stress can...
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