... regulates cathepsin L, eventually leading to degradation of several DNA damage repair proteins, hence impairing DNA damage repair pathways and increasing genomic instability. It is established in ovarian cancer, that the extent of alteration in nuclear morphology can determine the degree of genetic changes...

...Emanuela Carollo; Bianca Paris; Priya Samuel; Paschalia Pantazi; Thais Fernanda Bartelli; Emmanuel Dias-Neto; Susan Ann Brooks; Ryan Charles Pink; David Raul Francisco Carter Ovarian cancer (OC) is the deadliest gynecological malignancy. Most patients are diagnosed when they are already...

... to these references for a thorough consideration of these mechanisms which are beyond the scope this article. Correspondence: J. Paul Chapple ( j.p.chapple@qmul.ac.uk ) 2 6 2016 22 7 2016 17 8 2016 breast cancers cilia endocrine cancer ovarian cancer prostate cancer Von Hippel...

...Elizabeth Robinson; Natalie Fisher; Vasileios Stamelos; Charles Redman; Alan Richardson Ovarian cancer usually responds well to chemotherapy, but once the disease becomes resistant to chemotherapy, the treatment options available are inadequate. A number of strategies are currently undergoing...