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Biochem Soc Trans (2021) 49 (2): 747–759.
Published: 30 April 2021
... molecules and phlebotomy. An early diagnostic can be decisive to limit the progression of musculoskeletal complications like osteoarthritis and osteoporosis because of iron toxicity. In iron-related osteoarthritis, aggravation can be associated to a few events that can contribute to joints articular...
Biochem Soc Trans (2021) 49 (2): 1013–1026.
Published: 12 April 2021
... also been shown to drive pathological mechanisms in many common diseases. Osteoarthritis is a degenerative joint disorder, characterised by the progressive destruction of articular cartilage. This breakdown of the cartilage is driven by the metalloproteinases, and it has long been established...
Biochem Soc Trans (2020) 48 (4): 1433–1445.
Published: 14 August 2020
...Mark Lemoine; Sarah M. Casey; John M. O'Byrne; Daniel J. Kelly; Fergal J. O'Brien Due to the limited regenerative capacity of cartilage, untreated joint defects can advance to more extensive degenerative conditions such as osteoarthritis. While some biomaterial-based tissue-engineered scaffolds...
Biochem Soc Trans (2014) 42 (2): 538–542.
Published: 20 March 2014
...Usman Ahmed; Paul J. Thornalley; Naila Rabbani OA (osteoarthritis) and RA (rheumatoid arthritis) lead to deterioration of the joints. Early OA is associated with loss of bone due to increased bone remodelling. A role for inflammation is thought to be integral to the pathology. RA is a chronic...
Biochem Soc Trans (2010) 38 (6): 1627–1631.
Published: 24 November 2010
... genetic models. This level of cellular regulation represents an as yet unexplored area of potential intervention for the treatment of degenerative cartilage disorders such as osteoarthritis. 1 To whom correspondence should be addressed (email firstname.lastname@example.org ). 9 6 2010...
Biochem Soc Trans (2007) 35 (4): 669–671.
Published: 20 July 2007
.... There is increasing evidence that HtrA1 regulates several pathological processes, including tumour development, Alzheimer's disease, age-related macular degeneration and osteoarthritis, although the mechanism(s) by which it regulates these processes have not been fully elucidated. Using overexpression and knock-down...
Biochem Soc Trans (2002) 30 (6): 886–889.
Published: 01 November 2002
...S. J. Gilbert; V. C. Duance; D. J. Mason Our previous analysis of the genes regulated in cartilage at the onset of spontaneous osteoarthritis in the guinea pig knee revealed up-regulation of the gene for protein kinase R (PKR)-activating protein (PACT), which encodes the cellular activator...