...Jan Ewald; Martin Bartl; Christoph Kaleta Understanding optimality principles shaping the evolution of regulatory networks controlling metabolism is crucial for deriving a holistic picture of how metabolism is integrated into key cellular processes such as growth, adaptation and pathogenicity...

... to vascular endothelial growth factor (VEGF) using optimality principles based on Murray's laws [ 37 ]. However, the secretion of VEGF is up-regulated by the Wnt signalling pathway and is highly dependent on the average oxygen level in the tissue [ 38 , 39 ]. Although the intra-tissue level of metabolites...