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Keywords: oncogenes
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Biochem Soc Trans (2022) 50 (6): 1911–1920.
Published: 10 November 2022
.... They often contain enhancers and driver oncogenes that are highly expressed. The circular ecDNA topology leads to an open chromatin conformation and generates new gene regulatory interactions, including with distal enhancers. The absence of centromeres leads to random distribution of ecDNAs during cell...