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Dinuka M. De Silva, Arpita Roy, Takashi Kato, Fabiola Cecchi, Young H. Lee, Kunio Matsumoto, Donald P. Bottaro
Biochem Soc Trans (2017) 45 (4): 855–870.
Published: 03 July 2017
... information, analytical reagents and model systems available regarding normal and oncogenic HGF/Met signaling will continue to be invaluable in meeting these challenges and moving expeditiously toward more effective cancer treatment. The human HGF gene consists of 18 exons and 16 introns spanning 68 Mb...
Biochem Soc Trans (2016) 44 (3): 925–931.
Published: 09 June 2016
..., and the impact on the pathways in which that protein is involved. In this paper we examine the mutation patterns observed in oncogenes and tumour suppressors, and discuss different approaches that have been developed to identify driver mutations within cancers that contribute to the disease progress. We also...
Includes: Supplementary data
Biochem Soc Trans (2013) 41 (4): 1029–1036.
Published: 18 July 2013
... © The Authors Journal compilation © 2013 Biochemical Society 2013 ErbB3 oncogene pseudokinase Ror2 receptor tyrosine kinase RTKs (receptor tyrosine kinases) are key regulators of critical cellular processes, such as proliferation and differentiation, cell survival and metabolism...
Biochem Soc Trans (2012) 40 (1): 251–256.
Published: 19 January 2012
... of tumour cell invasion and migration. Several oncogenes can stimulate ERK5 activity, and protein levels are increased by a novel amplification at chromosome locus 17p11 and by down-regulation of the microRNAs miR-143 and miR-145 . Together, these finding underscore the case for further investigation...
Biochem Soc Trans (2008) 36 (4): 599–602.
Published: 22 July 2008
...Lezanne Ooi; Ian C. Wood Many human diseases are the result of inappropriate changes in gene expression resulting in deleterious phenotypes of specific cells. For example, loss of expression of tumour suppressors and/or ectopic expression of oncogenes underlie many cancers, a switch from an adult...
Biochem Soc Trans (2008) 36 (4): 629–631.
Published: 22 July 2008
... in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult...
Biochem Soc Trans (2005) 33 (2): 343–345.
Published: 01 April 2005
... of phosphatases is the usual method of terminating such signalling. glycogen inhibitor insulin kinase oncogene phosphatase The other major abnormality is the failure of muscle to produce sufficient glycogen. This reaction requires glucokinase, and GS (glycogen synthase). Conversion back...