... cleavage Creutzfeldt–Jakob disease octapeptide repeat prion processing reactive oxygen species (ROS) ADAM a disintegrin and metalloproteinase CDP chronic demyelinating polyneuropathy CJD Creutzfeldt–Jakob disease OR octapeptide repeat PrP prion protein PrP C...

... [ 12 ]. These protective responses to ROS are not observed in the cells expressing PrPΔoct, which fails to undergo β-cleavage, or in cells expressing wtPrP, where β-cleavage is blocked by the binding of antibody SAF32 to the octapeptide repeats [ 12 ]. The observation that ROS-mediated β-cleavage...