..., the stage in mRNA translation that consumes almost all the energy and amino acids consumed by protein synthesis. In addition to activation by Ca/CaM, eEF2K is also regulated by an array of other regulatory inputs, which include inhibition by the nutrient- and growth-factor activated signalling pathways...

... to nutrient signalling, thus coupling environmental stimuli to secretory capacity. 1 To whom correspondence should be addressed (email c.rabouille@hubrecht.eu ) . 10 11 2014 After synthesis in the ER, newly synthesized cargo leave the ER at dedicated sites called ER exit sites (ERESs...

...Alejo Efeyan; David M. Sabatini Growth factors and nutrients regulate the mTORC1 [mammalian (or mechanistic) target of rapamycin complex 1] by different mechanisms. The players that link growth factors and mTORC1 activation have been known for several years and mouse models have validated its...