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Keywords: nucleotide-binding domain
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Biochem Soc Trans (2005) 33 (5): 1003–1007.
Published: 26 October 2005
... and closing of its anion-selective pore are linked to ATP binding and hydrolysis at CFTR's two NBDs (nucleotide-binding domains), NBD1 and NBD2. Isolated NBDs of prokaryotic ABC proteins form homodimers upon binding ATP, but separate after hydrolysis of the ATP. By combining mutagenesis with single-channel...
Biochem Soc Trans (2002) 30 (2): 323–327.
Published: 01 April 2002
... to the N-terminus of Kir6.2; (ii) the two nucleotide binding domains (NBDs) of SUR1 -NBD1 and NBD2 - are in proximity; (iii) transmembrane helix 12 of SUR1 is orientated in such a way that it can make contact with Kir6.2; (iv) formation of the glibenclamide binding site requires that the two cytosolic...