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Keywords: nucleosome
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Articles
Biochem Soc Trans (2014) 42 (5): 1409–1413.
Published: 18 September 2014
...Michela Borghesan; Gianluigi Mazzoccoli; Fareeba Sheedfar; Jude Oben; Valerio Pazienza; Manlio Vinciguerra Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief...
Articles
Biochem Soc Trans (2012) 40 (2): 347–350.
Published: 21 March 2012
...Timothy J. Richmond Nucleosomes are actively positioned along DNA by ATP-dependent, chromatin remodelling factors. A structural model for the ISW1a chromatin remodelling factor from Saccharomyces cerevisiae in complex with a dinucleosome substrate was constructed from the X-ray structures of ISW1a...
Articles
Biochem Soc Trans (2012) 40 (2): 351–356.
Published: 21 March 2012
...Song Tan The nucleosome repeating unit of chromatin is the target of chromatin enzymes and factors that regulate gene activity in a eukaryotic cell. How the nucleosome is recognized by chromatin enzymes and factors is poorly understood, even though such interaction is fundamental to gene regulation...
Articles
Biochem Soc Trans (2012) 40 (2): 370–376.
Published: 21 March 2012
... are histones. Histones are highly abundant and basic proteins that interact with DNA to form the basic unit of chromatin, the nucleosome [ 4 ]. The nucleosome consists of an octamer containing two copies each of the four core histones, H2A, H2B, H3 and H4, along with ~146 bp of DNA packaged around the histone...
Articles
Biochem Soc Trans (2012) 40 (2): 335–340.
Published: 21 March 2012
...-specified positioning of nucleosomes and the determination of NDRs (nucleosome-depleted regions) or barriers. We argue that, in budding yeast, while DNA sequence-specified nucleosome positioning may contribute to positions flanking the regions lacking nucleosomes, DNA thermodynamic stability is a major...
Articles
Biochem Soc Trans (2012) 40 (2): 357–363.
Published: 21 March 2012
...Wallace H. Liu; Mair E.A. Churchill The eukaryotic processes of nucleosome assembly and disassembly govern chromatin dynamics, in which histones exchange in a highly regulated manner to promote genome accessibility for all DNA-dependent processes. This regulation is partly carried out by histone...
Articles
Biochem Soc Trans (2010) 38 (5): 1251–1256.
Published: 24 September 2010
... compilation © 2010 Biochemical Society 2010 coupling histone modification nucleosome RNA polymerase small nuclear ribonucleoprotein particle (snRNP) spliceosome When protein encoding transcripts are produced by RNAPII (RNA polymerase II), they are subject to processing at their 5′-ends...
Articles
Biochem Soc Trans (2009) 37 (4): 756–761.
Published: 22 July 2009
... rates and amino acid choice. Exploring the role of selection at the DNA and RNA level, we specifically address how the need (i) to specify exonic splice enhancer motifs in pre-mRNA, and (ii) to ensure nucleosome positioning on DNA have an impact on amino acid choice and rates of evolution. For both, we...
Articles
Biochem Soc Trans (2008) 36 (4): 619–624.
Published: 22 July 2008
... in this area. 1 To whom correspondence should be addressed (email j.zomerdijk@dundee.ac.uk ). 13 5 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 chromatin chromatin remodelling nucleosome ribosomal DNA (rDNA) rRNA gene RNA polymerase I transcription...
Articles
Biochem Soc Trans (2008) 36 (4): 732–737.
Published: 22 July 2008
... Biochemical Society 2008 architectural protein DNA histone micromanipulation nucleosome Organisms in all three domains of life are faced with the challenging task of organizing and compacting their genome to reduce its effective volume below that of the cell, in the case of bacteria...
Articles
Biochem Soc Trans (2003) 31 (5): 893–905.
Published: 01 October 2003
... of many nuclear processes. Recently, significant progress has been made in defining the alterations to chromatin structure that these enzymes generate. The ability to alter nucleosome positioning may be a common feature of all ATP-dependent remodelling enzymes, but the spectrum of positions to which...
Articles
Biochem Soc Trans (2000) 28 (4): 405–410.
Published: 01 August 2000
...G. L. Hager; T. M. Fletcher; N. Xiao; C. T. Baumann; W. G. Müller; J. G. McNally Activation of the murine-mammary-tumour virus (MMTV) promoter by the glucocorticoid receptor (GR) is associated with a chromatin structural transition in the B nucleosome region of the viral long terminal repeat (LTR...