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Keywords: nuclear lamina
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Biochem Soc Trans (2022) 50 (2): 1035–1044.
Published: 19 April 2022
...Ezequiel Nazer Lamins are components of the nuclear lamina, a protein meshwork that underlies the nuclear membrane. Lamins interact with chromatin in transcriptionally silent regions defined as lamina-associated-domains (LADs). However, recent studies have shown that lamins regulate active...
Biochem Soc Trans (2011) 39 (6): 1780–1785.
Published: 21 November 2011
... review, we discuss the importance of the nuclear lamina in the spatial organization of nuclear signalling events, including the DNA-damage response. In particular, we focus on the evidence suggesting that prelamin A accumulation interferes with nuclear spatial compartmentalization by disrupting chromatin...
Biochem Soc Trans (2011) 39 (6): 1758–1763.
Published: 21 November 2011
...Jose M. González; Vicente Andrés The mammalian NE (nuclear envelope), which separates the nucleus from the cytoplasm, is a complex structure composed of nuclear pore complexes, the outer and inner nuclear membranes, the perinuclear space and the nuclear lamina (A- and B-type lamins). The NE...