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Articles

Regulation of neovascularization by S-glutathionylation via the Wnt5a/sFlt-1 pathway

Colin E. Murdoch, Markus M. Bachschmid, Reiko Matsui

Biochem Soc Trans (2014) 42 (6): 1665–1670.

DOI: https://doi.org/10.1042/BST20140213

Published: 17 November 2014

... signalling function to proteins with redox-sensitive thiols. Glrx can regulate vascular hypertrophy and inflammation by regulating the activity of nuclear factor κB (NF-κB) and actin polymerization. Vascular endothelial growth factor (VEGF)-induced endothelial cell (EC) migration is inhibited by Glrx...

View article titled, Regulation of neovascularization by S-glutathionylation via the Wnt5a/sFlt-1 pathway

Articles

NF-κB and the cell cycle

Adeline C. Ledoux, Neil D. Perkins

Biochem Soc Trans (2014) 42 (1): 76–81.

DOI: https://doi.org/10.1042/BST20130156

Published: 23 January 2014

...@ncl.ac.uk ). 17 7 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cancer cell cycle cyclin D1 mitosis nuclear factor κB (NF-κB) p53 NF-κB (nuclear factor κB) consists of the homo- and hetero-dimers formed from a family of five transcription factors...

View article titled, NF-κB and the cell cycle

Articles

The impact of hypoxia on cell death pathways

Colin R. Lenihan, Cormac T. Taylor

Biochem Soc Trans (2013) 41 (2): 657–663.

DOI: https://doi.org/10.1042/BST20120345

Published: 21 March 2013

... of hypoxia and the regulation of cell death pathways. 1 To whom correspondence should be addressed (email cormac.taylor@ucd.ie ). 22 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 apoptosis B-cell lymphoma (Bcl) hypoxia nuclear factor κB (NF-κB...

View article titled, The impact of hypoxia on cell death pathways

Articles

Genetic relationships between A20/TNFAIP3 , chronic inflammation and autoimmune disease

Lars Vereecke, Rudi Beyaert, Geert van Loo

Biochem Soc Trans (2011) 39 (4): 1086–1091.

DOI: https://doi.org/10.1042/BST0391086

Published: 20 July 2011

... of A20 defects in disease pathogenesis and summarizes the identified A20 polymorphisms associated with different immunopathologies. A20 autoimmunity B-cell inflammatory bowel disease (IBD) nuclear factor κB (NF-κB) tumour necrosis factor α-induced protein 3 (TNFAIP3) Persistent NF-κB...

View article titled, Genetic relationships between A20/TNFAIP3 , chronic inflammation and autoimmune disease

Articles

Spatial and temporal information coding and noise in the NF-κB system

Marco Marcello, Michael R.H. White

Biochem Soc Trans (2010) 38 (5): 1247–1250.

DOI: https://doi.org/10.1042/BST0381247

Published: 24 September 2010

... Journal compilation © 2010 Biochemical Society 2010 gene expression regulation inflammatory response nuclear factor κB (NF-κB) oscillation phosphorylation single-cell imaging The NF-κB pathway has many factors that together influence its activity. Since its characterization...

View article titled, Spatial and temporal information coding and noise in the NF-κB system

Articles

Antiviral activity of resveratrol

Michela Campagna, Carmen Rivas

Biochem Soc Trans (2010) 38 (1): 50–53.

DOI: https://doi.org/10.1042/BST0380050

Published: 19 January 2010

... crivas@cnb.csic.es ). 26 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 antiviral activity nuclear factor κB (NF-κB) p53 resveratrol virus Resveratrol (3,4′,5-trihydroxy- trans -stilbene) is a phenolic compound produced by various members...

View article titled, Antiviral activity of resveratrol

Articles

Regulation of cyclin D1 gene expression

Ini-Isabée Witzel, Li Fang Koh, Neil D. Perkins

Biochem Soc Trans (2010) 38 (1): 217–222.

DOI: https://doi.org/10.1042/BST0380217

Published: 19 January 2010

... contributed equally to this work. 2 To whom correspondence should be addressed (email n.d.perkins@bristol.ac.uk ). 17 7 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 cyclin D1 nuclear factor κB (NF-κB) RNA processing Smad nuclear interacting protein 1...

View article titled, Regulation of cyclin D1 gene expression

Articles

Regulation of the RelA (p65) transactivation domain

John M. O'shea, Neil D. Perkins

Biochem Soc Trans (2008) 36 (4): 603–608.

DOI: https://doi.org/10.1042/BST0360603

Published: 22 July 2008

... proteins. Moreover, we discuss how analysis of its evolutionary conservation reveals distinct subdomains and conserved residues that might give insights into its regulation and function. co-activator co-repressor nuclear factor κB (NF-κB) p65 RelA transactivation NF-κB (nuclear factor κB...

View article titled, Regulation of the RelA (p65) transactivation domain

Includes: Supplementary data

Articles

Role of NF-κB in β-cell death

Danielle Melloul

Biochem Soc Trans (2008) 36 (3): 334–339.

DOI: https://doi.org/10.1042/BST0360334

Published: 21 May 2008

... IL-1β- and IFN-γ-induced apoptosis, the activation of NF-κB and NO production [ 47 ]. apoptosis β-cell cytokine islet graft rejection nuclear factor κB (NF-κB) Type 1 diabetes Type 1 and Type 2 are the two main forms of diabetes mellitus. T1DM (Type 1 diabetes mellitus...

View article titled, Role of NF-κB in β-cell death

Articles

Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2

Andrew G. Bowie

Biochem Soc Trans (2008) 36 (3): 449–452.

DOI: https://doi.org/10.1042/BST0360449

Published: 21 May 2008

... Biochemical Society 2008 intracellular signalling interleukin-1-receptor-associated kinase (IRAK) nuclear factor κB (NF-κB) Toll-like receptor tumour-necrosis-factor-receptor-associated factor-6 (TRAF-6) vaccinia virus The question of how the immune system initially detects the presence...

View article titled, Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2

Articles

A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins

K. Kersse, T. Vanden Berghe, M. Lamkanfi, P. Vandenabeele

Biochem Soc Trans (2007) 35 (6): 1508–1511.

DOI: https://doi.org/10.1042/BST0351508

Published: 23 November 2007

... maturation and NF-κB activation. © The Authors Journal compilation © 2007 Biochemical Society 2007 apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) caspase 1 caspase recruitment domain (CARD) inflammation interleukin-1β (IL-1β) nuclear factor κB (NF-κB...

View article titled, A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins

Articles

Nod1 and Nod2 in innate immunity and human inflammatory disorders

L. Le Bourhis, S. Benko, S.E. Girardin

Biochem Soc Trans (2007) 35 (6): 1479–1484.

DOI: https://doi.org/10.1042/BST0351479

Published: 23 November 2007

...) nuclear factor κB (NF-κB) pattern-recognition molecule (PRM) Sensing and defeating microbial infections is essential for the survival of metazoan species. All living organisms are constantly exposed to microbes that are, most of the time, neutral or beneficial to the host, but sometimes cause...

View article titled, Nod1 and Nod2 in innate immunity and human inflammatory disorders

Articles

Ubiquitin signals in the NF-κB pathway

J. Terzic, I. Marinovic-Terzic, F. Ikeda, I. Dikic

Biochem Soc Trans (2007) 35 (5): 942–945.

DOI: https://doi.org/10.1042/BST0350942

Published: 25 October 2007

... Journal compilation © 2007 Biochemical Society 2007 de-ubiquitinating enzyme inhibitory κB kinase (IKK) nuclear factor κB (NF-κB) transcription factor tumour necrosis factor receptor (TNFR) ubiquitination The NF-κB (nuclear factor κB) transcription factors are key regulators of immune...

View article titled, Ubiquitin signals in the NF-κB pathway

Articles

Protein transduction: identification, characterization and optimization

J. Tilstra, K.K. Rehman, T. Hennon, S.E. Plevy, P. Clemens, P.D. Robbins

Biochem Soc Trans (2007) 35 (4): 811–815.

DOI: https://doi.org/10.1042/BST0350811

Published: 20 July 2007

... Society 2007 cell-penetrating peptide (CPP) inflammation nuclear factor κB (NF-κB) protein transduction domain PTDs (protein transduction domains) or CPPs (cell-penetrating peptides) are small peptides which are able to carry much larger molecules such as oligonucleotides, peptides, full...

View article titled, Protein transduction: identification, characterization and optimization

Articles

The role of SHIP1 in T-lymphocyte life and death

G. Gloire, C. Erneux, J. Piette

Biochem Soc Trans (2007) 35 (2): 277–280.

DOI: https://doi.org/10.1042/BST0350277

Published: 20 March 2007

... ] T-cells H 2 O 2 Anti-apoptotic [ 38 ] 1 To whom correspondence should be addressed (email geoffrey.gloire@ulg.ac.be ). 9 9 2006 © 2007 The Biochemical Society 2007 apoptosis cell proliferation nuclear factor κB (NF-κB) phosphoinositide 3-kinase (PI3K) Src...

View article titled, The role of SHIP1 in T-lymphocyte life and death

Articles

The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses

S. Weldon, N. McGarry, C.C. Taggart, N.G. McElvaney

Biochem Soc Trans (2007) 35 (2): 273–276.

DOI: https://doi.org/10.1042/BST0350273

Published: 20 March 2007

... Meeting held at Wolfson Conference Centre, Hammersmith Hospital, London, U.K., 6 October 2006. Organized and Edited by I. Adcock and P. Evans (National Heart and Lung Institute, Imperial College London, U.K.). antiprotease host response inflammatory lung disease monocyte nuclear factor κB (NF-κB...

View article titled, The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses

Articles

IKKα in the regulation of inflammation and adaptive immunity

T. Lawrence, M. Bebien

Biochem Soc Trans (2007) 35 (2): 270–272.

DOI: https://doi.org/10.1042/BST0350270

Published: 20 March 2007

... t.lawrence@imperial.ac.uk ). 1 11 2006 © 2007 The Biochemical Society 2007 adaptive immunity chemokine dendritic cell (DC) inflammation inhibitor of nuclear factor κB kinase (IKK) nuclear factor κB (NF-κB) Figure 2 Schematic diagram showing the interaction between acute...

View article titled, IKKα in the regulation of inflammation and adaptive immunity

Articles

Resolution of Inflammatory Responses: a brief introduction

I. Adcock, P.C. Evans

Biochem Soc Trans (2007) 35 (2): 261–262.

DOI: https://doi.org/10.1042/BST0350261

Published: 20 March 2007

.... Organized and Edited by I. Adcock and P. Evans (National Heart and Lung Institute, Imperial College London, U.K.). inflammation inhibitor of nuclear factor κB (IκB) nuclear factor κB (NF-κB) phagocytosis post-translational modification protein degradation The resolution of inflammatory...

View article titled, Resolution of Inflammatory Responses: a brief introduction

Articles

Impact of post-translational modifications of proteins on the inflammatory process

K. Ito

Biochem Soc Trans (2007) 35 (2): 281–283.

DOI: https://doi.org/10.1042/BST0350281

Published: 20 March 2007

...) glucocorticoid histone deacetylase (HDAC) nuclear factor κB (NF-κB) post-translational modification PTM (post-translational modification) is the chemical modification of a protein after its translation, and there are hundreds of different PTMs, such as phosphorylation, nitration, ADP-ribosylation...

View article titled, Impact of post-translational modifications of proteins on the inflammatory process

Articles

Single-cell time-lapse imaging of the dynamic control of NF-κB signalling

K. Sillitoe, C. Horton, D.G. Spiller, M.R.H. White

Biochem Soc Trans (2007) 35 (2): 263–266.

DOI: https://doi.org/10.1042/BST0350263

Published: 20 March 2007

... The Biochemical Society 2007 inflammatory response nuclear factor κB (NF-κB) oscillation RelA single-cell imaging The NF-κB signalling pathway has been shown to be active in virtually all cell types and to regulate a number of essential cellular functions. These include inflammation, apoptosis...

View article titled, Single-cell time-lapse imaging of the dynamic control of NF-κB signalling

Articles

Control of the NF-κB inhibitor IκBα in pathogen infection

M. Naumann

Biochem Soc Trans (2007) 35 (2): 267–269.

DOI: https://doi.org/10.1042/BST0350267

Published: 20 March 2007

... of nuclear factor κB (IκB) inhibitor of nuclear factor κB α kinase complex (IKK complex) NEDD8 nuclear factor κB (NF-κB) β-transducin repeat-containing protein (β-TrCP) In most cases the epithelial cell layer represents the first barrier for microbial pathogens and triggers the innate...

View article titled, Control of the NF-κB inhibitor IκBα in pathogen infection

Articles

De-ubiquitinating enzymes: intracellular signalling and disease

J.A. Johnston, J.F. Burrows

Biochem Soc Trans (2006) 34 (5): 764–769.

DOI: https://doi.org/10.1042/BST0340764

Published: 25 October 2006

... have been identified as de-ubiquitinating enzymes and it is unclear whether the removal of ubiquitin is the only function of the JAMM domain [ 12 ]. de-ubiquitinating enzyme DNA repair ovarian tumour protease intracellular signalling nuclear factor κB (NF-κB) ubiquitin C-terminal...

View article titled, De-ubiquitinating enzymes: intracellular signalling and disease

Articles

NF-κB signalling in cerebral ischaemia

M. Schwaninger, I. Inta, O. Herrmann

Biochem Soc Trans (2006) 34 (6): 1291–1294.

DOI: https://doi.org/10.1042/BST0341291

Published: 25 October 2006

... κB (IκB) kinase (IKK) nuclear factor κB (NF-κB) stroke tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) Stroke is a frequent clinical disorder. The WHO (World Health Organization) estimates that worldwide 5–6 million people die from strokes every year. Thrombolysis has...

View article titled, NF-κB signalling in cerebral ischaemia

Articles

Post-translational modification of RelA(p65) NF-κB

K.J. Campbell, N.D. Perkins

Biochem Soc Trans (2004) 32 (6): 1087–1089.

DOI: https://doi.org/10.1042/BST0321087

Published: 26 October 2004

... total NF-κB inhibition. 1 To whom correspondence should be addressed (email k.j.campbell@dundee.ac.uk ). 5 7 2004 © 2004 The Biochemical Society 2004 chemotherapy nuclear factor κB (NF-κB) post-translational modification RelA transcription UV light NF-κB...

View article titled, Post-translational modification of RelA(p65) NF-κB

Articles

Characterization of the survival effect of tumour necrosis factor-α in human neutrophils

S.R. Walmsley, A.S. Cowburn, A. Sobolewski, J. Murray, N. Farahi, I. Sabroe, E.R. Chilvers

Biochem Soc Trans (2004) 32 (3): 456–460.

DOI: https://doi.org/10.1042/bst0320456

Published: 01 June 2004

... neutrophil nuclear factor κB (NF-κB) phosphoinositide 3-kinase tumour necrosis factor-α Abbreviations used: BAL, bronchoalveolar lavage; GM-CSF, granulocyte/macrophage colony-stimulating factor; I-κBα, inhibitory κB-α; IL-2, interleukin-2; mAb, monoclonal antibody; MDM, Iscove's modified...

View article titled, Characterization of the survival effect of tumour necrosis factor-α in human neutrophils

Articles

B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-κB (nuclear factor κB) via a mechanism that involves diacylglycerol

P. Antony, J.B. Petro, G. Carlesso, N.P. Shinners, J. Lowe, W.N. Khan

Biochem Soc Trans (2004) 32 (1): 113–115.

DOI: https://doi.org/10.1042/bst0320113

Published: 01 February 2004

..., diacylglycerol; NFAT, nuclear factor of activated T-cells; NF-κB, nuclear factor κB; PKC, protein kinase C; MG, monoacylglycerol; NEFA, non-esterified fatty acid; TG, triacylglycerol. B lymphocyte Bruton's tyrosine kinase diacylglycerol nuclear factor of activated T-cells (NFAT) nuclear factor κB...

View article titled, B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-κB (nuclear factor κB) via a mechanism that involves diacylglycerol

NARROW

Regulation of neovascularization by S-glutathionylation via the Wnt5a/sFlt-1 pathway

NF-κB and the cell cycle

The impact of hypoxia on cell death pathways

Genetic relationships between A20/TNFAIP3 , chronic inflammation and autoimmune disease

Spatial and temporal information coding and noise in the NF-κB system

Antiviral activity of resveratrol

Regulation of cyclin D1 gene expression

Regulation of the RelA (p65) transactivation domain

Role of NF-κB in β-cell death

Insights from vaccinia virus into Toll-like receptor signalling proteins and their regulation by ubiquitin: role of IRAK-2

A phylogenetic and functional overview of inflammatory caspases and caspase-1-related CARD-only proteins

Nod1 and Nod2 in innate immunity and human inflammatory disorders

Ubiquitin signals in the NF-κB pathway

Protein transduction: identification, characterization and optimization

The role of SHIP1 in T-lymphocyte life and death

The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses

IKKα in the regulation of inflammation and adaptive immunity

Resolution of Inflammatory Responses: a brief introduction

Impact of post-translational modifications of proteins on the inflammatory process

Single-cell time-lapse imaging of the dynamic control of NF-κB signalling

Control of the NF-κB inhibitor IκBα in pathogen infection

De-ubiquitinating enzymes: intracellular signalling and disease

NF-κB signalling in cerebral ischaemia

Post-translational modification of RelA(p65) NF-κB

Characterization of the survival effect of tumour necrosis factor-α in human neutrophils

B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-κB (nuclear factor κB) via a mechanism that involves diacylglycerol

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