... factors (e.g. mechanical force) that can lead to nuclear envelope ‘herniations’, a broad catch-all term that reveals little about the underlying molecular mechanisms that contribute to these morphological defects. While there are many genetic perturbations that could ultimately change nuclear shape, here...

... 2017 31 10 2017 2 11 2017 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cardiomyopathy extracellular signal-regulated kinases lamin mechanistic target of rapamycin nuclear envelope protein kinase B The human lamin...

... budding, and what we have learned about the ESCRT pathway from studying this process. These advances are discussed in the context of areas of cell biology that have been transformed by research in the ESCRT field, including cytokinetic abscission, nuclear envelope resealing and plasma membrane repair...

... the molecular mechanisms of nuclear envelope assembly in echinoderm and mammalian cells. Our findings have led to the demonstration of a direct role for phosphoinositides and their derivatives in nuclear membrane formation. We have shown that phosphoinositides and their derivatives, as well as acting as second...

...Vlastimil Srsen; Nadia Korfali; Eric C. Schirmer The nuclear envelope is a complex double membrane system that serves as a dynamic interface between the nuclear and cytoplasmic compartments. Among its many roles is to provide an anchor for gene regulatory proteins on its nucleoplasmic surface...

...Ricardo A. Figueroa; Santhosh Gudise; Einar Hallberg The LINC (linker of nucleoskeleton and cytoskeleton) complex forms a transcisternal bridge across the NE (nuclear envelope) that connects the cytoskeleton with the nuclear interior. This enables some proteins of the NE to communicate...

...Ashraf N. Malhas; David J. Vaux The nuclear envelope is not only important for the structural integrity of the nucleus, but also involved in a number of cellular functions. It has been shown to be important for maintaining and controlling chromatin organization, sequestering transcription factors...

... adenine methyltransferase identification (DamID) heterochromatin lamina nuclear envelope The nuclear envelope is composed of two distinct membranes. The outer nuclear membrane is contiguous with the endoplasmic reticulum and fuses with the inner nuclear membrane at NPCs (nuclear pore complexes...

... mechanisms of reproductive aging are not well understood, although a number of factors, both intrinsic and extrinsic to an organism's germline, may contribute to aging phenotypes. Recent work in a variety of organisms suggests that nuclear organization and nuclear envelope proteins may play a role...

...Andreas Brachner; Roland Foisner The nuclear envelope in eukaryotic cells has important roles in chromatin organization. The inner nuclear membrane contains over 60 transmembrane proteins. LEM [LAP2 (lamina-associated polypeptide 2)/emerin/MAN1] domain-containing proteins of the inner nuclear...

...Jose M. González; Vicente Andrés The mammalian NE (nuclear envelope), which separates the nucleus from the cytoplasm, is a complex structure composed of nuclear pore complexes, the outer and inner nuclear membranes, the perinuclear space and the nuclear lamina (A- and B-type lamins). The NE...

... microscopy and manipulation at the subcellular level. This paper introduces the collected papers resulting from Organelle Biogenesis and Positioning in Plants, the 2009 Biochemical Society Annual Symposium. Including papers on the nuclear envelope and all major organelles, it considers current knowledge...

..., touch and infection. Positioning is also essential in the division and replication of nuclear components, ranging from chromosome attachment to the breakdown and reformation of the nuclear envelope. Although description and understanding of the processes involved have advanced rapidly in recent years...

...Jindriska Fiserova; Martin W. Goldberg The nuclear envelope comprises a distinct compartment at the nuclear periphery that provides a platform for communication between the nucleus and cytoplasm. Signal transfer can proceed by multiple means. Primarily, this is by nucleocytoplasmic trafficking...

... component of the nuclear envelope. Impaired processing results in aberrant retention of a farnesyl group at the C-terminus of lamin A, leading to altered membrane dynamics. It has been widely proposed that persistence of the farnesyl moiety is the major factor responsible for the disease, prompting clinical...

... of an older generation of HIV-PI to mouse embryonic fibroblasts generated a complex NR (nucleoplasmic reticulum) inside the nuclei ( Figure 2 ). The NR is composed of the nuclear envelope containing NPCs (nuclear pore complexes) with a nucleoplasmic to nucleoplasmic orientation. It has been previously...

... chromatin lamin mitosis nuclear assembly nuclear envelope Lamins are nuclear IF (intermediate filament) proteins that, like all IF proteins, contain a central α-helical rod domain flanked by N- and C-terminal globular domains [ 1 , 2 ]. In vitro , lamin homodimers associate head-to-tail to form...

...Howard J. Worman; Roland Foisner The nuclear envelope has long been a focus of basic research for a highly specialized group of cell biologists. More recently, an expanding group of scientists and physicians have developed a keen interest in the nuclear envelope since mutations in the genes...

...Tatiana V. Cohen; Lidia Hernandez; Colin L. Stewart Recent findings that some 24 inherited diseases and anomalies are caused by defects in proteins of the NE (nuclear envelope) and lamina have resulted in a fundamental reassessment of the functions of the NE and underlying lamina. Instead of just...

...Martin W. Goldberg; Jindriska Fiserova; Irm Huttenlauch; Reimer Stick Lamins are intermediate filament proteins that form a network lining the inner nuclear membrane. They provide mechanical strength to the nuclear envelope, but also appear to have many other functions as reflected in the array...

... (anchorage 1)/SYNE (synaptic nuclear envelope protein) homology]-domain family, which function primarily as exclusive outer nuclear membrane scaffolds that associate with the cytoskeleton, the centrosome and the motor protein apparatus. In the present paper, we propose a novel model, which may explain why...

... and EMD , responsible for EDMD (Emery–Dreifuss muscular dystrophy). LMNA encodes A-type lamins, whereas EMD encodes emerin, both located in the nuclear envelope. Mutation or loss of A-type lamins or emerin in the terminally differentiated myonuclei of muscle fibres results in muscle damage. Importantly...

... junctions mediate a unique microautophagic process called ‘piecemeal microautophagy of the nucleus’ (PMN) that targets portions of the yeast nucleus for degradation in the vacuole [ 10 ]. During PMN, the nuclear envelope and associated nucleoplasmic components, such as nucleolar pre-ribosomes...