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Keywords: nonsense-mediated decay
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Biochem Soc Trans (2023) 51 (3): 1121–1129.
Published: 05 May 2023
... of the Biochemical Society 2023 alternative splicing exon-junction complexes nonsense-mediated decay RNA decay translation Nonsense-mediated RNA decay (NMD) is a quality control process that degrades transcripts that contain a premature termination codon (PTC) arising from nonsense, frameshift...
Biochem Soc Trans (2023) 51 (1): 31–39.
Published: 25 January 2023
... ( karel.riha@ceitec.muni.cz ) or Vivek K. Raxwal ( vivek.raxwal@ceitec.muni.cz ) 14 11 2022 11 1 2023 13 1 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 alternative splicing Arabidopsis thaliana nonsense-mediated decay...
Biochem Soc Trans (2012) 40 (4): 856–864.
Published: 20 July 2012
... as premature translation termination. As a result of their aberrant translation termination, PTC-containing mRNAs can be recognized by the mRNA-surveillance machinery and subjected to NMD (nonsense-mediated decay). In mammals, NMD appears to be triggered by UPF (up-frameshift) 2-containing EJCs (exon-junction...
Biochem Soc Trans (2005) 33 (3): 457–460.
Published: 01 June 2005
...-operatively to interspersed sites and displace PTB from the pyrimidine tract. Exon 11 of PTB pre-mRNA is repressed by PTB in an autoregulatory feedback loop. Exon 11-skipped RNA gets degraded through nonsense-mediated decay. Less than 1% of steady-state PTB mRNA is represented by this isoform, but inhibition...