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Keywords: non-coding RNA
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Articles
Biochem Soc Trans (2022) 50 (2): 723–736.
Published: 14 March 2022
... methylation [ 117 , 118 ]. The most understood mechanism of gene regulation is found at the pachytene stage of murine male germ cells, when the transcription factor MYBL1 coordinates the transcription of piRNA-precursors long non-coding RNAs, in addition to protein-coding genes involved in piRNA metabolism...
Articles
Biochem Soc Trans (2021) 49 (4): 1867–1879.
Published: 02 August 2021
...David Llères; Yui Imaizumi; Robert Feil Different classes of non-coding RNA (ncRNA) influence the organization of chromatin. Imprinted gene domains constitute a paradigm for exploring functional long ncRNAs (lncRNAs). Almost all express an lncRNA in a parent-of-origin dependent manner. The mono...
Articles
Biochem Soc Trans (2020) 48 (3): 1269–1285.
Published: 08 June 2020
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 BMP9 crosstalk non-coding rna osteogenesis therapeutics Oral and maxillofacial surgery often aims for both functional and esthetic outcomes, both of which are mostly dependent on the underlying...
Articles
Biochem Soc Trans (2020) 48 (2): 595–612.
Published: 08 April 2020
.... While many known regulatory factors are proteins or small nucleolar ribonucleoproteins, microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) are emerging as a novel modulatory layer controlling ribosome production. Here, we summarize work uncovering non-coding RNAs (ncRNAs) as novel regulators...
Articles
Biochem Soc Trans (2020) 48 (1): 207–219.
Published: 24 December 2019
... on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . biotechnology CRISPR DNA binding endonucleases genome editing non-coding RNA Horizontal gene transfer plays a crucial role in the evolution of prokaryotes [ 1–4 ]. Invading...
Articles
Biochem Soc Trans (2018) 46 (3): 619–630.
Published: 09 May 2018
...Arlene M.A. Glasgow; Chiara De Santi; Catherine M. Greene Non-coding RNAs (ncRNAs) are an abundant class of RNAs that include small ncRNAs, long non-coding RNAs (lncRNA) and pseudogenes. The human ncRNA atlas includes thousands of these specialised RNA molecules that are further subcategorised...
Articles
Biochem Soc Trans (2017) 45 (4): 895–904.
Published: 03 July 2017
...Oliver M. Rogoyski; Jose Ignacio Pueyo; Juan Pablo Couso; Sarah F. Newbury Genomic analysis has found that the transcriptome in both humans and Drosophila melanogaster features large numbers of long non-coding RNA transcripts (lncRNAs). This recently discovered class of RNAs regulates gene...
Articles
Biochem Soc Trans (2017) 45 (1): 51–64.
Published: 15 February 2017
...-coding RNAs supports tumour progression is poorly understood. Here, we review new lines of evidence linking long and short types of non-coding RNAs to signalling pathways activated in the course of cancer progression by growth factors and by the tumour micro-environment. Resolving the new dimension...
Articles
Biochem Soc Trans (2013) 41 (6): 1416–1421.
Published: 20 November 2013
.... Programmable plasmid interference by the CRISPR-Cas system in Thermococcus kodakarensis RNA Biol. 2013 10 828 840 clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR-associated (Cas) non-coding RNA prokaryotic immunity Pyrococcus furiosus virus To defend...
Articles
Biochem Soc Trans (2012) 40 (4): 907–911.
Published: 20 July 2012
... of these ncRNAs (non-coding RNAs) are functional, and if so, what their function is. In this review, we describe recent discoveries in the field of ncRNAs in the yeast Saccharomyces cerevisiae . Newly identified ncRNAs in this budding yeast, their functions in gene regulation and possible mechanisms of action...
Articles
Biochem Soc Trans (2011) 39 (2): 482–486.
Published: 22 March 2011
...Gwyn T. Williams; Mirna Mourtada-Maarabouni; Farzin Farzaneh Non-coding RNA GAS5 (growth arrest-specific transcript 5) is a 5′-TOP (5′-terminal oligopyrimidine tract) RNA, whose translation, and consequently also stability, is controlled by the mTOR (mammalian target of rapamycin) pathway. GAS5...
Articles
Biochem Soc Trans (2008) 36 (6): 1197–1200.
Published: 19 November 2008
...Jan Stenvang; Morten Lindow; Sakari Kauppinen miRNAs (microRNAs) comprise a class of small endogenous non-coding RNAs that post-transcriptionally repress gene expression by base-pairing with their target mRNAs. Recent evidence has shown that miRNAs play important roles in a wide variety of human...
Articles
Biochem Soc Trans (2007) 35 (5): 1306–1309.
Published: 25 October 2007
...P. Keller; N. Vollaard; J. Babraj; D. Ball; D.A. Sewell; J.A. Timmons We predict that RNA level regulation is as diverse and powerful as protein level regulation when considering physiological adaptation. Non-coding RNA molecules, such as miRNAs (microRNAs), have emerged as a powerful mechanism...
Articles
Biochem Soc Trans (2006) 34 (6): 1148–1150.
Published: 25 October 2006
... antisense non-coding RNA transcription More than two decades have passed since endogenously transcribed antisense RNA was first described in mammals [ 1 ], while in the last year thousands of examples of ncNAT [non-coding NAT (natural antisense)] have been discovered [ 2 ]. Our view has moved from...