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Keywords: neutrophil
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Articles
Biochem Soc Trans (2019) 47 (6): 1921–1930.
Published: 22 November 2019
...Maximilien Euler; Markus H. Hoffmann While there are numerous studies showing that neutrophil extracellular traps (NETs) contribute to autoimmune inflammation and cause bystander tissue injury, human individuals with genetic impairments in NET formation curiously often suffer from exacerbated...
Articles
Biochem Soc Trans (2018) 46 (3): 649–658.
Published: 09 May 2018
... induce changes in the endothelial lining of the blood vessels and in leukocytes. This results in increased vascular permeability and increased expression of adhesion proteins, and promotes adhesion of leukocytes, especially neutrophils to the endothelium. Adhesion is a prerequisite for neutrophil...
Articles
Biochem Soc Trans (2018) 46 (2): 371–377.
Published: 09 March 2018
... infectious disease neutrophil proteoglycan syndecan Infectious diseases represent a major worldwide burden to human health, affecting individuals in both developed and developing countries. Mortality due to infections is extremely high in developing countries, especially in children where lower...
Articles
Biochem Soc Trans (2011) 39 (5): 1409–1415.
Published: 21 September 2011
... in particular host neutrophil proteases [NE (neutrophil elastase), cathepsin-G and proteinase-3] and as such, able to limit maladaptive tissue damage during inflammation, it has become apparent that these molecules have a variety of other functions (direct antimicrobial activity, bacterial opsonization...
Articles
Biochem Soc Trans (2011) 39 (5): 1441–1446.
Published: 21 September 2011
...Marie-Louise Zani; Annabelle Tanga; Ahlame Saidi; Hélène Serrano; Sandrine Dallet-Choisy; Kévin Baranger; Thierry Moreau It is now clear that NSPs (neutrophil serine proteases), including elastase, Pr3 (proteinase 3) and CatG (cathepsin G) are major pathogenic determinants in chronic inflammatory...
Articles
Biochem Soc Trans (2007) 35 (5): 1161–1162.
Published: 25 October 2007
... inflamed tissue to promote leucocyte recruitment to otherwise ‘resting’ endothelial cells. adhesion endothelial cell fibroblast leucocyte neutrophil stromal cell 1 To whom correspondence should be addressed (email helenmcgettrick@yahoo.com ). 4 7 2007 © The Authors...
Articles
Biochem Soc Trans (2007) 35 (5): 1163–1165.
Published: 25 October 2007
... 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 atherosclerosis chemokine interleukin neutrophil stroke systemic inflammation Most stroke patients present with co-morbidities, such as atherosclerosis, hypertension, diabetes or infection, all...
Articles
Biochem Soc Trans (2007) 35 (2): 215–218.
Published: 20 March 2007
... ‘knockout’ mice lacking a particular phosphoinositide-metabolizing enzyme, we have been able to evaluate the contribution of each enzyme to PI(3,4,5) P 3 localization in migrating neutrophils. Our results indicate that PI3Kγ and the PI(3,4,5) P 3 phosphatase SHIP1 [SH2 (Src homology 2)-containing inositol...
Articles
Biochem Soc Trans (2007) 35 (2): 288–291.
Published: 20 March 2007
... of proteins directly involved in the control of apoptosis, such as Bcl-2 family members and caspases, can be targeted in vivo to influence inflammatory resolution. Recently, it has been shown that CDK (cyclin-dependent kinase) inhibitor drugs induce caspase-dependent human neutrophil apoptosis possibly...
Articles
Biochem Soc Trans (2004) 32 (5): 679–681.
Published: 26 October 2004
...D. Scheel-Toellner; K. Wang; L.K. Assi; P.R. Webb; R.M. Craddock; M. Salmon; J.M. Lord Neutrophils die by apoptosis spontaneously within 12–24 h of their release from the bone marrow. The mechanism regulating entry of neutrophils into apoptosis at the end of their life-span is currently under...
Articles
Biochem Soc Trans (2004) 32 (3): 452–455.
Published: 01 June 2004
... held at New Edinburgh Royal Infirmary, Little France, Nr. Edinburgh, 19–20 November 2003 11 December 2003 © 2004 Biochemical Society 2004 apoptosis eosinophil granulocyte HIV-TAT neutrophil protein transduction Abbreviations used: ERK, extracellular-signal-regulated...
Articles
Biochem Soc Trans (2004) 32 (3): 465–467.
Published: 01 June 2004
... of constitutive apoptosis in neutrophils and eosinophils and cause these cells to respond to the pro-apoptotic effects of TNF-α (tumour necrosis factor-α). Results from both in vivo and in vitro experiments suggest that there are at least two important waves of NF-κB activation in inflammatory loci, which...
Articles
Biochem Soc Trans (2004) 32 (3): 474–476.
Published: 01 June 2004
...S.D. Kobayashi; F.R. DeLeo Human PMNs (polymorphonuclear leucocytes or neutrophils) are essential to the innate immune response against bacterial pathogens and are a key part of the acute inflammatory response. Although progress has been made, the molecular basis for termination of inflammation...
Articles
Biochem Soc Trans (2004) 32 (3): 485–488.
Published: 01 June 2004
... November 2003 © 2004 Biochemical Society 2004 apoptosis caspase eosinophil mammalian Sterile20-like kinase mitogen-activated protein kinase neutrophil Abbreviations used: GCK, germinal centre kinase; ICAD, inhibitor of caspase-activated DNase; JNK, c-Jun N-terminal kinase; MAPK...
Articles
Biochem Soc Trans (2004) 32 (3): 456–460.
Published: 01 June 2004
... have shown that TNFα (tumour necrosis factor-α) has a bi-modal influence on the rate of constitutive neutrophil apoptosis in vitro , causing early acceleration and late inhibition of this process. The pro-apoptotic effect is uniquely TNFR1 (TNF receptor 1) and TNFR2-dependent and the latter survival...
Articles
Biochem Soc Trans (2004) 32 (3): 468–469.
Published: 01 June 2004
...I. Sabroe; L.R. Prince; S.K. Dower; S.R. Walmsley; E.R Chilvers; M.K.B. Whyte Neutrophil purification has traditionally been performed by centrifugation of leucocytes through density gradients. These reliable methods produce populations that are typically >95% pure neutrophils, and have allowed...
Articles
Biochem Soc Trans (2004) 32 (3): 499–501.
Published: 01 June 2004
...M.C.M. Vissers; M.B. Hampton We have investigated the role of neutrophil oxidants in the surface changes that result in recognition and uptake of neutrophils by macrophages. We have shown that H 2 O 2 produced by stimulated neutrophils is essential for the surface expression of phosphatidylserine...
Articles
Biochem Soc Trans (2004) 32 (3): 461–464.
Published: 01 June 2004
...D. Scheel-Toellner; K.-Q. Wang; P.R. Webb; S.H. Wong; R. Craddock; L.K. Assi; M. Salmon; J.M. Lord Neutrophils are very abundant, short-lived leucocytes and their death by apoptosis is central to homoeostasis and the resolution of inflammation, yet the trigger for apoptosis is still a topic...
Articles
Biochem Soc Trans (2004) 32 (3): 489–492.
Published: 01 June 2004
...S.W. Edwards; M. Derouet; M. Howse; R.J. Moots Neutrophils rapidly undergo spontaneous apoptosis, but this process can be considerably delayed by exposure to a variety of agents such as pro-inflammatory cytokines. The anti-apoptotic protein of the Bcl-2 family, Mcl-1, plays a key role...
Articles
Biochem Soc Trans (2004) 32 (3): 470–473.
Published: 01 June 2004
... inflammation, particularly the neutrophil. However, delays in this response result in the persistence of inflammation and the development of inflammatory disorders. Understanding the mechanism that inhibits the process of cell death may be helpful in the treatment of inflammatory disorders. Inflammatory...
Articles
Biochem Soc Trans (2004) 32 (3): 447–451.
Published: 01 June 2004
...I. Dransfield; A.G. Rossi The neutrophil granulocyte is a key factor in cellular innate defence mechanisms against infection or tissue damage. Granulocyte apoptosis is now acknowledged to have a critical role in progression of inflammatory responses. Granulocytes are preprogrammed to die...
Articles
Biochem Soc Trans (2004) 32 (3): 502–506.
Published: 01 June 2004
...L. Harper; J.M. Williams; C.O. Savage The primary small-vessel systemic vasculitides are disorders that target small blood vessels, inducing vessel wall inflammation, and are associated with the development of anti-neutrophil cytoplasmic antibodies. Multiple organs are attacked, including the lungs...
Articles
Biochem Soc Trans (2004) 32 (2): 378–382.
Published: 01 April 2004
...) lymphocyte mast cell neutrophil phosphoinositide 3-kinase (PI 3-kinase) Abbreviations used: ARDS, acute respiratory distress syndrome; Bad, Bcl-2/Bcl-X L -antagonist, causing cell death; Bcl-2, B-cell leukaemia/lymphoma 2; COPD, chronic obstructive pulmonary disease; EPO, eosinophil peroxidase...
Articles
Biochem Soc Trans (2003) 31 (2): 449–451.
Published: 01 April 2003
...S.K. Butcher; V. Killampalli; H. Chahal; E. Kaya Alpar; J.M. Lord Previous work has demonstrated an age-related decline in neutrophil function, including a decline in phagocytic capacity, with age in healthy individuals. This decline in function may contribute to increased susceptibility...
Articles
Biochem Soc Trans (2002) 30 (4): 722–724.
Published: 01 August 2002
... To whom correspondence should be addressed (e-mail andrew.t.mckie@kcl.ac.uk ) 10 4 2002 © 2002 Biochemical Society 2002 duodenal cytochrome b intestine neutrophil Dcytb, duodenal cytochrome b DCT, divalent-cation transporter Biometals 2002: Third International...