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Articles

The double-edged role of neutrophil extracellular traps in inflammation

Maximilien Euler, Markus H. Hoffmann

Biochem Soc Trans (2019) 47 (6): 1921–1930.

https://doi.org/10.1042/BST20190629

Published: 22 November 2019

...Maximilien Euler; Markus H. Hoffmann While there are numerous studies showing that neutrophil extracellular traps (NETs) contribute to autoimmune inflammation and cause bystander tissue injury, human individuals with genetic impairments in NET formation curiously often suffer from exacerbated...

View article titled, The double-edged role of neutrophil extracellular traps in inflammation

Articles

Small GTPase-dependent regulation of leukocyte–endothelial interactions in inflammation

Julia Y. Chu, Barry McCormick, Sonja Vermeren

Biochem Soc Trans (2018) 46 (3): 649–658.

https://doi.org/10.1042/BST20170530

Published: 09 May 2018

... induce changes in the endothelial lining of the blood vessels and in leukocytes. This results in increased vascular permeability and increased expression of adhesion proteins, and promotes adhesion of leukocytes, especially neutrophils to the endothelium. Adhesion is a prerequisite for neutrophil...

View article titled, Small GTPase-dependent regulation of leukocyte–endothelial interactions in inflammation

Articles

Glycobiology of syndecan-1 in bacterial infections

Rafael S. Aquino, Yvonne Hui-Fang Teng, Pyong Woo Park

Biochem Soc Trans (2018) 46 (2): 371–377.

https://doi.org/10.1042/BST20170395

Published: 09 March 2018

..., heparosan, and N -sulfated heparosan, did not. 2- O -sulfate HS motifs in Sdc1 ectodomains were determined to promote S. aureus corneal infection by interfering with neutrophil-mediated bacterial killing. © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society...

View article titled, Glycobiology of syndecan-1 in bacterial infections

Articles

WAP domain proteins as modulators of mucosal immunity

Thomas S. Wilkinson, Ali Roghanian, Alexander John Simpson, Jean-Michel Sallenave

Biochem Soc Trans (2011) 39 (5): 1409–1415.

https://doi.org/10.1042/BST0391409

Published: 21 September 2011

... in particular host neutrophil proteases [NE (neutrophil elastase), cathepsin-G and proteinase-3] and as such, able to limit maladaptive tissue damage during inflammation, it has become apparent that these molecules have a variety of other functions (direct antimicrobial activity, bacterial opsonization...

View article titled, WAP domain proteins as modulators of mucosal immunity

Articles

SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions

Marie-Louise Zani, Annabelle Tanga, Ahlame Saidi, Hélène Serrano, Sandrine Dallet-Choisy, Kévin Baranger, Thierry Moreau

Biochem Soc Trans (2011) 39 (5): 1441–1446.

https://doi.org/10.1042/BST0391441

Published: 21 September 2011

...Marie-Louise Zani; Annabelle Tanga; Ahlame Saidi; Hélène Serrano; Sandrine Dallet-Choisy; Kévin Baranger; Thierry Moreau It is now clear that NSPs (neutrophil serine proteases), including elastase, Pr3 (proteinase 3) and CatG (cathepsin G) are major pathogenic determinants in chronic inflammatory...

View article titled, SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions

Articles

Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment

H.M. McGettrick, A. Filer, G.E. Rainger, C.D. Buckley, G.B. Nash

Biochem Soc Trans (2007) 35 (5): 1161–1162.

https://doi.org/10.1042/BST0351161

Published: 25 October 2007

... correspondence should be addressed (email helenmcgettrick@yahoo.com ). 4 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 adhesion endothelial cell fibroblast leucocyte neutrophil stromal cell A fundamental requirement for an inflammatory response...

View article titled, Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment

Articles

Systemic inflammation and stroke: aetiology, pathology and targets for therapy

B.W. McColl, S.M. Allan, N.J. Rothwell

Biochem Soc Trans (2007) 35 (5): 1163–1165.

https://doi.org/10.1042/BST0351163

Published: 25 October 2007

.... Tohoku J. Exp. Med. 2007 211 387 393 1 To whom correspondence should be addressed (email barry.mccoll@manchester.ac.uk ). 27 6 2007 atherosclerosis chemokine interleukin neutrophil stroke systemic inflammation Most stroke patients present with co-morbidities...

View article titled, Systemic inflammation and stroke: aetiology, pathology and targets for therapy

Articles

Non-invasive visualization of the lipid product of class I PI3K in transgenic mouse models

T. Sasaki, J. Sasaki, K. Watanabe, A. Suzuki

Biochem Soc Trans (2007) 35 (2): 215–218.

https://doi.org/10.1042/BST0350215

Published: 20 March 2007

... ‘knockout’ mice lacking a particular phosphoinositide-metabolizing enzyme, we have been able to evaluate the contribution of each enzyme to PI(3,4,5) P 3 localization in migrating neutrophils. Our results indicate that PI3Kγ and the PI(3,4,5) P 3 phosphatase SHIP1 [SH2 (Src homology 2)-containing inositol...

View article titled, Non-invasive visualization of the lipid product of class I PI3K in transgenic mouse models

Articles

Modulation of granulocyte apoptosis can influence the resolution of inflammation

A.G. Rossi, J.M. Hallett, D.A. Sawatzky, M.M. Teixeira, C. Haslett

Biochem Soc Trans (2007) 35 (2): 288–291.

https://doi.org/10.1042/BST0350288

Published: 20 March 2007

... of proteins directly involved in the control of apoptosis, such as Bcl-2 family members and caspases, can be targeted in vivo to influence inflammatory resolution. Recently, it has been shown that CDK (cyclin-dependent kinase) inhibitor drugs induce caspase-dependent human neutrophil apoptosis possibly...

View article titled, Modulation of granulocyte apoptosis can influence the resolution of inflammation

Articles

Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosis

D. Scheel-Toellner, K. Wang, L.K. Assi, P.R. Webb, R.M. Craddock, M. Salmon, J.M. Lord

Biochem Soc Trans (2004) 32 (5): 679–681.

https://doi.org/10.1042/BST0320679

Published: 26 October 2004

...D. Scheel-Toellner; K. Wang; L.K. Assi; P.R. Webb; R.M. Craddock; M. Salmon; J.M. Lord Neutrophils die by apoptosis spontaneously within 12–24 h of their release from the bone marrow. The mechanism regulating entry of neutrophils into apoptosis at the end of their life-span is currently under...

View article titled, Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosis

Articles

Getting to grips with the granulocyte: manipulation of granulocyte behaviour and apoptosis by protein transduction methods

A.G. Rossi, C. Ward, I. Dransfield

Biochem Soc Trans (2004) 32 (3): 452–455.

https://doi.org/10.1042/bst0320452

Published: 01 June 2004

... Meeting held at New Edinburgh Royal Infirmary, Little France, Nr. Edinburgh, 19–20 November 2003 11 December 2003 © 2004 Biochemical Society 2004 apoptosis eosinophil granulocyte HIV-TAT neutrophil protein transduction Abbreviations used: ERK, extracellular-signal...

View article titled, Getting to grips with the granulocyte: manipulation of granulocyte behaviour and apoptosis by protein transduction methods

Articles

Regulation of granulocyte apoptosis by NF-κB

C. Ward, A. Walker, I. Dransfield, C. Haslett, A.G. Rossi

Biochem Soc Trans (2004) 32 (3): 465–467.

https://doi.org/10.1042/bst0320465

Published: 01 June 2004

... of constitutive apoptosis in neutrophils and eosinophils and cause these cells to respond to the pro-apoptotic effects of TNF-α (tumour necrosis factor-α). Results from both in vivo and in vitro experiments suggest that there are at least two important waves of NF-κB activation in inflammatory loci, which...

View article titled, Regulation of granulocyte apoptosis by NF-κB

Articles

An apoptosis differentiation programme in human polymorphonuclear leucocytes

S.D. Kobayashi, F.R. DeLeo

Biochem Soc Trans (2004) 32 (3): 474–476.

https://doi.org/10.1042/bst0320474

Published: 01 June 2004

...S.D. Kobayashi; F.R. DeLeo Human PMNs (polymorphonuclear leucocytes or neutrophils) are essential to the innate immune response against bacterial pathogens and are a key part of the acute inflammatory response. Although progress has been made, the molecular basis for termination of inflammation...

View article titled, An apoptosis differentiation programme in human polymorphonuclear leucocytes

Articles

Mammalian Sterile20-like kinase 1 and the regulation of apoptosis

P.M. de Souza, M.A. Lindsay

Biochem Soc Trans (2004) 32 (3): 485–488.

https://doi.org/10.1042/bst0320485

Published: 01 June 2004

... November 2003 © 2004 Biochemical Society 2004 apoptosis caspase eosinophil mammalian Sterile20-like kinase mitogen-activated protein kinase neutrophil Abbreviations used: GCK, germinal centre kinase; ICAD, inhibitor of caspase-activated DNase; JNK, c-Jun N-terminal kinase; MAPK...

View article titled, Mammalian Sterile20-like kinase 1 and the regulation of apoptosis

Articles

Characterization of the survival effect of tumour necrosis factor-α in human neutrophils

S.R. Walmsley, A.S. Cowburn, A. Sobolewski, J. Murray, N. Farahi, I. Sabroe, E.R. Chilvers

Biochem Soc Trans (2004) 32 (3): 456–460.

https://doi.org/10.1042/bst0320456

Published: 01 June 2004

... have shown that TNFα (tumour necrosis factor-α) has a bi-modal influence on the rate of constitutive neutrophil apoptosis in vitro , causing early acceleration and late inhibition of this process. The pro-apoptotic effect is uniquely TNFR1 (TNF receptor 1) and TNFR2-dependent and the latter survival...

View article titled, Characterization of the survival effect of tumour necrosis factor-α in human neutrophils

Articles

What can we learn from highly purified neutrophils?

I. Sabroe, L.R. Prince, S.K. Dower, S.R. Walmsley, E.R Chilvers, M.K.B. Whyte

Biochem Soc Trans (2004) 32 (3): 468–469.

https://doi.org/10.1042/bst0320468

Published: 01 June 2004

...I. Sabroe; L.R. Prince; S.K. Dower; S.R. Walmsley; E.R Chilvers; M.K.B. Whyte Neutrophil purification has traditionally been performed by centrifugation of leucocytes through density gradients. These reliable methods produce populations that are typically >95% pure neutrophils, and have allowed...

View article titled, What can we learn from highly purified neutrophils?

Articles

The role of oxidants and vitamin C on neutrophil apoptosis and clearance

M.C.M. Vissers, M.B. Hampton

Biochem Soc Trans (2004) 32 (3): 499–501.

https://doi.org/10.1042/bst0320499

Published: 01 June 2004

...M.C.M. Vissers; M.B. Hampton We have investigated the role of neutrophil oxidants in the surface changes that result in recognition and uptake of neutrophils by macrophages. We have shown that H 2 O 2 produced by stimulated neutrophils is essential for the surface expression of phosphatidylserine...

View article titled, The role of oxidants and vitamin C on neutrophil apoptosis and clearance

Articles

Early events in spontaneous neutrophil apoptosis

D. Scheel-Toellner, K.-Q. Wang, P.R. Webb, S.H. Wong, R. Craddock, L.K. Assi, M. Salmon, J.M. Lord

Biochem Soc Trans (2004) 32 (3): 461–464.

https://doi.org/10.1042/bst0320461

Published: 01 June 2004

...D. Scheel-Toellner; K.-Q. Wang; P.R. Webb; S.H. Wong; R. Craddock; L.K. Assi; M. Salmon; J.M. Lord Neutrophils are very abundant, short-lived leucocytes and their death by apoptosis is central to homoeostasis and the resolution of inflammation, yet the trigger for apoptosis is still a topic...

View article titled, Early events in spontaneous neutrophil apoptosis

Articles

Regulation of neutrophil apoptosis by Mcl-1

S.W. Edwards, M. Derouet, M. Howse, R.J. Moots

Biochem Soc Trans (2004) 32 (3): 489–492.

https://doi.org/10.1042/bst0320489

Published: 01 June 2004

...S.W. Edwards; M. Derouet; M. Howse; R.J. Moots Neutrophils rapidly undergo spontaneous apoptosis, but this process can be considerably delayed by exposure to a variety of agents such as pro-inflammatory cytokines. The anti-apoptotic protein of the Bcl-2 family, Mcl-1, plays a key role...

View article titled, Regulation of neutrophil apoptosis by Mcl-1

Articles

Gene profiling of in vitro and in vivo models of delayed neutrophil apoptosis: a common pathway?

A. O'Neill, M.C. Greenan, B. Doyle, J.M. Fitzpatrick, R.W.G. Watson

Biochem Soc Trans (2004) 32 (3): 470–473.

https://doi.org/10.1042/bst0320470

Published: 01 June 2004

... inflammation, particularly the neutrophil. However, delays in this response result in the persistence of inflammation and the development of inflammatory disorders. Understanding the mechanism that inhibits the process of cell death may be helpful in the treatment of inflammatory disorders. Inflammatory...

View article titled, Gene profiling of in vitro and in vivo models of delayed neutrophil apoptosis: a common pathway?

Articles

Granulocyte apoptosis: who would work with a ‘real’ inflammatory cell?

I. Dransfield, A.G. Rossi

Biochem Soc Trans (2004) 32 (3): 447–451.

https://doi.org/10.1042/bst0320447

Published: 01 June 2004

...I. Dransfield; A.G. Rossi The neutrophil granulocyte is a key factor in cellular innate defence mechanisms against infection or tissue damage. Granulocyte apoptosis is now acknowledged to have a critical role in progression of inflammatory responses. Granulocytes are preprogrammed to die...

View article titled, Granulocyte apoptosis: who would work with a ‘real’ inflammatory cell?

Articles

The importance of resolution of inflammation in the pathogenesis of ANCA-associated vasculitis

L. Harper, J.M. Williams, C.O. Savage

Biochem Soc Trans (2004) 32 (3): 502–506.

https://doi.org/10.1042/bst0320502

Published: 01 June 2004

...L. Harper; J.M. Williams; C.O. Savage The primary small-vessel systemic vasculitides are disorders that target small blood vessels, inducing vessel wall inflammation, and are associated with the development of anti-neutrophil cytoplasmic antibodies. Multiple organs are attacked, including the lungs...

View article titled, The importance of resolution of inflammation in the pathogenesis of ANCA-associated vasculitis

Articles

PI 3-kinase inhibition: a therapeutic target for respiratory disease

P.M. Finan, M.J. Thomas

Biochem Soc Trans (2004) 32 (2): 378–382.

https://doi.org/10.1042/bst0320378

Published: 01 April 2004

...) lymphocyte mast cell neutrophil phosphoinositide 3-kinase (PI 3-kinase) Abbreviations used: ARDS, acute respiratory distress syndrome; Bad, Bcl-2/Bcl-X L -antagonist, causing cell death; Bcl-2, B-cell leukaemia/lymphoma 2; COPD, chronic obstructive pulmonary disease; EPO, eosinophil peroxidase...

View article titled, PI 3-kinase inhibition: a therapeutic target for respiratory disease

Articles

Effect of age on susceptibility to post-traumatic infection in the elderly

S.K. Butcher, V. Killampalli, H. Chahal, E. Kaya Alpar, J.M. Lord

Biochem Soc Trans (2003) 31 (2): 449–451.

https://doi.org/10.1042/bst0310449

Published: 01 April 2003

...S.K. Butcher; V. Killampalli; H. Chahal; E. Kaya Alpar; J.M. Lord Previous work has demonstrated an age-related decline in neutrophil function, including a decline in phagocytic capacity, with age in healthy individuals. This decline in function may contribute to increased susceptibility...

View article titled, Effect of age on susceptibility to post-traumatic infection in the elderly

Articles

Molecular evidence for the role of a ferric reductase in iron transport

A. T. McKie, G. O. Latunde-Dada, S. Miret, J. A. McGregor, G. J. Anderson, C. D. Vulpe, J. M. Wrigglesworth, R. J. Simpson

Biochem Soc Trans (2002) 30 (4): 722–724.

https://doi.org/10.1042/bst0300722

Published: 01 August 2002

... © 2002 Biochemical Society 2002 duodenal cytochrome b intestine neutrophil Dcytb, duodenal cytochrome b DCT, divalent-cation transporter Biometals 2002: Third International Biometals Symposium: Focused Meeting Organized by S. Andrews (School of Animal and Microbial...

View article titled, Molecular evidence for the role of a ferric reductase in iron transport

NARROW

The double-edged role of neutrophil extracellular traps in inflammation

Small GTPase-dependent regulation of leukocyte–endothelial interactions in inflammation

Glycobiology of syndecan-1 in bacterial infections

WAP domain proteins as modulators of mucosal immunity

SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions

Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment

Systemic inflammation and stroke: aetiology, pathology and targets for therapy

Non-invasive visualization of the lipid product of class I PI3K in transgenic mouse models

Modulation of granulocyte apoptosis can influence the resolution of inflammation

Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosis

Getting to grips with the granulocyte: manipulation of granulocyte behaviour and apoptosis by protein transduction methods

Regulation of granulocyte apoptosis by NF-κB

An apoptosis differentiation programme in human polymorphonuclear leucocytes

Mammalian Sterile20-like kinase 1 and the regulation of apoptosis

Characterization of the survival effect of tumour necrosis factor-α in human neutrophils

What can we learn from highly purified neutrophils?

The role of oxidants and vitamin C on neutrophil apoptosis and clearance

Early events in spontaneous neutrophil apoptosis

Regulation of neutrophil apoptosis by Mcl-1

Gene profiling of in vitro and in vivo models of delayed neutrophil apoptosis: a common pathway?

Granulocyte apoptosis: who would work with a ‘real’ inflammatory cell?

The importance of resolution of inflammation in the pathogenesis of ANCA-associated vasculitis

PI 3-kinase inhibition: a therapeutic target for respiratory disease

Effect of age on susceptibility to post-traumatic infection in the elderly

Molecular evidence for the role of a ferric reductase in iron transport

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