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Keywords: neuroinflammation
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Articles
Biochem Soc Trans (2017) 45 (1): 131–139.
Published: 15 February 2017
... the brain to reach a critical threshold of inflammation, triggering a self-perpetuating cycle of inflammation and neuronal death ( Figure 1 ). Figure 1. LRRK2 and microglia-driven neuroinflammation in PD. (Top panel) In this scenario, mutations in PD genes exert their effects directly in neurones...
Articles
Biochem Soc Trans (2017) 45 (1): 261–267.
Published: 15 February 2017
... Russo , I. , Bubacco , L. and Greggio , E. ( 2014 ) LRRK2 and neuroinflammation: partners in crime in Parkinson's disease? J. Neuroinflammation 11 , 52 doi: 10.1186/1742-2094-11-52 13 Parisiadou , L. , Yu , J. , Sgobio , C. , Xie , C. , Liu , G. , Sun...
Articles
Biochem Soc Trans (2015) 43 (4): 702–706.
Published: 03 August 2015
... in preadipocytes Arterioscler. Thromb. Vasc. Biol. 2009 29 239 245 10.1161/ATVBAHA.108.174219 19057021 blood–brain barrier endothelial interleukin-6 (IL-6) NADPH oxidase neuroinflammation tumour necrosis factor-α (TNF-α) This mini review will examine therefore our current...
Articles
Biochem Soc Trans (2015) 43 (4): 586–592.
Published: 03 August 2015
... as neurodegenerative and psychiatric conditions. It is therefore a target of interest for molecular strategies aimed at imaging neuroinflammation in vivo . For more than 20 years, positron emission tomography (PET) has allowed the imaging of TSPO density in brain using [ 11 C]-( R )-PK11195, a radiolabelled-specific...
Articles
Biochem Soc Trans (2014) 42 (2): 557–563.
Published: 20 March 2014
... (email pierre.gressens@inserm.fr ). 6 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 cerebral palsy neurodevelopment neuroinflammation oligodendrocyte perinatal brain damage Damage to the immature brain around the time of birth presents a serious...
Articles
Biochem Soc Trans (2013) 41 (6): 1583–1587.
Published: 20 November 2013
... have multiple physiological roles including involvement in learning and memory, neuroinflammation, oxidative stress, neuroprotection and neurogenesis. They have also been implicated in the pathology of, or perhaps protective responses to, neurodegenerative diseases. This is particularly the case...
Articles
Biochem Soc Trans (2010) 38 (2): 476–481.
Published: 22 March 2010
... participate in the elimination of synapses and synaptic dysfunction in the developing and diseased brain. complement neurodegeneration neuroimmune mediator neuroinflammation retinal ganglion cell (RGC) synaptic pruning In order to form the precise finely tuned neural circuitry of the mature...
Articles
Biochem Soc Trans (2007) 35 (5): 1166–1167.
Published: 25 October 2007
.... bacterial meningitis brain abscess lipoteichoic acid microglia neurodegeneration neuroinflammation Gram-positive bacterial infections of the CNS (central nervous system) occur either as bacterial meningitis or as brain abscess, being localized to the membranes surrounding the brain or in its...
Articles
Biochem Soc Trans (2007) 35 (5): 1127–1132.
Published: 25 October 2007
... neuroinflammation and explain the interconnected relationship between deleterious microglial activation, DA neuron damage and neurodegenerative disease. dopaminergic neuron microglia NADPH oxidase neuroinflammation Parkinson's disease reactive oxygen species Microglia, the resident innate immune...