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Keywords: neurofibrillary tangle
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Biochem Soc Trans (2010) 38 (4): 953–954.
Published: 26 July 2010
... Alzheimer's disease frontotemporal dementia with parkinsonism linked to chromosome 17 microtubule neurofibrillary tangle tau tauopathy Although scientific meetings regarding the pathogenesis and potential treatments of a single disease are not uncommon, a meeting focused on a single protein...
Biochem Soc Trans (2010) 38 (4): 973–976.
Published: 26 July 2010
..., amyloid β-peptide. Protein aggregation is a common pathological hallmark of many neurological disorders. In a subset of these diseases, including AD (Alzheimer's disease), the protein tau has been identified as the main component of aggregates called NFTs (neurofibrillary tangles) [ 1...
Biochem Soc Trans (2010) 38 (2): 564–570.
Published: 22 March 2010
... before neuronal death in the early stages of the disease. The mechanism by which hyperphosphorylated tau, the building block of neurofibrillary tangles, one of the pathological hallmarks of AD, disrupts neuronal and synaptic function is unclear. There is a theory that hyperphosphorylated tau does...