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Keywords: neurodegenerative disease
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Articles
Biochem Soc Trans (2014) 42 (2): 600–604.
Published: 20 March 2014
... glutamatergic pathway neurodegenerative disease Parkinson’s disease PD (Parkinson's disease) is characterized by some typical motor signs and symptoms (hypokinesia, bradykinesia, resting tremor, rigidity) that are caused by striatal dopamine depletion and improved by dopamine replacement therapy...
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Biochem Soc Trans (2008) 36 (6): 1304–1308.
Published: 19 November 2008
... Society 2008 iron chelation metal ion neurodegenerative disease oxidative stress protein aggregation therapy A classification of neurodegeneration can be achieved on the basis of the principal neuropathological changes, characterized by the presence of abnormal protein components [ 1...
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Biochem Soc Trans (2007) 35 (5): 1122–1126.
Published: 25 October 2007
... 2007 inflammation interleukin-1 (IL-1) interleukin-1 receptor antagonist (IL-1RA) ischaemia neurodegenerative disease stroke Inflammation is generally a beneficial response of an organism to infection but, when prolonged or inappropriate, it can be detrimental. Neuronal loss in acute...
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Biochem Soc Trans (2007) 35 (5): 1232–1235.
Published: 25 October 2007
...K.J. Krishnan; A.K. Reeve; D.M. Turnbull A decline in mitochondrial function has long been shown to exist in neurodegenerative disease. Whether this decline is a secondary consequence of other factors or whether it causes the eventual death of a cell is unknown. In this review, we will discuss some...
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Biochem Soc Trans (2005) 33 (5): 1113–1115.
Published: 26 October 2005
... correspondence should be addressed (email david.a.middleton@manchester.ac.uk ). 4 7 2005 aggregation circular dichroism (CD) electron microscopy (EM) fibril morphology neurodegenerative disease α-synuclein Amyloid fibril formation is thought to be a central event in various...
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Biochem Soc Trans (2002) 30 (4): 548–551.
Published: 01 August 2002
...L. Masino; A. Pastore A growing number of neurodegenerative diseases are caused by expansion of CAG trinucleotide repeats coding for polyglutamine. The presence of intranuclear inclusions in the affected neuronal cells has suggested a mechanism for pathogenesis based on protein misfolding...
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Biochem Soc Trans (2002) 30 (2): 222–225.
Published: 01 April 2002
... neurodegenerative disease plasticity microglia Biochemical Society Transactions (2002) Volume 30, part 2 Tissue plasminogen activator as a modulator of neuronal survival and function S. E. Tsirka' Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY I 1794-865 I...