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Keywords: neurodegeneration
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (2): 571–577.
Published: 09 March 2023
... neurodegenerative diseases, which implicate either enhanced or reduced ER–mitochondria contacts in neurodegeneration. Taken together, the discussed studies highlight the need for further research into the role of triple organelle contacts, as well as into the exact mechanisms of increased and decreased ER...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 245–257.
Published: 16 February 2023
...Safak Er; Mikko Airavaara Synucleinopathies constitute a disease family named after alpha-synuclein protein, which is a significant component of the intracellular inclusions called Lewy bodies. Accompanying the progressive neurodegeneration, Lewy bodies and neurites are the main histopathologies...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 147–159.
Published: 11 January 2023
... membrane, compromising its integrity, and affecting the function of receptors. These facts indicate that the interaction between Aβ oligomers and cell membranes may be one of the central molecular level factors responsible for the onset of neurodegeneration. The present review provides a structural...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1457–1469.
Published: 05 October 2022
... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy neurodegeneration organelles protein quality control ubiquitin Valosin-containing protein (VCP, also p97, or Cdc48p in yeast...
Articles
Barbara Tedesco, Veronica Ferrari, Marta Cozzi, Marta Chierichetti, Elena Casarotto, Paola Pramaggiore, Francesco Mina, Margherita Piccolella, Riccardo Cristofani, Valeria Crippa, Paola Rusmini, Mariarita Galbiati, Angelo Poletti
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (5): 1489–1503.
Published: 16 September 2022
... in which neurodegeneration mainly affects upper and/or lower motor neurons (MNs). Although the involvement of specific MNs, symptoms, age of onset, and progression differ in MNDs, the main pathogenic mechanism common to most MNDs is represented by proteostasis alteration and proteotoxicity...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 799–811.
Published: 28 March 2022
...). Published by Portland Press Limited on behalf of the Biochemical Society 2022 inflammation linear ubiquitination LUBAC LUBAC inhibitors neurodegeneration Ubiquitin is a 76-amino acid protein that is expressed in all eukaryotic cells; it modifies substrate proteins to regulate...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (2): 759–771.
Published: 21 March 2022
... ( emily.sontag@marquette.edu ) 14 1 2022 28 2 2022 2 3 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 ageing neurodegeneration protein aggregation proteostasis Protein homeostasis (proteostasis) is the process...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2022) 50 (1): 119–134.
Published: 23 December 2021
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 liquid-liquid phase separation neurodegeneration RAN translation repeat expansion diseases The human genome contains many simple sequence repeats composed of a short repeat unit known as a short tandem...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (6): 2777–2786.
Published: 23 November 2021
... in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. alpha-synuclein electron microcopy neurodegeneration tau protein Many neurodegenerative diseases are characterized by the presence in the brain...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2020) 48 (4): 1795–1806.
Published: 14 August 2020
... lateral sclerosis molecular chaperones neurodegeneration Parkinson's disease pharmacological chaperones protein misfolding The central dogma of molecular biology dictates that information flows from DNA through RNA to proteins. That information, comprising the primary sequence, is sufficient...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (6): 1651–1660.
Published: 17 December 2019
... such as in brain tumors, following injury and in neurodegenerative disorders and is highly associated with glial reactivity as well as scar formation. As a key modulator of the immune response during neurodegeneration in the CNS, tenascin-C is highlighted in this mini-review. Tenascin-C has a tenascin-C assembly...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (3): 827–838.
Published: 13 May 2019
... with both familial and sporadic forms of the disease, the question of whether there is cross-talk between the various proteins encoded by the different genes is highly relevant. Several studies addressed the physiological and pathological roles of LRRK2 and how they may relate to neurodegeneration...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (2): 663–670.
Published: 05 March 2019
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 biomarker exosome LRRK2 neurodegeneration Parkinson disease Genome-wide association studies have identified variants in or nearby the leucine-rich repeat kinase 2 (LRRK2) gene in Parkinson's...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (5): 1063–1072.
Published: 21 September 2018
..., including cancer and neurodegeneration, are associated with the loss of the Golgi ribbon and the appearance of a dispersed fragmented Golgi. Here, we review the emerging theme of the Golgi as a cell sensor and highlight the relationship between the morphological status of the Golgi in vertebrate cells...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2018) 46 (4): 829–842.
Published: 09 July 2018
... in disease. Recent advances in understanding mitochondrially controlled cell death pathways and elucidating the mitochondrial permeability pore bioarchitecture are beginning to present new avenues to target neurodegeneration. Novel mitochondrial roles of deubiquitinating enzymes are coming to light...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (6): 1295–1303.
Published: 17 November 2017
... the Creative Commons Attribution License 4.0 (CC BY) . antioxidants neurodegeneration oxidative stress transcription factors Reactive oxygen species (ROS) are oxygen-containing molecules which are primarily formed as a result of incomplete oxygen reduction [ 1 – 3 ]. These substances can...
Articles
Andrey Y. Abramov, Alexey V. Berezhnov, Evgeniya I. Fedotova, Valery P. Zinchenko, Ludmila P. Dolgacheva
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (4): 1025–1033.
Published: 21 July 2017
... on behalf of the Biochemical Society 2017 α-synuclein β-amyloid mitochondria neurodegeneration ROS tau proteins The amyloid precursor protein is cleaved by β- and γ-secretase, generating a range of β-amyloid (βA) peptides between 39 and 43 amino acid residues long, where...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (2): 381–387.
Published: 13 April 2017
.... Correspondence: Shantá D. Hinton ( sdhinton@wm.edu ) 30 11 2016 17 1 2017 20 1 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 MK-STYX neurite outgrowths neurodegeneration phospho-serine–threonine/tyrosine-binding protein...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 163–172.
Published: 15 February 2017
... are known to form aggregates in PD brains harboring LRRK2 mutations, to neurodegeneration in LRRK2 rodent models. We aim to provide a clear and unbiased review of some of the key mechanisms that are important for LRRK2-dependent neurodegeneration in PD. Correspondence: Darren J. Moore ( darren.moore...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 101–112.
Published: 15 February 2017
... of the Biochemical Society 2017 neurodegeneration protein phosphatases therapeutics translation factors unfolded protein response With the greater access to healthcare, many countries have seen sharp increases in the lifespan of their populations. This in turn has contributed to a rising global...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 155–162.
Published: 15 February 2017
...) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy leucine-rich repeat kinase neurodegeneration Parkinson's disease Leucine-rich repeat...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (6): 1625–1634.
Published: 02 December 2016
... ) 12 8 2016 15 9 2016 23 9 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 GTPases leucine-rich repeat kinase neurodegeneration Parkinson's disease Wnt proteins Parkinson's disease (PD) is the second most...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (2): 659–661.
Published: 11 April 2016
... genetics motor neuron disease neurodegeneration parkinsonism Identifying and diagnosing selective vulnerability is the essence of neurological practice: the practice of ascertaining neurological symptoms is largely the elucidation of lesion location. Yet it is largely mysterious why diseases...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2016) 44 (1): 177–184.
Published: 09 February 2016
... lysosome neurodegeneration PIKfyve Vac14 Phosphorylated phosphatidylinositol lipids are crucial for most eukaryotes and have diverse cellular functions. They regulate multiple pathways, including organization of the cytoskeleton, cellular motility, endocytosis and provide spatial and temporal...
Articles
Eleonora Da Pozzo, Chiara Giacomelli, Elisabetta Barresi, Barbara Costa, Sabrina Taliani, Federico Da Settimo Passetti, Claudia Martini
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 559–565.
Published: 03 August 2015
... or therapeutic agents. Recent researches have reported that TSPO ligands might be valuable in the treatment of brain diseases. This review focuses on currently available TSPO ligands, as useful tools for the treatment of neurodegeneration, neuro-inflammation and neurotrauma. 1 To whom correspondence...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 621–626.
Published: 03 August 2015
... kinase beta (IKKβ) Kelch-like ECH-associated protein 1 (Keap1) nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear factor-κB (NF-κB) neurodegeneration Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor controlling many aspects of cell homoeostasis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 627–631.
Published: 03 August 2015
... in the tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (3): 333–337.
Published: 01 June 2015
... extended to treatment of chronic neurodegenerative diseases in two mouse models. Concurrently studies have demonstrated the importance of the regulation of protein synthesis, translation, to the cooling response, which is also emerging as a targetable process in neurodegeneration. Through these studies...
Articles
Graziella Cappelletti, Francesca Casagrande, Alessandra Calogero, Carmelita De Gregorio, Gianni Pezzoli, Daniele Cartelli
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (2): 292–296.
Published: 07 April 2015
...-dependent functions neurodegeneration parkin Parkinson's disease The molecular pathways implicated in neurodegenerative disorders are gradually being elucidated and several contributing factors have been identified. To date, aetiopathogenic mechanisms in Parkinson's disease (PD) converge...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (5): 1291–1301.
Published: 18 September 2014
... the role of glia in neurodegeneration in an attempt to identify novel targets that could be used to develop much-needed strategies for the containment and cure of neurodegenerative disorders. We discuss this in the context of glial roles in the homoeostasis and defence of the brain. We consider...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1069–1074.
Published: 11 August 2014
...Paola Venco; Sabrina Dusi; Lorella Valletta; Valeria Tiranti NBIA (neurodegeneration with brain iron accumulation) comprises a heterogeneous group of neurodegenerative diseases having as a common denominator, iron overload in specific brain areas, mainly basal ganglia and globus pallidus...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1075–1079.
Published: 11 August 2014
... be addressed (email o.c.m.sibon@umcg.nl ). 1 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 coenzyme A (CoA) metabolic cofactor NAD neurodegeneration pantothenate kinase (PANK) CoA (coenzyme A) was first described in 1947, as a coenzyme functioning...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1025–1032.
Published: 11 August 2014
... Biochemical Society 2014 anti-metabolite coenzyme A (CoA) neurodegeneration pantothenate protein acetylation vanin Anyone who took a first year undergraduate biochemistry course will (hopefully!) recall that coenzyme A (CoA) is a ubiquitous coenzyme which functions as an acyl group carrier...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 593–599.
Published: 20 March 2014
... that this approach has in providing novel treatments that have protective and even restorative properties that no current drug treatment can offer. 1 email c.holscher@lancaster.ac.uk 8 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 memory neurodegeneration...
Articles
Daniel García-Ovejero, Ángel Arévalo-Martín, Beatriz Navarro-Galve, Emmanuel Pinteaux, Eduardo Molina-Holgado, Francisco Molina-Holgado
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1577–1582.
Published: 20 November 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 brain cannabinoid system interleukin-1β neural stem cell fate neurodegeneration neurogenesis neuroprotection Although much has been learnt in recent years about the causes of degeneration within the brain, in terms...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1541–1545.
Published: 20 November 2013
... © The Authors Journal compilation © 2013 Biochemical Society 2013 antioxidant defence astrocyte neurodegeneration neuron neuroprotection oxidative stress According to the theory of neuronal health, neurons exist in a dynamic spectrum of states, which range from highly resilient...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1483–1488.
Published: 20 November 2013
...Jaime L. Schneider; Ana Maria Cuervo The importance of cellular quality-control systems in the maintenance of neuronal homoeostasis and in the defence against neurodegeneration is well recognized. Chaperones and proteolytic systems, the main components of these cellular surveillance mechanisms...
Articles
Mathilde Chivet, Charlotte Javalet, Fiona Hemming, Karin Pernet-Gallay, Karine Laulagnier, Sandrine Fraboulet, Rémy Sadoul
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 241–244.
Published: 29 January 2013
... remy.sadoul@ujf-grenoble.fr ). 18 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 exosome microvesicle neurodegeneration neuron synaptic plasticity The function of the brain relies on the capacity of billions of synapses to transmit patterns...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 101–105.
Published: 29 January 2013
... Journal compilation © 2013 Biochemical Society 2013 brain aging c-Jun N-terminal kinase (JNK) energy metabolism insulin/insulin-like growth factor-1 signalling mitochondrion neurodegeneration A decrease in energy metabolism, leading to a hypometabolic state, is associated with brain...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (5): 1123–1128.
Published: 19 September 2012
... genetics of Parkinson's disease leucine-rich repeat kinase 2 (LRRK2) neurodegeneration Parkinson's disease treatment Wnt signalling PD (Parkinson's disease) is the second most prevalent neurodegenerative disease worldwide. Individuals with PD present with typical motor symptoms...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 656–660.
Published: 20 July 2012
... will require the identification of common mechanisms of tau neurotoxicity, and pathways that can be modulated to protect against neurodegeneration. Model organisms, such as Caenorhabditis elegans , provide methods for identifying novel genes and pathways that are involved in tau pathology and may be exploited...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 739–745.
Published: 20 July 2012
... ). 9 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 Drosophila genetic modifier genetic screening Huntington's disease neurodegeneration HD (Huntington's disease) is a fatal neurodegenerative disorder predominantly characterized by the selective...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 687–692.
Published: 20 July 2012
...Tara M. Caffrey; Richard Wade-Martins The microtubule-associated protein tau ( MAPT or tau) is of great interest in the field of neurodegeneration as there is a well-established genetic link between the MAPT gene locus and tauopathies, a diverse group of neurodegenerative dementias and movement...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 85–89.
Published: 19 January 2012
...) mitogen-activated protein kinase (MAPK) mitogen-activated protein kinase kinase 4 (MKK4) mitogen-activated protein kinase kinase 7 (MKK7) neurodegeneration Cells have the ability to communicate with each other and modify their behaviour according to changes in their environment. The information...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 924–932.
Published: 20 July 2011
... detrimental effects. 1 email yhuang@gladstone.ucsf.edu 27 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) animal model apolipoprotein E (apoE) cognitive impairment neurodegeneration AD (Alzheimer's disease) causes...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 862–867.
Published: 20 July 2011
... ). In the field of neurodegeneration, this provides a unique tool for comparing the effect of expressing a WT (wild-type) gene with that of a gene harbouring a mutation known to be associated with disease. This review discusses recent results obtained through the use of BAC-transgenic mice. Figure 1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (3): 819–822.
Published: 20 May 2011
... to Ca 2+ dysregulation in AD and propose cholesterol enrichment in rafts as a protector of the Aβ-mediated inhibition on PMCA. 10 12 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging Alzheimer's disease cholesterol lipid raft neurodegeneration plasma...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (5): 1179–1188.
Published: 24 September 2010
... -acetylglucosamine) modification is one such glycosylation with considerable medical interest, reflecting its implication in diseases such as Type 2 diabetes and neurodegeneration. In the present paper, we review recent structural and mechanistic studies into the enzymes responsible for this modification...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 973–976.
Published: 26 July 2010
...Jeanna M. Wheeler; Chris R. Guthrie; Brian C. Kraemer We previously developed a transgenic Caenorhabditis elegans model of human tauopathy disorders by expressing human tau in nematode worm neurons to explore genetic pathways contributing to tau-induced neurodegeneration. This animal model...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 977–980.
Published: 26 July 2010
... of the dentate gyrus. Once neuronal degeneration takes place, intracellular tau is secreted to the extracellular space. The present review discusses the toxicity of this extracellular tau for surrounding neurons. dentate gyrus glycogen synthase kinase 3 (GSK3) microtubule neurodegeneration phosphorylation...
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