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Articles

New discoveries in ER–mitochondria communication

Margret Helene Bülow, Julia Sellin

Biochem Soc Trans (2023) 51 (2): 571–577.

https://doi.org/10.1042/BST20221305

Published: 09 March 2023

... neurodegenerative diseases, which implicate either enhanced or reduced ER–mitochondria contacts in neurodegeneration. Taken together, the discussed studies highlight the need for further research into the role of triple organelle contacts, as well as into the exact mechanisms of increased and decreased ER...

View article titled, New discoveries in ER–mitochondria communication

Articles

Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease

Safak Er, Mikko Airavaara

Biochem Soc Trans (2023) 51 (1): 245–257.

https://doi.org/10.1042/BST20220770

Published: 16 February 2023

...Safak Er; Mikko Airavaara Synucleinopathies constitute a disease family named after alpha-synuclein protein, which is a significant component of the intracellular inclusions called Lewy bodies. Accompanying the progressive neurodegeneration, Lewy bodies and neurites are the main histopathologies...

View article titled, Protective mechanisms by glial cell line-derived neurotrophic factor and cerebral dopamine neurotrophic factor against the α-synuclein accumulation in Parkinson's disease

Articles

The interactions of amyloid β aggregates with phospholipid membranes and the implications for neurodegeneration

Rima Budvytyte, Gintaras Valincius

Biochem Soc Trans (2023) 51 (1): 147–159.

https://doi.org/10.1042/BST20220434

Published: 11 January 2023

... membrane, compromising its integrity, and affecting the function of receptors. These facts indicate that the interaction between Aβ oligomers and cell membranes may be one of the central molecular level factors responsible for the onset of neurodegeneration. The present review provides a structural...

View article titled, The interactions of amyloid β aggregates with phospholipid membranes and the implications for neurodegeneration

Articles

The functional importance of VCP to maintaining cellular protein homeostasis

Brittany A. Ahlstedt, Rakesh Ganji, Malavika Raman

Biochem Soc Trans (2022) 50 (5): 1457–1469.

https://doi.org/10.1042/BST20220648

Published: 05 October 2022

... 2022 9 9 2022 15 9 2022 autophagy neurodegeneration organelles protein quality control ubiquitin © 2022 The Author(s) 2022 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons...

View article titled, The functional importance of VCP to maintaining cellular protein homeostasis

Articles

The role of autophagy-lysosomal pathway in motor neuron diseases

Barbara Tedesco, Veronica Ferrari, Marta Cozzi, Marta Chierichetti, Elena Casarotto, Paola Pramaggiore, Francesco Mina, Margherita Piccolella, Riccardo Cristofani, Valeria Crippa, Paola Rusmini, Mariarita Galbiati, Angelo Poletti

Biochem Soc Trans (2022) 50 (5): 1489–1503.

https://doi.org/10.1042/BST20220778

Published: 16 September 2022

... in which neurodegeneration mainly affects upper and/or lower motor neurons (MNs). Although the involvement of specific MNs, symptoms, age of onset, and progression differ in MNDs, the main pathogenic mechanism common to most MNDs is represented by proteostasis alteration and proteotoxicity...

View article titled, The role of autophagy-lysosomal pathway in motor neuron diseases

Articles

Linear ubiquitination in immune and neurodegenerative diseases, and beyond

In Collection

Cell death and survival

Fuminori Tokunaga, Fumiyo Ikeda

Biochem Soc Trans (2022) 50 (2): 799–811.

https://doi.org/10.1042/BST20211078

Published: 28 March 2022

...). Published by Portland Press Limited on behalf of the Biochemical Society 2022 inflammation linear ubiquitination LUBAC LUBAC inhibitors neurodegeneration Ubiquitin is a 76-amino acid protein that is expressed in all eukaryotic cells; it modifies substrate proteins to regulate...

View article titled, Linear ubiquitination in immune and neurodegenerative diseases, and beyond

Articles

Spatial sequestration of misfolded proteins in neurodegenerative diseases

Sarah Rolli, Emily Mitchell Sontag

Biochem Soc Trans (2022) 50 (2): 759–771.

https://doi.org/10.1042/BST20210862

Published: 21 March 2022

... ( emily.sontag@marquette.edu ) 14 1 2022 28 2 2022 2 3 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 ageing neurodegeneration protein aggregation proteostasis Protein homeostasis (proteostasis) is the process...

View article titled, Spatial sequestration of misfolded proteins in neurodegenerative diseases

Articles

The molecular pathogenesis of repeat expansion diseases

Yuzo Fujino, Yoshitaka Nagai

Biochem Soc Trans (2022) 50 (1): 119–134.

https://doi.org/10.1042/BST20200143

Published: 23 December 2021

...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 liquid-liquid phase separation neurodegeneration RAN translation repeat expansion diseases The human genome contains many simple sequence repeats composed of a short repeat unit known as a short tandem...

View article titled, The molecular pathogenesis of repeat expansion diseases

Articles

Insights into neurodegeneration from electron microscopy studies

R. Anthony Crowther

Biochem Soc Trans (2021) 49 (6): 2777–2786.

https://doi.org/10.1042/BST20210719

Published: 23 November 2021

... in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC. alpha-synuclein electron microcopy neurodegeneration tau protein Many neurodegenerative diseases are characterized by the presence in the brain...

View article titled, Insights into neurodegeneration from electron microscopy studies

Articles

Molecular and pharmacological chaperones for SOD1

Gareth S.A. Wright

Biochem Soc Trans (2020) 48 (4): 1795–1806.

https://doi.org/10.1042/BST20200318

Published: 14 August 2020

... group member [ 61 ]. Binding of the correct HSP70 chaperone to mutant SOD1 is, therefore, an important indicator of the fate, and therefore the toxicity, of a mutant SOD1 molecule. amyotrophic lateral sclerosis molecular chaperones neurodegeneration Parkinson's disease pharmacological...

View article titled, Molecular and pharmacological chaperones for SOD1

Articles

Immunomodulatory role of the extracellular matrix protein tenascin-C in neuroinflammation

Susanne Wiemann, Jacqueline Reinhard, Andreas Faissner

Biochem Soc Trans (2019) 47 (6): 1651–1660.

https://doi.org/10.1042/BST20190081

Published: 17 December 2019

... such as in brain tumors, following injury and in neurodegenerative disorders and is highly associated with glial reactivity as well as scar formation. As a key modulator of the immune response during neurodegeneration in the CNS, tenascin-C is highlighted in this mini-review. extracellular matrix glial scar...

View article titled, Immunomodulatory role of the extracellular matrix protein tenascin-C in neuroinflammation

Articles

LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?

Tiago Fleming Outeiro, Kirsten Harvey, Antonio Dominguez-Meijide, Ellen Gerhardt

Biochem Soc Trans (2019) 47 (3): 827–838.

https://doi.org/10.1042/BST20180466

Published: 13 May 2019

... alpha-synuclein LRRK2 neurodegeneration Parkinson's disease tau Parkinson's disease (PD) is a complex neurodegenerative disorder clinically known for typical motor features that include muscular rigidity, resting tremor, bradykinesia, and postural instability. In addition, a variety of non...

View article titled, LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?

Articles

Caught in the act: LRRK2 in exosomes

Shijie Wang, Andrew B. West

Biochem Soc Trans (2019) 47 (2): 663–670.

https://doi.org/10.1042/BST20180467

Published: 05 March 2019

... in LRRK2 mutation carriers. Correspondence: Andrew B. West ( Andrew.West@Duke.edu ) 17 11 2018 15 1 2019 31 1 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 biomarker exosome LRRK2 neurodegeneration...

View article titled, Caught in the act: LRRK2 in exosomes

Articles

The Golgi architecture and cell sensing

Christian Makhoul, Prajakta Gosavi, Paul A. Gleeson

Biochem Soc Trans (2018) 46 (5): 1063–1072.

https://doi.org/10.1042/BST20180323

Published: 21 September 2018

..., including cancer and neurodegeneration, are associated with the loss of the Golgi ribbon and the appearance of a dispersed fragmented Golgi. Here, we review the emerging theme of the Golgi as a cell sensor and highlight the relationship between the morphological status of the Golgi in vertebrate cells...

View article titled, The Golgi architecture and cell sensing

Articles

Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention

Thomas Briston, Amy R. Hicks

Biochem Soc Trans (2018) 46 (4): 829–842.

https://doi.org/10.1042/BST20180025

Published: 09 July 2018

... in disease. Recent advances in understanding mitochondrially controlled cell death pathways and elucidating the mitochondrial permeability pore bioarchitecture are beginning to present new avenues to target neurodegeneration. Novel mitochondrial roles of deubiquitinating enzymes are coming to light...

View article titled, Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention

Articles

Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory

Scott W. Burnside, Giles E. Hardingham

Biochem Soc Trans (2017) 45 (6): 1295–1303.

https://doi.org/10.1042/BST20170013

Published: 17 November 2017

... the Creative Commons Attribution License 4.0 (CC BY) . antioxidants neurodegeneration oxidative stress transcription factors Reactive oxygen species (ROS) are oxygen-containing molecules which are primarily formed as a result of incomplete oxygen reduction [ 1 – 3 ]. These substances can...

View article titled, Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory

Articles

Interaction of misfolded proteins and mitochondria in neurodegenerative disorders

Andrey Y. Abramov, Alexey V. Berezhnov, Evgeniya I. Fedotova, Valery P. Zinchenko, Ludmila P. Dolgacheva

Biochem Soc Trans (2017) 45 (4): 1025–1033.

https://doi.org/10.1042/BST20170024

Published: 21 July 2017

... aggregation could be related to progressive neuronal death in different forms of neurodegeneration. For long time, the role of misfolded proteins in mitochondrial function was disputable due to lack of evidence of the location of misfolded aggregates in mitochondria. Recent studies demonstrated...

View article titled, Interaction of misfolded proteins and mitochondria in neurodegenerative disorders

Articles

Antagonistic roles for STYX pseudophosphatases in neurite outgrowth

Arya Dahal, Shantá D. Hinton

Biochem Soc Trans (2017) 45 (2): 381–387.

https://doi.org/10.1042/BST20160273

Published: 13 April 2017

.... Correspondence: Shantá D. Hinton ( sdhinton@wm.edu ) 30 11 2016 17 1 2017 20 1 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 MK-STYX neurite outgrowths neurodegeneration phospho-serine–threonine/tyrosine-binding protein...

View article titled, Antagonistic roles for STYX pseudophosphatases in neurite outgrowth

Articles

Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation

Md. Shariful Islam, Darren J. Moore

Biochem Soc Trans (2017) 45 (1): 163–172.

https://doi.org/10.1042/BST20160264

Published: 15 February 2017

... are known to form aggregates in PD brains harboring LRRK2 mutations, to neurodegeneration in LRRK2 rodent models. We aim to provide a clear and unbiased review of some of the key mechanisms that are important for LRRK2-dependent neurodegeneration in PD. Correspondence: Darren J. Moore ( darren.moore...

View article titled, Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation

Articles

Translating protein phosphatase research into treatments for neurodegenerative diseases

Jeyapriya R. Sundaram, Irene C.J. Lee, Shirish Shenolikar

Biochem Soc Trans (2017) 45 (1): 101–112.

https://doi.org/10.1042/BST20160157

Published: 15 February 2017

... protein response (UPR) plays a critical role in neurodegeneration [ 1 – 4 ]. This has focused attention on the UPR signaling pathways that are activated following the accumulation of misfolded proteins in the endoplasmic reticulum (ER) with the notion that pharmacological modulation of these pathways may...

View article titled, Translating protein phosphatase research into treatments for neurodegenerative diseases

Articles

The LRRK2–macroautophagy axis and its relevance to Parkinson's disease

Claudia Manzoni

Biochem Soc Trans (2017) 45 (1): 155–162.

https://doi.org/10.1042/BST20160265

Published: 15 February 2017

...) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy leucine-rich repeat kinase neurodegeneration Parkinson's disease Leucine-rich repeat...

View article titled, The LRRK2–macroautophagy axis and its relevance to Parkinson's disease

Articles

L'RRK de Triomphe: a solution for LRRK2 GTPase activity?

Jonathon Nixon-Abell, Daniel C. Berwick, Kirsten Harvey

Biochem Soc Trans (2016) 44 (6): 1625–1634.

https://doi.org/10.1042/BST20160240

Published: 02 December 2016

... for pathogenic RocCOR tandem domain mutations ( Table 1 ). Taken together, these observations are consistent with GTP-bound LRRK2 being pathogenic and raise the possibility of targeting LRRK2 GTP-binding for PD treatment. Intriguingly, a LRRK2 GTP-binding inhibitor has been reported to reduce neurodegeneration...

View article titled, L'RRK de Triomphe: a solution for LRRK2 GTPase activity?

Articles

Catastrophic cliffs: a partial suggestion for selective vulnerability in neurodegenerative diseases

John Hardy

Biochem Soc Trans (2016) 44 (2): 659–661.

https://doi.org/10.1042/BST20150287

Published: 11 April 2016

... leads to disease spread between neurons and also that mutations in this one gene can lead to widely different neuronal selectivities and clinical features. ataxia dementia genetics motor neuron disease neurodegeneration parkinsonism Identifying and diagnosing selective vulnerability...

View article titled, Catastrophic cliffs: a partial suggestion for selective vulnerability in neurodegenerative diseases

Articles

Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time

Natsuko Jin, Michael J. Lang, Lois S. Weisman

Biochem Soc Trans (2016) 44 (1): 177–184.

https://doi.org/10.1042/BST20150174

Published: 09 February 2016

... 4 lysosome neurodegeneration PIKfyve Vac14 Fab1–PIKfyve is the sole lipid kinase that synthesizes PI(3,5)P 2 from phosphatidylinositol-3-phosphate (PI(3) P ) [ 6 , 9 , 10 ]. Fab1 was identified in the budding yeast S. cerevisiae [ 11 ] and was shown to function as a vacuolar PI(3) P...

View article titled, Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time

Articles

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

Joanna D. Wardyn, Amy H. Ponsford, Christopher M. Sanderson

Biochem Soc Trans (2015) 43 (4): 621–626.

https://doi.org/10.1042/BST20150014

Published: 03 August 2015

.... Imbalance between Nrf2 and NF-κB pathways is associated with a significant number of diseases ranging from neurodegeneration, autoimmune disorders and cancer [ 21 ]. It is well recognized that the Nrf2 and NF-κB pathways must interplay through multiple molecular interactions, the complexity and consequences...

View article titled, Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

Articles

Redox-based regulation of neural stem cell function and Nrf2

Lalitha Madhavan

Biochem Soc Trans (2015) 43 (4): 627–631.

https://doi.org/10.1042/BST20150016

Published: 03 August 2015

... in the tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...

View article titled, Redox-based regulation of neural stem cell function and Nrf2

Articles

Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection

Eleonora Da Pozzo, Chiara Giacomelli, Elisabetta Barresi, Barbara Costa, Sabrina Taliani, Federico Da Settimo Passetti, Claudia Martini

Biochem Soc Trans (2015) 43 (4): 559–565.

https://doi.org/10.1042/BST20150028

Published: 03 August 2015

... or therapeutic agents. Recent researches have reported that TSPO ligands might be valuable in the treatment of brain diseases. This review focuses on currently available TSPO ligands, as useful tools for the treatment of neurodegeneration, neuro-inflammation and neurotrauma. 1 To whom correspondence...

View article titled, Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection

Articles

Control of translation in the cold: implications for therapeutic hypothermia

John R.P. Knight, Anne E. Willis

Biochem Soc Trans (2015) 43 (3): 333–337.

https://doi.org/10.1042/BST20150052

Published: 01 June 2015

... extended to treatment of chronic neurodegenerative diseases in two mouse models. Concurrently studies have demonstrated the importance of the regulation of protein synthesis, translation, to the cooling response, which is also emerging as a targetable process in neurodegeneration. Through these studies...

View article titled, Control of translation in the cold: implications for therapeutic hypothermia

Articles

Linking microtubules to Parkinson's disease: the case of parkin

Graziella Cappelletti, Francesca Casagrande, Alessandra Calogero, Carmelita De Gregorio, Gianni Pezzoli, Daniele Cartelli

Biochem Soc Trans (2015) 43 (2): 292–296.

https://doi.org/10.1042/BST20150007

Published: 07 April 2015

.... Missing pieces in the Parkinson's disease puzzle Nat. Med. 2010 16 653 661 10.1038/nm.2165 20495568 3 Shapira A.H.V. Olanow C.W. Greenamyer J.T. Bezard E. Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives Lancet...

View article titled, Linking microtubules to Parkinson's disease: the case of parkin

Articles

Glia in the pathogenesis of neurodegenerative diseases

Alexei Verkhratsky, Vladimir Parpura, Marcela Pekna, Milos Pekny, Michael Sofroniew

Biochem Soc Trans (2014) 42 (5): 1291–1301.

https://doi.org/10.1042/BST20140107

Published: 18 September 2014

... the role of glia in neurodegeneration in an attempt to identify novel targets that could be used to develop much-needed strategies for the containment and cure of neurodegenerative disorders. We discuss this in the context of glial roles in the homoeostasis and defence of the brain. We consider...

View article titled, Glia in the pathogenesis of neurodegenerative diseases

Articles

Coenzyme A, more than ‘just’ a metabolic cofactor

Balaji Srinivasan, Ody C.M. Sibon

Biochem Soc Trans (2014) 42 (4): 1075–1079.

https://doi.org/10.1042/BST20140125

Published: 11 August 2014

... NAD neurodegeneration pantothenate kinase (PANK) Figure 2 Schematic representation of diverse roles of CoA in cellular physiology Coenzyme A and Its Derivatives in Cellular Metabolism and Disease: A Biochemical Society Focused Meeting held at Charles Darwin House, London, U.K...

View article titled, Coenzyme A, more than ‘just’ a metabolic cofactor

Articles

Coenzyme A and its derivatives: renaissance of a textbook classic

Frederica L. Theodoulou, Ody C.M. Sibon, Suzanne Jackowski, Ivan Gout

Biochem Soc Trans (2014) 42 (4): 1025–1032.

https://doi.org/10.1042/BST20140176

Published: 11 August 2014

... Biochemical Society 2014 anti-metabolite coenzyme A (CoA) neurodegeneration pantothenate protein acetylation vanin Anyone who took a first year undergraduate biochemistry course will (hopefully!) recall that coenzyme A (CoA) is a ubiquitous coenzyme which functions as an acyl group carrier...

View article titled, Coenzyme A and its derivatives: renaissance of a textbook classic

Articles

Alteration of the coenzyme A biosynthetic pathway in neurodegeneration with brain iron accumulation syndromes

Paola Venco, Sabrina Dusi, Lorella Valletta, Valeria Tiranti

Biochem Soc Trans (2014) 42 (4): 1069–1074.

https://doi.org/10.1042/BST20140106

Published: 11 August 2014

...Paola Venco; Sabrina Dusi; Lorella Valletta; Valeria Tiranti NBIA (neurodegeneration with brain iron accumulation) comprises a heterogeneous group of neurodegenerative diseases having as a common denominator, iron overload in specific brain areas, mainly basal ganglia and globus pallidus...

View article titled, Alteration of the coenzyme A biosynthetic pathway in neurodegeneration with brain iron accumulation syndromes

Articles

Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

Christian Hölscher

Biochem Soc Trans (2014) 42 (2): 593–599.

https://doi.org/10.1042/BST20140016

Published: 20 March 2014

... that this approach has in providing novel treatments that have protective and even restorative properties that no current drug treatment can offer. 1 email c.holscher@lancaster.ac.uk 8 1 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 memory neurodegeneration...

View article titled, Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

Articles

Neuroimmmune interactions of cannabinoids in neurogenesis: focus on interleukin-1β (IL-1β) signalling

Daniel García-Ovejero, Ángel Arévalo-Martín, Beatriz Navarro-Galve, Emmanuel Pinteaux, Eduardo Molina-Holgado, Francisco Molina-Holgado

Biochem Soc Trans (2013) 41 (6): 1577–1582.

https://doi.org/10.1042/BST20130198

Published: 20 November 2013

... The Authors Journal compilation © 2013 Biochemical Society 2013 brain cannabinoid system interleukin-1β neural stem cell fate neurodegeneration neurogenesis neuroprotection Although much has been learnt in recent years about the causes of degeneration within the brain, in terms...

View article titled, Neuroimmmune interactions of cannabinoids in neurogenesis: focus on interleukin-1β (IL-1β) signalling

Articles

Insight into a neuron's preferential susceptibility to oxidative stress

Karen F.S. Bell

Biochem Soc Trans (2013) 41 (6): 1541–1545.

https://doi.org/10.1042/BST20130245

Published: 20 November 2013

... • ), alkoxyl radicals (RO • ), peroxyradicals (ROO • ), hypochlorous acid (HOCl), nitric oxide (NO • ), peroxynitrite (ONOO − ), nitrogen dioxide ( • NO 2 ) and dinitrogen trioxide (N 2 O 3 ). antioxidant defence astrocyte neurodegeneration neuron neuroprotection oxidative stress ROS...

View article titled, Insight into a neuron's preferential susceptibility to oxidative stress

Articles

Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena

Jaime L. Schneider, Ana Maria Cuervo

Biochem Soc Trans (2013) 41 (6): 1483–1488.

https://doi.org/10.1042/BST20130126

Published: 20 November 2013

...Jaime L. Schneider; Ana Maria Cuervo The importance of cellular quality-control systems in the maintenance of neuronal homoeostasis and in the defence against neurodegeneration is well recognized. Chaperones and proteolytic systems, the main components of these cellular surveillance mechanisms...

View article titled, Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena

Articles

Exosomes as a novel way of interneuronal communication

Mathilde Chivet, Charlotte Javalet, Fiona Hemming, Karin Pernet-Gallay, Karine Laulagnier, Sandrine Fraboulet, Rémy Sadoul

Biochem Soc Trans (2013) 41 (1): 241–244.

https://doi.org/10.1042/BST20120266

Published: 29 January 2013

... disease Front. Physiol. 2012 3 229 exosome microvesicle neurodegeneration neuron synaptic plasticity The function of the brain relies on the capacity of billions of synapses to transmit patterns of electrical information through neuronal circuits. Reinforcement of circuits...

View article titled, Exosomes as a novel way of interneuronal communication

Articles

Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling

Fei Yin, Tianyi Jiang, Enrique Cadenas

Biochem Soc Trans (2013) 41 (1): 101–105.

https://doi.org/10.1042/BST20120260

Published: 29 January 2013

...) energy metabolism insulin/insulin-like growth factor-1 signalling mitochondrion neurodegeneration A decrease in energy metabolism, leading to a hypometabolic state, is associated with brain aging and the early stages of neurodegenerative disorders, such as Alzheimer's disease [ 1 ]. Neurons...

View article titled, Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling

Articles

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

Daniel C. Berwick, Kirsten Harvey

Biochem Soc Trans (2012) 40 (5): 1123–1128.

https://doi.org/10.1042/BST20120122

Published: 19 September 2012

... of dopaminergic neurons, and also suggest the intriguing possibility that the requirement of canonical Wnt signalling could be partly due to β-catenin-dependent co-activation of Nurr1-mediated gene expression. genetics of Parkinson's disease leucine-rich repeat kinase 2 (LRRK2) neurodegeneration...

View article titled, The importance of Wnt signalling for neurodegeneration in Parkinson's disease

Articles

Potential neuroprotective strategies against tauopathy

Jeanna M. Wheeler, Chris R. Guthrie, Brian C. Kraemer

Biochem Soc Trans (2012) 40 (4): 656–660.

https://doi.org/10.1042/BST20120017

Published: 20 July 2012

... will require the identification of common mechanisms of tau neurotoxicity, and pathways that can be modulated to protect against neurodegeneration. Model organisms, such as Caenorhabditis elegans , provide methods for identifying novel genes and pathways that are involved in tau pathology and may be exploited...

View article titled, Potential neuroprotective strategies against tauopathy

Articles

Choosing and using Drosophila models to characterize modifiers of Huntington's disease

Edward W. Green, Flaviano Giorgini

Biochem Soc Trans (2012) 40 (4): 739–745.

https://doi.org/10.1042/BST20120072

Published: 20 July 2012

... [ 7 ]. Drosophila genetic modifier genetic screening Huntington's disease neurodegeneration HD (Huntington's disease) is a fatal neurodegenerative disorder predominantly characterized by the selective loss of medium spiny neurons in the striatum of patients, leading...

View article titled, Choosing and using Drosophila models to characterize modifiers of Huntington's disease

Articles

The role of MAPT sequence variation in mechanisms of disease susceptibility

Tara M. Caffrey, Richard Wade-Martins

Biochem Soc Trans (2012) 40 (4): 687–692.

https://doi.org/10.1042/BST20120063

Published: 20 July 2012

...Tara M. Caffrey; Richard Wade-Martins The microtubule-associated protein tau ( MAPT or tau) is of great interest in the field of neurodegeneration as there is a well-established genetic link between the MAPT gene locus and tauopathies, a diverse group of neurodegenerative dementias and movement...

View article titled, The role of MAPT sequence variation in mechanisms of disease susceptibility

Articles

Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies

Clare Davies, Cathy Tournier

Biochem Soc Trans (2012) 40 (1): 85–89.

https://doi.org/10.1042/BST20110641

Published: 19 January 2012

... to explore the pathogenesis of Parkinson's disease Ann. N.Y. Acad. Sci. 2003 991 189 198 19 LaFerla F.M. Tinkle B.T. Bieberich C.J. Haudenschild C.C. Jay G. The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice Nat. Genet. 1995...

View article titled, Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies

Articles

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models

Yadong Huang

Biochem Soc Trans (2011) 39 (4): 924–932.

https://doi.org/10.1042/BST0390924

Published: 20 July 2011

... detrimental effects. 1 email yhuang@gladstone.ucsf.edu 27 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) animal model apolipoprotein E (apoE) cognitive impairment neurodegeneration ApoE, a 299-amino-acid...

View article titled, Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models

Articles

A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2 , SNCA and MAPT BAC-transgenic mice

Sara J. Johnson, Richard Wade-Martins

Biochem Soc Trans (2011) 39 (4): 862–867.

https://doi.org/10.1042/BST0390862

Published: 20 July 2011

... chromosome transgenics (BAC transgenics) leucine-rich repeat kinase 2 (LRRK2) microtubule-associated protein tau neurodegeneration Parkinson's disease Traditionally, transgenic mice are generated by the injection of a transgene expression cassette containing the gene of interest, driven...

View article titled, A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2 , SNCA and MAPT BAC-transgenic mice

Articles

Impairment of the activity of the plasma membrane Ca 2+ -ATPase in Alzheimer's disease

Ana M. Mata, María Berrocal, M. Rosario Sepúlveda

Biochem Soc Trans (2011) 39 (3): 819–822.

https://doi.org/10.1042/BST0390819

Published: 20 May 2011

... aging Alzheimer's disease cholesterol lipid raft neurodegeneration plasma membrane Ca 2+ -ATPase (PMCA) AD (Alzheimer's disease) is one of the most common dementias worldwide associated with aging. It is characterized by a progressive loss of cognitive abilities and severe neurodegeneration...

View article titled, Impairment of the activity of the plasma membrane Ca 2+ -ATPase in Alzheimer's disease

Articles

The O-GlcNAc modification: three-dimensional structure, enzymology and the development of selective inhibitors to probe disease

Gideon J. Davies, Carlos Martinez-Fleites

Biochem Soc Trans (2010) 38 (5): 1179–1188.

https://doi.org/10.1042/BST0381179

Published: 24 September 2010

... -acetylglucosamine) modification is one such glycosylation with considerable medical interest, reflecting its implication in diseases such as Type 2 diabetes and neurodegeneration. In the present paper, we review recent structural and mechanistic studies into the enzymes responsible for this modification...

View article titled, The O-GlcNAc modification: three-dimensional structure, enzymology and the development of selective inhibitors to probe disease

Articles

The role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy?

Jeanna M. Wheeler, Chris R. Guthrie, Brian C. Kraemer

Biochem Soc Trans (2010) 38 (4): 973–976.

https://doi.org/10.1042/BST0380973

Published: 26 July 2010

...Jeanna M. Wheeler; Chris R. Guthrie; Brian C. Kraemer We previously developed a transgenic Caenorhabditis elegans model of human tauopathy disorders by expressing human tau in nematode worm neurons to explore genetic pathways contributing to tau-induced neurodegeneration. This animal model...

View article titled, The role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy?

Articles

Tau phosphorylation in hippocampus results in toxic gain-of-function

Jesús Avila, Elena Gómez de Barreda, Tobias Engel, Jose J. Lucas, Félix Hernández

Biochem Soc Trans (2010) 38 (4): 977–980.

https://doi.org/10.1042/BST0380977

Published: 26 July 2010

... of the dentate gyrus. Once neuronal degeneration takes place, intracellular tau is secreted to the extracellular space. The present review discusses the toxicity of this extracellular tau for surrounding neurons. dentate gyrus glycogen synthase kinase 3 (GSK3) microtubule neurodegeneration phosphorylation...

View article titled, Tau phosphorylation in hippocampus results in toxic gain-of-function

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