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Keywords: neurodegeneration
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Articles
Biochem Soc Trans (2022) 50 (5): 1457–1469.
Published: 05 October 2022
... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy neurodegeneration organelles protein quality control ubiquitin Valosin-containing protein (VCP, also p97, or Cdc48p in yeast...
Articles
Biochem Soc Trans (2022) 50 (5): 1489–1503.
Published: 16 September 2022
... in which neurodegeneration mainly affects upper and/or lower motor neurons (MNs). Although the involvement of specific MNs, symptoms, age of onset, and progression differ in MNDs, the main pathogenic mechanism common to most MNDs is represented by proteostasis alteration and proteotoxicity...
Articles
Biochem Soc Trans (2022) 50 (2): 799–811.
Published: 28 March 2022
... disease' [ 23 ]. Studies have also linked LUBAC with Alzheimer's disease [ 24 ]. These findings suggest that LUBAC dysfunction contributes to various human diseases. inflammation linear ubiquitination LUBAC LUBAC inhibitors neurodegeneration Ubiquitin is a 76-amino acid protein...
Articles
Biochem Soc Trans (2022) 50 (2): 759–771.
Published: 21 March 2022
... ( emily.sontag@marquette.edu ) 14 1 2022 28 2 2022 2 3 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 ageing neurodegeneration protein aggregation proteostasis Protein homeostasis (proteostasis) is the process...
Articles
Biochem Soc Trans (2022) 50 (1): 119–134.
Published: 23 December 2021
...(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 liquid-liquid phase separation neurodegeneration RAN translation repeat expansion diseases The human genome contains many simple sequence repeats composed of a short repeat unit known as a short tandem...
Articles
Biochem Soc Trans (2021) 49 (6): 2777–2786.
Published: 23 November 2021
... structures of brain derived filaments as targets. Another technique that may have application for studying neurodegeneration is cryo-electron tomography (cryo-ET). Unlike imaging of dispersed single particles or filaments, cryo-ET can be used to study sections of frozen tissue or bundles of filaments...
Articles
Biochem Soc Trans (2020) 48 (4): 1795–1806.
Published: 14 August 2020
... lateral sclerosis molecular chaperones neurodegeneration Parkinson's disease pharmacological chaperones protein misfolding The central dogma of molecular biology dictates that information flows from DNA through RNA to proteins. That information, comprising the primary sequence, is sufficient...
Articles
Biochem Soc Trans (2019) 47 (6): 1651–1660.
Published: 17 December 2019
... such as in brain tumors, following injury and in neurodegenerative disorders and is highly associated with glial reactivity as well as scar formation. As a key modulator of the immune response during neurodegeneration in the CNS, tenascin-C is highlighted in this mini-review. Correspondence: Andreas Faissner...
Articles
Biochem Soc Trans (2019) 47 (3): 827–838.
Published: 13 May 2019
... kinase activity is terminated ( Figure 2 ) [ 18 ]. © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 alpha-synuclein LRRK2 neurodegeneration Parkinson's disease tau The LRRK2 kinase domain shows high similarity to stress-activated mixed...
Articles
Biochem Soc Trans (2019) 47 (2): 663–670.
Published: 05 March 2019
... some of these issues. Correspondence: Andrew B. West ( Andrew.West@Duke.edu ) 17 11 2018 15 1 2019 31 1 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 biomarker exosome LRRK2 neurodegeneration Parkinson...
Articles
Biochem Soc Trans (2018) 46 (5): 1063–1072.
Published: 21 September 2018
..., including cancer and neurodegeneration, are associated with the loss of the Golgi ribbon and the appearance of a dispersed fragmented Golgi. Here, we review the emerging theme of the Golgi as a cell sensor and highlight the relationship between the morphological status of the Golgi in vertebrate cells...
Articles
Biochem Soc Trans (2018) 46 (4): 829–842.
Published: 09 July 2018
... in disease. Recent advances in understanding mitochondrially controlled cell death pathways and elucidating the mitochondrial permeability pore bioarchitecture are beginning to present new avenues to target neurodegeneration. Novel mitochondrial roles of deubiquitinating enzymes are coming to light...
Articles
Biochem Soc Trans (2017) 45 (6): 1295–1303.
Published: 17 November 2017
... integrity, accumulatively resulting in significant cellular apoptosis, neuronal excitotoxicity and neurodegeneration over time [ 7 ]. As such, neurons require a complex network of antioxidant enzymes and detoxifying species which can work synergistically to mitigate ROS accumulation and maintain a steady...
Articles
Biochem Soc Trans (2017) 45 (4): 1025–1033.
Published: 21 July 2017
... on behalf of the Biochemical Society 2017 α-synuclein β-amyloid mitochondria neurodegeneration ROS tau proteins Ageing of the population in the majority of countries leads to increase in the number of people with age-related disorders, including neurodegenerative diseases. Despite...
Articles
Biochem Soc Trans (2017) 45 (2): 381–387.
Published: 13 April 2017
.... Correspondence: Shantá D. Hinton ( sdhinton@wm.edu ) 30 11 2016 17 1 2017 20 1 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 MK-STYX neurite outgrowths neurodegeneration phospho-serine–threonine/tyrosine-binding protein...
Articles
Biochem Soc Trans (2017) 45 (1): 163–172.
Published: 15 February 2017
... are known to form aggregates in PD brains harboring LRRK2 mutations, to neurodegeneration in LRRK2 rodent models. We aim to provide a clear and unbiased review of some of the key mechanisms that are important for LRRK2-dependent neurodegeneration in PD. Correspondence: Darren J. Moore ( darren.moore...
Articles
Biochem Soc Trans (2017) 45 (1): 101–112.
Published: 15 February 2017
... development of therapies to preserve neuronal function and treat neurodegenerative disease. neurodegeneration protein phosphatases therapeutics translation factors unfolded protein response PD is the second most common neurodegenerative disorder after AD, affecting ∼1% of the elderly population...
Articles
Biochem Soc Trans (2017) 45 (1): 155–162.
Published: 15 February 2017
...) 2017 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy leucine-rich repeat kinase neurodegeneration Parkinson's disease Leucine-rich repeat...
Articles
Biochem Soc Trans (2016) 44 (6): 1625–1634.
Published: 02 December 2016
... ) 12 8 2016 15 9 2016 23 9 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 GTPases leucine-rich repeat kinase neurodegeneration Parkinson's disease Wnt proteins Parkinson's disease (PD) is the second most...
Articles
Biochem Soc Trans (2016) 44 (2): 659–661.
Published: 11 April 2016
... and neurodegeneration Exp. Neurol. 2010 224 331 335 10.1016/j.expneurol.2010.03.028 20362572 7 Cannon J.R. Tapias V. Na H.M. Honick A.S. Drolet R.E. Greenamyre J.T. A highly reproducible rotenone model of Parkinson's disease Neurobiol. Dis. 2009 34 279 290 10.1016/j.nbd...
Articles
Biochem Soc Trans (2016) 44 (1): 177–184.
Published: 09 February 2016
...@umich.edu ). 2 11 2015 © 2016 Authors; published by Portland Press Limited 2016 Fab1 Fig 4 lysosome neurodegeneration PIKfyve Vac14 Phosphorylated phosphatidylinositol lipids are crucial for most eukaryotes and have diverse cellular functions. They regulate multiple pathways...
Articles
Biochem Soc Trans (2015) 43 (4): 559–565.
Published: 03 August 2015
... or therapeutic agents. Recent researches have reported that TSPO ligands might be valuable in the treatment of brain diseases. This review focuses on currently available TSPO ligands, as useful tools for the treatment of neurodegeneration, neuro-inflammation and neurotrauma. The mechanisms underlying...
Articles
Biochem Soc Trans (2015) 43 (4): 621–626.
Published: 03 August 2015
... kinase beta (IKKβ) Kelch-like ECH-associated protein 1 (Keap1) nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear factor-κB (NF-κB) neurodegeneration Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor controlling many aspects of cell homoeostasis...
Articles
Biochem Soc Trans (2015) 43 (4): 627–631.
Published: 03 August 2015
... in the tissue microenvironment. However, both aging and neurodegeneration involve an up-regulation of processes, such as oxidative stress, inflammation, somatic mutations, and reduction in growth factors in neural tissues, which threaten the robust functioning of NSCs. Nevertheless, recent evidence also...
Articles
Biochem Soc Trans (2015) 43 (3): 333–337.
Published: 01 June 2015
... extended to treatment of chronic neurodegenerative diseases in two mouse models. Concurrently studies have demonstrated the importance of the regulation of protein synthesis, translation, to the cooling response, which is also emerging as a targetable process in neurodegeneration. Through these studies...
Articles
Biochem Soc Trans (2015) 43 (2): 292–296.
Published: 07 April 2015
...-dependent functions neurodegeneration parkin Parkinson's disease The molecular pathways implicated in neurodegenerative disorders are gradually being elucidated and several contributing factors have been identified. To date, aetiopathogenic mechanisms in Parkinson's disease (PD) converge...
Articles
Biochem Soc Trans (2014) 42 (5): 1291–1301.
Published: 18 September 2014
... the role of glia in neurodegeneration in an attempt to identify novel targets that could be used to develop much-needed strategies for the containment and cure of neurodegenerative disorders. We discuss this in the context of glial roles in the homoeostasis and defence of the brain. We consider...
Articles
Biochem Soc Trans (2014) 42 (4): 1069–1074.
Published: 11 August 2014
...Paola Venco; Sabrina Dusi; Lorella Valletta; Valeria Tiranti NBIA (neurodegeneration with brain iron accumulation) comprises a heterogeneous group of neurodegenerative diseases having as a common denominator, iron overload in specific brain areas, mainly basal ganglia and globus pallidus...
Articles
Biochem Soc Trans (2014) 42 (4): 1075–1079.
Published: 11 August 2014
... be addressed (email o.c.m.sibon@umcg.nl ). 1 5 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 coenzyme A (CoA) metabolic cofactor NAD neurodegeneration pantothenate kinase (PANK) ATM ataxia telangiectasia CaMKII calcium/calmodulin-dependent...
Articles
Biochem Soc Trans (2014) 42 (4): 1025–1032.
Published: 11 August 2014
... biosynthetic enzymes and its thioesters in cellular metabolism and diseases and to discuss challenges and opportunities for the future. anti-metabolite coenzyme A (CoA) neurodegeneration pantothenate protein acetylation vanin Anyone who took a first year undergraduate biochemistry course...
Articles
Biochem Soc Trans (2014) 42 (2): 593–599.
Published: 20 March 2014
..., first clinical trials testing insulin or exendin-4 showed promising initial results. These findings suggests that these drugs may be used as a novel treatment for AD or PD [ 62 – 67 ]. memory neurodegeneration oxidative stress synaptic plasticity The majority of AD (Alzheimer's disease...
Articles
Biochem Soc Trans (2013) 41 (6): 1577–1582.
Published: 20 November 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 brain cannabinoid system interleukin-1β neural stem cell fate neurodegeneration neurogenesis neuroprotection Supported by the Ministry of Economy and Competitiveness (Instituto de Salud Carlos III) [PI: 11/1729] (Spain...
Articles
Biochem Soc Trans (2013) 41 (6): 1541–1545.
Published: 20 November 2013
... 299 305 2 Andersen J.K. Oxidative stress in neurodegeneration: cause or consequence? Nat. Med. 2004 10 Suppl. S18 S25 3 Tauskela J.S. Brunette E. Monette R. Comas T. Morley P. Preconditioning of cortical neurons by oxygen-glucose deprivation...
Articles
Biochem Soc Trans (2013) 41 (6): 1483–1488.
Published: 20 November 2013
...Jaime L. Schneider; Ana Maria Cuervo The importance of cellular quality-control systems in the maintenance of neuronal homoeostasis and in the defence against neurodegeneration is well recognized. Chaperones and proteolytic systems, the main components of these cellular surveillance mechanisms...
Articles
Biochem Soc Trans (2013) 41 (1): 241–244.
Published: 29 January 2013
... Joseph Fourier, Fondation France Alzheimer and ANR [grant number 08-Blanc-0271 (to R.S.)]. exosome microvesicle neurodegeneration neuron synaptic plasticity The function of the brain relies on the capacity of billions of synapses to transmit patterns of electrical information through...
Articles
Biochem Soc Trans (2013) 41 (1): 101–105.
Published: 29 January 2013
...) energy metabolism insulin/insulin-like growth factor-1 signalling mitochondrion neurodegeneration A decrease in energy metabolism, leading to a hypometabolic state, is associated with brain aging and the early stages of neurodegenerative disorders, such as Alzheimer's disease [ 1 ]. Neurons...
Articles
Biochem Soc Trans (2012) 40 (5): 1123–1128.
Published: 19 September 2012
... development, synaptic function and maintenance. Taken together with the established links between dysregulated Wnt signalling and neurodegeneration, it is evident that disruption of Wnt signalling pathways could also underlie the pathogenesis of PD. Direct evidence supporting this idea comes from studies...
Articles
Biochem Soc Trans (2012) 40 (4): 656–660.
Published: 20 July 2012
... will require the identification of common mechanisms of tau neurotoxicity, and pathways that can be modulated to protect against neurodegeneration. Model organisms, such as Caenorhabditis elegans , provide methods for identifying novel genes and pathways that are involved in tau pathology and may be exploited...
Articles
Biochem Soc Trans (2012) 40 (4): 739–745.
Published: 20 July 2012
... makes them an attractive proposition for genetic modifier screening. Drosophila genetic modifier genetic screening Huntington's disease neurodegeneration HD (Huntington's disease) is a fatal neurodegenerative disorder predominantly characterized by the selective loss of medium spiny...
Articles
Biochem Soc Trans (2012) 40 (4): 687–692.
Published: 20 July 2012
...Tara M. Caffrey; Richard Wade-Martins The microtubule-associated protein tau ( MAPT or tau) is of great interest in the field of neurodegeneration as there is a well-established genetic link between the MAPT gene locus and tauopathies, a diverse group of neurodegenerative dementias and movement...
Articles
Biochem Soc Trans (2012) 40 (1): 85–89.
Published: 19 January 2012
...) mitogen-activated protein kinase (MAPK) mitogen-activated protein kinase kinase 4 (MKK4) mitogen-activated protein kinase kinase 7 (MKK7) neurodegeneration Cells have the ability to communicate with each other and modify their behaviour according to changes in their environment. The information...
Articles
Biochem Soc Trans (2011) 39 (4): 924–932.
Published: 20 July 2011
... detrimental effects. 1 email yhuang@gladstone.ucsf.edu 27 2 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Alzheimer's disease (AD) animal model apolipoprotein E (apoE) cognitive impairment neurodegeneration AD (Alzheimer's disease) causes...
Articles
Biochem Soc Trans (2011) 39 (4): 862–867.
Published: 20 July 2011
... chromosome transgenics (BAC transgenics) leucine-rich repeat kinase 2 (LRRK2) microtubule-associated protein tau neurodegeneration Parkinson's disease Traditionally, transgenic mice are generated by the injection of a transgene expression cassette containing the gene of interest, driven...
Articles
Biochem Soc Trans (2011) 39 (3): 819–822.
Published: 20 May 2011
... aging Alzheimer's disease cholesterol lipid raft neurodegeneration plasma membrane Ca 2+ -ATPase (PMCA) AD (Alzheimer's disease) is one of the most common dementias worldwide associated with aging. It is characterized by a progressive loss of cognitive abilities and severe neurodegeneration...
Articles
Biochem Soc Trans (2010) 38 (5): 1179–1188.
Published: 24 September 2010
... -acetylglucosamine) modification is one such glycosylation with considerable medical interest, reflecting its implication in diseases such as Type 2 diabetes and neurodegeneration. In the present paper, we review recent structural and mechanistic studies into the enzymes responsible for this modification...
Articles
Biochem Soc Trans (2010) 38 (4): 973–976.
Published: 26 July 2010
...Jeanna M. Wheeler; Chris R. Guthrie; Brian C. Kraemer We previously developed a transgenic Caenorhabditis elegans model of human tauopathy disorders by expressing human tau in nematode worm neurons to explore genetic pathways contributing to tau-induced neurodegeneration. This animal model...
Articles
Biochem Soc Trans (2010) 38 (4): 977–980.
Published: 26 July 2010
... function could result in neurodegeneration. When neurons die, tau can reach the extracellular space and, consequently, this extracellular tau might be toxic for the surrounding neurons, spreading tau toxicity [ 33 – 35 ]. Extracellular tau in its monomeric [ 35 ] or aggregated form [ 35 , 36 ] might...
Articles
Biochem Soc Trans (2010) 38 (2): 545–551.
Published: 22 March 2010
... prion pathology when early dysfunctions have progressed to overt neuronal loss. 1 To whom correspondence should be addressed (email asuni@mac.com ). 15 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 Alzheimer's disease ME7 neurodegeneration...
Articles
Biochem Soc Trans (2010) 38 (2): 471–475.
Published: 22 March 2010
... and/or compensatory reaction to counteract the synaptic loss. 1 To whom correspondence should be addressed (email z.siskova@soton.ac.uk ). 27 8 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 hypertrophy ME7 neurodegeneration prion structural dynamics synapse...
Articles
Biochem Soc Trans (2010) 38 (2): 559–563.
Published: 22 March 2010
... ). 7 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 The discovery of the essential role of CSP in preventing neurodegeneration and its functional overlap with α-synuclein have increased the urgency for further study of this protein in nematodes. C. elegans...