... proteins in a native membrane-like environment that is water-soluble and detergent-free. This review provides an overview of recent developments in the membrane mimetic field, with a focus on nanodiscs, Saposin lipid nanoparticles (SapNPs), peptidiscs, and SMA lipid particles (SMALPs) — and highlights...

... membrane proteins nanodiscs Membrane proteins are a major focus of biochemical and biophysical research and are one of the largest classes of drug targets. The study of membrane proteins whilst mimicking their native lipid environment has been notoriously difficult using biophysical techniques...

... and nanodiscs: the first step is based on detergent solubilization, necessitating optimization of the nature and the concentration of the detergent(s) used, creating potential difficulties in reconstitution and of course loss of protein activity. 1 To whom correspondence should be addressed (email...