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Keywords: mycobacteria
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Biochem Soc Trans (2023) 51 (5): 1777–1787.
Published: 16 October 2023
... using Niemann–Pick disease type C as an example. inborn errors of metabolism lysosomal storage diseases lysosomes mycobacteria sphingolipids Tangier disease Lysosomal storage diseases (LSDs) are a group of rare inborn errors of metabolism [ 1 ]. At the cellular level...
Biochem Soc Trans (2003) 31 (3): 625–630.
Published: 01 June 2003
... protein) reductase] and KasA (the 3-oxoacyl ACP synthase) have been demonstrated to be targets for isoniazid [4,5]. Alterations in target Key words: cytochrome P450 CYP121, multidrug resistance, mycobacteria, tuberculosis. Abbreviations used: TB, tuberculosis; Mtb, Mycobacterium tuberculosis; WHO, World...
Biochem Soc Trans (2003) 31 (3): 615–619.
Published: 01 June 2003
... and phenotypic analyses of organisms (both mice and prokaryotes) following genetic modifications of the nat genes are leading to an understanding of the potentially diverse roles of NAT in endogenous and xenobiotic metabolism. These studies have indicated that NAT, particularly in Mycobacteria, has the potential...
Biochem Soc Trans (2001) 29 (2): 122–128.
Published: 01 May 2001
... been discovered in mycobacteria where antifungal azoles have effect and might be of value against tuberculosis. Evolutionary and therapeutic aspects of CYP51 studies are discussed. 1 To whom correspondence should be addressed (e-mail les@aber.ac.uk ) 6 11 2000 © 2001 Biochemical...