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Keywords: mutagenesis
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Biochem Soc Trans (2020) 48 (6): 2811–2822.
Published: 16 November 2020
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 DNA polymerases DNA replication and recommbination mutagenesis PCNA proten-protein interaction translesion DNA synthesis DNA replication is one of the most basic cellular processes that ensures...
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Biochem Soc Trans (2020) 48 (2): 451–462.
Published: 20 March 2020
... replication and recombination DNA synthesis and repair mutagenesis phenotypic heterogeneity single-cell analysis The maintenance of genome integrity is crucial for essential cell functions and accurate transfer of the genetic information across generations. For this reason, all organisms rely...
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Biochem Soc Trans (2016) 44 (3): 863–868.
Published: 09 June 2016
... side of the active site to the canopy. The mechanism of hydrogen activation has been dissected by site-directed mutagenesis to identify the catalytic base responsible for splitting molecular hydrogen and possible proton transfer pathways to/from the active site. Previous reported attempts to mutate...
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Biochem Soc Trans (2016) 44 (1): 129–142.
Published: 09 February 2016
... development. 1 To whom correspondence should be addressed (email xiichen@ucdavis.edu ). 18 11 2015 © 2016 Authors; published by Portland Press Limited 2016 carbohydrate directed evolution enzymatic synthesis glycosyltransferase mutagenesis protein engineering A growing...
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Biochem Soc Trans (2013) 41 (1): 180–184.
Published: 29 January 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 alanine scan family A GPCRs family B GPCRs mutagenesis secretin-like GPCR structure–activity relationship Family B GPCRs have a number of conserved proline residues, including a proline towards the middle of TM helix 6...
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Biochem Soc Trans (2012) 40 (6): 1492–1497.
Published: 21 November 2012
... lantibiotic mutagenesis nisin Figure 1 Biosynthesis of nisin ( A ) Formation of rings A and B only (see B ) is shown for clarily. Serine and threonine residues of the unmodified core peptide (with N-terminal leader peptide attached; not shown) are dehydrated by NisB, forming dehydroalanine (DHA...
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Biochem Soc Trans (2012) 40 (2): 433–437.
Published: 21 March 2012
... calcitonin mutagenesis receptor activity-modifying protein secretin-like G-protein-coupled receptor structure–activity relationship GPCRs form a number of families. The best characterized of these are the rhodopsin-like or family A GPCRs. The secretin-like or family B GPCRs form receptors...
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Articles
Biochem Soc Trans (2009) 37 (6): 1343–1346.
Published: 19 November 2009
..., and specific interactions between GABA and some of these residues have been determined. In the present paper, I show how a cation–π interaction for one of the binding site residues has allowed the production of models of GABA docked into the binding site, and these orientations are supported by mutagenesis...
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Biochem Soc Trans (2009) 37 (4): 838–842.
Published: 22 July 2009
... both gene-driven (reverse genetics) and phenotype-driven (forward genetics) approaches. A high-efficiency ENU approach results in approx. 25 functional mutations per genome; most of these will result in hypomorphic alleles. Our group has recently begun using ENU mutagenesis as a tool for understanding...
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Biochem Soc Trans (2008) 36 (6): 1313–1316.
Published: 19 November 2008
... perturbations. Random mutagenesis was induced, and individual mutagenized chromosomes were recovered by classic crossing schemes involving phenotypical markers and balancer chromosomes. In wild-type larvae, ferritin is predominantly localized in the brain, in regions of the intestine, in wreath cells...
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Biochem Soc Trans (2007) 35 (5): 1334–1337.
Published: 25 October 2007
... mutagenesis translesion synthesis ubiquitin The stability of our genetic material is endangered both by DNA-damaging agents from the environment and by endogenous problems during DNA replication arising from spontaneous damage [ 1 ]. DNA repair pathways, the cell's first line of defence against many...
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Biochem Soc Trans (2007) 35 (4): 709–712.
Published: 20 July 2007
... for secretin binding based on receptor mutagenesis and photoaffinity labelling studies. Full agonist analogues of secretin incorporating a photolabile moiety at various positions throughout the pharmacophore covalently label residues within this region, while only N-terminal probes have labelled the core...
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Biochem Soc Trans (2005) 33 (5): 1206–1209.
Published: 26 October 2005
... amphotericin B antifungal activity mutagenesis nystatin sterol yeast After more than 40 years of use in antifungal therapy, polyene macrolides nystatin and amphotericin B ( Figure 1 ) still represent the first line treatment of severe systemic fungal infections and several topical mycoses...
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Biochem Soc Trans (2004) 32 (6): 1037–1039.
Published: 26 October 2004
... cAMP regulatory element (CRE)-luciferase glucagon G-protein-coupled receptor (GPCR) mutagenesis receptor activation ternary complex The extended ternary complex model for GPCR (G-protein-coupled receptor) activation suggests that they interchange between inactive (R) and active (R*) states...
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Biochem Soc Trans (2003) 31 (5): 1042–1046.
Published: 01 October 2003
... in 2D and 3D, a Biochemical Society Focused Meeting held at University of Nottingham, 19–20 June 2003 20 June 2003 © 2003 Biochemical Society 2003 fluorescence spectroscopy mutagenesis secondary-structure prediction steroid receptor transactivation Abbreviations used...
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