... in the brain's response to hypertension and their possible role in promoting amyloid deposition in the brain, we have performed and investigated in depth different murine models of hypertension, induced either pharmacologically or mechanically, leading in the long term to plaque formation in the brain parenchyma...

... Biochemical Society 2008 IgM innate immunity mannose-binding lectin (MBL) mannose-binding lectin-associated serine protease (MASP) murine model pathogen Many model studies of disease have been undertaken using genetically modified mice that mimic human immunodeficiencies and other disease...

... a defect in apoptosis in vivo , they rapidly undergo apoptosis ex vivo , suggesting that CLL cells are dependent on microenvironmental signals to enhance cell survival. One approach used to define the cellular and molecular events that govern CLL has been the development of murine models that replicate...