... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 ABC transporters conformations human disease multidrug resistance transport mechanism ATP-binding cassette (ABC) transporters are one of the largest superfamilies of membrane transporters...

... transport proteins electron microscopy molecular modelling multidrug resistance pharmacokinetics transmembrane proteins It is getting close to 50 years since the first seeds in a new field of membrane protein research were sown with the identification of energy-dependent nutrient uptake systems...

... of the vesicles. Drug resistance can be defined as the ability of cancer cells to survive exposure to a wide range of anti-cancer drugs, and anti-tumour chemotherapeutic treatments are often impaired by innate or acquired MDR (multidrug resistance). Microvesicles released upon chemotherapeutic agents prevent...

... and structural features. Some of these similarities and their implications for the mechanism of transport by ABC multidrug transporters will be discussed. 28 6 2005 © 2005 The Biochemical Society 2005 ATP-binding cassette transporter (ABC transporter) carboxylate LmrA multidrug resistance...

... in clinical outcome; however, critical studies aimed at proving the hypothesis using Pgp inhibitors in clinical trials have to date failed. Identification of the MRP (multidrug resistance protein)/ABCC subfamily expanded the possible mechanisms of reduced drug accumulation, and the discovery of ABCG2 added...

... Meeting of the Biochemical Society held at the University of Essex, Colchester, 2–4 July 2003 3 July 2003 © 2003 Biochemical Society 2003 glycation glyoxalase methylglyoxal mutagenesis multidrug resistance tumour Abbreviations used: AGE, advanced glycation end-product...

...A.W. Munro; K.J. McLean; K.R. Marshall; A.J. Warman; G. Lewis; O. Roitel; M.J. Sutcliffe; C.A. Kemp; S. Modi; N.S. Scrutton; D. Leys Novel drug strategies are desperately needed to combat the global threat posed by multidrug-resistant strains of Mycobacterium tuberculosis (Mtb). The genome sequence...

... molecular recognition multidrug resistance © 2000 Biochemical Society 2000 13 4 2000 1 To whom correspondence should be addressed (e-mail neyfakh@uic.edu ) Efflux Proteins This research was supported by the BBSRC, North of England 5 Structural Biology Centre, the European Union...