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Keywords: multidrug resistance
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Biochem Soc Trans (2019) 47 (1): 23–36.
Published: 09 January 2019
... The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 ABC transporters conformations human disease multidrug resistance transport mechanism ATP-binding cassette (ABC) transporters are one of the largest superfamilies of membrane transporters...
Biochem Soc Trans (2018) 46 (6): 1485–1494.
Published: 21 November 2018
... transport proteins electron microscopy molecular modelling multidrug resistance pharmacokinetics transmembrane proteins It is getting close to 50 years since the first seeds in a new field of membrane protein research were sown with the identification of energy-dependent nutrient uptake systems...
Biochem Soc Trans (2013) 41 (1): 293–298.
Published: 29 January 2013
... of the vesicles. Drug resistance can be defined as the ability of cancer cells to survive exposure to a wide range of anti-cancer drugs, and anti-tumour chemotherapeutic treatments are often impaired by innate or acquired MDR (multidrug resistance). Microvesicles released upon chemotherapeutic agents prevent...
Biochem Soc Trans (2005) 33 (5): 1008–1011.
Published: 26 October 2005
... and structural features. Some of these similarities and their implications for the mechanism of transport by ABC multidrug transporters will be discussed. 28 6 2005 © 2005 The Biochemical Society 2005 ATP-binding cassette transporter (ABC transporter) carboxylate LmrA multidrug resistance...
Biochem Soc Trans (2005) 33 (1): 241–245.
Published: 01 February 2005
... in clinical outcome; however, critical studies aimed at proving the hypothesis using Pgp inhibitors in clinical trials have to date failed. Identification of the MRP (multidrug resistance protein)/ABCC subfamily expanded the possible mechanisms of reduced drug accumulation, and the discovery of ABCG2 added...
Biochem Soc Trans (2000) 28 (4): 517–520.
Published: 01 August 2000
... molecular recognition multidrug resistance © 2000 Biochemical Society 2000 13 4 2000 1 To whom correspondence should be addressed (e-mail neyfakh@uic.edu ) Efflux Proteins This research was supported by the BBSRC, North of England 5 Structural Biology Centre, the European Union...