...-ordinated beating of motile cilia. This mechanism of lung defence is reliant upon a flowing mucus gel, and the major macromolecular components that determine the rheological properties of mucus are the polymeric mucins, MUC5AC and MUC5B. These large O-linked glycoproteins have direct roles in maintaining...

...Breanna A. Symmes; Adrianne L. Stefanski; Chelsea M. Magin; Christopher M. Evans In humans and mice, the first line of innate defense against inhaled pathogens and particles in the respiratory tract is airway mucus. The primary solid components of the mucus layer are the mucins MUC5AC and MUC5B...

... 2016 Authors; published by Portland Press Limited 2016 sulfatase arylsulfatase radical SAM radical AdoMet microbiota microbiome metagenomic glycosaminoglycan mucin The human microbiota is a complex ecosystem constituted by a trillion of commensal microorganisms mostly represented...

..., but it may be useful in monitoring treatment of pancreatic cancer (e.g. the effectiveness of chemotherapy), as a complement to other diagnostic methods. Some other carbohydrate markers of pancreatic cancer may be considered, such as CEA (carcinoembryonic antigen), CA 50 and CA 242, and the mucins MUC1, MUC2...

...@vumc.nl ). 11 10 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 cancer carcinoembryonic antigen (CEA) C-type lectin dendritic cell glycosylation mucin Glycosylation of proteins and lipids in mammalian cells is mediated by a large number...

...M. Carmen Galan; Anthony P. Corfield The present article provides an overview on mucins and their role in biological processes, while aiming to familiarize readers with the current tools available for the synthesis of structurally defined mucin-type glycan probes including the advantages...

... the differentiation markers that are lost and gained in the differentiation switch. On the basis of newly identified markers of gastric and intestinal differentiation, namely mucin markers, a new classification of IM emerged. The new approach defines two main IM types: complete, or intestinal IM, and incomplete...

...Ben Nicholas; Ratko Djukanović Sputum is recognized as a sampling method for the monitoring and assessment of chronic lung diseases such as asthma, COPD (chronic obstructive pulmonary disease) and cystic fibrosis. Sputum samples the central airways and its protein components (e.g. mucins...

... that resists digestion, may be biologically significant. Increased TF expression by cancer cells also allows interaction with the human galactose-binding lectin, galectin-3. This lectin has increased concentration in the sera of patients with metastatic cancer and binds TF on cancer cell surface MUC1 (mucin 1...

...-glycans formed. 1 To whom correspondence should be addressed (email tony.corfield@bristol.ac.uk ). 9 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 apoptosis benzyl- O - N -acetyl- D -galactosamine colorectal cancer O-glycosylation mucin signal...

... 25 June 2003 © 2003 Biochemical Society 2003 chitosan glue protein micron size complex mucin ultracentrifuge Abbreviations used: SEC-MALLs, size-exclusion chromatography coupled to multi-angle laser light scattering; M w , weight-average molecular mass; M z , z...

...I. Brockhausen This review summarizes the occurrence, properties and role in mucin O-glycosylation pathways of the various members of glycoprotein sulphotransferase families. Although a number of sulphotransferases have been cloned that act on mucin-type substrates in vitro , it is still difficult...

...J. D. Aplin; M. Meseguer; C. Simon; M. E. Ortíz; H. Croxatto; C. J. P. Jones As it approaches the maternal surface, the attaching embryo encounters the epithelial glycocalyx, which contains the mucin, MUC1. A high density of MUC1 at the cell surface can inhibit cell adhesion. This raises...

...K. L. Carraway; N. Idris Sialomucin complex (SMC/rat Muc4) is a hetero-dimeric glycoprotein complex composed of an anti-adhesive mucin subunit ascites sialoglyco-protein (ASGP)-1 and a transmembrane subunit ASGP-2. SMC expression is tightly regulated in the uterus, and its expression appears...