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Keywords: mtDNA
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Biochem Soc Trans (2023) 51 (2): 735–745.
Published: 04 April 2023
..., including mitochondrial DNA — the small, circular, double-stranded DNA molecule found in multiple copies in the organelle. mtDNA can be sensed by at least three molecules: the Toll-like receptor 9, the NLRP3 inflammasomes, and the cyclic GMP–AMP synthase (cGAS). All these sensors can lead to the release...
Biochem Soc Trans (2023) 51 (1): 457–472.
Published: 23 February 2023
...Rosalie Heilig; Jordan Lee; Stephen W.G. Tait Cytosolic DNA is recognized by the innate immune system as a potential threat. During apoptotic cell death, mitochondrial DNA (mtDNA) release activates the DNA sensor cyclic GMP–AMP synthase (cGAS) to promote a pro-inflammatory type I interferon...
Biochem Soc Trans (2020) 48 (3): 787–797.
Published: 26 May 2020
...Sophie L. Penman; Alice S. Carter; Amy E. Chadwick The mitochondrion is an essential organelle responsible for generating cellular energy. Additionally, mitochondria are a source of inter-individual variation as they contain their own genome. Evidence has revealed that mitochondrial DNA (mtDNA...
Biochem Soc Trans (2019) 47 (5): 1367–1382.
Published: 04 September 2019
...Iain G. Johnston; Joerg P. Burgstaller Mitochondrial DNA (mtDNA) encodes vital respiratory machinery. Populations of mtDNA molecules exist in most eukaryotic cells, subject to replication, degradation, mutation, and other population processes. These processes affect the genetic makeup of cellular...
Biochem Soc Trans (2017) 45 (5): 1159–1171.
Published: 12 September 2017
... on the DNA:RNA hybrid substrates [ 63 ]. © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 DNA enzyme kinetics enzyme–substrate interactions G-quadruplex helicase mtDNA Helicases are a family of molecular motors involved in all phases...
Biochem Soc Trans (2016) 44 (6): 1717–1724.
Published: 02 December 2016
... 8 2016 2 9 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 AKAP Larp miRNA mitochondrial transcription factor A mtDNA PINK1 The Authors declare that there are no competing interests associated with the manuscript...