... 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 glycosyltransferases intestinal development mouse models Notch signalling pathway O-glycans The intestine functions in the absorption and digestion of nutrients, and in endocrine...

... the haematopoietic fate. Understanding how to modulate the requirement for TGFβ signalling in HSC emergence may have critical implications for the generation of these cells in vitro for therapeutic use. BMP endothelial to haematopoietic transition haemogenic endothelium mouse models TGFβ zebrafish...

...-specific manner. In this review, we summarise the existing nesprin mouse models, compare their phenotypes and discuss the potential mechanisms underlying nesprin-associated diseases. Correspondence: Qiuping Zhang ( qp.zhang@kcl.ac.uk ) 6 2 2018 5 4 2018 20 4 2018 © 2018...

... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . gene therapy mitochondria mitochondrial dysfunction mouse models therapeutics Beside mtDNA-encoded proteins, the vast majority of the ∼1500 polypeptides forming...

... damage DNA mismatch repair (MMR) mouse models At present, it is not entirely clear what apoptotic pathways are activated by MMR in response to the different types of DNA-damaging agents. MMR-mediated apoptosis appears to require both p53-dependent and -independent pathways and can also involve...