... 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 DEAD-box RNA helicase motor neuron disease RNA RNP SMN complex survival motor neuron DEAD-box RNA helicases or unwindases are distinguished by the presence of several...

... genetics motor neuron disease neurodegeneration parkinsonism Identifying and diagnosing selective vulnerability is the essence of neurological practice: the practice of ascertaining neurological symptoms is largely the elucidation of lesion location. Yet it is largely mysterious why diseases...

... that eEF1A2, but not eEF1A1, is also expressed at high levels in motor neurons in the spinal cord. Wasted mice develop many pathological features of motor neuron degeneration and may represent a good model for early onset of motor neuron disease. Molecular modelling of the eEF1A1 and eEF1A2 protein structures...