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Keywords: motor neuron disease
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Biochem Soc Trans (2018) 46 (2): 329–341.
Published: 09 March 2018
... of the Biochemical Society 2018 DEAD-box RNA helicase motor neuron disease RNA RNP SMN complex survival motor neuron DEAD-box RNA helicases or unwindases are distinguished by the presence of several conserved motifs within the helicase core including the Asp-Glu-Ala-Asp or DEAD (in one-letter code...
Biochem Soc Trans (2016) 44 (2): 659–661.
Published: 11 April 2016
... leads to disease spread between neurons and also that mutations in this one gene can lead to widely different neuronal selectivities and clinical features. ataxia dementia genetics motor neuron disease neurodegeneration parkinsonism Identifying and diagnosing selective vulnerability...
Biochem Soc Trans (2009) 37 (6): 1293–1297.
Published: 19 November 2009
... that eEF1A2, but not eEF1A1, is also expressed at high levels in motor neurons in the spinal cord. Wasted mice develop many pathological features of motor neuron degeneration and may represent a good model for early onset of motor neuron disease. Molecular modelling of the eEF1A1 and eEF1A2 protein structures...