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Keywords: molecular misreadingClose
Journal: Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 738–742.
Published: 25 October 2006
... by the lysosomes. We focused on the UPS (ubiquitin–proteasome system). As a result of molecular misreading, misframed UBB (ubiquitin B) (UBB +1 ) is generated. UBB +1 accumulates in the neuritic plaques and neurofibrillary tangles in all patients with AD (Alzheimer's disease) and in the neuronal and glial...