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Keywords: modelling
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Biochem Soc Trans (2017) 45 (3): 785–791.
Published: 15 June 2017
... test kits for on-site identification of viruses (Zika and Ebola), while gene circuit cascades can be tested, debugged and re-designed within rapid turnover times. Coupled with mathematical modelling, this discipline lends itself towards the precision engineering of new synthetic life. The next stages...
Biochem Soc Trans (2016) 44 (3): 745–752.
Published: 09 June 2016
... and to evaluate the functional relevance of heavy and light subunit interactions for the amino acid transport cycle. amino acid transporters heterodimer heteromeric amino acid transporter (HAT) modelling structure transport mechanism 1 In memory of Steve Baldwin, who put us on the right...
Biochem Soc Trans (2016) 44 (2): 574–581.
Published: 11 April 2016
... modelling protocol (HGMP) and the fragment molecular orbital (FMO) quantum mechanics (QM) method to explore the interactions and selectivity of the human orexin-2 receptor (OX 2 R) and its recently discovered nonpeptidic agonists. HGMP generates a 3D model of GPCR structures and its complexes with small...
Biochem Soc Trans (2013) 41 (1): 135–136.
Published: 29 January 2013
... of relating observations on isolated receptors or receptors expressed in model systems to receptor function in vivo . 1 To whom correspondence should be addressed (email D.R.Poyner@aston.ac.uk ). 20 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 β...
Biochem Soc Trans (2010) 38 (5): 1206–1209.
Published: 24 September 2010
...Igor Goryanin Modelling and optimization principles become a key concept in many biological areas, especially in biochemistry. Definitions of objective function, fitness and co-evolution, although they differ between biology and mathematics, are similar in a general sense. Although successful...
Biochem Soc Trans (2005) 33 (6): 1427–1429.
Published: 26 October 2005
... producing synthetic data sets by simulation of realistic biochemical network models with the purpose of comparing data analysis methods. Because we have full knowledge of the underlying ‘biochemistry’ of these models, we are better able to judge how well the analyses reflect true knowledge about the system...
Biochem Soc Trans (2005) 33 (3): 503–506.
Published: 01 June 2005
...M.P. Williamson Systems biology describes the collection of a set of measurements on a system, integrated with a mathematical model of that system. The model and the measurements must be made together and refined iteratively, requiring close collaboration between biologists and modellers...
Biochem Soc Trans (2004) 32 (3): 540–546.
Published: 01 June 2004
... in Ligand-Gated Ion Channel Function: a Biochemical Society Focused Meeting held at Merck Shape & Dohme, Harlow, 29 January 2004 25 February 2003 © 2004 Biochemical Society 2004 γ-aminobutyric acid (GABA) ligand-gated ion channel (LGIC) LGIC activation LGIC structure modelling...
Biochem Soc Trans (2003) 31 (6): 1513–1515.
Published: 01 December 2003
... biochemical network modelling Petri Net simulation systems biology Unravelling Nature s Networks 1513 Petri Net representations in systems biology J.W. Pinney1, D.R. Westhead and G.A. McConkey Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K. Abstract The mathematical structures...