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Keywords: mitotic checkpoint
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Biochem Soc Trans (2013) 41 (6): 1755–1760.
Published: 20 November 2013
... and form a signalling cascade of protein–protein interactions and protein phosphorylation. Mad2 and Mad3/BubR1 bind directly to and thereby disable the activator of the APC/C, Cdc20. This effector complex is called MCC (mitotic checkpoint complex) and in many organisms additionally contains Bub3, which...
Biochem Soc Trans (2010) 38 (6): 1660–1666.
Published: 24 November 2010
...María Dolores Vázquez-Novelle; Lesia Mirchenko; Frank Uhlmann; Mark Petronczki Two closely connected mechanisms safeguard the fidelity of chromosome segregation in eukaryotic cells. The mitotic checkpoint monitors the attachment of kinetochores to microtubules and delays anaphase onset until all...
Biochem Soc Trans (2009) 37 (5): 971–975.
Published: 21 September 2009
...Geert J.P.L. Kops Error-free chromosome segregation during cell division relies on chromosome biorientation and mitotic checkpoint activity. A group of unrelated kinases controls various aspects of both processes. The present short review outlines our current understanding of the roles...
Biochem Soc Trans (2009) 37 (4): 910–913.
Published: 22 July 2009
... is dependent on the extent of aneuploidy induced. The mitotic checkpoint plays a pivotal role in the maintenance of genome stability and has been the focus of work investigating the distinct outcomes of aneuploidy. In the present article, we review the molecular mechanisms involved and discuss the potential...