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Keywords: mitophagy
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Biochem Soc Trans (2022) 50 (2): 783–797.
Published: 21 March 2022
... in mitophagy, the process of selective autophagic elimination of damaged mitochondria. Impaired mitophagy has been associated with sporadic Parkinson's and agents that damage mitochondria are known to induce Parkinson's-like motor symptoms in humans and animal models. Thus, modulating mitophagy pathways may...
Biochem Soc Trans (2021) 49 (2): 551–562.
Published: 26 March 2021
... in this disease. In recent years, defective mitochondrial elimination through autophagy, termed mitophagy, has emerged as a potential contributing factor to disease pathology. PINK1 and Parkin, two proteins mutated in familial PD, were found to eliminate mitochondria under distinct mitochondrial depolarisation...
Biochem Soc Trans (2018) 46 (4): 829–842.
Published: 09 July 2018
... and present an opportunity for a new class of proteins to target therapeutically with the aim of promoting mitophagy and the ubiquitin–proteasome system. The brain is enormously metabolically active, placing a large emphasis on maintaining ATP supply. Therefore, identifying mechanisms to sustain mitochondrial...
Biochem Soc Trans (2017) 45 (6): 1213–1223.
Published: 20 October 2017
... and oxidative stress, mitochondrial DNA lesions, electron transfer chain impairments, mitochondrial apoptosis and mitophagy has been outlined. Meanwhile, considerable efforts have been made towards understanding the role of platelet mitochondrial dysfunction in human diseases, such as diabetes mellitus, sepsis...
Biochem Soc Trans (2016) 44 (4): 1091–1100.
Published: 15 August 2016
... that are transgenic for fluorescent LC3 (the hallmark of autophagy) we quantified autophagosomes in cleavage stage embryos. We confirmed that the autophagosome count peaks in four-cell embryos and this correlates with a drop in the mtDNA content of the whole embryo. This suggests removal by mitophagy (mitochondria...
Biochem Soc Trans (2015) 43 (2): 297–301.
Published: 07 April 2015
... Journal compilation © 2015 Biochemical Society 2015 apoptosis endoplasmic reticulum (ER)-mitochondria contacts mitophagy mitochondrial dynamics phosphatase and tensin homologue-induced putative kinase 1 (PINK1) Parkin In addition to Mfn2, Parkin was shown to interact...
Biochem Soc Trans (2015) 43 (2): 287–291.
Published: 07 April 2015
... 2015 © The Authors Journal compilation © 2015 Biochemical Society 2015 mitochondria mitophagy organellar quality control phosphatase and tensin homologue-induced kinase 1 (PINK1) protein import Mitochondria have been traditionally regarded mainly as sources for energy...
Biochem Soc Trans (2015) 43 (1): 108–110.
Published: 26 January 2015
..., most of which we may not have identified yet. © The Authors Journal compilation © 2015 Biochemical Society 2015 Cdc48/VCP/p97 endoplasmic-reticulum–mitochondria encounter structure (ERMES) lipid metabolism mitochondria mitophagy small GTPase The communication between...
Biochem Soc Trans (2014) 42 (5): 1302–1310.
Published: 18 September 2014
... mitophagy trafficking Astrocytes are a subset of glial cells that provide trophic and structural support for neurons. Accumulating evidence over the last few years has revealed that astrocytes are active regulators of information processing in the central nervous system (CNS) [ 1 – 5...
Biochem Soc Trans (2013) 41 (6): 1525–1531.
Published: 20 November 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 calcium sensing mitochondrial Rho (Miro) mitochondrion mitophagy molecular motor trafficking The brain is only 2% of the body's weight, but it uses 20% of the body's resting energy production. This high level of energy...
Biochem Soc Trans (2011) 39 (5): 1514–1519.
Published: 21 September 2011
..., aggregated proteins or dysfunctional mitochondria. This is considered to counteract the development of a number of neurodegenerative disorders and aging. Here we review the role of mitophagy and mitochondrial dynamics in ensuring quality control of mitochondria. In particular, we provide possible...
Biochem Soc Trans (2010) 38 (3): 789–795.
Published: 24 May 2010
... compilation © 2010 Biochemical Society 2010 clueless cytoskeleton FRIENDLY mitochondrial dynamics mitophagy Parkin The discovery of mitochondria cannot be attributed to a single person, because many of the granular bodies observed by cytologists during the years 1850–1890, and given...