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Keywords: mitochondrion
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1069–1074.
Published: 11 August 2014
... To whom correspondence should be addressed (email: tiranti@istituto-besta.it ). 22 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 brain coenzyme A (CoA) inborn error of metabolism mitochondrion neurodegeneration pantothenate kinase 2 (PANK2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 939–944.
Published: 11 August 2014
... studies support the development of new anti-cancer drugs to target this organelle. apoptosis chemotherapy lymphoma metabolism mitochondrion redox homoeostasis Cancer cells frequently function with a more oxidized redox environment [ 1 ]. An expanded set of cancer hallmarks was proposed...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1012–1016.
Published: 11 August 2014
... 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 inflammation liver failure manganese superoxide dismutase mitochondrion reactive oxygen species Apart from being a substrate in various enzyme reactions, oxygen appears to be also the universal electron...
Articles
Kate Geary, Leslie A. Knaub, Irene E. Schauer, Amy C. Keller, Peter A. Watson, Matthew W. Miller, Chrystelle V. Garat, Kristen J. Nadeau, Melanie Cree-Green, Subbiah Pugazhenthi, Judith G. Regensteiner, Dwight J. Klemm, Jane E.B. Reusch
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 231–238.
Published: 20 March 2014
...) cardiovascular disease diabetes exercise mitochondrion nitric oxide synthase (NOS) Diabetes is a leading cause of death and disability worldwide and a leading cause of blindness, end-stage renal disease, non-traumatic amputation and CVD (cardiovascular disease). Interventions to optimize glucose...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (2): 265–269.
Published: 20 March 2014
... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling The IMS is the second aqueous compartment of mitochondria (the other being the matrix). The IMS is defined by the OMM and IMM and has emerged as a significant regulatory domain in the co-ordination...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1618–1624.
Published: 20 November 2013
... on the individual mitochondrion and the cell within which they reside. Neurons are post-mitotic energy-dependent cells and, as such, are particularly vulnerable to alterations in cellular bioenergetics and increased stress that may occur as a direct or indirect result of mitochondrial dysfunction. The trafficking...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1503–1508.
Published: 20 November 2013
... Biochemical Society 2013 autophagy dopaminergic neuron induced pluripotent stem cell (iPSC) leucine-rich repeat kinase 2 (LRRK2) mitochondrion Parkinson’s disease (PD) Variability between iPSC lines is one of the major potential limitations to this technology. Typically several colonies...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (6): 1525–1531.
Published: 20 November 2013
... GTPases, where GTP or GDP binding affects downstream signalling and binding partners [ 64 ]. 1 To whom correspondence should be addressed (email j.kittler@ucl.ac.uk ). 2 10 2013 calcium sensing mitochondrial Rho (Miro) mitochondrion mitophagy molecular motor trafficking...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1227–1234.
Published: 23 September 2013
... mitochondrion Cryo-ET is a relatively new technique that can image cellular features in three dimensions as well as the distribution and, in favourable cases, the structure of protein complexes in situ . The technique has been used to investigate biological structures ranging from isolated protein...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1272–1279.
Published: 23 September 2013
... 2013 © 2013 The Authors 2013 accessory subunit assembly mitochondrion NADH:ubiquinone oxidoreductase respiratory complex I Proton-translocating NADH:ubiquinone oxidoreductase (respiratory complex I) is a very large and complex membrane protein [ 1 ]. Fourteen central subunits...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (5): 1335–1341.
Published: 23 September 2013
... protein) mitochondrion oxidative phosphorylation complex (OXPHOS complex) Reorganization of the eukaryotic cell after the endosymbiotic event triggered an increase in complexity of the mitochondrial OXPHOS complexes and metabolic pathways. LYRM proteins contribute to the higher complexity...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (2): 620–624.
Published: 21 March 2013
... conformational change knot mitochondrion molecular dynamics protein translocation In recent years, there has been a surge of interest in the properties and functions of knotted proteins. As more and more knotted structures are deposited in the PDB, it becomes increasingly important to understand how...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 101–105.
Published: 29 January 2013
... kinase) pathway is induced by increased oxidative stress and JNK translocation to the mitochondrion results in impairment of energy metabolism. Moreover, IIS and JNK signalling interact with and antagonize each other. This review focuses on functional outcomes of a metabolic triad that entails the co...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 106–110.
Published: 29 January 2013
...-glutamylcysteine glutathione mitochondrion reactive oxygen species One of the most efficient forms for energy production in aerobic organisms is carried out by mitochondria, which have been referred to as the ‘powerhouse’ of the cell. To produce ATP, the estimated 3–30 μM O 2 concentration...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 1–16.
Published: 29 January 2013
... chloroplast energy cost mitochondrion protonmotive force rotor stator “From the earliest times breathing and the warmth of the body were recognized as the chief manifestations of life”. So wrote David Keilin at the beginning of the first chapter of his book The History of Cell Respiration...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 111–117.
Published: 29 January 2013
...) of the mitochondrion in the cell. Overall, a greater understanding of how the original relationships between the mitochondrion and the nucleus evolved to allow for the adaptation of cell function will facilitate discovery of the mechanisms of how common disease develops. Translating the Powerhouse: Redox...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2013) 41 (1): 124–126.
Published: 29 January 2013
.... This signalling pathway is shown in Figure 2 , suggesting key roles for both MEK5 and p90 RSK in the Crabtree effect. Figure 2 Proposed signalling pathway linking high glucose to respiratory inhibition cancer Crabtree effect extracellular-signal-regulated kinase 5 (ERK5) mitochondrion p90...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (6): 1426–1432.
Published: 21 November 2012
... endoplasmic reticulum (ER) Golgi complex GTPase mitochondria-associated membrane (MAM) mitochondrion Rab The organelles of eukaryotic cells exhibit a unique protein composition consistent with the defined individual functions of these organelles. Nevertheless, trafficking and direct contacts...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (4): 865–869.
Published: 20 July 2012
... of this complicated process, which ultimately regulates the protein production in cells, or more specifically what governs RNA catabolism in a particular subcompartment of human cells: the mitochondrion. 1 To whom correspondence should be addressed (email zofia.chrzanowska-lightowlers@ncl.ac.uk ). 26...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (2): 445–450.
Published: 21 March 2012
... mitochondrion Many mitochondrial enzymes are Ca 2+ -dependent, therefore Ca 2+ signalling within the mitochondria is critical for the generation of ATP. Moreover, mitochondrial Ca 2+ participates in triggering apoptosis, indicating that mitochondrial Ca 2+ must be tightly regulated [ 7 ]. For a long...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2012) 40 (1): 158–167.
Published: 19 January 2012
... or passively buffers the [Ca 2+ ] c rise. 1 To whom correspondence should be addressed (email john.mccarron@strath.ac.uk ). 12 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 calcium uptake local calcium signalling mitochondrion store organization...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1482–1487.
Published: 21 September 2011
... to either of these authors (email M.F.Tuite@kent.ac.uk and C.W.Gourlay@kent.ac.uk ). 30 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 amyotrophic lateral sclerosis (ALS) fused in sarcoma (FUS) mitochondrion protein aggregation Saccharomyces cerevisiae...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1488–1492.
Published: 21 September 2011
... certain thresholds, programmed cell death brings the life of individual P. anserina to an end. 1 email osiewacz@bio.uni-frankfurt.de 11 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging mitochondrion Podospora anserina reactive oxygen species...
Articles
Maria João Sousa, Flávìa Azevedo, Ana Pedras, Carolina Marques, Olga P. Coutinho, Ana Preto, Hernâni Gerós, Susana R. Chaves, Manuela Côrte-Real
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1533–1537.
Published: 21 September 2011
.... Nilsson C. Kågedal K. Roberg K. Öllinger K. Regulation of apoptosis-associated lysosomal membrane permeabilization Apoptosis 2010 15 527 540 3 Repnik U. Turk B. Lysosomal–mitochondrial cross-talk during cell death Mitochondrion 2010 10 662 669 4 Turk...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1538–1543.
Published: 21 September 2011
... mitochondrion programmed cell death (PCD) reactive oxygen species (ROS) Saccharomyces cerevisiae YCA1 The term PCD (programmed cell death) describes a highly heterogeneous process regulated by distinct but sometimes overlapping pathways including apoptosis, autophagic cell death, and necrosis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1221–1225.
Published: 21 September 2011
... and HPLC to detect and quantify O 2 •− formed in cells and tissues [ 4 , 5 ]. cell signalling fluorescence mitochondrion reactive nitrogen species (RNS) reactive oxygen species (ROS) redox biology superoxide © The Authors Journal compilation © 2011 Biochemical Society 2011 15 7...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1305–1309.
Published: 21 September 2011
... correspondence should be addressed (email irina.shabalina@wgi.su.se ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (5): 1509–1513.
Published: 21 September 2011
... organismal viability. 1 To whom correspondence should be addressed (email rutter@biochem.utah.edu ). 15 6 2011 cell division cycle 48 (Cdc48) mitochondrion p97 parkin ubiquitin–proteasome system VCP (p97)/Cdc48-associated mitochondrial-stress-responsive 1 (Vms1...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (3): 799–806.
Published: 20 May 2011
... mitochondrial DNA mutation (mtDNA mutation) mitochondrion NADH:ubiquinone oxidoreductase (complex I) ND subunit Complex I (NADH:ubiquinone oxidoreductase) is a complicated multisubunit enzyme found in the mitochondrial inner membrane of many eukaryotes and in the cytoplasmic membrane of many aerobic...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (1): 1–13.
Published: 19 January 2011
... it. © The Authors Journal compilation © 2011 Biochemical Society 2011 AMP-activated protein kinase (AMPK) cancer cell metabolism energy balance mitochondrion Type 2 diabetes 1 email d.g.hardie@dundee.ac.uk 11 9 2010 The classical stimuli that activate...
Articles
Ricarda Richter, Aleksandra Pajak, Sven Dennerlein, Agata Rozanska, Robert N. Lightowlers, Zofia M.A. Chrzanowska-Lightowlers
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (6): 1523–1526.
Published: 24 November 2010
... compilation © 2010 Biochemical Society 2010 mitochondrion protein synthesis release factor stop codon translation termination Mitochondria are vital organelles that are present in all nucleated cells of higher eukaryotes. They play critical roles in many processes, including calcium...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (5): 1322–1328.
Published: 24 September 2010
... 2010 Biochemical Society 2010 arginine half-life mathematical model mitochondrion NaH 14 CO 3 pulse–chase We are interested in mitochondrial turnover because replacing damaged mitochondria is an important potential quality control mechanism. Mitochondrial dysfunction...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (4): 841–860.
Published: 26 July 2010
... if the stimulus is large enough. brain cardioprotection heart mitochondrion permeability transition pore (PTP) reperfusion injury David Keilin was a pioneer in the study of mitochondrial electron transfer and bioenergetics who discovered the key role of cytochromes in substrate oxidation...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2010) 38 (3): 817–822.
Published: 24 May 2010
... in the division of these metabolically associated plant organelles. © The Authors Journal compilation © 2010 Biochemical Society 2010 1 To whom correspondence should be addressed (email huji@msu.edu ). 15 12 2009 Arabidopsis dynamin-related protein 5B (DRP5B) light mitochondrion...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1389–1393.
Published: 19 November 2009
... excitotoxicity glutamate mitochondrion spine Dysfunction in fast axonal transport has been implicated in the pathogenesis of neurodegenerative diseases [ 43 ]. It is known that long-range (calcium-sensitive) mitochondrial transport is driven by molecular motors. These motors utilize ATP hydrolysis...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2009) 37 (6): 1385–1388.
Published: 19 November 2009
... and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures. 1 email dnicholls@buckinstitute.org 4 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 ATP excitotoxicity glutamate ischaemia mitochondrion...
Articles
Lorenzo Galluzzi, Eugenia Morselli, José Miguel Vicencio, Oliver Kepp, Nicholas Joza, Nicolas Tajeddine, Guido Kroemer
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 786–790.
Published: 19 September 2008
... compilation © 2008 Biochemical Society 2008 apoptosis atg gene Bcl-2 Beclin 1 macroautophagy mitochondrion The term autophagy (i.e. self-eating, from the Greek words auto =self and phagein =to eat) comprises a number of multiple intracellular processes, including CMA (chaperone-mediated...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 976–980.
Published: 19 September 2008
... mitochondrion NADH:ubiquinone oxidoreductase oxidative stress reactive oxygen species (ROS) reverse electron transport The electron transport chain in mitochondria is a significant source of cellular ROS. Historically, respiratory complexes I and III have been considered two major sources...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (5): 1045–1050.
Published: 19 September 2008
... that are the targets for dicarbonyl glycation. 1 To whom correspondence should be addressed (email P.J.Thornalley@warwick.ac.uk ). 1 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 advanced glycation end-product (AGE) dicarbonyl glycation mitochondrion oxidative...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2008) 36 (3): 517–519.
Published: 21 May 2008
... Biochemical Society 2008 mitochondrion mRNA stability polyadenylation polynucleotide phosphorylase (PNPase) Human mtDNA (hmtDNA) is a small (16569 nt) double-stranded circular molecule containing no introns, with the main regulatory elements involved in replication and transcription...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (6): 1643–1647.
Published: 23 November 2007
...@cyllene.uwa.edu.au ). 2 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 Arabidopsis thaliana chloroplast mitochondrion pentatricopeptide repeat (PPR) RNA binding tetratricopeptide repeat (TPR) As most PPR proteins lack any known catalytic sites, the RNA...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1052–1054.
Published: 25 October 2007
... of the heart to ischaemic injury. 1 To whom correspondence should be addressed (email mochly@stanford.edu ). 27 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cardioprotection ischaemia ischaemic preconditioning mitochondrion protein kinase Cϵ (PKCϵ...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1224–1227.
Published: 25 October 2007
... during oxidative stress and bioenergetic crises ( Figure 1 ). AMP-activated protein kinase astrocyte mitochondrion neurodegeneration pentose phosphate pathway (PPP) 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Figure 1 NO controls neural vulnerability to oxidative stress...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1228–1231.
Published: 25 October 2007
.... Genet. 2001 28 211 212 50 Naviaux R.K. Nguyen K.V. Ann. Neurol. 2004 55 706 712 amyotrophic lateral sclerosis (ALS) Friedreich's ataxia mitochondrion Morbus Parkinson neurodegenerative disorder This review summarizes recent functional and genetic findings...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1180–1186.
Published: 25 October 2007
... acid metabolism diabetes gene expression glucose insulin secretion mitochondrion The endocrine islets of Langerhans contain four major cell types: insulin-secreting β-cells, glucagon-secreting α-cells, somatostatin-releasing δ-cells and pancreatic polypeptide-producing cells. Nutrients...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 343–348.
Published: 20 March 2007
... and resemble thermosensitizers [ 16 ]. These results suggest that the combination of hyperthermia and spermine enzymatic oxidation products could prove to be useful in cancer treatment and mainly effective against MDR cells. hyperthermia lysosome mitochondrion polyamine spermine oxidation tumour cell...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 391–395.
Published: 20 March 2007
... ). 2 These authors contributed equally to this work. 2 10 2006 © 2007 The Biochemical Society 2007 cell cycle cell proliferation mitochondrion ornithine decarboxylase (ODC) potassium channel quinidine Potassium channels are found ubiquitously in animal and plant...
Articles
M.A. Grillo, V. Battaglia, S. Colombatto, C.A. Rossi, A.R. Simonian, M. Salvi, A.R. Khomutov, A. Toninello
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (2): 401–404.
Published: 20 March 2007
... is a single-binding, centre-gated pore rather than a channel. 1 To whom correspondence should be addressed (email antonio.toninello@unipd.it ). 26 10 2006 © 2007 The Biochemical Society 2007 agmatine amino acid guanidine compound mitochondrion polyamine transport ADC...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (5): 811–814.
Published: 25 October 2006
... importance [ 6 ]. However, this shuttle is particularly active in tissues that rapidly metabolize glucose, such as skeletal muscle. Aralar1 β-cell energy metabolism malate–aspartate shuttle mitochondrion redox shuttle The significance of redox shuttle mechanisms has been extensively...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2006) 34 (6): 1283–1286.
Published: 25 October 2006
... cerebral ischaemia mitochondrion p53 pifithrin-α Current evidence indicates that the tumour suppressor gene p53 encodes a sequence-specific transcription factor that controls the expression of genes whose products mediate apoptosis [ 1 ]. Furthermore, evidence for transcription-independent p53...
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