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Keywords: mitochondrion
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Articles
Biochem Soc Trans (2014) 42 (4): 1069–1074.
Published: 11 August 2014
.... 1 To whom correspondence should be addressed (email: tiranti@istituto-besta.it ). 22 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 brain coenzyme A (CoA) inborn error of metabolism mitochondrion neurodegeneration pantothenate kinase 2 (PANK2...
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Biochem Soc Trans (2014) 42 (4): 1012–1016.
Published: 11 August 2014
... 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 inflammation liver failure manganese superoxide dismutase mitochondrion reactive oxygen species Apart from being a substrate in various enzyme reactions, oxygen appears to be also the universal electron...
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Biochem Soc Trans (2014) 42 (4): 939–944.
Published: 11 August 2014
... lymphoma metabolism mitochondrion redox homoeostasis Cancer cells frequently function with a more oxidized redox environment [ 1 ]. An expanded set of cancer hallmarks was proposed by Luo et al. in 2009 [ 2 ] and includes oxidative stress. Indications of altered cellular redox homoeostasis...
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Biochem Soc Trans (2014) 42 (2): 265–269.
Published: 20 March 2014
... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling Mitochondria are marvels of compartmentalization, and this property is intimately connected with their function. Compartmentalization of these organelles is achieved thanks to two structures...
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Biochem Soc Trans (2014) 42 (2): 231–238.
Published: 20 March 2014
... To whom correspondence should be addressed (email jane.reusch@ucdenver.edu ). 19 12 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 cAMP-response-element-binding protein (CREB) cardiovascular disease diabetes exercise mitochondrion nitric oxide synthase (NOS...
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Biochem Soc Trans (2013) 41 (6): 1618–1624.
Published: 20 November 2013
... on the individual mitochondrion and the cell within which they reside. Neurons are post-mitotic energy-dependent cells and, as such, are particularly vulnerable to alterations in cellular bioenergetics and increased stress that may occur as a direct or indirect result of mitochondrial dysfunction. The trafficking...
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Biochem Soc Trans (2013) 41 (6): 1503–1508.
Published: 20 November 2013
... Biochemical Society 2013 autophagy dopaminergic neuron induced pluripotent stem cell (iPSC) leucine-rich repeat kinase 2 (LRRK2) mitochondrion Parkinson’s disease (PD) Despite decades of research, the complex multi-factorial aetiology of PD (Parkinson's disease) is still not well understood...
Articles
Biochem Soc Trans (2013) 41 (6): 1525–1531.
Published: 20 November 2013
... mitochondrial Rho (Miro) mitochondrion mitophagy molecular motor trafficking The brain is only 2% of the body's weight, but it uses 20% of the body's resting energy production. This high level of energy consumption is mainly used to reverse the ion fluxes that underlie action potential signalling...
Articles
Biochem Soc Trans (2013) 41 (5): 1227–1234.
Published: 23 September 2013
... research. 1 To whom correspondence should be addressed (email karen.davies@biophys.mpg.de ). 13 3 2013 © 2013 The Authors 2013 chloroplast cryo-electron tomography membrane bioenergetics membrane protein organization mitochondrion Membrane bioenergetics is the study...
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Biochem Soc Trans (2013) 41 (5): 1272–1279.
Published: 23 September 2013
... 2013 © 2013 The Authors 2013 accessory subunit assembly mitochondrion NADH:ubiquinone oxidoreductase respiratory complex I Proton-translocating NADH:ubiquinone oxidoreductase (respiratory complex I) is a very large and complex membrane protein [ 1 ]. Fourteen central subunits...
Articles
Biochem Soc Trans (2013) 41 (5): 1335–1341.
Published: 23 September 2013
... protein) mitochondrion oxidative phosphorylation complex (OXPHOS complex) Mitochondria harbour fundamental functions of cell metabolism. The mitochondrial OXPHOS (oxidative phosphorylation) complexes are central for the efficient production of ATP. In addition to supplying energy, mitochondria...
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Biochem Soc Trans (2013) 41 (2): 620–624.
Published: 21 March 2013
... of knotted protein translocation, which show how the knot can indeed block the pore. 1 email piotr.szymczak@fuw.edu.pl 1 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 conformational change knot mitochondrion molecular dynamics protein...
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Biochem Soc Trans (2013) 41 (1): 101–105.
Published: 29 January 2013
... kinase) pathway is induced by increased oxidative stress and JNK translocation to the mitochondrion results in impairment of energy metabolism. Moreover, IIS and JNK signalling interact with and antagonize each other. This review focuses on functional outcomes of a metabolic triad that entails the co...
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Biochem Soc Trans (2013) 41 (1): 106–110.
Published: 29 January 2013
... be addressed (email jbolanos@usal.es ). 26 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 γ-glutamylcysteine glutathione mitochondrion reactive oxygen species One of the most efficient forms for energy production in aerobic organisms is carried out...
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Biochem Soc Trans (2013) 41 (1): 1–16.
Published: 29 January 2013
... synthase bacterium chloroplast energy cost mitochondrion protonmotive force rotor stator “From the earliest times breathing and the warmth of the body were recognized as the chief manifestations of life”. So wrote David Keilin at the beginning of the first chapter of his book The History...
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Biochem Soc Trans (2013) 41 (1): 124–126.
Published: 29 January 2013
...), in the Crabtree effect. 1 To whom correspondence should be addressed (email paul_brookes@urmc.rochester.edu ). 24 10 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 cancer Crabtree effect extracellular-signal-regulated kinase 5 (ERK5) mitochondrion p90...
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Biochem Soc Trans (2012) 40 (6): 1426–1432.
Published: 21 November 2012
... of autophagosomes. 1 To whom correspondence should be addressed (email Thomas.Simmen@ualberta.ca ). 27 6 2012 © 2012 The Authors Journal 2012 endoplasmic reticulum (ER) Golgi complex GTPase mitochondria-associated membrane (MAM) mitochondrion Rab The organelles of eukaryotic...
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Biochem Soc Trans (2012) 40 (4): 865–869.
Published: 20 July 2012
... of this complicated process, which ultimately regulates the protein production in cells, or more specifically what governs RNA catabolism in a particular subcompartment of human cells: the mitochondrion. 1 To whom correspondence should be addressed (email zofia.chrzanowska-lightowlers@ncl.ac.uk ). 26...
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Biochem Soc Trans (2012) 40 (2): 445–450.
Published: 21 March 2012
... ). 1 11 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 cardiolipin cytosol endoplasmic reticulum (ER) endoplasmic reticulum–mitochondria encounter structure (ERMES) lipid binding mitochondrion The eukaryotic cell is a highly complex entity that carries...
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Biochem Soc Trans (2012) 40 (1): 158–167.
Published: 19 January 2012
... calcium uptake local calcium signalling mitochondrion store organization tether Mitochondria provide energy, in the form of ATP, for many cellular processes via oxidative phosphorylation through the electron-transport chain and, in addition to energy production, mitochondria accumulate...
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Biochem Soc Trans (2011) 39 (5): 1488–1492.
Published: 21 September 2011
... certain thresholds, programmed cell death brings the life of individual P. anserina to an end. 1 email osiewacz@bio.uni-frankfurt.de 11 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging mitochondrion Podospora anserina reactive oxygen species...
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Biochem Soc Trans (2011) 39 (5): 1305–1309.
Published: 21 September 2011
... correspondence should be addressed (email irina.shabalina@wgi.su.se ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...
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Biochem Soc Trans (2011) 39 (5): 1221–1225.
Published: 21 September 2011
... dichlorodihydrofluorescein or dihydrorhodamine. 1 email balarama@mcw.edu . 15 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell signalling fluorescence mitochondrion reactive nitrogen species (RNS) reactive oxygen species (ROS) redox biology superoxide...
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Biochem Soc Trans (2011) 39 (5): 1509–1513.
Published: 21 September 2011
... organismal viability. 1 To whom correspondence should be addressed (email rutter@biochem.utah.edu ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell division cycle 48 (Cdc48) mitochondrion p97 parkin ubiquitin–proteasome system VCP (p97)/Cdc48...
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Biochem Soc Trans (2011) 39 (5): 1538–1543.
Published: 21 September 2011
... of the mammalian cell: from respiration to apoptosis Mitochondrion 2011 11 369 381 37 Skulachev V.P. Cytochrome c in the apoptotic and antioxidant cascades FEBS Lett. 1998 423 275 280 38 Uren A.G. O'Rourke K. Aravind L.A. Pisabarro M.T. Seshagiri S. Koonin E.V...
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Biochem Soc Trans (2011) 39 (5): 1482–1487.
Published: 21 September 2011
... results in an increased inner membrane space localization that correlates with an increase in protection against oxidative damage [ 28 ]. amyotrophic lateral sclerosis (ALS) fused in sarcoma (FUS) mitochondrion protein aggregation Saccharomyces cerevisiae superoxide dismutase 1 (SOD1) TAR DNA...
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Biochem Soc Trans (2011) 39 (1): 1–13.
Published: 19 January 2011
... it. © The Authors Journal compilation © 2011 Biochemical Society 2011 AMP-activated protein kinase (AMPK) cancer cell metabolism energy balance mitochondrion Type 2 diabetes Living cells are molecular machines that require a considerable amount of energy to maintain their highly...
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Biochem Soc Trans (2010) 38 (6): 1523–1526.
Published: 24 November 2010
... compilation © 2010 Biochemical Society 2010 mitochondrion protein synthesis release factor stop codon translation termination Mitochondria are vital organelles that are present in all nucleated cells of higher eukaryotes. They play critical roles in many processes, including calcium...
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Biochem Soc Trans (2010) 38 (5): 1322–1328.
Published: 24 September 2010
... the numbers of experimental animals used are a concern. 1 To whom correspondence should be addressed (email satomi.miwa@ncl.ac.uk ). 12 3 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 arginine half-life mathematical model mitochondrion NaH 14 CO...
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Biochem Soc Trans (2010) 38 (4): 841–860.
Published: 26 July 2010
... and regulatory mechanisms of the MPTP (see [ 42 – 44 ] for reviews). Although there remain many uncertainties and areas of ignorance, considerable progress has been made, as discussed below. brain cardioprotection heart mitochondrion permeability transition pore (PTP) reperfusion injury David...
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Biochem Soc Trans (2010) 38 (3): 817–822.
Published: 24 May 2010
... factor HYH can bind to the LRE (light-responsible element)-enriched promoter of PEX11b in gel-shift assays. Arabidopsis dynamin-related protein 5B (DRP5B) light mitochondrion peroxisomal and mitochondrial division 1 (PMD1) peroxisome division and proliferation Peroxisomes exist...
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Biochem Soc Trans (2009) 37 (6): 1385–1388.
Published: 19 November 2009
... 1 email dnicholls@buckinstitute.org 4 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 ATP excitotoxicity glutamate ischaemia mitochondrion oxidative stress The ability of the ubiquitous amino acid glutamate to act as a specific...
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Biochem Soc Trans (2009) 37 (6): 1389–1393.
Published: 19 November 2009
... Biochemical Society 2009 dendrite dendritic bead excitotoxicity glutamate mitochondrion spine Immediate neuronal responses to insult include the rapid formation of neuritic swellings (termed varicosities or beads), mitochondrial dysfunction, decreased ATP concentration, microtubule collapse...
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Biochem Soc Trans (2008) 36 (5): 786–790.
Published: 19 September 2008
.... apoptosis atg gene Bcl-2 Beclin 1 macroautophagy mitochondrion The term autophagy (i.e. self-eating, from the Greek words auto =self and phagein =to eat) comprises a number of multiple intracellular processes, including CMA (chaperone-mediated autophagy), micro- and macro-autophagy, which...
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Biochem Soc Trans (2008) 36 (5): 976–980.
Published: 19 September 2008
... mitochondrion NADH:ubiquinone oxidoreductase oxidative stress reactive oxygen species (ROS) reverse electron transport The electron transport chain in mitochondria is a significant source of cellular ROS. Historically, respiratory complexes I and III have been considered two major sources...
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Biochem Soc Trans (2008) 36 (5): 1045–1050.
Published: 19 September 2008
... Mitochondrion 2001 1 33 49 8 Augustin S. Nolden M. Muller S. Hardt O. Arnold I. Langer T. Characterization of peptides released from mitochondria: evidence for constant proteolysis and peptide efflux J. Biol. Chem. 2005 280 2691 2699 9 Tatsuta T. Langer...
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Biochem Soc Trans (2008) 36 (3): 517–519.
Published: 21 May 2008
... that may be involved in that process. 1 To whom correspondence should be addressed (email agnieszka.bobrowicz@ncl.ac.uk ). 22 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 mitochondrion mRNA stability polyadenylation polynucleotide phosphorylase...
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Biochem Soc Trans (2007) 35 (6): 1643–1647.
Published: 23 November 2007
...@cyllene.uwa.edu.au ). 2 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 Arabidopsis thaliana chloroplast mitochondrion pentatricopeptide repeat (PPR) RNA binding tetratricopeptide repeat (TPR) The RNA-binding property of PPR proteins was confirmed by several...
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Biochem Soc Trans (2007) 35 (5): 1052–1054.
Published: 25 October 2007
... in cardioprotective signalling in the setting of ischaemia/reperfusion injury. © The Authors Journal compilation © 2007 Biochemical Society 2007 cardioprotection ischaemia ischaemic preconditioning mitochondrion protein kinase Cϵ (PKCϵ) receptor for activated C-kinase (RACK) D.M.-R...
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Biochem Soc Trans (2007) 35 (5): 1224–1227.
Published: 25 October 2007
... 2007 Biochemical Society 2007 AMP-activated protein kinase astrocyte mitochondrion neurodegeneration pentose phosphate pathway (PPP) 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase NO is formed by NOS (NO synthase) from L -arginine [ 1 ] in all brain cells [ 2 ]. In neurons...
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Biochem Soc Trans (2007) 35 (5): 1228–1231.
Published: 25 October 2007
... sporadic ALS SOD superoxide dismutase amyotrophic lateral sclerosis (ALS) Friedreich's ataxia mitochondrion Morbus Parkinson neurodegenerative disorder This review summarizes recent functional and genetic findings reporting a mitochondrial impairment in certain...
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Biochem Soc Trans (2007) 35 (5): 1180–1186.
Published: 25 October 2007
.... 1 To whom correspondence should be addressed (email philip.newsholme@ucd.ie ). 25 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 amino acid metabolism diabetes gene expression glucose insulin secretion mitochondrion Only a relatively...
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Biochem Soc Trans (2007) 35 (2): 401–404.
Published: 20 March 2007
... is a single-binding, centre-gated pore rather than a channel. 1 To whom correspondence should be addressed (email antonio.toninello@unipd.it ). 26 10 2006 © 2007 The Biochemical Society 2007 agmatine amino acid guanidine compound mitochondrion polyamine transport RLM...
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Biochem Soc Trans (2006) 34 (5): 811–814.
Published: 25 October 2006
..., which is dedicated to the memory of Cecile Pickart. Aralar1 β-cell energy metabolism malate–aspartate shuttle mitochondrion redox shuttle The significance of redox shuttle mechanisms has been extensively described in brain, smooth muscle and cardiac tissue [ 1 – 3 ]. However, recent...
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Biochem Soc Trans (2006) 34 (5): 819–823.
Published: 25 October 2006
... with a particular diabetic subtype, designated MIDD (maternally inherited diabetes and deafness). This mutation causes an imbalance in the mitochondrion between proteins encoded by the nuclear and mitochondrial genomes, resulting in a gradual deterioration of glucose homoeostasis during life. Remarkably, carriers...