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Keywords: mitochondrion
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Articles
Biochem Soc Trans (2014) 42 (4): 1069–1074.
Published: 11 August 2014
.... 22 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 brain coenzyme A (CoA) inborn error of metabolism mitochondrion neurodegeneration pantothenate kinase 2 (PANK2) To date, ten genes have been associated with specific forms of NBIA (neurodegeneration...
Articles
Biochem Soc Trans (2014) 42 (4): 1012–1016.
Published: 11 August 2014
... failure manganese superoxide dismutase mitochondrion reactive oxygen species Apart from being a substrate in various enzyme reactions, oxygen appears to be also the universal electron acceptor in electron transfer processes occurring in various aerobic living species. During these events some...
Articles
Biochem Soc Trans (2014) 42 (4): 939–944.
Published: 11 August 2014
... and development Curr. Opin. Chem. Biol. 2011 15 156 161 10.1016/j.cbpa.2010.10.016 21075043 38 Holley A.K. Dhar S.K. St Clair D.K. Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect? Mitochondrion 2013 13 170 188 10.1016/j.mito...
Articles
Biochem Soc Trans (2014) 42 (2): 231–238.
Published: 20 March 2014
...-response-element-binding protein (CREB) cardiovascular disease diabetes exercise mitochondrion nitric oxide synthase (NOS) Diabetes is a leading cause of death and disability worldwide and a leading cause of blindness, end-stage renal disease, non-traumatic amputation and CVD (cardiovascular...
Articles
Biochem Soc Trans (2014) 42 (2): 265–269.
Published: 20 March 2014
... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling In its simplest form, i.e. generation of messenger in response to extracellular stimuli followed by activation of its effectors and termination by PDEs, the cAMP signalling cascade is not sufficient...
Articles
Biochem Soc Trans (2013) 41 (6): 1618–1624.
Published: 20 November 2013
... on the individual mitochondrion and the cell within which they reside. Neurons are post-mitotic energy-dependent cells and, as such, are particularly vulnerable to alterations in cellular bioenergetics and increased stress that may occur as a direct or indirect result of mitochondrial dysfunction. The trafficking...
Articles
Biochem Soc Trans (2013) 41 (6): 1503–1508.
Published: 20 November 2013
... Biochemical Society 2013 autophagy dopaminergic neuron induced pluripotent stem cell (iPSC) leucine-rich repeat kinase 2 (LRRK2) mitochondrion Parkinson’s disease (PD) Despite decades of research, the complex multi-factorial aetiology of PD (Parkinson's disease) is still not well understood...
Articles
Biochem Soc Trans (2013) 41 (6): 1525–1531.
Published: 20 November 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 calcium sensing mitochondrial Rho (Miro) mitochondrion mitophagy molecular motor trafficking The brain is only 2% of the body's weight, but it uses 20% of the body's resting energy production. This high level of energy...
Articles
Biochem Soc Trans (2013) 41 (5): 1227–1234.
Published: 23 September 2013
... research. chloroplast cryo-electron tomography membrane bioenergetics membrane protein organization mitochondrion Subtomogram averaging is a technique which can both identify known proteins and determine previously unknown protein structures within tomograms [ 14 , 16 – 18 , 40 ] ( Figure 2 E...
Articles
Biochem Soc Trans (2013) 41 (5): 1272–1279.
Published: 23 September 2013
... 2013 © 2013 The Authors 2013 accessory subunit assembly mitochondrion NADH:ubiquinone oxidoreductase respiratory complex I Table 1 Accessory subunits of mitochondrial complex I Y. lipolytica * (kDa) Human † Bovine ‡ (kDa) Remarks Associated disease(s...
Articles
Biochem Soc Trans (2013) 41 (5): 1335–1341.
Published: 23 September 2013
... protein) mitochondrion oxidative phosphorylation complex (OXPHOS complex) Mitochondria harbour fundamental functions of cell metabolism. The mitochondrial OXPHOS (oxidative phosphorylation) complexes are central for the efficient production of ATP. In addition to supplying energy, mitochondria...
Articles
Biochem Soc Trans (2013) 41 (2): 620–624.
Published: 21 March 2013
... of molecular dynamics simulations of knotted protein translocation process using a coarse-grained model of both the pore and the protein. conformational change knot mitochondrion molecular dynamics protein translocation The process of knot tightening in proteins has been analysed in three...
Articles
Biochem Soc Trans (2013) 41 (1): 101–105.
Published: 29 January 2013
... kinase) pathway is induced by increased oxidative stress and JNK translocation to the mitochondrion results in impairment of energy metabolism. Moreover, IIS and JNK signalling interact with and antagonize each other. This review focuses on functional outcomes of a metabolic triad that entails the co...
Articles
Biochem Soc Trans (2013) 41 (1): 106–110.
Published: 29 January 2013
... residues [ 39 ], or preserve the mitochondrial genome, respiration and cell division [ 40 ]. γ-glutamylcysteine glutathione mitochondrion reactive oxygen species Under certain pathophysiological conditions it has been shown that the mitochondrial ROS production exceeds the detoxification...
Articles
Biochem Soc Trans (2013) 41 (1): 1–16.
Published: 29 January 2013
... is shown leaving those interfaces. adenosine triphosphate (ATP) ATP synthase bacterium chloroplast energy cost mitochondrion protonmotive force rotor stator “From the earliest times breathing and the warmth of the body were recognized as the chief manifestations of life”. So wrote...
Articles
Biochem Soc Trans (2013) 41 (1): 111–117.
Published: 29 January 2013
.... bioenergetics disease susceptibility mitochondrion oxidant In this respect, mitochondrial genetics and biology could act in a complementary fashion with nuclear genetics to more lucidly explain individual disease susceptibility. Wallace and colleagues proposed that mtDNA (mitochondrial DNA) missense...
Articles
Biochem Soc Trans (2013) 41 (1): 124–126.
Published: 29 January 2013
.... This signalling pathway is shown in Figure 2 , suggesting key roles for both MEK5 and p90 RSK in the Crabtree effect. Figure 2 Proposed signalling pathway linking high glucose to respiratory inhibition cancer Crabtree effect extracellular-signal-regulated kinase 5 (ERK5) mitochondrion p90...
Articles
Biochem Soc Trans (2012) 40 (6): 1426–1432.
Published: 21 November 2012
... of autophagosomes. 27 6 2012 © 2012 The Authors Journal 2012 endoplasmic reticulum (ER) Golgi complex GTPase mitochondria-associated membrane (MAM) mitochondrion Rab The organelles of eukaryotic cells exhibit a unique protein composition consistent with the defined individual...
Articles
Biochem Soc Trans (2012) 40 (4): 865–869.
Published: 20 July 2012
... of this complicated process, which ultimately regulates the protein production in cells, or more specifically what governs RNA catabolism in a particular subcompartment of human cells: the mitochondrion. 1 To whom correspondence should be addressed (email zofia.chrzanowska-lightowlers@ncl.ac.uk ). 26...
Articles
Biochem Soc Trans (2012) 40 (2): 445–450.
Published: 21 March 2012
...) endoplasmic reticulum–mitochondria encounter structure (ERMES) lipid binding mitochondrion The eukaryotic cell is a highly complex entity that carries out many distinct functions that are interdependent and interconnected. Organelles are compartments dedicated to the realization of specific...
Articles
Biochem Soc Trans (2012) 40 (1): 158–167.
Published: 19 January 2012
... signals. In the present paper, we review the organization of mitochondria and the organelles role in Ca 2+ signalling. calcium uptake local calcium signalling mitochondrion store organization tether Mitochondria provide energy, in the form of ATP, for many cellular processes via oxidative...
Articles
Biochem Soc Trans (2011) 39 (5): 1482–1487.
Published: 21 September 2011
... to either of these authors (email M.F.Tuite@kent.ac.uk and C.W.Gourlay@kent.ac.uk ). 30 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 amyotrophic lateral sclerosis (ALS) fused in sarcoma (FUS) mitochondrion protein aggregation Saccharomyces cerevisiae...
Articles
Biochem Soc Trans (2011) 39 (5): 1488–1492.
Published: 21 September 2011
... certain thresholds, programmed cell death brings the life of individual P. anserina to an end. 1 email osiewacz@bio.uni-frankfurt.de 11 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging mitochondrion Podospora anserina reactive oxygen species...
Articles
Biochem Soc Trans (2011) 39 (5): 1221–1225.
Published: 21 September 2011
... dichlorodihydrofluorescein or dihydrorhodamine. 1 email balarama@mcw.edu . 15 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell signalling fluorescence mitochondrion reactive nitrogen species (RNS) reactive oxygen species (ROS) redox biology superoxide...
Articles
Biochem Soc Trans (2011) 39 (5): 1305–1309.
Published: 21 September 2011
... correspondence should be addressed (email irina.shabalina@wgi.su.se ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...
Articles
Biochem Soc Trans (2011) 39 (5): 1509–1513.
Published: 21 September 2011
... organismal viability. 1 To whom correspondence should be addressed (email rutter@biochem.utah.edu ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell division cycle 48 (Cdc48) mitochondrion p97 parkin ubiquitin–proteasome system VCP (p97)/Cdc48...
Articles
Biochem Soc Trans (2011) 39 (5): 1533–1537.
Published: 21 September 2011
.... 1 To whom correspondence should be addressed (email mcortereal@bio.uminho.pt ). 31 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 apoptosis cathepsin D lysosome mitochondrion Pep4p vacuole In the last decade, it has been demonstrated...
Articles
Biochem Soc Trans (2011) 39 (5): 1538–1543.
Published: 21 September 2011
... Society 2011 cytochrome c mitochondrion programmed cell death (PCD) reactive oxygen species (ROS) Saccharomyces cerevisiae YCA1 The term PCD (programmed cell death) describes a highly heterogeneous process regulated by distinct but sometimes overlapping pathways including apoptosis...
Articles
Biochem Soc Trans (2011) 39 (3): 799–806.
Published: 20 May 2011
... mitochondrial DNA mutation (mtDNA mutation) mitochondrion NADH:ubiquinone oxidoreductase (complex I) ND subunit Complex I (NADH:ubiquinone oxidoreductase) is a complicated multisubunit enzyme found in the mitochondrial inner membrane of many eukaryotes and in the cytoplasmic membrane of many aerobic...
Articles
Biochem Soc Trans (2011) 39 (1): 1–13.
Published: 19 January 2011
... it. 1 email d.g.hardie@dundee.ac.uk 11 9 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 AMP-activated protein kinase (AMPK) cancer cell metabolism energy balance mitochondrion Type 2 diabetes Living cells are molecular machines that require...
Articles
Biochem Soc Trans (2010) 38 (6): 1523–1526.
Published: 24 November 2010
... presequence that targets the protein to the mitochondrion, but this is not cleaved after successful import into the matrix of the organelle, as is the case for many of the nuclear-encoded but mitochondrially destined proteins [ 28 ]. Alignment with numerous RRF sequences suggests that the human mtRRF has a 79...
Articles
Biochem Soc Trans (2010) 38 (5): 1322–1328.
Published: 24 September 2010
... 2010 Biochemical Society 2010 arginine half-life mathematical model mitochondrion NaH 14 CO 3 pulse–chase We are interested in mitochondrial turnover because replacing damaged mitochondria is an important potential quality control mechanism. Mitochondrial dysfunction...
Articles
Biochem Soc Trans (2010) 38 (4): 841–860.
Published: 26 July 2010
... Society 2010 brain cardioprotection heart mitochondrion permeability transition pore (PTP) reperfusion injury David Keilin was a pioneer in the study of mitochondrial electron transfer and bioenergetics who discovered the key role of cytochromes in substrate oxidation [ 1...
Articles
Biochem Soc Trans (2010) 38 (3): 817–822.
Published: 24 May 2010
... to be involved in organelle division and positioning in several model organisms (see below), we first focused on finding the peroxisomal coiled-coil proteins. Arabidopsis dynamin-related protein 5B (DRP5B) light mitochondrion peroxisomal and mitochondrial division 1 (PMD1) peroxisome division...
Articles
Biochem Soc Trans (2009) 37 (6): 1385–1388.
Published: 19 November 2009
... and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures. 1 email dnicholls@buckinstitute.org 4 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 ATP excitotoxicity glutamate ischaemia mitochondrion...
Articles
Biochem Soc Trans (2009) 37 (6): 1389–1393.
Published: 19 November 2009
... The Authors Journal compilation © 2009 Biochemical Society 2009 dendrite dendritic bead excitotoxicity glutamate mitochondrion spine Immediate neuronal responses to insult include the rapid formation of neuritic swellings (termed varicosities or beads), mitochondrial dysfunction, decreased...
Articles
Biochem Soc Trans (2008) 36 (5): 786–790.
Published: 19 September 2008
... (Barcelona, Spain), Manuel Rodríguez (CICbioGUNE, Derio, Spain), Eduardo Salido (La Laguna, Tenerife, Spain) and Dimitris Xirodimas (Dundee, U.K.). apoptosis atg gene Bcl-2 Beclin 1 macroautophagy mitochondrion The term autophagy (i.e. self-eating, from the Greek words auto =self...
Articles
Biochem Soc Trans (2008) 36 (5): 976–980.
Published: 19 September 2008
... mitochondrion NADH:ubiquinone oxidoreductase oxidative stress reactive oxygen species (ROS) reverse electron transport Information about the site(s) of ROS production of complex I is provided by differences in the rates of ROS production (observed in mitochondria and submitochondrial particles...
Articles
Biochem Soc Trans (2008) 36 (5): 1045–1050.
Published: 19 September 2008
... in these studies. Immunohistochemistry of tissues with 6D12 and anti-AGE antibodies 1F6, and 2A2 all showed mitochondrial immunoreactivity in human tissues [ 30 ]. advanced glycation end-product (AGE) dicarbonyl glycation mitochondrion oxidative stress AGE advanced glycation end-product AKRd...
Articles
Biochem Soc Trans (2008) 36 (3): 517–519.
Published: 21 May 2008
... agnieszka.bobrowicz@ncl.ac.uk ). 22 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 mitochondrion mRNA stability polyadenylation polynucleotide phosphorylase (PNPase) One undeniable reason for polyadenylation of certain mt-mRNAs is the necessity of completing...
Articles
Biochem Soc Trans (2007) 35 (6): 1643–1647.
Published: 23 November 2007
...@cyllene.uwa.edu.au ). 2 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 Arabidopsis thaliana chloroplast mitochondrion pentatricopeptide repeat (PPR) RNA binding tetratricopeptide repeat (TPR) Transcription in plant organelles often yields multiple primary...
Articles
Biochem Soc Trans (2007) 35 (5): 1224–1227.
Published: 25 October 2007
... © 2007 Biochemical Society 2007 AMP-activated protein kinase astrocyte mitochondrion neurodegeneration pentose phosphate pathway (PPP) 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase NO is formed by NOS (NO synthase) from L -arginine [ 1 ] in all brain cells [ 2...
Articles
Biochem Soc Trans (2007) 35 (5): 1228–1231.
Published: 25 October 2007
... compilation © 2007 Biochemical Society 2007 amyotrophic lateral sclerosis (ALS) Friedreich's ataxia mitochondrion Morbus Parkinson neurodegenerative disorder This review summarizes recent functional and genetic findings reporting a mitochondrial impairment in certain neurodegenerative...
Articles
Biochem Soc Trans (2007) 35 (5): 1180–1186.
Published: 25 October 2007
... To whom correspondence should be addressed (email philip.newsholme@ucd.ie ). 25 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 amino acid metabolism diabetes gene expression glucose insulin secretion mitochondrion The endocrine islets...
Articles
Biochem Soc Trans (2007) 35 (5): 1052–1054.
Published: 25 October 2007
.... 2006 41 426 430 1 To whom correspondence should be addressed (email mochly@stanford.edu ). 27 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cardioprotection ischaemia ischaemic preconditioning mitochondrion protein kinase Cϵ (PKCϵ...
Articles
Biochem Soc Trans (2007) 35 (2): 401–404.
Published: 20 March 2007
... is a single-binding, centre-gated pore rather than a channel. 1 To whom correspondence should be addressed (email antonio.toninello@unipd.it ). 26 10 2006 © 2007 The Biochemical Society 2007 agmatine amino acid guanidine compound mitochondrion polyamine transport...
Articles
Biochem Soc Trans (2007) 35 (2): 343–348.
Published: 20 March 2007
... were observed. 1 To whom correspondence should be addressed (email enzo.agostinelli@uniroma1.it ). 25 10 2006 © 2007 The Biochemical Society 2007 hyperthermia lysosome mitochondrion polyamine spermine oxidation tumour cell The cytotoxicity of BSAO (bovine serum...
Articles
Biochem Soc Trans (2007) 35 (2): 391–395.
Published: 20 March 2007
... ). 2 These authors contributed equally to this work. 2 10 2006 © 2007 The Biochemical Society 2007 cell cycle cell proliferation mitochondrion ornithine decarboxylase (ODC) potassium channel quinidine Intracellular-free calcium was measured on a Bio-Rad MRC-600...
Articles
Biochem Soc Trans (2006) 34 (5): 811–814.
Published: 25 October 2006
... metabolism in the β-cells. 1 To whom correspondence should be addressed (email philip.newsholme@ucd.ie ). 6 7 2006 © 2006 The Biochemical Society 2006 Aralar1 β-cell energy metabolism malate–aspartate shuttle mitochondrion redox shuttle The significance of redox...
Articles
Biochem Soc Trans (2006) 34 (5): 989–992.
Published: 25 October 2006
... ATPase synthase aurovertin catalytic domain crystal structure inhibitory site mitochondrion The ATP synthases (F 1 F o -ATPases) are multisubunit assemblies found in the membranes of bacteria, the thylakoid membranes of chloroplasts and the inner membranes of mitochondria. They couple...