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Articles

Alteration of the coenzyme A biosynthetic pathway in neurodegeneration with brain iron accumulation syndromes

Paola Venco, Sabrina Dusi, Lorella Valletta, Valeria Tiranti

Biochem Soc Trans (2014) 42 (4): 1069–1074.

https://doi.org/10.1042/BST20140106

Published: 11 August 2014

... To whom correspondence should be addressed (email: tiranti@istituto-besta.it ). 22 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 brain coenzyme A (CoA) inborn error of metabolism mitochondrion neurodegeneration pantothenate kinase 2 (PANK2...

View article titled, Alteration of the coenzyme A biosynthetic pathway in neurodegeneration with brain iron accumulation syndromes

Articles

Mitochondria and redox homoeostasis as chemotherapeutic targets

Margaret M. Briehl, Margaret E. Tome, Sarah T. Wilkinson, Melba C. Jaramillo, Kristy Lee

Biochem Soc Trans (2014) 42 (4): 939–944.

https://doi.org/10.1042/BST20140087

Published: 11 August 2014

... studies support the development of new anti-cancer drugs to target this organelle. apoptosis chemotherapy lymphoma metabolism mitochondrion redox homoeostasis Cancer cells frequently function with a more oxidized redox environment [ 1 ]. An expanded set of cancer hallmarks was proposed...

View article titled, Mitochondria and redox homoeostasis as chemotherapeutic targets

Articles

Manganese superoxide dismutase in carcinogenesis: friend or foe?

Anja Konzack, Thomas Kietzmann

Biochem Soc Trans (2014) 42 (4): 1012–1016.

https://doi.org/10.1042/BST20140076

Published: 11 August 2014

... 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 inflammation liver failure manganese superoxide dismutase mitochondrion reactive oxygen species Apart from being a substrate in various enzyme reactions, oxygen appears to be also the universal electron...

View article titled, Manganese superoxide dismutase in carcinogenesis: friend or foe?

Articles

Targeting mitochondria to restore failed adaptation to exercise in diabetes

Kate Geary, Leslie A. Knaub, Irene E. Schauer, Amy C. Keller, Peter A. Watson, Matthew W. Miller, Chrystelle V. Garat, Kristen J. Nadeau, Melanie Cree-Green, Subbiah Pugazhenthi, Judith G. Regensteiner, Dwight J. Klemm, Jane E.B. Reusch

Biochem Soc Trans (2014) 42 (2): 231–238.

https://doi.org/10.1042/BST20130283

Published: 20 March 2014

...) cardiovascular disease diabetes exercise mitochondrion nitric oxide synthase (NOS) Diabetes is a leading cause of death and disability worldwide and a leading cause of blindness, end-stage renal disease, non-traumatic amputation and CVD (cardiovascular disease). Interventions to optimize glucose...

View article titled, Targeting mitochondria to restore failed adaptation to exercise in diabetes

Articles

cAMP signalling meets mitochondrial compartments

Konstantinos Lefkimmiatis

Biochem Soc Trans (2014) 42 (2): 265–269.

https://doi.org/10.1042/BST20130281

Published: 20 March 2014

... Society 2014 cAMP compartmentalization mitochondrion protein kinase A (PKA) signalling The IMS is the second aqueous compartment of mitochondria (the other being the matrix). The IMS is defined by the OMM and IMM and has emerged as a significant regulatory domain in the co-ordination...

View article titled, cAMP signalling meets mitochondrial compartments

Articles

Monitoring mitochondrial dynamics and complex I dysfunction in neurons: implications for Parkinson's disease

Eve M. Simcox, Amy Reeve, Doug Turnbull

Biochem Soc Trans (2013) 41 (6): 1618–1624.

https://doi.org/10.1042/BST20130189

Published: 20 November 2013

... on the individual mitochondrion and the cell within which they reside. Neurons are post-mitotic energy-dependent cells and, as such, are particularly vulnerable to alterations in cellular bioenergetics and increased stress that may occur as a direct or indirect result of mitochondrial dysfunction. The trafficking...

View article titled, Monitoring mitochondrial dynamics and complex I dysfunction in neurons: implications for Parkinson's disease

Articles

Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease

Joel E. Beevers, Tara M. Caffrey, Richard Wade-Martins

Biochem Soc Trans (2013) 41 (6): 1503–1508.

https://doi.org/10.1042/BST20130194

Published: 20 November 2013

... Biochemical Society 2013 autophagy dopaminergic neuron induced pluripotent stem cell (iPSC) leucine-rich repeat kinase 2 (LRRK2) mitochondrion Parkinson’s disease (PD) Variability between iPSC lines is one of the major potential limitations to this technology. Typically several colonies...

View article titled, Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease

Articles

Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins

Nicol Birsa, Rosalind Norkett, Nathalie Higgs, Guillermo Lopez-Domenech, Josef T. Kittler

Biochem Soc Trans (2013) 41 (6): 1525–1531.

https://doi.org/10.1042/BST20130234

Published: 20 November 2013

... GTPases, where GTP or GDP binding affects downstream signalling and binding partners [ 64 ]. 1 To whom correspondence should be addressed (email j.kittler@ucl.ac.uk ). 2 10 2013 calcium sensing mitochondrial Rho (Miro) mitochondrion mitophagy molecular motor trafficking...

View article titled, Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins

Articles

Role of cryo-ET in membrane bioenergetics research

Karen M. Davies, Bertram Daum

Biochem Soc Trans (2013) 41 (5): 1227–1234.

https://doi.org/10.1042/BST20130029

Published: 23 September 2013

... mitochondrion Cryo-ET is a relatively new technique that can image cellular features in three dimensions as well as the distribution and, in favourable cases, the structure of protein complexes in situ . The technique has been used to investigate biological structures ranging from isolated protein...

View article titled, Role of cryo-ET in membrane bioenergetics research

Articles

Accessory subunits of mitochondrial complex I

Katarzyna Kmita, Volker Zickermann

Biochem Soc Trans (2013) 41 (5): 1272–1279.

https://doi.org/10.1042/BST20130091

Published: 23 September 2013

... 2013 © 2013 The Authors 2013 accessory subunit assembly mitochondrion NADH:ubiquinone oxidoreductase respiratory complex I Proton-translocating NADH:ubiquinone oxidoreductase (respiratory complex I) is a very large and complex membrane protein [ 1 ]. Fourteen central subunits...

View article titled, Accessory subunits of mitochondrial complex I

Articles

The superfamily of mitochondrial Complex1_LYR motif-containing (LYRM) proteins

Heike Angerer

Biochem Soc Trans (2013) 41 (5): 1335–1341.

https://doi.org/10.1042/BST20130116

Published: 23 September 2013

... protein) mitochondrion oxidative phosphorylation complex (OXPHOS complex) Reorganization of the eukaryotic cell after the endosymbiotic event triggered an increase in complexity of the mitochondrial OXPHOS complexes and metabolic pathways. LYRM proteins contribute to the higher complexity...

View article titled, The superfamily of mitochondrial Complex1_LYR motif-containing (LYRM) proteins

Articles

Tight knots in proteins: can they block the mitochondrial pores?

Piotr Szymczak

Biochem Soc Trans (2013) 41 (2): 620–624.

https://doi.org/10.1042/BST20120261

Published: 21 March 2013

... conformational change knot mitochondrion molecular dynamics protein translocation In recent years, there has been a surge of interest in the properties and functions of knotted proteins. As more and more knotted structures are deposited in the PDB, it becomes increasingly important to understand how...

View article titled, Tight knots in proteins: can they block the mitochondrial pores?

Articles

Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling

Fei Yin, Tianyi Jiang, Enrique Cadenas

Biochem Soc Trans (2013) 41 (1): 101–105.

https://doi.org/10.1042/BST20120260

Published: 29 January 2013

... kinase) pathway is induced by increased oxidative stress and JNK translocation to the mitochondrion results in impairment of energy metabolism. Moreover, IIS and JNK signalling interact with and antagonize each other. This review focuses on functional outcomes of a metabolic triad that entails the co...

View article titled, Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling

Articles

Glutathione and γ-glutamylcysteine in the antioxidant and survival functions of mitochondria

Ruben Quintana-Cabrera, Juan P. Bolaños

Biochem Soc Trans (2013) 41 (1): 106–110.

https://doi.org/10.1042/BST20120252

Published: 29 January 2013

...-glutamylcysteine glutathione mitochondrion reactive oxygen species One of the most efficient forms for energy production in aerobic organisms is carried out by mitochondria, which have been referred to as the ‘powerhouse’ of the cell. To produce ATP, the estimated 3–30 μM O 2 concentration...

View article titled, Glutathione and γ-glutamylcysteine in the antioxidant and survival functions of mitochondria

Articles

The ATP synthase: the understood, the uncertain and the unknown

John E. Walker

Biochem Soc Trans (2013) 41 (1): 1–16.

https://doi.org/10.1042/BST20110773

Published: 29 January 2013

... chloroplast energy cost mitochondrion protonmotive force rotor stator “From the earliest times breathing and the warmth of the body were recognized as the chief manifestations of life”. So wrote David Keilin at the beginning of the first chapter of his book The History of Cell Respiration...

View article titled, The ATP synthase: the understood, the uncertain and the unknown

Articles

Beyond retrograde and anterograde signalling: mitochondrial–nuclear interactions as a means for evolutionary adaptation and contemporary disease susceptibility

Scott W. Ballinger

Biochem Soc Trans (2013) 41 (1): 111–117.

https://doi.org/10.1042/BST20120227

Published: 29 January 2013

...) of the mitochondrion in the cell. Overall, a greater understanding of how the original relationships between the mitochondrion and the nucleus evolved to allow for the adaptation of cell function will facilitate discovery of the mechanisms of how common disease develops. Translating the Powerhouse: Redox...

View article titled, Beyond retrograde and anterograde signalling: mitochondrial–nuclear interactions as a means for evolutionary adaptation and contemporary disease susceptibility

Articles

Role of p90 RSK in regulating the Crabtree effect: implications for cancer

Emily K. Redman, Paul S. Brookes, Marcin K. Karcz

Biochem Soc Trans (2013) 41 (1): 124–126.

https://doi.org/10.1042/BST20120277

Published: 29 January 2013

.... This signalling pathway is shown in Figure 2 , suggesting key roles for both MEK5 and p90 RSK in the Crabtree effect. Figure 2 Proposed signalling pathway linking high glucose to respiratory inhibition cancer Crabtree effect extracellular-signal-regulated kinase 5 (ERK5) mitochondrion p90...

View article titled, Role of p90 RSK in regulating the Crabtree effect: implications for cancer

Articles

Rab proteins of the endoplasmic reticulum: functions and interactors

Carolina Ortiz Sandoval, Thomas Simmen

Biochem Soc Trans (2012) 40 (6): 1426–1432.

https://doi.org/10.1042/BST20120158

Published: 21 November 2012

... endoplasmic reticulum (ER) Golgi complex GTPase mitochondria-associated membrane (MAM) mitochondrion Rab The organelles of eukaryotic cells exhibit a unique protein composition consistent with the defined individual functions of these organelles. Nevertheless, trafficking and direct contacts...

View article titled, Rab proteins of the endoplasmic reticulum: functions and interactors

Articles

The mystery of mitochondrial RNases

Francesco Bruni, Pasqua Gramegna, Robert N. Lightowlers, Zofia M.A. Chrzanowska-Lightowlers

Biochem Soc Trans (2012) 40 (4): 865–869.

https://doi.org/10.1042/BST20120022

Published: 20 July 2012

... of this complicated process, which ultimately regulates the protein production in cells, or more specifically what governs RNA catabolism in a particular subcompartment of human cells: the mitochondrion. 1 To whom correspondence should be addressed (email zofia.chrzanowska-lightowlers@ncl.ac.uk ). 26...

View article titled, The mystery of mitochondrial RNases

Articles

The ERMES complex and ER–mitochondria connections

Agnès H. Michel, Benoît Kornmann

Biochem Soc Trans (2012) 40 (2): 445–450.

https://doi.org/10.1042/BST20110758

Published: 21 March 2012

... mitochondrion Many mitochondrial enzymes are Ca 2+ -dependent, therefore Ca 2+ signalling within the mitochondria is critical for the generation of ATP. Moreover, mitochondrial Ca 2+ participates in triggering apoptosis, indicating that mitochondrial Ca 2+ must be tightly regulated [ 7 ]. For a long...

View article titled, The ERMES complex and ER–mitochondria connections

Articles

Mitochondrial organization and Ca 2+ uptake

Marnie L. Olson, Susan Chalmers, John G. McCarron

Biochem Soc Trans (2012) 40 (1): 158–167.

https://doi.org/10.1042/BST20110705

Published: 19 January 2012

... or passively buffers the [Ca 2+ ] c rise. 1 To whom correspondence should be addressed (email john.mccarron@strath.ac.uk ). 12 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 calcium uptake local calcium signalling mitochondrion store organization...

View article titled, Mitochondrial organization and Ca 2+ uptake

Articles

Using yeast models to probe the molecular basis of amyotrophic lateral sclerosis

Emma L. Bastow, Campbell W. Gourlay, Mick F. Tuite

Biochem Soc Trans (2011) 39 (5): 1482–1487.

https://doi.org/10.1042/BST0391482

Published: 21 September 2011

... to either of these authors (email M.F.Tuite@kent.ac.uk and C.W.Gourlay@kent.ac.uk ). 30 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 amyotrophic lateral sclerosis (ALS) fused in sarcoma (FUS) mitochondrion protein aggregation Saccharomyces cerevisiae...

View article titled, Using yeast models to probe the molecular basis of amyotrophic lateral sclerosis

Articles

Mitochondrial quality control in aging and lifespan control of the fungal aging model Podospora anserina

Heinz D. Osiewacz

Biochem Soc Trans (2011) 39 (5): 1488–1492.

https://doi.org/10.1042/BST0391488

Published: 21 September 2011

... certain thresholds, programmed cell death brings the life of individual P. anserina to an end. 1 email osiewacz@bio.uni-frankfurt.de 11 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 aging mitochondrion Podospora anserina reactive oxygen species...

View article titled, Mitochondrial quality control in aging and lifespan control of the fungal aging model Podospora anserina

Articles

Vacuole–mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome–mitochondria-mediated apoptosis in mammals

Maria João Sousa, Flávìa Azevedo, Ana Pedras, Carolina Marques, Olga P. Coutinho, Ana Preto, Hernâni Gerós, Susana R. Chaves, Manuela Côrte-Real

Biochem Soc Trans (2011) 39 (5): 1533–1537.

https://doi.org/10.1042/BST0391533

Published: 21 September 2011

.... Nilsson C. Kågedal K. Roberg K. Öllinger K. Regulation of apoptosis-associated lysosomal membrane permeabilization Apoptosis 2010 15 527 540 3 Repnik U. Turk B. Lysosomal–mitochondrial cross-talk during cell death Mitochondrion 2010 10 662 669 4 Turk...

View article titled, Vacuole–mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome–mitochondria-mediated apoptosis in mammals

Articles

Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways

Nicoletta Guaragnella, Lucia Antonacci, Salvatore Passarella, Ersilia Marra, Sergio Giannattasio

Biochem Soc Trans (2011) 39 (5): 1538–1543.

https://doi.org/10.1042/BST0391538

Published: 21 September 2011

... mitochondrion programmed cell death (PCD) reactive oxygen species (ROS) Saccharomyces cerevisiae YCA1 The term PCD (programmed cell death) describes a highly heterogeneous process regulated by distinct but sometimes overlapping pathways including apoptosis, autophagic cell death, and necrosis...

View article titled, Achievements and perspectives in yeast acetic acid-induced programmed cell death pathways

Articles

Oxidative chemistry of fluorescent dyes: implications in the detection of reactive oxygen and nitrogen species

Balaraman Kalyanaraman

Biochem Soc Trans (2011) 39 (5): 1221–1225.

https://doi.org/10.1042/BST0391221

Published: 21 September 2011

... and HPLC to detect and quantify O 2 •− formed in cells and tissues [ 4 , 5 ]. cell signalling fluorescence mitochondrion reactive nitrogen species (RNS) reactive oxygen species (ROS) redox biology superoxide © The Authors Journal compilation © 2011 Biochemical Society 2011 15 7...

View article titled, Oxidative chemistry of fluorescent dyes: implications in the detection of reactive oxygen and nitrogen species

Articles

Mitochondrial (‘mild’) uncoupling and ROS production: physiologically relevant or not?

Irina G. Shabalina, Jan Nedergaard

Biochem Soc Trans (2011) 39 (5): 1305–1309.

https://doi.org/10.1042/BST0391305

Published: 21 September 2011

... correspondence should be addressed (email irina.shabalina@wgi.su.se ). 15 6 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 carbonyl cyanide p -trifluoromethoxyphenylhydrazone (FCCP) membrane potential mitochondrion oxidative stress reactive oxygen species (ROS...

View article titled, Mitochondrial (‘mild’) uncoupling and ROS production: physiologically relevant or not?

Articles

Mitochondrial quality control by the ubiquitin–proteasome system

Eric B. Taylor, Jared Rutter

Biochem Soc Trans (2011) 39 (5): 1509–1513.

https://doi.org/10.1042/BST0391509

Published: 21 September 2011

... organismal viability. 1 To whom correspondence should be addressed (email rutter@biochem.utah.edu ). 15 6 2011 cell division cycle 48 (Cdc48) mitochondrion p97 parkin ubiquitin–proteasome system VCP (p97)/Cdc48-associated mitochondrial-stress-responsive 1 (Vms1...

View article titled, Mitochondrial quality control by the ubiquitin–proteasome system

Articles

The mitochondrial-encoded subunits of respiratory complex I (NADH:ubiquinone oxidoreductase): identifying residues important in mechanism and disease

Hannah R. Bridges, James A. Birrell, Judy Hirst

Biochem Soc Trans (2011) 39 (3): 799–806.

https://doi.org/10.1042/BST0390799

Published: 20 May 2011

... mitochondrial DNA mutation (mtDNA mutation) mitochondrion NADH:ubiquinone oxidoreductase (complex I) ND subunit Complex I (NADH:ubiquinone oxidoreductase) is a complicated multisubunit enzyme found in the mitochondrial inner membrane of many eukaryotes and in the cytoplasmic membrane of many aerobic...

View article titled, The mitochondrial-encoded subunits of respiratory complex I (NADH:ubiquinone oxidoreductase): identifying residues important in mechanism and disease

Articles

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

D. Grahame Hardie

Biochem Soc Trans (2011) 39 (1): 1–13.

https://doi.org/10.1042/BST0390001

Published: 19 January 2011

... it. © The Authors Journal compilation © 2011 Biochemical Society 2011 AMP-activated protein kinase (AMPK) cancer cell metabolism energy balance mitochondrion Type 2 diabetes 1 email d.g.hardie@dundee.ac.uk 11 9 2010 The classical stimuli that activate...

View article titled, AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

Articles

Translation termination in human mitochondrial ribosomes

Ricarda Richter, Aleksandra Pajak, Sven Dennerlein, Agata Rozanska, Robert N. Lightowlers, Zofia M.A. Chrzanowska-Lightowlers

Biochem Soc Trans (2010) 38 (6): 1523–1526.

https://doi.org/10.1042/BST0381523

Published: 24 November 2010

... compilation © 2010 Biochemical Society 2010 mitochondrion protein synthesis release factor stop codon translation termination Mitochondria are vital organelles that are present in all nucleated cells of higher eukaryotes. They play critical roles in many processes, including calcium...

View article titled, Translation termination in human mitochondrial ribosomes

Articles

Correction of radiolabel pulse–chase data by a mathematical model: application to mitochondrial turnover studies

Satomi Miwa, Conor Lawless, Thomas von Zglinicki

Biochem Soc Trans (2010) 38 (5): 1322–1328.

https://doi.org/10.1042/BST0381322

Published: 24 September 2010

... 2010 Biochemical Society 2010 arginine half-life mathematical model mitochondrion NaH 14 CO 3 pulse–chase We are interested in mitochondrial turnover because replacing damaged mitochondria is an important potential quality control mechanism. Mitochondrial dysfunction...

View article titled, Correction of radiolabel pulse–chase data by a mathematical model: application to mitochondrial turnover studies

Articles

A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection

Andrew P. Halestrap

Biochem Soc Trans (2010) 38 (4): 841–860.

https://doi.org/10.1042/BST0380841

Published: 26 July 2010

... if the stimulus is large enough. brain cardioprotection heart mitochondrion permeability transition pore (PTP) reperfusion injury David Keilin was a pioneer in the study of mitochondrial electron transfer and bioenergetics who discovered the key role of cytochromes in substrate oxidation...

View article titled, A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection

Articles

Peroxisome division and proliferation in plants

Kyaw Aung, Xinchun Zhang, Jianping Hu

Biochem Soc Trans (2010) 38 (3): 817–822.

https://doi.org/10.1042/BST0380817

Published: 24 May 2010

... in the division of these metabolically associated plant organelles. © The Authors Journal compilation © 2010 Biochemical Society 2010 1 To whom correspondence should be addressed (email huji@msu.edu ). 15 12 2009 Arabidopsis dynamin-related protein 5B (DRP5B) light mitochondrion...

View article titled, Peroxisome division and proliferation in plants

Articles

Rapid dendritic and axonal responses to neuronal insults

Sarah M. Mizielinska, Sam M. Greenwood, Hemanth Tummala, Christopher N. Connolly

Biochem Soc Trans (2009) 37 (6): 1389–1393.

https://doi.org/10.1042/BST0371389

Published: 19 November 2009

... excitotoxicity glutamate mitochondrion spine Dysfunction in fast axonal transport has been implicated in the pathogenesis of neurodegenerative diseases [ 43 ]. It is known that long-range (calcium-sensitive) mitochondrial transport is driven by molecular motors. These motors utilize ATP hydrolysis...

View article titled, Rapid dendritic and axonal responses to neuronal insults

Articles

Spare respiratory capacity, oxidative stress and excitotoxicity

David G. Nicholls

Biochem Soc Trans (2009) 37 (6): 1385–1388.

https://doi.org/10.1042/BST0371385

Published: 19 November 2009

... and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures. 1 email dnicholls@buckinstitute.org 4 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 ATP excitotoxicity glutamate ischaemia mitochondrion...

View article titled, Spare respiratory capacity, oxidative stress and excitotoxicity

Articles

Life, death and burial: multifaceted impact of autophagy

Lorenzo Galluzzi, Eugenia Morselli, José Miguel Vicencio, Oliver Kepp, Nicholas Joza, Nicolas Tajeddine, Guido Kroemer

Biochem Soc Trans (2008) 36 (5): 786–790.

https://doi.org/10.1042/BST0360786

Published: 19 September 2008

... compilation © 2008 Biochemical Society 2008 apoptosis atg gene Bcl-2 Beclin 1 macroautophagy mitochondrion The term autophagy (i.e. self-eating, from the Greek words auto =self and phagein =to eat) comprises a number of multiple intracellular processes, including CMA (chaperone-mediated...

View article titled, Life, death and burial: multifaceted impact of autophagy

Articles

The production of reactive oxygen species by complex I

Judy Hirst, Martin S. King, Kenneth R. Pryde

Biochem Soc Trans (2008) 36 (5): 976–980.

https://doi.org/10.1042/BST0360976

Published: 19 September 2008

... mitochondrion NADH:ubiquinone oxidoreductase oxidative stress reactive oxygen species (ROS) reverse electron transport The electron transport chain in mitochondria is a significant source of cellular ROS. Historically, respiratory complexes I and III have been considered two major sources...

View article titled, The production of reactive oxygen species by complex I

Articles

Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress

Naila Rabbani, Paul J. Thornalley

Biochem Soc Trans (2008) 36 (5): 1045–1050.

https://doi.org/10.1042/BST0361045

Published: 19 September 2008

... that are the targets for dicarbonyl glycation. 1 To whom correspondence should be addressed (email P.J.Thornalley@warwick.ac.uk ). 1 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 advanced glycation end-product (AGE) dicarbonyl glycation mitochondrion oxidative...

View article titled, Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress

Articles

Polyadenylation and degradation of mRNA in mammalian mitochondria: a missing link?

Agnieszka J. Bobrowicz, Robert N. Lightowlers, Zofia Chrzanowska-Lightowlers

Biochem Soc Trans (2008) 36 (3): 517–519.

https://doi.org/10.1042/BST0360517

Published: 21 May 2008

... Biochemical Society 2008 mitochondrion mRNA stability polyadenylation polynucleotide phosphorylase (PNPase) Human mtDNA (hmtDNA) is a small (16569 nt) double-stranded circular molecule containing no introns, with the main regulatory elements involved in replication and transcription...

View article titled, Polyadenylation and degradation of mRNA in mammalian mitochondria: a missing link?

Articles

Pentatricopeptide repeat (PPR) proteins as sequence-specificity factors in post-transcriptional processes in organelles

E. Delannoy, W.A. Stanley, C.S. Bond, I.D. Small

Biochem Soc Trans (2007) 35 (6): 1643–1647.

https://doi.org/10.1042/BST0351643

Published: 23 November 2007

...@cyllene.uwa.edu.au ). 2 7 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 Arabidopsis thaliana chloroplast mitochondrion pentatricopeptide repeat (PPR) RNA binding tetratricopeptide repeat (TPR) As most PPR proteins lack any known catalytic sites, the RNA...

View article titled, Pentatricopeptide repeat (PPR) proteins as sequence-specificity factors in post-transcriptional processes in organelles

Articles

Mitochondrial protein kinase Cϵ (PKCϵ): emerging role in cardiac protection from ischaemic damage

G.R. Budas, D. Mochly-Rosen

Biochem Soc Trans (2007) 35 (5): 1052–1054.

https://doi.org/10.1042/BST0351052

Published: 25 October 2007

... of the heart to ischaemic injury. 1 To whom correspondence should be addressed (email mochly@stanford.edu ). 27 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cardioprotection ischaemia ischaemic preconditioning mitochondrion protein kinase Cϵ (PKCϵ...

View article titled, Mitochondrial protein kinase Cϵ (PKCϵ): emerging role in cardiac protection from ischaemic damage

Articles

Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide

J.P. Bolaños, A. Herrero-Mendez, S. Fernandez-Fernandez, A. Almeida

Biochem Soc Trans (2007) 35 (5): 1224–1227.

https://doi.org/10.1042/BST0351224

Published: 25 October 2007

... during oxidative stress and bioenergetic crises ( Figure 1 ). AMP-activated protein kinase astrocyte mitochondrion neurodegeneration pentose phosphate pathway (PPP) 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Figure 1 NO controls neural vulnerability to oxidative stress...

View article titled, Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide

Articles

Mitochondrial dysfunction in neurodegenerative disorders

M. Baron, A.P. Kudin, W.S. Kunz

Biochem Soc Trans (2007) 35 (5): 1228–1231.

https://doi.org/10.1042/BST0351228

Published: 25 October 2007

.... Genet. 2001 28 211 212 50 Naviaux R.K. Nguyen K.V. Ann. Neurol. 2004 55 706 712 amyotrophic lateral sclerosis (ALS) Friedreich's ataxia mitochondrion Morbus Parkinson neurodegenerative disorder This review summarizes recent functional and genetic findings...

View article titled, Mitochondrial dysfunction in neurodegenerative disorders

Articles

Amino acid metabolism, insulin secretion and diabetes

P. Newsholme, K. Bender, A. Kiely, L. Brennan

Biochem Soc Trans (2007) 35 (5): 1180–1186.

https://doi.org/10.1042/BST0351180

Published: 25 October 2007

... acid metabolism diabetes gene expression glucose insulin secretion mitochondrion The endocrine islets of Langerhans contain four major cell types: insulin-secreting β-cells, glucagon-secreting α-cells, somatostatin-releasing δ-cells and pancreatic polypeptide-producing cells. Nutrients...

View article titled, Amino acid metabolism, insulin secretion and diabetes

Articles

MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells

E. Agostinelli, G. Tempera, L. Dalla Vedova, M. Condello, G. Arancia

Biochem Soc Trans (2007) 35 (2): 343–348.

https://doi.org/10.1042/BST0350343

Published: 20 March 2007

... and resemble thermosensitizers [ 16 ]. These results suggest that the combination of hyperthermia and spermine enzymatic oxidation products could prove to be useful in cancer treatment and mainly effective against MDR cells. hyperthermia lysosome mitochondrion polyamine spermine oxidation tumour cell...

View article titled, MDL 72527 and spermine oxidation products induce a lysosomotropic effect and mitochondrial alterations in tumour cells

Articles

Potassium channel blockers quinidine and caesium halt cell proliferation in C6 glioma cells via a polyamine-dependent mechanism

T.M. Weiger, S. Colombatto, V. Kainz, W. Heidegger, M.A. Grillo, A. Hermann

Biochem Soc Trans (2007) 35 (2): 391–395.

https://doi.org/10.1042/BST0350391

Published: 20 March 2007

... ). 2 These authors contributed equally to this work. 2 10 2006 © 2007 The Biochemical Society 2007 cell cycle cell proliferation mitochondrion ornithine decarboxylase (ODC) potassium channel quinidine Potassium channels are found ubiquitously in animal and plant...

View article titled, Potassium channel blockers quinidine and caesium halt cell proliferation in C6 glioma cells via a polyamine-dependent mechanism

Articles

Inhibition of agmatine transport in liver mitochondria by new charge-deficient agmatine analogues

M.A. Grillo, V. Battaglia, S. Colombatto, C.A. Rossi, A.R. Simonian, M. Salvi, A.R. Khomutov, A. Toninello

Biochem Soc Trans (2007) 35 (2): 401–404.

https://doi.org/10.1042/BST0350401

Published: 20 March 2007

... is a single-binding, centre-gated pore rather than a channel. 1 To whom correspondence should be addressed (email antonio.toninello@unipd.it ). 26 10 2006 © 2007 The Biochemical Society 2007 agmatine amino acid guanidine compound mitochondrion polyamine transport ADC...

View article titled, Inhibition of agmatine transport in liver mitochondria by new charge-deficient agmatine analogues

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The importance of redox shuttles to pancreatic β-cell energy metabolism and function

K. Bender, P. Newsholme, L. Brennan, P. Maechler

Biochem Soc Trans (2006) 34 (5): 811–814.

https://doi.org/10.1042/BST0340811

Published: 25 October 2006

... importance [ 6 ]. However, this shuttle is particularly active in tissues that rapidly metabolize glucose, such as skeletal muscle. Aralar1 β-cell energy metabolism malate–aspartate shuttle mitochondrion redox shuttle The significance of redox shuttle mechanisms has been extensively...

View article titled, The importance of redox shuttles to pancreatic β-cell energy metabolism and function

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Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia

H. Endo, A. Saito, P.H. Chan

Biochem Soc Trans (2006) 34 (6): 1283–1286.

https://doi.org/10.1042/BST0341283

Published: 25 October 2006

... cerebral ischaemia mitochondrion p53 pifithrin-α Current evidence indicates that the tumour suppressor gene p53 encodes a sequence-specific transcription factor that controls the expression of genes whose products mediate apoptosis [ 1 ]. Furthermore, evidence for transcription-independent p53...

View article titled, Mitochondrial translocation of p53 underlies the selective death of hippocampal CA1 neurons after global cerebral ischaemia

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