...). Modeling these disorders is revealing how mitochondrial dysfunction may drive ALS and PD pathogenesis by a gain of function mechanism, driven by protein misfolding of CHCHD2 and CHCHD10 into toxic species. It is also laying the groundwork for precision therapy of CHCHD2/CHCHD10-related neurodegeneration...

... that drug-induced mitochondrial dysfunction plays an important role in a variety of drug-induced organ toxicities [ 11 , 12 ]. Due to the role of mitochondrial dysfunction in the onset of ADRs, it has been hypothesised that variation in mtDNA may underpin some of the idiosyncrasies associated with drug...

... mitochondria mitochondrial dysfunction reactive oxygen species superoxide There is a wealth of literature describing how mitochondrial superoxide and hydrogen peroxide act as messengers in redox signalling through different pathways. The ability of mitochondrial ROS to act as messengers is accepted...

... The Author(s) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bypass therapy gene therapy mitochondrial biogenesis mitochondrial dysfunction rapamycin...

... on behalf of the Biochemical Society 2018 Alzheimer's disease mitochondrial dysfunction Parkinson's disease therapeutics The mitochondria are essential organelles to all eukaryotic cells. They are a highly dynamic double membrane-bound structure, containing their own circular, double...

... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioenergetics cardiac hypertrophy metabolism mitochondrial dysfunction sodium Cardiovascular disease is the leading cause of mortality worldwide with its incidence projected to rise significantly in the immediate...

... Attribution License 4.0 (CC BY) . gene therapy mitochondria mitochondrial dysfunction mouse models therapeutics The main function of mitochondria is to convert the energy derived from nutrients into heat and ATP, a high-energy molecule exploited by the cell biochemical machineries...

... higher than that in non-transgenic mice and non-AD brains [ 15 ]. More recent studies indicate that mitochondrial dysfunction and the accumulation of mitochondrial Aβ [and ABAD (amyloid-binding alcohol dehydrogenase): see below] can be observed in the early stages of AD in other commonly used transgenic...

... of the major evidence surrounding mitochondrial DNA mutations leading to mitochondrial dysfunction in neurodegenerative disease and discuss their possible role in neurodegeneration. 7 6 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 1 To whom correspondence should...