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Keywords: mitochondrial dysfunction
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Articles
Biochem Soc Trans (2020) 48 (3): 787–797.
Published: 26 May 2020
.... adverse drug reactions antiretroviral haplogroup mitochondrial dysfunction mtDNA The mitochondrion is an important organelle in the evolution of eukaryotic cells. The main function of which is the generation of cellular energy in the form of adenosine triphosphate (ATP) via two coupled...
Articles
Biochem Soc Trans (2019) 47 (5): 1461–1469.
Published: 10 September 2019
... mitochondria mitochondrial dysfunction reactive oxygen species superoxide There is a wealth of literature describing how mitochondrial superoxide and hydrogen peroxide act as messengers in redox signalling through different pathways. The ability of mitochondrial ROS to act as messengers...
Articles
Biochem Soc Trans (2018) 46 (5): 1247–1261.
Published: 09 October 2018
... The Author(s) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bypass therapy gene therapy mitochondrial biogenesis mitochondrial dysfunction rapamycin...
Articles
Biochem Soc Trans (2018) 46 (4): 891–909.
Published: 19 July 2018
... on behalf of the Biochemical Society 2018 Alzheimer's disease mitochondrial dysfunction Parkinson's disease therapeutics The mitochondria are essential organelles to all eukaryotic cells. They are a highly dynamic double membrane-bound structure, containing their own circular, double...
Articles
Biochem Soc Trans (2018) 46 (4): 817–827.
Published: 03 July 2018
... and distributed under the Creative Commons Attribution License 4.0 (CC BY) . bioenergetics cardiac hypertrophy metabolism mitochondrial dysfunction sodium Cardiovascular disease is the leading cause of mortality worldwide with its incidence projected to rise significantly in the immediate...
Articles
Biochem Soc Trans (2016) 44 (5): 1483–1490.
Published: 19 October 2016
... Attribution License 4.0 (CC BY) . gene therapy mitochondria mitochondrial dysfunction mouse models therapeutics Table 1 Overview of the therapeutic strategies for primary mitochondrial diseases Advantages Disadvantages Examples General strategies Wide applicability...
Articles
Biochem Soc Trans (2011) 39 (4): 868–873.
Published: 20 July 2011
...) cyclohexenyl amine naphthalene alcohol (CHANA) cyclophilin D (CypD) intracellular amyloid β-peptide (intracellular Aβ) mitochondrial dysfunction A link between mitochondrial dysfunction and neurodegenerative conditions, such as AD (Alzheimer's disease), has long been suggested to exist. Observations...
Articles
Biochem Soc Trans (2007) 35 (5): 1232–1235.
Published: 25 October 2007
... of the major evidence surrounding mitochondrial DNA mutations leading to mitochondrial dysfunction in neurodegenerative disease and discuss their possible role in neurodegeneration. 1 To whom correspondence should be addressed (email k.j.krishnan@ncl.ac.uk ). 7 6 2007 © The Authors Journal...