... to the C-terminal domain or the extracellular loops of Cx43 and thus are likely to function by different means. However, both block channel function and have been shown to enhance cell migration rates. In recent years, non-channel functions have emerged for Cx43, many of which are linked to cytoskeletal...

... © The Authors Journal compilation © 2015 Biochemical Society 2015 clusters immune synapse (IS) migration super resolution localization microscopy T-cells travel huge distances in the blood and the lymphatics, undergoing thousands of transient interactions with antigen presenting...

... that PKCs regulate the production of inflammatory cytokines and the cytotoxic responses of various T-cell subsets. Central to the T-cell immune response is a requirement to migrate to various organs and tissues in search of pathogens and micro-organisms. T-cell migration is guided by specific sets...

... roles in tumour cell migration, invasion, proliferation, communication with stromal cells and the development of drug resistance. As a consequence, Rab proteins may be novel potential candidates for the development of anticancer drugs and, in this context, the preliminary results obtained...

... of tumour cell invasion and migration. Several oncogenes can stimulate ERK5 activity, and protein levels are increased by a novel amplification at chromosome locus 17p11 and by down-regulation of the microRNAs miR-143 and miR-145 . Together, these finding underscore the case for further investigation...

...Dale Powner; Petra M. Kopp; Susan J. Monkley; David R. Critchley; Fedor Berditchevski Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked...

... a putative kinesin-1 receptor localized to ER membranes and focal adhesion components is intriguing, and together with the effects of PTP1B on adhesion formation and dynamics, support the hypothesis that direct contact between ER tubules and focal adhesions plays a role in cell migration. Although we...

...R. David; F.M. Marelli-Berg Migration of primed T-cells to the antigenic site is an essential event in the development of effective immunity. This process is tightly regulated in order to ensure efficient and specific responses. Most studies have focused on non-specific mediators of T-cell...

... that lycopene inhibited PDGF-BB (platelet-derived growth factor-BB)-induced signalling and cell migration in human cultured skin fibroblasts through a novel mechanism of action, i.e. direct binding to PDGF-BB. Trapping of PDGF by lycopene also compromised melanoma-induced fibroblast migration and attenuated...

... the normal maintenance of this tissue: differentiation, migration, proliferation and apoptosis. Indeed, APC is involved in the regulation of β-catenin and it also is an important regulator of the cytoskeleton. Thus mutations in APC lead to the accumulation of β-catenin, which causes changes...

...: apoptosis, inflammation, keratinocyte, migration, peroxisome-proliferator-activated receptor (PPAR), wound repair. Abbreviations used: PPAR, peroxisome proliferator-activated receptor; PPRE, PPAR response element; RXR, retinoid X receptor; TNF , tumour necrosis factor ; ILK, integrin-linked kinase; PDK1, 3...

...-mail peter.parker@cancer.org.uk ). Signalling the Future, a Biochemical Society-sponsored meeting held at University of Liverpool, Liverpool, 4–6 September 2002 6 September 2002 Copyright 2003 Biochemical Society 2003 adherence migration phosphorylation Abbreviations used: ERM...

...) mesenchyme and the maternal decidual stroma beneath. From the periphery of these columns, large numbers of trophoblast cells detach, migrate through the decidua and eventually colonize and transform maternal arteries. In this way the placenta increases and gives priority to the maternal blood supply...