... the cell by fusion with the plasma membrane [ 3 ]. In contrast with exosomes, microvesicles are formed by the outward budding and fission of the plasma membrane and are released directly into the intracellular milieu [ 3 ]. The unequal distribution of lipids within the plasma membrane can drive...

... of these particular ‘puzzle pieces’ may change substantially due to their mutual interactions. The present review concerns different opinions on interactions that occur between monocytes, tumour cells and TMVs (tumour-derived microvesicles). 1 To whom correspondence should be addressed (email mibaj@cyf...

...Jameel M. Inal; Una Fairbrother; Sheelagh Heugh The important roles of extracellular vesicles in the pathogenesis of various diseases are rapidly being elucidated. As important vehicles of intercellular communication, extracellular vesicles, which comprise microvesicles and exosomes, are revealing...

... disease Front. Physiol. 2012 3 229 exosome microvesicle neurodegeneration neuron synaptic plasticity The function of the brain relies on the capacity of billions of synapses to transmit patterns of electrical information through neuronal circuits. Reinforcement of circuits...

...Jr-Ming Yang; Stephen J. Gould Proteins bud from cells in small single-membraned vesicles (~50–250 nm) that have the same topology as the cell. Known variously as exosomes and microvesicles (EMVs), these extracellular organelles are enriched for specific proteins, lipids, carbohydrates and nucleic...

... calcium concentration during coxsackievirus infection, would result in a release of host cell-derived microvesicles. If so, we speculate that maybe such microvesicles, increasingly recognized as major vehicles mediating intercellular communication, could play a role in the intercellular transmission...

... be addressed (email veronika.kralj-iglic@fe.uni-lj.si ). 18 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 exosome gastrointestinal stromal tumour (GIST) imatinib microparticle microvesicle For isolation of NVs, 2.7 ml of blood was taken by vein...

... donation funds and the Governmental funding of clinical research within the national health services (ALF). References 1 Ratajczak J. Wysoczynski M. Hayek F. Janowska-Wieczorek A. Ratajczak M.Z. Membrane-derived microvesicles: important and underappreciated mediators of cell...

...Samireh Jorfi; Jameel M. Inal Microvesicles are shed constitutively, or upon activation, from both normal and malignant cells. The process is dependent on an increase in cytosolic Ca 2+ , which activates different enzymes, resulting in depolymerization of the actin cytoskeleton and release...

... therapy have been attributed to soluble factors released from stem cells. In this context, MVs (microvesicles) released as exosomes from the endosomal compartment, or as shedding vesicles from the cell surface, may play a relevant role in the intercellular communication between stem and injured cells...

... differential ultracentrifugation extracellular vesicle haemoglobin microvesicle spectrophotometry Extracellular vesicles are particles originating from cells. They have attracted tremendous scientific interest because of their (potential) role in cell–cell communication, diagnostics and drug...

...Poliana Deolindo; Ingrid Evans-Osses; Marcel Ivan Ramirez Cells release extracellular vesicles in response to external factors or in a physiological way. Microvesicles and exosomes originate in cells in different ways and, depending on their contents, may have multiple biological effects on other...

...Jameel M. Inal; Ephraim A. Ansa-Addo; Sigrun Lange The release of extracellular vesicles, whether MVs (microvesicles) or exosomes, from host cells or intracellular pathogens is likely to play a significant role in the infection process. Host MVs may fuse with pathogen surfaces to deliver host...