... and microtubule dynamics. Not surprisingly, formins are best known as key regulators of the cytoskeleton in a variety of morphogenetic processes. However, mounting evidence implicates several formins in the assembly and organization of actin within and around the nucleus. In addition, actin-independent roles...

... microtubule-associated protein centromeric protein F (Cenp-F) is recruited to mitochondria by the mitochondrial Rho GTPase (Miro) to promote mitochondrial transport and re-distribution following cell division. 1 To whom correspondence should be addressed (email benoit.kornmann@bc.biol.ethz.ch...

...Graziella Cappelletti; Francesca Casagrande; Alessandra Calogero; Carmelita De Gregorio; Gianni Pezzoli; Daniele Cartelli Microtubules (MTs) are dynamic polymers consisting of α/β tubulin dimers and playing a plethora of roles in eukaryotic cells. Looking at neurons, they are key determinants...

...Alice Bachmann; Anne Straube Human cells express 45 kinesins, microtubule motors that transport a variety of molecules and organelles within the cell. Many kinesins also modulate the tracks they move on by either bundling or sliding or regulating the dynamic assembly and disassembly...

... pathway. The activation of either pathway leads to changes in microtubule dynamics within growing axons and growth cones and these underlie fast axon growth rates. Microtubule dynamics is regulated by microtubule-associated proteins and in the MAPK pathway this function is subserved by microtubule...

... (flux analysis), thermodynamic (microcalorimetry and fluores- cence spectroscopy), structural ( in silico) and Key words: kinetics, metabolism, microtubules, mutant protein. Abbreviations used: DHAP, dihydroxyacetone phosphate: DSC, differential scanning calorimetry; GIu-6-PDH, glucose-6- phosphate...