1-13 of 13
Keywords: microglia
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Biochem Soc Trans (2023) 51 (1): 259–274.
Published: 06 January 2023
... neuronal infection does not appear to determine whether a viral strain causes neurological complications. The cellular mechanisms underlying the neurological consequences of viral infection are not fully understood, but they involve neuroimmune interactions that have so far focused mainly on microglia...
Biochem Soc Trans (2021) 49 (4): 1791–1802.
Published: 20 August 2021
...Lorenzo Ceccarelli; Laura Marchetti; Chiara Giacomelli; Claudia Martini Microglia are the major component of the innate immune system in the central nervous system. They promote the maintenance of brain homeostasis as well as support inflammatory processes that are often related to pathological...
Biochem Soc Trans (2021) 49 (3): 1375–1384.
Published: 07 May 2021
.... However, despite the significant amount of research done in the past decade, the contribution of LRRK2 mutations to PD pathogenesis remains unknown. Growing evidence highlights that LRRK2 controls multiple processes in brain immune cells, microglia and astrocytes, and suggests that deregulated LRRK2...
Biochem Soc Trans (2019) 47 (6): 1651–1660.
Published: 17 December 2019
... for tenascin-C on immune cells is TLR4. Below we provide a current view on the impact of tenascin-C and TLR4-signaling especially in microglia and astrocyte activation. Microglia are brain-resident macrophages and play an important role during neurodegenerative and neuroinflammatory processes [ 26 , 27...
Biochem Soc Trans (2017) 45 (1): 131–139.
Published: 15 February 2017
... function of LRRK2 protein remains largely elusive, increasing evidence suggests that it plays a role in innate immunity, a process that also has been implicated in neurodegenerative diseases, including PD. Innate immunity involves macrophages and microglia, in which endogenous LRRK2 expression is precisely...
Biochem Soc Trans (2017) 45 (1): 261–267.
Published: 15 February 2017
... kinase A (PKA)-mediated signaling is a key regulator of brain function. PKA-dependent pathways play an important role in brain homeostasis, neuronal development, synaptic plasticity, control of microglia activation and inflammation. On the other hand, a decline of PKA signaling was shown to contribute...
Biochem Soc Trans (2015) 43 (5): 920–923.
Published: 09 October 2015
... not appear to be related to changes in APP processing (C-terminal fragment analysis), which led us to assess other mechanism by which ABCA7 may modulate Aβ homoeostasis. As we have shown that microglia express high levels of ABCA7, we examined a role for ABCA7 in the phagocytic clearance of Aβ. Our data...
Biochem Soc Trans (2015) 43 (4): 586–592.
Published: 03 August 2015
...Federico E. Turkheimer; Gaia Rizzo; Peter S. Bloomfield; Oliver Howes; Paolo Zanotti-Fregonara; Alessandra Bertoldo; Mattia Veronese The 18-kDA translocator protein (TSPO) is consistently elevated in activated microglia of the central nervous system (CNS) in response to a variety of insults as well...
Biochem Soc Trans (2011) 39 (4): 945–953.
Published: 20 July 2011
... microglia microglial priming systemic inflammation It has been known for many years that inflammation has a role in the progression of AD (Alzheimer's disease). Patients taking NSAIDs (non-steroidal anti-inflammatory drugs) for the amelioration of rheumatoid arthritis are significantly protected...
Biochem Soc Trans (2007) 35 (5): 1166–1167.
Published: 25 October 2007
... activation in vitro and in vivo . It does so by binding to Toll-like receptor-2 on microglia and astrocytes, rapidly activating ERK1/2 (extracellular-signal-regulated kinase 1/2) and p38 MAPKs (mitogen-activated protein kinases), causing NF-κB (nuclear factor κB) activation and leading to the production...
Biochem Soc Trans (2007) 35 (5): 1127–1132.
Published: 25 October 2007
...M.L. Block; J.-S. Hong PD (Parkinson's disease) is characterized by the selective and progressive loss of DA neurons (dopaminergic neurons) in the substantia nigra. Inflammation and activation of microglia, the resident innate immune cell in the brain, have been strongly linked to neurodegenerative...
Biochem Soc Trans (2002) 30 (2): 222–225.
Published: 01 April 2002
... of the extracellular matrix and the establishment of chemoattractant gradients for microglia, or facilitates neurite outgrowth through the processing of extracellular matrix proteoglycans. The second pathway for tPA does not involve its proteolytic activity: rather tPA functions as an agonist to stimulate a cell...