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1-13 of 13
Keywords: microglia
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Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2023) 51 (1): 259–274.
Published: 06 January 2023
... neuronal infection does not appear to determine whether a viral strain causes neurological complications. The cellular mechanisms underlying the neurological consequences of viral infection are not fully understood, but they involve neuroimmune interactions that have so far focused mainly on microglia...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (4): 1791–1802.
Published: 20 August 2021
...Lorenzo Ceccarelli; Laura Marchetti; Chiara Giacomelli; Claudia Martini Microglia are the major component of the innate immune system in the central nervous system. They promote the maintenance of brain homeostasis as well as support inflammatory processes that are often related to pathological...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2021) 49 (3): 1375–1384.
Published: 07 May 2021
.... However, despite the significant amount of research done in the past decade, the contribution of LRRK2 mutations to PD pathogenesis remains unknown. Growing evidence highlights that LRRK2 controls multiple processes in brain immune cells, microglia and astrocytes, and suggests that deregulated LRRK2...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2019) 47 (6): 1651–1660.
Published: 17 December 2019
... and underlying signaling pathways of the ECM glycoprotein tenascin-C during neurodegenerative and inflammatory processes. Collectively, we highlight evidence that tenascin-C constitutes an important player of the neuro-immune axis. In the CNS, immunological processes are highly associated with microglia...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 131–139.
Published: 15 February 2017
... function of LRRK2 protein remains largely elusive, increasing evidence suggests that it plays a role in innate immunity, a process that also has been implicated in neurodegenerative diseases, including PD. Innate immunity involves macrophages and microglia, in which endogenous LRRK2 expression is precisely...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2017) 45 (1): 261–267.
Published: 15 February 2017
... kinase A (PKA)-mediated signaling is a key regulator of brain function. PKA-dependent pathways play an important role in brain homeostasis, neuronal development, synaptic plasticity, control of microglia activation and inflammation. On the other hand, a decline of PKA signaling was shown to contribute...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (5): 920–923.
Published: 09 October 2015
... not appear to be related to changes in APP processing (C-terminal fragment analysis), which led us to assess other mechanism by which ABCA7 may modulate Aβ homoeostasis. As we have shown that microglia express high levels of ABCA7, we examined a role for ABCA7 in the phagocytic clearance of Aβ. Our data...
Articles
Federico E. Turkheimer, Gaia Rizzo, Peter S. Bloomfield, Oliver Howes, Paolo Zanotti-Fregonara, Alessandra Bertoldo, Mattia Veronese
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2015) 43 (4): 586–592.
Published: 03 August 2015
...Federico E. Turkheimer; Gaia Rizzo; Peter S. Bloomfield; Oliver Howes; Paolo Zanotti-Fregonara; Alessandra Bertoldo; Mattia Veronese The 18-kDA translocator protein (TSPO) is consistently elevated in activated microglia of the central nervous system (CNS) in response to a variety of insults as well...
Articles
Andrzej Szutowicz, Hanna Bielarczyk, Anna Ronowska, Sylwia Gul-Hinc, Joanna Klimaszewska-Łata, Aleksandra Dyś, Marlena Zyśk, Tadeusz Pawełczyk
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2014) 42 (4): 1101–1106.
Published: 11 August 2014
... Biochemical Society 2014 acetyl-astragalin cholinergic neurons CoA microglia neurotoxicity Brain neurons require large amounts of acetyl-CoA for energy production to support their neurotransmitter functions and synthetic acetylation reactions. Glial cells use less acetyl-CoA due...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2011) 39 (4): 945–953.
Published: 20 July 2011
... disease (AD) animal model delirium dementia microglia microglial priming systemic inflammation It has been known for many years that inflammation has a role in the progression of AD (Alzheimer's disease). Patients taking NSAIDs (non-steroidal anti-inflammatory drugs) for the amelioration...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1166–1167.
Published: 25 October 2007
... activation in vitro and in vivo . It does so by binding to Toll-like receptor-2 on microglia and astrocytes, rapidly activating ERK1/2 (extracellular-signal-regulated kinase 1/2) and p38 MAPKs (mitogen-activated protein kinases), causing NF-κB (nuclear factor κB) activation and leading to the production...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2007) 35 (5): 1127–1132.
Published: 25 October 2007
...M.L. Block; J.-S. Hong PD (Parkinson's disease) is characterized by the selective and progressive loss of DA neurons (dopaminergic neurons) in the substantia nigra. Inflammation and activation of microglia, the resident innate immune cell in the brain, have been strongly linked to neurodegenerative...
Articles
Journal:
Biochemical Society Transactions
Biochem Soc Trans (2002) 30 (2): 222–225.
Published: 01 April 2002
... of the extracellular matrix and the establishment of chemoattractant gradients for microglia, or facilitates neurite outgrowth through the processing of extracellular matrix proteoglycans. The second pathway for tPA does not involve its proteolytic activity: rather tPA functions as an agonist to stimulate a cell...