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Articles

miRNAs in post-ischaemic angiogenesis and vascular remodelling

Jaimy Saif, Costanza Emanueli

Biochem Soc Trans (2014) 42 (6): 1629–1636.

DOI: https://doi.org/10.1042/BST20140263

Published: 17 November 2014

... the potential of miRNAs as new clinical biomarkers and therapeutic targets. 1 To whom correspondence should be addressed (email Costanza.Emanueli@bristol.ac.uk ). 30 9 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis ischaemia microRNA (miRNA...

View article titled, miRNAs in post-ischaemic angiogenesis and vascular remodelling

Articles

Acute kidney injury: a paradigm for miRNA regulation of the cell cycle

Usman Khalid, Timothy Bowen, Donald J. Fraser, Robert H. Jenkins

Biochem Soc Trans (2014) 42 (4): 1219–1223.

DOI: https://doi.org/10.1042/BST20140093

Published: 11 August 2014

... 2014 Biochemical Society 2014 acute kidney injury cell cycle microRNA (miRNA) p53 miRNAs are a large family of endogenous, small non-coding RNAs that have emerged as essential post-transcriptional regulators of gene expression. miRNAs are implicated in diverse cellular processes...

View article titled, Acute kidney injury: a paradigm for miRNA regulation of the cell cycle

Articles

The diverse roles of the eIF4A family: you are the company you keep

Wei-Ting Lu, Anna Wilczynska, Ewan Smith, Martin Bushell

Biochem Soc Trans (2014) 42 (1): 166–172.

DOI: https://doi.org/10.1042/BST20130161

Published: 23 January 2014

... initiation factor 4A (eIF4A) helicase microRNA (miRNA) translation The role of the archetypal member of the eIF4A (eukaryotic initiation factor 4A) family, eIF4A1, was first characterized through its requirement in translation [ 1 ] and was later identified as a component of the eIF4F translation...

View article titled, The diverse roles of the eIF4A family: you are the company you keep

Articles

miRNAs in development and pathogenesis of the nervous system

Jakub S. Nowak, Gracjan Michlewski

Biochem Soc Trans (2013) 41 (4): 815–820.

DOI: https://doi.org/10.1042/BST20130044

Published: 18 July 2013

... The Authors Journal compilation © 2013 Biochemical Society 2013 microRNA (miRNA) microRNA biogenesis nervous system neuropathogenesis synaptic plasticity Non-coding RNAs are vital functional and regulatory elements of all biological systems. A class of small phylogenetically conserved 21–22...

View article titled, miRNAs in development and pathogenesis of the nervous system

Articles

Biogenesis and function of non-coding RNAs in muscle differentiation and in Duchenne muscular dystrophy

Shyam Twayana, Ivano Legnini, Marcella Cesana, Davide Cacchiarelli, Mariangela Morlando, Irene Bozzoni

Biochem Soc Trans (2013) 41 (4): 844–849.

DOI: https://doi.org/10.1042/BST20120353

Published: 18 July 2013

...-coding RNA (lncRNA) microRNA (miRNA) muscle differentiation The skeletal muscle system of vertebrates originates through a discrete series of complex morphogenetic events, globally known as myogenesis. During embryogenesis, muscles of the trunk and limbs derive from somites, which are able...

View article titled, Biogenesis and function of non-coding RNAs in muscle differentiation and in Duchenne muscular dystrophy

Articles

The primary target of let-7 microRNA

Amy E. Pasquinelli

Biochem Soc Trans (2013) 41 (4): 821–824.

DOI: https://doi.org/10.1042/BST20130020

Published: 18 July 2013

... targeted by Argonaute. 1 email apasquinelli@ucsd.edu 4 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 Argonaute biogenesis Caenorhabditis elegans let-7 microRNA (miRNA) The founding members of the miRNA family, lin-4 and let-7...

View article titled, The primary target of let-7 microRNA

Articles

Discovery of novel small RNAs in the quest to unravel genome complexity

Adam E. Hall, Tamas Dalmay

Biochem Soc Trans (2013) 41 (4): 866–870.

DOI: https://doi.org/10.1042/BST20120347

Published: 18 July 2013

... January 2013. Organized and Edited by Richard Bowater (University of East Anglia, U.K.), Amy Buck (Edinburgh, U.K.) and Javier Cáceres (Edinburgh, U.K.). © The Authors Journal compilation © 2013 Biochemical Society 2013 microRNA (miRNA) next generation sequencing sequencing bias small non...

View article titled, Discovery of novel small RNAs in the quest to unravel genome complexity

Articles

Functional diversification of Argonautes in nematodes: an expanding universe

Amy H. Buck, Mark Blaxter

Biochem Soc Trans (2013) 41 (4): 881–886.

DOI: https://doi.org/10.1042/BST20130086

Published: 18 July 2013

... the terms of the Creative Commons Attribution Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. Argonaute helminth microRNA (miRNA) nematode RNA interference...

View article titled, Functional diversification of Argonautes in nematodes: an expanding universe

Articles

Argonaute and GW182 proteins: an effective alliance in gene silencing

Janina Pfaff, Gunter Meister

Biochem Soc Trans (2013) 41 (4): 855–860.

DOI: https://doi.org/10.1042/BST20130047

Published: 18 July 2013

...@vkl.uni-regensburg.de ). 10 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 Argonaute protein gene silencing GW182 protein microRNA (miRNA) RNA interference (RNAi) Small RNAs such as miRNAs (microRNAs) or siRNAs (short interfering RNAs) have emerged...

View article titled, Argonaute and GW182 proteins: an effective alliance in gene silencing

Articles

Cellular functions of the microprocessor

Sara Macias, Ross A. Cordiner, Javier F. Cáceres

Biochem Soc Trans (2013) 41 (4): 838–843.

DOI: https://doi.org/10.1042/BST20130011

Published: 18 July 2013

... of the microprocessor. 1 To whom correspondence should be addressed (email Javier.Caceres@igmm.ed.ac.uk ). 1 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 DGCR8 Dicer Drosha microprocessor microRNA (miRNA) small RNA miRNAs (microRNAs) are small non...

View article titled, Cellular functions of the microprocessor

Articles

The role of microRNA in the response to cisplatin treatment

Ross M. Drayton

Biochem Soc Trans (2012) 40 (4): 821–825.

DOI: https://doi.org/10.1042/BST20120055

Published: 20 July 2012

... of cisplatin treatment on microRNA expression, and the ability of microRNAs to modulate cisplatin resistance. 1 email r.m.drayton@sheffield.ac.uk 17 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cisplatin microRNA (miRNA) protein expression tumour...

View article titled, The role of microRNA in the response to cisplatin treatment

Articles

MicroRNA expression profiling of human islets from individuals with and without Type 2 diabetes: promises and pitfalls

Jonathan M. Locke, Lorna W. Harries

Biochem Soc Trans (2012) 40 (4): 800–803.

DOI: https://doi.org/10.1042/BST20120049

Published: 20 July 2012

... of such an approach. 1 To whom correspondence should be addressed (email jonathan.locke@pms.ac.uk ). 24 2 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 β-cell insulin secretion islet dysfunction microRNA (miRNA) Type 2 diabetes miRNAs (microRNAs...

View article titled, MicroRNA expression profiling of human islets from individuals with and without Type 2 diabetes: promises and pitfalls

Articles

Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat

Ananya Gupta, Emer Caffrey, Grace Callagy, Sanjeev Gupta

Biochem Soc Trans (2012) 40 (4): 752–758.

DOI: https://doi.org/10.1042/BST20110763

Published: 20 July 2012

... compilation © 2012 Biochemical Society 2012 breast cancer microRNA (miRNA) oestrogen signalling 3′-untranslated region (3′-UTR) Cancer progression frequently involves the malfunction of signalling pathways, otherwise involved in normal cellular processes of proliferation, development...

View article titled, Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat

Articles

The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover

Matthew Brook, Nicola K. Gray

Biochem Soc Trans (2012) 40 (4): 856–864.

DOI: https://doi.org/10.1042/BST20120100

Published: 20 July 2012

...-Commercial Licence ( http://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cytoplasmic poly(A)-binding protein (PABP) deadenylation microRNA (miRNA) mRNA decay...

View article titled, The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover

Articles

Analysis of urinary microRNAs in chronic kidney disease

Cristina Beltrami, Aled Clayton, Aled O. Phillips, Donald J. Fraser, Timothy Bowen

Biochem Soc Trans (2012) 40 (4): 875–879.

DOI: https://doi.org/10.1042/BST20120090

Published: 20 July 2012

... bowent@cf.ac.uk ). 26 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 biomarker chronic kidney disease (CKD) exosome microRNA (miRNA) urine CKD is the 12th most prevalent cause of death, and 17th highest cause of disability worldwide [ 1 ]. Global...

View article titled, Analysis of urinary microRNAs in chronic kidney disease

Articles

Pleiotropy of microRNA-192 in the kidney

Robert H. Jenkins, John Martin, Aled O. Phillips, Timothy Bowen, Donald J. Fraser

Biochem Soc Trans (2012) 40 (4): 762–767.

DOI: https://doi.org/10.1042/BST20120085

Published: 20 July 2012

... in extracellular matrix deposition and cell differentiation. 1 To whom correspondence should be addressed (email jenkinsrh2@cf.ac.uk ). 19 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 hepatocyte nuclear factor (HNF) microRNA (miRNA) p53 renal fibrosis...

View article titled, Pleiotropy of microRNA-192 in the kidney

Articles

Extracellular small RNAs: what, where, why?

Anna M. Hoy, Amy H. Buck

Biochem Soc Trans (2012) 40 (4): 886–890.

DOI: https://doi.org/10.1042/BST20120019

Published: 20 July 2012

...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. extracellular small RNA microRNA (miRNA) RNA RNA-induced silencing complex (RISC) Mandel and Métais first described...

View article titled, Extracellular small RNAs: what, where, why?

Articles

The roles of miRNAs in wing imaginal disc development in Drosophila

Joseph A. Waldron, Sarah F. Newbury

Biochem Soc Trans (2012) 40 (4): 891–895.

DOI: https://doi.org/10.1042/BST20120035

Published: 20 July 2012

... Drosophila microRNA (miRNA) sensory organ precursor signalling pathway Ultrabithorax wing imaginal disc development miRNAs are endogenous small non-protein coding RNAs of ~22 nt in length that have emerged as important regulators of post-transcriptional gene regulation. They were first...

View article titled, The roles of miRNAs in wing imaginal disc development in Drosophila

Articles

Regulation of signalling by microRNAs

Roi Avraham, Yosef Yarden

Biochem Soc Trans (2012) 40 (1): 26–30.

DOI: https://doi.org/10.1042/BST20110623

Published: 19 January 2012

... mini-review, we use a set of examples to illustrate the extensive interdependence between miRNAs and signalling networks. cancer growth factor microRNA (miRNA) network tyrosine kinase Growth factors are compact polypeptides that transmit fate-determining signals to target cells...

View article titled, Regulation of signalling by microRNAs

Articles

ERK5 and its role in tumour development

Pamela A. Lochhead, Rebecca Gilley, Simon J. Cook

Biochem Soc Trans (2012) 40 (1): 251–256.

DOI: https://doi.org/10.1042/BST20110663

Published: 19 January 2012

... into understanding the role of ERK5 in cancer. 1 To whom correspondence should be addressed (email pamela.lochhead@babraham.ac.uk ). 25 7 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiogenesis cancer extracellular-signal-regulated kinase 5 (ERK5) microRNA...

View article titled, ERK5 and its role in tumour development

Articles

Cell autonomous and systemic factors in progeria development

Fernando G. Osorio, Alejandro P. Ugalde, Guillermo Mariño, Xose S. Puente, José M.P. Freije, Carlos López-Otín

Biochem Soc Trans (2011) 39 (6): 1710–1714.

DOI: https://doi.org/10.1042/BST20110677

Published: 21 November 2011

... in normal human fibroblasts J. Clin. Invest. 2011 121 2833 2844 1 To whom correspondence should be addressed (email clo@uniovi.es ). 27 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 alternative splicing laminopathy microRNA (miRNA...

View article titled, Cell autonomous and systemic factors in progeria development

Articles

SLPI and inflammatory lung disease in females

Paul J. McKiernan, Noel G. McElvaney, Catherine M. Greene

Biochem Soc Trans (2011) 39 (5): 1421–1426.

DOI: https://doi.org/10.1042/BST0391421

Published: 21 September 2011

... therapy and in those taking oral contraceptives [ 47 ]. cystic fibrosis (CF) lung disease microRNA (miRNA) oestrogen secretory leucoprotease inhibitor (SLPI) SLPI is a member of the WAP (whey acidic protein) family of proteins. These proteins share a conserved cysteine-rich FDC (four...

View article titled, SLPI and inflammatory lung disease in females

Articles

Analysis of post-transcriptional regulation using the FunREG method

Benoît Laloo, Marion Maurel, Sandra Jalvy-Delvaille, Francis Sagliocco, Christophe F. Grosset

Biochem Soc Trans (2010) 38 (6): 1608–1614.

DOI: https://doi.org/10.1042/BST0381608

Published: 24 November 2010

... integrated and quantitative method to measure post-transcriptional regulation (FunREG) hepatocellular carcinoma microRNA (miRNA) mRNA post-transcriptional regulation RNA-binding protein Post-transcriptional regulation is a set of biological processes controlling cell transcripts from their birth...

View article titled, Analysis of post-transcriptional regulation using the FunREG method

Articles

mRNA-specific regulation of translation by poly(A)-binding proteins

Hannah M. Burgess, Nicola K. Gray

Biochem Soc Trans (2010) 38 (6): 1517–1522.

DOI: https://doi.org/10.1042/BST0381517

Published: 24 November 2010

... first recognized. 1 To whom correspondence should be addressed (email n.gray@hrsu.mrc.ac.uk ). 5 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 DAZ microRNA (miRNA) mRNA-specific translational control poly(A)-binding protein (PABP) sex-lethal...

View article titled, mRNA-specific regulation of translation by poly(A)-binding proteins

Articles

Regulation and biological function of the liver-specific miR - 122

Andrew P. Lewis, Catherine L. Jopling

Biochem Soc Trans (2010) 38 (6): 1553–1557.

DOI: https://doi.org/10.1042/BST0381553

Published: 24 November 2010

... by the cytoplasmic poly(A) polymerase GLD-2 Genes Dev. 2009 23 433 438 cancer circadian rhythm hepatitis C virus liver microRNA (miRNA) miR - 122 miRNAs (microRNAs) were first identified in Caenorhabditis elegans when a gene involved in the heterochronic pathway, lin - 4 , was shown...

View article titled, Regulation and biological function of the liver-specific miR - 122

Articles

Cytoplasmic mRNA: move it, use it or lose it!

Mark J. Coldwell, Nicola K. Gray, Matthew Brook

Biochem Soc Trans (2010) 38 (6): 1495–1499.

DOI: https://doi.org/10.1042/BST0381495

Published: 24 November 2010

..., which are discussed by Yagüe and Raguz [ 27 ]. Together, these represent sites where translationally repressed mRNAs are sequestered before being either returned to the translating pool or degraded. gene expression localization microRNA (miRNA) mRNA repression translation turnover...

View article titled, Cytoplasmic mRNA: move it, use it or lose it!

Articles

Translation deregulation in B-cell lymphomas

Emilie Horvilleur, Lindsay A. Wilson, Anne E. Willis

Biochem Soc Trans (2010) 38 (6): 1593–1597.

DOI: https://doi.org/10.1042/BST0381593

Published: 24 November 2010

... ribosomal entry segment (IRES) microRNA (miRNA) transcription factor Lymphomas are a disparate group of neoplastic disorders of lymphoid tissues. In the West, lymphomas have an incidence of one case per 5000 people, and, of these, 95% are of B-cell origin. Within B-cell lymphomas, distinction...

View article titled, Translation deregulation in B-cell lymphomas

Articles

Post-transcriptional gene regulation in chondrocytes

Simon R. Tew, Peter D. Clegg

Biochem Soc Trans (2010) 38 (6): 1627–1631.

DOI: https://doi.org/10.1042/BST0381627

Published: 24 November 2010

... morphogenic protein 2-responsive microRNA, regulates chondrogenesis via direct targeting to Smad1 J. Biol. Chem. 2009 284 11326 11335 © The Authors Journal compilation © 2010 Biochemical Society 2010 cartilage chondrocyte microRNA (miRNA) osteoarthritis post-transcriptional regulation...

View article titled, Post-transcriptional gene regulation in chondrocytes

Articles

The involvement of microRNAs in Type 2 diabetes

David Ferland-McCollough, Susan E. Ozanne, Kenneth Siddle, Anne E. Willis, Martin Bushell

Biochem Soc Trans (2010) 38 (6): 1565–1570.

DOI: https://doi.org/10.1042/BST0381565

Published: 24 November 2010

... be addressed (email dfm3@le.ac.uk ). 6 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 β-cell dysfunction insulin resistance microRNA (miRNA) Type 2 diabetes T2D (Type 2 diabetes mellitus) has now reached epidemic proportions worldwide. In 2009...

View article titled, The involvement of microRNAs in Type 2 diabetes

Articles

Post-transcriptional and post-translational regulation of Bcl2

Shaun Willimott, Simon D. Wagner

Biochem Soc Trans (2010) 38 (6): 1571–1575.

DOI: https://doi.org/10.1042/BST0381571

Published: 24 November 2010

... chromatin condensation and fragmentation, cell membrane blebbing and the formation of apoptotic bodies. apoptosis AU-rich-element (ARE) Bcl2 chronic lymphocytic leukaemia (CLL) microRNA (miRNA) © The Authors Journal compilation © 2010 Biochemical Society 2010 AREs are typically...

View article titled, Post-transcriptional and post-translational regulation of Bcl2

Articles

Functions of microRNAs in Drosophila development

Christopher I. Jones, Sarah F. Newbury

Biochem Soc Trans (2010) 38 (4): 1137–1143.

DOI: https://doi.org/10.1042/BST0381137

Published: 26 July 2010

... development Drosophila microRNA (miRNA) mRNA RNA stability RNA turnover miRNAs are a family of non-protein coding RNAs that have emerged as important regulators of gene expression. miRNAs are expressed as long-hairpin-forming precursor RNAs which are cleaved into partially double-stranded RNAs...

View article titled, Functions of microRNAs in Drosophila development

Articles

Through a generation darkly: small RNAs in the gametophyte

Robert T. Grant-Downton

Biochem Soc Trans (2010) 38 (2): 617–621.

DOI: https://doi.org/10.1042/BST0380617

Published: 22 March 2010

... and function in the gametophyte is reviewed. 1 email robert.grant-downton@plants.ox.ac.uk 11 9 2009 11 9 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 gametophyte microRNA (miRNA) short interfering RNA (siRNA) small RNA trans -acting short...

View article titled, Through a generation darkly: small RNAs in the gametophyte

Articles

microRNA in erythrocytes

Andrew J. Hamilton

Biochem Soc Trans (2010) 38 (1): 229–231.

DOI: https://doi.org/10.1042/BST0380229

Published: 19 January 2010

... microRNA in these cells. 1 email a.hamilton@clinmed.gla.ac.uk 4 11 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 erythrocyte microRNA (miRNA) ribosome Ro translation Y RNA Vast numbers (~2–3×10 13 ) of erythrocytes circulate...

View article titled, microRNA in erythrocytes

Articles

On track with P-bodies

Meeta Kulkarni, Sevim Ozgur, Georg Stoecklin

Biochem Soc Trans (2010) 38 (1): 242–251.

DOI: https://doi.org/10.1042/BST0380242

Published: 19 January 2010

... 2010 Biochemical Society 2010 AU-rich element deadenylation decapping GW-body microRNA (miRNA) mRNA degradation P-bodies are small cytoplasmic foci that contain most enzymes required for mRNA degradation ( Figure 1 ). These foci were discovered more than a decade ago when Bashkirov...

View article titled, On track with P-bodies

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Articles

Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease

Angela Bithell, Rory Johnson, Noel J. Buckley

Biochem Soc Trans (2009) 37 (6): 1270–1275.

DOI: https://doi.org/10.1042/BST0371270

Published: 19 November 2009

... angela.bithell@kcl.ac.uk ). 27 7 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 brain-derived neurotrophic factor (BDNF) Huntingtin Huntington's disease (HD) microRNA (miRNA) neuronal dysfunction repressor element 1-silencing transcription factor (REST...

View article titled, Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease

Articles

High-throughput sequencing methods to study neuronal RNA–protein interactions

Jernej Ule

Biochem Soc Trans (2009) 37 (6): 1278–1280.

DOI: https://doi.org/10.1042/BST0371278

Published: 19 November 2009

... for the purpose of neuronal communication [ 16 ]. alternative splicing cross-linking and immunoprecipitation (CLIP) microRNA (miRNA) ribosome profiling synaptic plasticity UV-cross-linking In addition to cross-linking directly to individual proteins, RNAs also interact with larger RNP complexes...

View article titled, High-throughput sequencing methods to study neuronal RNA–protein interactions

Articles

miR-21 as a key regulator of oncogenic processes

S. Duygu Selcuklu, Mark T.A. Donoghue, Charles Spillane

Biochem Soc Trans (2009) 37 (4): 918–925.

DOI: https://doi.org/10.1042/BST0370918

Published: 22 July 2009

... The Authors Journal compilation © 2009 Biochemical Society 2009 cancer gene regulation microRNA (miRNA) miR-21 oncomir miRNAs are an abundant class of non-coding RNAs (∼20–23 nucleotides) which can be expressed in a cell- and tissue-specific manner [ 1 ]. Since their discovery, research...

View article titled, miR-21 as a key regulator of oncogenic processes

Articles

Regulation of B-cell differentiation by microRNAs and RNA-binding proteins

Alexander Ademokun, Martin Turner

Biochem Soc Trans (2008) 36 (6): 1191–1193.

DOI: https://doi.org/10.1042/BST0361191

Published: 19 November 2008

... The Authors Journal compilation © 2008 Biochemical Society 2008 B-cell cytokine microRNA (miRNA) RNA-binding protein T-cell tristetraprolin (TTP) Post-transcriptional regulation controls the abundance, turnover and translation of mRNA and offers the capacity to integrate signal transduction...

View article titled, Regulation of B-cell differentiation by microRNAs and RNA-binding proteins

Articles

Identification of genes targeted by microRNAs

Tamas Dalmay

Biochem Soc Trans (2008) 36 (6): 1194–1196.

DOI: https://doi.org/10.1042/BST0361194

Published: 19 November 2008

... than expected. The present paper reviews the different approaches to predict and experimentally identify genes targeted by miRNAs. antimir antagomir microRNA (miRNA) RNA-induced silencing complex (RISC) target prediction program 1 email t.dalmay@uea.ac.uk 9 9 2008 ©...

View article titled, Identification of genes targeted by microRNAs

Articles

How do microRNAs regulate gene expression?

Ian G. Cannell, Yi Wen Kong, Martin Bushell

Biochem Soc Trans (2008) 36 (6): 1224–1231.

DOI: https://doi.org/10.1042/BST0361224

Published: 19 November 2008

... -transcribed RNA microRNA (miRNA) polysomes protein synthesis translation miRNAs (microRNAs) are a class of recently discovered 21–25 nucleotide RNA molecules, which bind with imperfect complementarity to their target mRNAs, generally within the 3′-UTR (untranslated region). Since their discovery...

View article titled, How do microRNAs regulate gene expression?

Articles

Role of microRNAs in haemopoiesis, heart hypertrophy and cancer

Laura Fontana, Antonio Sorrentino, Gianluigi Condorelli, Cesare Peschle

Biochem Soc Trans (2008) 36 (6): 1206–1210.

DOI: https://doi.org/10.1042/BST0361206

Published: 19 November 2008

... in part by targeting the transcription factor NFI-A (nuclear factor I-A), whose down-regulation is critical for progression to monocytic differentiation [ 20 ]. cancer haemopoiesis heart hypertrophy microRNA (miRNA) miRNAs (microRNAs) are a rapidly expanding class of short (∼22 nt) single...

View article titled, Role of microRNAs in haemopoiesis, heart hypertrophy and cancer

Articles

Role of miRNA - 146a in the regulation of the innate immune response and cancer

Andrew E. Williams, Mark M. Perry, Sterghios A. Moschos, Hanna M. Larner-Svensson, Mark A. Lindsay

Biochem Soc Trans (2008) 36 (6): 1211–1215.

DOI: https://doi.org/10.1042/BST0361211

Published: 19 November 2008

... Biochemical Society 2008 cancer inflammation innate immune response lung microRNA (miRNA) miR - 146a miRNA (microRNA)-mediated RNA interference is a novel mechanism involved in the regulation of the gene expression at the translational level. At the present time, >700 human miRNAs have...

View article titled, Role of miRNA - 146a in the regulation of the innate immune response and cancer

Articles

Targeting of microRNAs for therapeutics

Jan Stenvang, Morten Lindow, Sakari Kauppinen

Biochem Soc Trans (2008) 36 (6): 1197–1200.

DOI: https://doi.org/10.1042/BST0361197

Published: 19 November 2008

... aminotransferase), ALT (alanine aminotransferase), total bilirubin and creatinine levels assessed in African green monkeys after treatment with PBS or three doses of 10 mg/kg LNA–antimiR. Adapted from [ 34 ] with permission. antisense locked nucleic acid (LNA) microRNA (miRNA) non-coding RNA...

View article titled, Targeting of microRNAs for therapeutics

Articles

Role of microRNAs in myeloid differentiation

Alessandro Fatica, Alessandro Rosa, Monica Ballarino, Maria Laura De Marchis, Kasper D. Rasmussen, Irene Bozzoni

Biochem Soc Trans (2008) 36 (6): 1201–1205.

DOI: https://doi.org/10.1042/BST0361201

Published: 19 November 2008

... with a great potential for use in diagnosis, prognosis and therapy of AML. acute myeloid leukaemia (AML) all- trans retinoic acid (ATRA) CCAAT/enhancer-binding protein (C/EBP) haemopoiesis microRNA (miRNA) myelopoiesis HSCs (haemopoietic stem cells) reside in the bone marrow and give rise...

View article titled, Role of microRNAs in myeloid differentiation

Articles

Target site effects in the RNA interference and microRNA pathways

Gregor Obernosterer, Hakim Tafer, Javier Martinez

Biochem Soc Trans (2008) 36 (6): 1216–1219.

DOI: https://doi.org/10.1042/BST0361216

Published: 19 November 2008

... on accessibility was determined. For all G/C classes, even for G/C content >60%, we could significantly separate functional and non-functional siRNAs. 4 7 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 cleavage microRNA (miRNA) RNA-induced silencing complex (RISC...

View article titled, Target site effects in the RNA interference and microRNA pathways

Articles

Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions

A. Abderrahmani, V. Plaisance, P. Lovis, R. Regazzi

Biochem Soc Trans (2006) 34 (5): 696–700.

DOI: https://doi.org/10.1042/BST0340696

Published: 25 October 2006

... (email Romano.Regazzi@unil.ch ). 16 6 2006 © 2006 The Biochemical Society 2006 diabetes mellitus exocytotic apparatus inducible cAMP early repressor (ICER) microRNA (miRNA) Rab transcription factor Convergence of data obtained in different model systems including yeast...

View article titled, Mechanisms controlling the expression of the components of the exocytotic apparatus under physiological and pathological conditions

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