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Keywords: microRNA (miRNA)
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Articles
Biochem Soc Trans (2014) 42 (6): 1629–1636.
Published: 17 November 2014
... the potential of miRNAs as new clinical biomarkers and therapeutic targets. 1 To whom correspondence should be addressed (email Costanza.Emanueli@bristol.ac.uk ). 30 9 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis ischaemia microRNA (miRNA...
Articles
Biochem Soc Trans (2014) 42 (4): 1219–1223.
Published: 11 August 2014
... 2014 Biochemical Society 2014 acute kidney injury cell cycle microRNA (miRNA) p53 miRNAs are essential for renal development, homoeostasis, cell phenotype and have been implicated in the pathology of renal diseases, including diabetic nephropathy, renal carcinoma, polycystic kidney...
Articles
Biochem Soc Trans (2014) 42 (1): 166–172.
Published: 23 January 2014
... by interacting partner proteins. The key differences between eIF4A family members are discussed in the present review. eukaryotic initiation factor 4A (eIF4A) helicase microRNA (miRNA) translation eIF eukaryotic initiation factor EJC exon junction complex FMDV foot and mouth...
Articles
Biochem Soc Trans (2013) 41 (4): 815–820.
Published: 18 July 2013
... The Authors Journal compilation © 2013 Biochemical Society 2013 microRNA (miRNA) microRNA biogenesis nervous system neuropathogenesis synaptic plasticity Non-coding RNAs are vital functional and regulatory elements of all biological systems. A class of small phylogenetically conserved 21–22...
Articles
Biochem Soc Trans (2013) 41 (4): 866–870.
Published: 18 July 2013
... 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 microRNA (miRNA) next generation sequencing sequencing bias small non-coding RNA tRNA fragment Y RNA One of the most striking discoveries in recent times was the realization of just how few genes...
Articles
Biochem Soc Trans (2013) 41 (4): 844–849.
Published: 18 July 2013
...-coding RNA (lncRNA) microRNA (miRNA) muscle differentiation The skeletal muscle system of vertebrates originates through a discrete series of complex morphogenetic events, globally known as myogenesis. During embryogenesis, muscles of the trunk and limbs derive from somites, which are able...
Articles
Biochem Soc Trans (2013) 41 (4): 821–824.
Published: 18 July 2013
... targeted by Argonaute. 1 email apasquinelli@ucsd.edu 4 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 Argonaute biogenesis Caenorhabditis elegans let-7 microRNA (miRNA) The founding members of the miRNA family, lin-4 and let-7...
Articles
Biochem Soc Trans (2013) 41 (4): 881–886.
Published: 18 July 2013
... the terms of the Creative Commons Attribution Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. Argonaute helminth microRNA (miRNA) nematode RNA interference...
Articles
Biochem Soc Trans (2013) 41 (4): 855–860.
Published: 18 July 2013
...@vkl.uni-regensburg.de ). 10 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 Argonaute protein gene silencing GW182 protein microRNA (miRNA) RNA interference (RNAi) Small RNAs such as miRNAs (microRNAs) or siRNAs (short interfering RNAs) have emerged...
Articles
Biochem Soc Trans (2013) 41 (4): 838–843.
Published: 18 July 2013
... of the microprocessor. 1 To whom correspondence should be addressed (email Javier.Caceres@igmm.ed.ac.uk ). 1 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 DGCR8 Dicer Drosha microprocessor microRNA (miRNA) small RNA miRNAs (microRNAs) are small non...
Articles
Biochem Soc Trans (2012) 40 (4): 875–879.
Published: 20 July 2012
... Biochemical Society 2012 biomarker chronic kidney disease (CKD) exosome microRNA (miRNA) urine 1 To whom correspondence should be addressed (email bowent@cf.ac.uk ). Microvesicles are formed by outward budding of the plasma membrane, while exosomes are manufactured within...
Articles
Biochem Soc Trans (2012) 40 (4): 762–767.
Published: 20 July 2012
... in extracellular matrix deposition and cell differentiation. 1 To whom correspondence should be addressed (email jenkinsrh2@cf.ac.uk ). 19 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 hepatocyte nuclear factor (HNF) microRNA (miRNA) p53 renal fibrosis...
Articles
Biochem Soc Trans (2012) 40 (4): 821–825.
Published: 20 July 2012
... of cisplatin treatment on microRNA expression, and the ability of microRNAs to modulate cisplatin resistance. 1 email r.m.drayton@sheffield.ac.uk 17 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cisplatin microRNA (miRNA) protein expression tumour...
Articles
Biochem Soc Trans (2012) 40 (4): 800–803.
Published: 20 July 2012
... of such an approach. 1 To whom correspondence should be addressed (email jonathan.locke@pms.ac.uk ). 24 2 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 β-cell insulin secretion islet dysfunction microRNA (miRNA) Type 2 diabetes miRNAs (microRNAs...
Articles
Biochem Soc Trans (2012) 40 (4): 856–864.
Published: 20 July 2012
..., distribution and reproduction in any medium, provided the original work is properly cited. cytoplasmic poly(A)-binding protein (PABP) deadenylation microRNA (miRNA) mRNA decay nonsense-mediated decay translation factor The extent to which an mRNA is utilized is determined by its lifespan...
Articles
Biochem Soc Trans (2012) 40 (4): 752–758.
Published: 20 July 2012
... compilation © 2012 Biochemical Society 2012 breast cancer microRNA (miRNA) oestrogen signalling 3′-untranslated region (3′-UTR) Cancer progression frequently involves the malfunction of signalling pathways, otherwise involved in normal cellular processes of proliferation, development...
Articles
Biochem Soc Trans (2012) 40 (4): 886–890.
Published: 20 July 2012
... of RNA in systemic circulation. In the present paper, we highlight some of the key issues surrounding the biological and medical meaning of extracellular miRNA (microRNA). extracellular small RNA microRNA (miRNA) RNA RNA-induced silencing complex (RISC) The first evidence that miRNAs...
Articles
Biochem Soc Trans (2012) 40 (4): 891–895.
Published: 20 July 2012
... levels of mei-P26 , hid and enabled [ 25 ]. Throughout the remainder of the imaginal disc bantam expression is up-regulated through the activity of Yorkie and Mad, contributing to increased growth and proliferation of these cells [ 27 ]. Drosophila microRNA (miRNA) sensory organ...
Articles
Biochem Soc Trans (2012) 40 (1): 26–30.
Published: 19 January 2012
... cancer growth factor microRNA (miRNA) network tyrosine kinase The advancement of high-throughput genomic screens, along with the development of software able to predict targets of miRNAs, will eventually yield high granularity maps combining signal transduction pathways, transcriptional...
Articles
Biochem Soc Trans (2012) 40 (1): 251–256.
Published: 19 January 2012
... into understanding the role of ERK5 in cancer. 1 To whom correspondence should be addressed (email pamela.lochhead@babraham.ac.uk ). 25 7 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 angiogenesis cancer extracellular-signal-regulated kinase 5 (ERK5) microRNA...
Articles
Biochem Soc Trans (2011) 39 (6): 1710–1714.
Published: 21 November 2011
... 7 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 alternative splicing laminopathy microRNA (miRNA) progeria senescence tumour suppressor The nuclear envelope is a complex structure that surrounds and protects the genome, playing essential roles...
Articles
Biochem Soc Trans (2011) 39 (5): 1421–1426.
Published: 21 September 2011
... © The Authors Journal compilation © 2011 Biochemical Society 2011 cystic fibrosis (CF) lung disease microRNA (miRNA) oestrogen secretory leucoprotease inhibitor (SLPI) SLPI is a member of the WAP (whey acidic protein) family of proteins. These proteins share a conserved cysteine...
Articles
Biochem Soc Trans (2010) 38 (6): 1608–1614.
Published: 24 November 2010
... Biochemical Society 2010 functional integrated and quantitative method to measure post-transcriptional regulation (FunREG) hepatocellular carcinoma microRNA (miRNA) mRNA post-transcriptional regulation RNA-binding protein Post-transcriptional regulation is a set of biological processes...
Articles
Biochem Soc Trans (2010) 38 (6): 1517–1522.
Published: 24 November 2010
... first recognized. 1 To whom correspondence should be addressed (email n.gray@hrsu.mrc.ac.uk ). 5 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 DAZ microRNA (miRNA) mRNA-specific translational control poly(A)-binding protein (PABP) sex-lethal...
Articles
Biochem Soc Trans (2010) 38 (6): 1553–1557.
Published: 24 November 2010
... circadian rhythm hepatitis C virus liver microRNA (miRNA) miR - 122 miRNAs (microRNAs) were first identified in Caenorhabditis elegans when a gene involved in the heterochronic pathway, lin - 4 , was shown to express a short non-coding RNA product instead of a protein [ 1 ]. Subsequently...
Articles
Biochem Soc Trans (2010) 38 (6): 1495–1499.
Published: 24 November 2010
... 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene expression localization microRNA (miRNA) mRNA repression translation turnover The broad characterization of the processes of gene expression into transcription and translation does a disservice...
Articles
Biochem Soc Trans (2010) 38 (6): 1565–1570.
Published: 24 November 2010
... to defective β-cell function and eventual cell death. β-cell dysfunction insulin resistance microRNA (miRNA) Type 2 diabetes T2D (Type 2 diabetes mellitus) has now reached epidemic proportions worldwide. In 2009, in the U.K. alone, 2.6 million individuals were considered diabetic (Diabetes...
Articles
Biochem Soc Trans (2010) 38 (6): 1571–1575.
Published: 24 November 2010
... sw227@le.ac.uk ). 6 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 apoptosis AU-rich-element (ARE) Bcl2 chronic lymphocytic leukaemia (CLL) microRNA (miRNA) Bcl2 and its related family members play a central role in the regulation of apoptosis...
Articles
Biochem Soc Trans (2010) 38 (6): 1593–1597.
Published: 24 November 2010
.... 1 To whom correspondence should be addressed (email eh118@le.ac.uk ). 6 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 B-cell lymphoma cancer immunoglobulin gene rearrangement internal ribosomal entry segment (IRES) microRNA (miRNA...
Articles
Biochem Soc Trans (2010) 38 (6): 1627–1631.
Published: 24 November 2010
... direct targeting to Smad1 J. Biol. Chem. 2009 284 11326 11335 © The Authors Journal compilation © 2010 Biochemical Society 2010 cartilage chondrocyte microRNA (miRNA) osteoarthritis post-transcriptional regulation A number of mouse genetic models have now been developed...
Articles
Biochem Soc Trans (2010) 38 (4): 1137–1143.
Published: 26 July 2010
... development Drosophila microRNA (miRNA) mRNA RNA stability RNA turnover During development, the expression of specific proteins is tightly controlled both spatially and temporally to produce a complex multicellular organism capable of reproduction. This requires gene expression to be controlled...
Articles
Biochem Soc Trans (2010) 38 (2): 617–621.
Published: 22 March 2010
... and function in the gametophyte is reviewed. gametophyte microRNA (miRNA) short interfering RNA (siRNA) small RNA trans -acting short interfering RNA (ta-siRNA) Over the last decade, the epigenetic mechanisms based on small non-coding RNAs have taken centre stage in biology. These small RNAs...
Articles
Biochem Soc Trans (2010) 38 (1): 242–251.
Published: 19 January 2010
... and resolved according to the amount of mRNA that is subject to silencing, be it translational arrest or targeting for rapid decay. AU-rich element deadenylation decapping GW-body microRNA (miRNA) mRNA degradation P-bodies are small cytoplasmic foci that contain most enzymes required...
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Articles
Biochem Soc Trans (2010) 38 (1): 229–231.
Published: 19 January 2010
.... The how and why of exocytic vesicles Transfusion 2006 46 143 152 1 email a.hamilton@clinmed.gla.ac.uk 4 11 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 erythrocyte microRNA (miRNA) ribosome Ro translation Y RNA Vast numbers (~2...
Articles
Biochem Soc Trans (2009) 37 (6): 1270–1275.
Published: 19 November 2009
... (BDNF) Huntingtin Huntington's disease (HD) microRNA (miRNA) neuronal dysfunction repressor element 1-silencing transcription factor (REST) The Htt (Huntingtin) gene was first identified in 1993 by the efforts of the Huntington's Disease Collaborative Research Group, where an abnormally...
Articles
Biochem Soc Trans (2009) 37 (6): 1278–1280.
Published: 19 November 2009
... alternative splicing cross-linking and immunoprecipitation (CLIP) microRNA (miRNA) ribosome profiling synaptic plasticity UV-cross-linking Diverse post-transcriptional mechanisms allow a cell to precisely control the proteins to be synthesized at different cellular locations. The role of RNA...
Articles
Biochem Soc Trans (2009) 37 (4): 918–925.
Published: 22 July 2009
... are listed for the human genome (miRBase: Database Release 12.0) [ 5 ]. cancer gene regulation microRNA (miRNA) miR-21 oncomir © The Authors Journal compilation © 2009 Biochemical Society 2009 27 1 2009 1 To whom correspondence should be addressed (email c.spillane...
Articles
Biochem Soc Trans (2008) 36 (6): 1206–1210.
Published: 19 November 2008
... e2236 cancer haemopoiesis heart hypertrophy microRNA (miRNA) The miR - 17 - 5p–92 cluster (also called oncomir-1) was the first miRNA with oncogenic properties to be discovered [ 41 ]. In a first study, the Hannon and Hammond laboratories showed that overexpression of the miR...
Articles
Biochem Soc Trans (2008) 36 (6): 1211–1215.
Published: 19 November 2008
... Biochemical Society 2008 cancer inflammation innate immune response lung microRNA (miRNA) miR - 146a miRNA (microRNA)-mediated RNA interference is a novel mechanism involved in the regulation of the gene expression at the translational level. At the present time, >700 human miRNAs have...
Articles
Biochem Soc Trans (2008) 36 (6): 1191–1193.
Published: 19 November 2008
... Dicer. T-cell-specific deletion of Dicer revealed a role for miRNAs in control of T-cell development, in particular development of T-helper and regulatory T-cells [ 15 – 17 ]. B-cell cytokine microRNA (miRNA) RNA-binding protein T-cell tristetraprolin (TTP) Post-transcriptional...
Articles
Biochem Soc Trans (2008) 36 (6): 1194–1196.
Published: 19 November 2008
... than expected. The present paper reviews the different approaches to predict and experimentally identify genes targeted by miRNAs. 1 email t.dalmay@uea.ac.uk 9 9 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 antimir antagomir microRNA (miRNA) RNA...
Articles
Biochem Soc Trans (2008) 36 (6): 1224–1231.
Published: 19 November 2008
... compilation © 2008 Biochemical Society 2008 gene expression in vitro -transcribed RNA microRNA (miRNA) polysomes protein synthesis translation miRNAs (microRNAs) are a class of recently discovered 21–25 nucleotide RNA molecules, which bind with imperfect complementarity to their target...
Articles
Biochem Soc Trans (2008) 36 (6): 1197–1200.
Published: 19 November 2008
... should be addressed (email sk@santaris.com ). 28 8 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 antisense locked nucleic acid (LNA) microRNA (miRNA) non-coding RNA therapeutic MicroRNAs (miRNAs) comprise an abundant class of small non-coding RNAs...
Articles
Biochem Soc Trans (2008) 36 (6): 1201–1205.
Published: 19 November 2008
...) haemopoiesis microRNA (miRNA) myelopoiesis HSCs (haemopoietic stem cells) reside in the bone marrow and give rise to progenitors that become progressively restricted to several or single blood cell lineages [ 1 ]. These progenitors are devoted to the production of mature blood cells, including red...
Articles
Biochem Soc Trans (2008) 36 (6): 1216–1219.
Published: 19 November 2008
... microRNA (miRNA) RNA-induced silencing complex (RISC) RNA cleavage small interfering RNA (siRNA) target site accessibility Over the past few years RNAi (RNA interference) has become an essential tool to investigate gene function by introducing siRNAs (small interfering RNAs) or shRNAs (short...
Articles
Biochem Soc Trans (2006) 34 (5): 696–700.
Published: 25 October 2006
... (email Romano.Regazzi@unil.ch ). 16 6 2006 © 2006 The Biochemical Society 2006 diabetes mellitus exocytotic apparatus inducible cAMP early repressor (ICER) microRNA (miRNA) Rab transcription factor Convergence of data obtained in different model systems including yeast...