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Keywords: microRNA (miRNA)
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Articles
Biochem Soc Trans (2014) 42 (6): 1629–1636.
Published: 17 November 2014
... The Authors Journal compilation © 2014 Biochemical Society 2014 angiogenesis ischaemia microRNA (miRNA) stem cell vascular cell miRNAs are a family of short (20–26 nt) evolutionary conserved non-coding ssRNAs that are known to regulate or silence gene expression by repressing protein...
Articles
Biochem Soc Trans (2014) 42 (4): 1219–1223.
Published: 11 August 2014
... acute kidney injury cell cycle microRNA (miRNA) p53 AGO Argonaute AKI acute kidney injury CDK cyclin-dependent kinase CKD chronic kidney disease DGF delayed graft function IPC ischaemic pre-conditioning IRI ischaemia/reperfusion injury MDM2 murine...
Articles
Biochem Soc Trans (2014) 42 (1): 166–172.
Published: 23 January 2014
... structure within the 5′-UTR, an event required for recruitment of the 43S pre-initiation complex [ 4 ]. eukaryotic initiation factor 4A (eIF4A) helicase microRNA (miRNA) translation © The Authors Journal compilation © 2014 Biochemical Society 2014 1 8 2013 1 To whom...
Articles
Biochem Soc Trans (2013) 41 (4): 815–820.
Published: 18 July 2013
.... A mouse model of the 22q11 deletion showed the abnormal levels of the mature miRNA fraction in the brain of the animals with this chromosomal aberration [ 44 ]. 1 To whom correspondence should be addressed (email gmichlew@staffmail.ed.ac.uk ). microRNA (miRNA) microRNA biogenesis...
Articles
Biochem Soc Trans (2013) 41 (4): 844–849.
Published: 18 July 2013
..., Cambridge, MA 02138, U.S.A. 3 To whom correspondence should be addressed (email irene.bozzoni@uniroma1.it ). 13 12 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 Duchenne muscular dystrophy long non-coding RNA (lncRNA) microRNA (miRNA) muscle...
Articles
Biochem Soc Trans (2013) 41 (4): 821–824.
Published: 18 July 2013
... Caenorhabditis elegans let-7 microRNA (miRNA) The founding members of the miRNA family, lin-4 and let-7 , were discovered as genes important for temporal development in the nematode Caenorhabditis elegans [ 1 , 2 ]. Well over 1000 miRNA genes are now recognized as regulators of gene expression...
Articles
Biochem Soc Trans (2013) 41 (4): 881–886.
Published: 18 July 2013
... article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) ( http://creativecommons.org/licenses/by/3.0/ ) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. Argonaute helminth microRNA (miRNA...
Articles
Biochem Soc Trans (2013) 41 (4): 866–870.
Published: 18 July 2013
... 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 microRNA (miRNA) next generation sequencing sequencing bias small non-coding RNA tRNA fragment Y RNA One of the most striking discoveries in recent times was the realization of just how few genes...
Articles
Biochem Soc Trans (2013) 41 (4): 855–860.
Published: 18 July 2013
... ]. 1 To whom correspondence should be addressed (email gunter.meister@vkl.uni-regensburg.de ). 10 4 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 Argonaute protein gene silencing GW182 protein microRNA (miRNA) RNA interference (RNAi) Small...
Articles
Biochem Soc Trans (2013) 41 (4): 838–843.
Published: 18 July 2013
... of the microprocessor. 1 To whom correspondence should be addressed (email Javier.Caceres@igmm.ed.ac.uk ). 1 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 DGCR8 Dicer Drosha microprocessor microRNA (miRNA) small RNA miRNAs (microRNAs) are small non...
Articles
Biochem Soc Trans (2012) 40 (4): 821–825.
Published: 20 July 2012
... of cisplatin treatment on microRNA expression, and the ability of microRNAs to modulate cisplatin resistance. 1 email r.m.drayton@sheffield.ac.uk 17 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cisplatin microRNA (miRNA) protein expression tumour...
Articles
Biochem Soc Trans (2012) 40 (4): 800–803.
Published: 20 July 2012
... of such an approach. 1 To whom correspondence should be addressed (email jonathan.locke@pms.ac.uk ). 24 2 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 β-cell insulin secretion islet dysfunction microRNA (miRNA) Type 2 diabetes An important role...
Articles
Biochem Soc Trans (2012) 40 (4): 856–864.
Published: 20 July 2012
.../licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. cytoplasmic poly(A)-binding protein (PABP) deadenylation microRNA (miRNA) mRNA decay nonsense-mediated decay translation factor...
Articles
Biochem Soc Trans (2012) 40 (4): 752–758.
Published: 20 July 2012
... compilation © 2012 Biochemical Society 2012 breast cancer microRNA (miRNA) oestrogen signalling 3′-untranslated region (3′-UTR) Cancer progression frequently involves the malfunction of signalling pathways, otherwise involved in normal cellular processes of proliferation, development...
Articles
Biochem Soc Trans (2012) 40 (4): 875–879.
Published: 20 July 2012
... (email bowent@cf.ac.uk ). 26 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 biomarker chronic kidney disease (CKD) exosome microRNA (miRNA) urine CKD is the 12th most prevalent cause of death, and 17th highest cause of disability worldwide [ 1...
Articles
Biochem Soc Trans (2012) 40 (4): 762–767.
Published: 20 July 2012
... in extracellular matrix deposition and cell differentiation. 1 To whom correspondence should be addressed (email jenkinsrh2@cf.ac.uk ). 19 3 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 hepatocyte nuclear factor (HNF) microRNA (miRNA) p53 renal fibrosis...
Articles
Biochem Soc Trans (2012) 40 (4): 886–890.
Published: 20 July 2012
... ]. extracellular small RNA microRNA (miRNA) RNA RNA-induced silencing complex (RISC) Mandel and Métais first described the presence of extracellular nucleic acids in human plasma in 1948 [ 1 ]. The concept of extracellular RNA emerged in a different context in the 1970s, when Kolodny et al. [ 2 , 3...
Articles
Biochem Soc Trans (2012) 40 (4): 891–895.
Published: 20 July 2012
... Drosophila microRNA (miRNA) sensory organ precursor signalling pathway Ultrabithorax wing imaginal disc development miRNAs are endogenous small non-protein coding RNAs of ~22 nt in length that have emerged as important regulators of post-transcriptional gene regulation. They were first...
Articles
Biochem Soc Trans (2012) 40 (1): 26–30.
Published: 19 January 2012
... cancer growth factor microRNA (miRNA) network tyrosine kinase The advancement of high-throughput genomic screens, along with the development of software able to predict targets of miRNAs, will eventually yield high granularity maps combining signal transduction pathways, transcriptional...
Articles
Biochem Soc Trans (2012) 40 (1): 251–256.
Published: 19 January 2012
... ]. COT causes cell transformation of NIH 3T3 fibroblasts by increasing c-Jun expression, and this is mediated by co-operative signals from ERK5, p38γ and JNK (c-Jun N-terminal kinase) [ 54 ]. angiogenesis cancer extracellular-signal-regulated kinase 5 (ERK5) microRNA (miRNA) migration...
Articles
Biochem Soc Trans (2011) 39 (6): 1710–1714.
Published: 21 November 2011
... 2011 alternative splicing laminopathy microRNA (miRNA) progeria senescence tumour suppressor The nuclear envelope is a complex structure that surrounds and protects the genome, playing essential roles in its regulation, organization and maintenance [ 1 ]. The nuclear envelope...
Articles
Biochem Soc Trans (2011) 39 (5): 1421–1426.
Published: 21 September 2011
... © The Authors Journal compilation © 2011 Biochemical Society 2011 cystic fibrosis (CF) lung disease microRNA (miRNA) oestrogen secretory leucoprotease inhibitor (SLPI) SLPI is a member of the WAP (whey acidic protein) family of proteins. These proteins share a conserved cysteine...
Articles
Biochem Soc Trans (2010) 38 (6): 1565–1570.
Published: 24 November 2010
... of components of the exocytotic machinery of insulin-secreting cells by microRNAs Biol. Chem. 2008 389 305 312 β-cell dysfunction insulin resistance microRNA (miRNA) Type 2 diabetes T2D (Type 2 diabetes mellitus) has now reached epidemic proportions worldwide. In 2009, in the U.K...
Articles
Biochem Soc Trans (2010) 38 (6): 1553–1557.
Published: 24 November 2010
... of miR - 122 expression is also considered. 1 To whom correspondence should be addressed (email Catherine.Jopling@nottingham.ac.uk ). 31 8 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 cancer circadian rhythm hepatitis C virus liver microRNA...
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Biochem Soc Trans (2010) 38 (6): 1495–1499.
Published: 24 November 2010
... 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 gene expression localization microRNA (miRNA) mRNA repression translation turnover The broad characterization of the processes of gene expression into transcription and translation does a disservice...
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Biochem Soc Trans (2010) 38 (6): 1593–1597.
Published: 24 November 2010
... ribosomal entry segment (IRES) microRNA (miRNA) transcription factor Lymphomas are a disparate group of neoplastic disorders of lymphoid tissues. In the West, lymphomas have an incidence of one case per 5000 people, and, of these, 95% are of B-cell origin. Within B-cell lymphomas, distinction...
Articles
Biochem Soc Trans (2010) 38 (6): 1627–1631.
Published: 24 November 2010
... cartilage chondrocyte microRNA (miRNA) osteoarthritis post-transcriptional regulation Articular chondrocytes are the resident cell type within articular cartilage and play the major role in maintaining this tissue within the synovial joint throughout life. The key role which they play...
Articles
Biochem Soc Trans (2010) 38 (6): 1608–1614.
Published: 24 November 2010
... integrated and quantitative method to measure post-transcriptional regulation (FunREG) hepatocellular carcinoma microRNA (miRNA) mRNA post-transcriptional regulation RNA-binding protein Post-transcriptional regulation is a set of biological processes controlling cell transcripts from their birth...
Articles
Biochem Soc Trans (2010) 38 (6): 1517–1522.
Published: 24 November 2010
... first recognized. 1 To whom correspondence should be addressed (email n.gray@hrsu.mrc.ac.uk ). 5 7 2010 © The Authors Journal compilation © 2010 Biochemical Society 2010 DAZ microRNA (miRNA) mRNA-specific translational control poly(A)-binding protein (PABP) sex-lethal...
Articles
Biochem Soc Trans (2010) 38 (6): 1571–1575.
Published: 24 November 2010
...-rich elements and associated factors: are there unifying principles? Nucleic Acids Res. 2006 33 7138 7150 apoptosis AU-rich-element (ARE) Bcl2 chronic lymphocytic leukaemia (CLL) microRNA (miRNA) Bcl2 and its related family members play a central role in the regulation...
Articles
Biochem Soc Trans (2010) 38 (4): 1137–1143.
Published: 26 July 2010
... microRNA (miRNA) mRNA RNA stability RNA turnover During development, the expression of specific proteins is tightly controlled both spatially and temporally to produce a complex multicellular organism capable of reproduction. This requires gene expression to be controlled at each step...
Articles
Biochem Soc Trans (2010) 38 (2): 617–621.
Published: 22 March 2010
... [ 33 ]. © The Authors Journal compilation © 2010 Biochemical Society 2010 gametophyte microRNA (miRNA) short interfering RNA (siRNA) small RNA trans -acting short interfering RNA (ta-siRNA) Over the last decade, the epigenetic mechanisms based on small non-coding RNAs have taken...
Articles
Biochem Soc Trans (2010) 38 (1): 229–231.
Published: 19 January 2010
... microvesicles PLoS ONE 2009 4 e4722 25 Tibor J.G. The how and why of exocytic vesicles Transfusion 2006 46 143 152 1 email a.hamilton@clinmed.gla.ac.uk 4 11 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 erythrocyte microRNA...
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Biochem Soc Trans (2010) 38 (1): 242–251.
Published: 19 January 2010
...@dkfz.de ). 29 7 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 AU-rich element deadenylation decapping GW-body microRNA (miRNA) mRNA degradation Figure 1 P-bodies ( A ) P-bodies visualized by immunofluorescence microscopy. African green monkey...
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Articles
Biochem Soc Trans (2009) 37 (6): 1270–1275.
Published: 19 November 2009
... (HD) microRNA (miRNA) neuronal dysfunction repressor element 1-silencing transcription factor (REST) The Htt (Huntingtin) gene was first identified in 1993 by the efforts of the Huntington's Disease Collaborative Research Group, where an abnormally long and unstable CAG repeat (CAG) n...
Articles
Biochem Soc Trans (2009) 37 (6): 1278–1280.
Published: 19 November 2009
..., that applications of new biochemical techniques followed by high-throughput sequencing will continue to provide important insights into the mechanisms of neuronal post-transcriptional regulation. alternative splicing cross-linking and immunoprecipitation (CLIP) microRNA (miRNA) ribosome profiling synaptic...
Articles
Biochem Soc Trans (2009) 37 (4): 918–925.
Published: 22 July 2009
... pathways is currently in its early stages. The unravelling of such RNA signalling pathways and networks will be key to understanding the role that dysregulated miRNA functioning can play in oncogenic processes. cancer gene regulation microRNA (miRNA) miR-21 oncomir 1 To whom...
Articles
Biochem Soc Trans (2008) 36 (6): 1216–1219.
Published: 19 November 2008
... 1273 1286 © The Authors Journal compilation © 2008 Biochemical Society 2008 cleavage microRNA (miRNA) RNA-induced silencing complex (RISC) RNA cleavage small interfering RNA (siRNA) target site accessibility Over the past few years RNAi (RNA interference) has become...
Articles
Biochem Soc Trans (2008) 36 (6): 1206–1210.
Published: 19 November 2008
... hypertrophy microRNA (miRNA) MicroRNAs and the Regulation of Biological Function: A Biochemical Society Focused Meeting held at Imperial College London, U.K., 8 July 2008. Organized and Edited by Tamas Dalmay (University of East Anglia, U.K.), Mark Lindsay (Imperial College London, U.K...
Articles
Biochem Soc Trans (2008) 36 (6): 1211–1215.
Published: 19 November 2008
... 2008 Biochemical Society 2008 cancer inflammation innate immune response lung microRNA (miRNA) miR - 146a miRNA (microRNA)-mediated RNA interference is a novel mechanism involved in the regulation of the gene expression at the translational level. At the present time, >700 human...
Articles
Biochem Soc Trans (2008) 36 (6): 1197–1200.
Published: 19 November 2008
... cholesterol by 30% [ 34 ]. antisense locked nucleic acid (LNA) microRNA (miRNA) non-coding RNA therapeutic MicroRNAs (miRNAs) comprise an abundant class of small non-coding RNAs that bind to partially complementary sites within the 3′-UTRs (untranslated regions) of target mRNAs and post...
Articles
Biochem Soc Trans (2008) 36 (6): 1191–1193.
Published: 19 November 2008
... a propensity to differentiate into Th2-cells which produce IL-4 and little IFNγ (interferon γ). Microarray analysis of miR - 155 -deficient Th2-cells identified over 100 genes that were overexpressed, including genes involved in driving Th2 differentiation. B-cell cytokine microRNA (miRNA) RNA...
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Biochem Soc Trans (2008) 36 (6): 1194–1196.
Published: 19 November 2008
... than expected. The present paper reviews the different approaches to predict and experimentally identify genes targeted by miRNAs. 1 email t.dalmay@uea.ac.uk 9 9 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 antimir antagomir microRNA (miRNA) RNA...
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Biochem Soc Trans (2008) 36 (6): 1224–1231.
Published: 19 November 2008
... compilation © 2008 Biochemical Society 2008 gene expression in vitro -transcribed RNA microRNA (miRNA) polysomes protein synthesis translation miRNAs (microRNAs) are a class of recently discovered 21–25 nucleotide RNA molecules, which bind with imperfect complementarity to their target...
Articles
Biochem Soc Trans (2008) 36 (6): 1201–1205.
Published: 19 November 2008
... retinoic acid (ATRA) CCAAT/enhancer-binding protein (C/EBP) haemopoiesis microRNA (miRNA) myelopoiesis HSCs (haemopoietic stem cells) reside in the bone marrow and give rise to progenitors that become progressively restricted to several or single blood cell lineages [ 1 ]. These progenitors...
Articles