... Press Limited on behalf of the Biochemical Society 2022 ceRNA Diseases of the nervous system lncrna microRNA In neurodegenerative diseases such as Alzheimer's disease (AD) [ 23–30 ] and Parkinson's disease (PD) [ 31–38 ], lncRNAs are strongly related to neuro-development...

.... In recent years, attention has moved from protein-coding genes to non-coding genes, such as microRNAs (miRNA). There is increasing evidence that these non-coding RNAs are playing roles during embryogenesis by regulating the expression of protein-coding genes. In this review, we give an introduction...

...Kirsten Riches-Suman MicroRNAs are short, non-coding RNAs that target messenger RNAs for degradation. miR-145 is a vascular-enriched microRNA that is important for smooth muscle cell (SMC) differentiation. Under healthy circumstances, SMC exist in a contractile, differentiated phenotype promoted...

.... Correspondence: Gal Haimovich ( gal.haimovich@weizmann.ac.il ) 14 10 2020 8 12 2020 10 12 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 microRNA mRNA plasmodesmata RNA transfer tunneling nanotubes viral RNA...

...Jiawei Zhang; Dandan Li; Rui Zhang; Peng Gao; Rongxue Peng; Jinming Li The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize...

...) . enzyme mechanism of action microRNA MSC exosome proteome In contrast with large living cells, nanosized, non-living exosomes would not occlude microvasculature, transform into inappropriate cell types or persist as permanent grafts upon cessation of therapy. Exosome manufacture is also...

... based on their size or function. Two of the more well-known and widely studied ncRNA species are microRNAs (miRNAs) and lncRNAs. These are regulatory RNAs and their altered expression has been implicated in the pathogenesis of a variety of human diseases. Failure to express a functional cystic fibrosis...

...David Mellis; Andrea Caporali MicroRNAs (miRNAs) are small non-coding RNAs of ∼22 nucleotides, which have increasingly been recognized as potent post-transcriptional regulators of gene expression. MiRNA targeting is defined by the complementarities between positions 2–8 of miRNA 5′-end...

... of post-transcriptional gene regulation. CDS, coding sequence. cancer microRNA noncoding RNAs The concept of ‘junk DNA’, i.e. regions of genomic DNA that lack protein-coding capacity and are thus thought to have no functional relevance, has long been a contested topic in biology...

... on behalf of the Biochemical Society 2017 cancer growth factor microRNA non-coding RNA signal transduction While studying chemical carcinogenesis in the 1940s and examining the somatic mutation theory of cancer, Berenblum and Shubik [ 1 ] proposed a three-stage model of cancer development...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . eukaryotic gene expression metabolic regulation microRNA mitochondrial respiration RNA-binding proteins The control of metabolic homeostasis is central...

...Catherine L. Jopling Most metazoan miRNAs (microRNAs) bind to sites in the 3′-UTRs (untranslated regions) of mRNA targets and negatively regulate protein synthesis. The liver-specific miR - 122 , however, exerts a positive effect on HCV (hepatitis C virus) RNA levels by binding directly to a site...

...P. Laporte; F. Merchan; B.B. Amor; S. Wirth; M. Crespi npcRNA (non-protein-coding RNAs) are an emerging class of regulators, so-called riboregulators, and include a large diversity of small RNAs [miRNAs (microRNAs)/siRNAs (small interfering RNAs)] that are involved in various developmental...

... Journal compilation © 2007 Biochemical Society 2007 Bcl-2 B-lymphocyte chronic lymphocytic leukaemia (CLL) microRNA murine model T-cell leukaemia/lymphoma-1 (Tcl-1) 1 To whom correspondence should be addressed (email a.michie@udcf.gla.ac.uk ). 11 6 2007 CLL (chronic...

...P. Keller; N. Vollaard; J. Babraj; D. Ball; D.A. Sewell; J.A. Timmons We predict that RNA level regulation is as diverse and powerful as protein level regulation when considering physiological adaptation. Non-coding RNA molecules, such as miRNAs (microRNAs), have emerged as a powerful mechanism...