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Keywords: microRNA
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Biochem Soc Trans (2022) 50 (2): 951–963.
Published: 06 April 2022
... Press Limited on behalf of the Biochemical Society 2022 ceRNA Diseases of the nervous system lncrna microRNA Long non-coding RNAs (lncRNAs) are a sort of non-coding RNA that have the length greater than 200 nt with a mRNA-like structure, containing a polyA tail and a promoter, and work...
Biochem Soc Trans (2022) 50 (2): 965–974.
Published: 06 April 2022
.... In recent years, attention has moved from protein-coding genes to non-coding genes, such as microRNAs (miRNA). There is increasing evidence that these non-coding RNAs are playing roles during embryogenesis by regulating the expression of protein-coding genes. In this review, we give an introduction...
Biochem Soc Trans (2021) 49 (1): 353–363.
Published: 22 February 2021
...Kirsten Riches-Suman MicroRNAs are short, non-coding RNAs that target messenger RNAs for degradation. miR-145 is a vascular-enriched microRNA that is important for smooth muscle cell (SMC) differentiation. Under healthy circumstances, SMC exist in a contractile, differentiated phenotype promoted...
Biochem Soc Trans (2021) 49 (1): 145–160.
Published: 24 December 2020
... significance of this pathway in health and disease. Correspondence: Gal Haimovich ( gal.haimovich@weizmann.ac.il ) 14 10 2020 8 12 2020 10 12 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 microRNA mRNA plasmodesmata...
Biochem Soc Trans (2020) 48 (5): 2295–2305.
Published: 29 October 2020
...Jiawei Zhang; Dandan Li; Rui Zhang; Peng Gao; Rongxue Peng; Jinming Li The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize...
Biochem Soc Trans (2018) 46 (4): 843–853.
Published: 09 July 2018
... mechanism of action microRNA MSC exosome proteome Therapeutic MSC exosome was first described in 2010 [ 19 ]. When a culture medium conditioned by MSCs was fractionated by size exclusion using high-performance liquid chromatography, the conditioned medium was found to contain a fraction...
Biochem Soc Trans (2018) 46 (3): 619–630.
Published: 09 May 2018
... based on their size or function. Two of the more well-known and widely studied ncRNA species are microRNAs (miRNAs) and lncRNAs. These are regulatory RNAs and their altered expression has been implicated in the pathogenesis of a variety of human diseases. Failure to express a functional cystic fibrosis...
Biochem Soc Trans (2018) 46 (1): 11–21.
Published: 01 December 2017
...David Mellis; Andrea Caporali MicroRNAs (miRNAs) are small non-coding RNAs of ∼22 nucleotides, which have increasingly been recognized as potent post-transcriptional regulators of gene expression. MiRNA targeting is defined by the complementarities between positions 2–8 of miRNA 5′-end...
Biochem Soc Trans (2017) 45 (3): 805–812.
Published: 15 June 2017
... on the target gene. Correspondence: Yvonne Tay ( yvonnetay@nus.edu.sg ) 28 2 2017 31 3 2017 6 4 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 cancer microRNA noncoding RNAs The concept of ‘junk DNA’, i.e...
Biochem Soc Trans (2017) 45 (1): 51–64.
Published: 15 February 2017
... or genome doublings. Correspondence: Yosef Yarden ( yosef.yarden@weizmann.ac.il ) 29 9 2016 26 11 2016 1 12 2016 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 cancer growth factor microRNA non-coding RNA signal...
Biochem Soc Trans (2016) 44 (5): 1491–1498.
Published: 19 October 2016
...) can broadly be defined as the control of gene expression at the level of RNA transcript abundance and includes aspects of RNA biology, such as transcript stability/RNA turnover, binding of the RNAs by RNA-binding proteins (RBPs) and post-transcriptional regulation by microRNAs (miRNAs). It is known...
Biochem Soc Trans (2008) 36 (6): 1220–1223.
Published: 19 November 2008
...Catherine L. Jopling Most metazoan miRNAs (microRNAs) bind to sites in the 3′-UTRs (untranslated regions) of mRNA targets and negatively regulate protein synthesis. The liver-specific miR - 122 , however, exerts a positive effect on HCV (hepatitis C virus) RNA levels by binding directly to a site...
Biochem Soc Trans (2007) 35 (6): 1638–1642.
Published: 23 November 2007
...P. Laporte; F. Merchan; B.B. Amor; S. Wirth; M. Crespi npcRNA (non-protein-coding RNAs) are an emerging class of regulators, so-called riboregulators, and include a large diversity of small RNAs [miRNAs (microRNAs)/siRNAs (small interfering RNAs)] that are involved in various developmental...
Biochem Soc Trans (2007) 35 (5): 1009–1012.
Published: 25 October 2007
... CLL chronic lymphocytic leukaemia GC germinal centre HSC haemopoietic stem cell Tcl-1 T-cell leukaemia/lymphoma-1 hTCL-1 human TCL-1 Ig immunoglobulin IgH Ig heavy-chain gene locus LPD lymphoproliferative disease M-CLL mutated CLL miRNA microRNA...
Biochem Soc Trans (2007) 35 (5): 1306–1309.
Published: 25 October 2007
...P. Keller; N. Vollaard; J. Babraj; D. Ball; D.A. Sewell; J.A. Timmons We predict that RNA level regulation is as diverse and powerful as protein level regulation when considering physiological adaptation. Non-coding RNA molecules, such as miRNAs (microRNAs), have emerged as a powerful mechanism...