... Press Limited on behalf of the Biochemical Society 2022 ceRNA Diseases of the nervous system lncrna microRNA Long non-coding RNAs (lncRNAs) are a sort of non-coding RNA that have the length greater than 200 nt with a mRNA-like structure, containing a polyA tail and a promoter, and work...

.... In recent years, attention has moved from protein-coding genes to non-coding genes, such as microRNAs (miRNA). There is increasing evidence that these non-coding RNAs are playing roles during embryogenesis by regulating the expression of protein-coding genes. In this review, we give an introduction...

...Kirsten Riches-Suman MicroRNAs are short, non-coding RNAs that target messenger RNAs for degradation. miR-145 is a vascular-enriched microRNA that is important for smooth muscle cell (SMC) differentiation. Under healthy circumstances, SMC exist in a contractile, differentiated phenotype promoted...

... significance of this pathway in health and disease. Correspondence: Gal Haimovich ( gal.haimovich@weizmann.ac.il ) 14 10 2020 8 12 2020 10 12 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 microRNA mRNA plasmodesmata...

...Jiawei Zhang; Dandan Li; Rui Zhang; Peng Gao; Rongxue Peng; Jinming Li The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize...

... mechanism of action microRNA MSC exosome proteome Therapeutic MSC exosome was first described in 2010 [ 19 ]. When a culture medium conditioned by MSCs was fractionated by size exclusion using high-performance liquid chromatography, the conditioned medium was found to contain a fraction...

... based on their size or function. Two of the more well-known and widely studied ncRNA species are microRNAs (miRNAs) and lncRNAs. These are regulatory RNAs and their altered expression has been implicated in the pathogenesis of a variety of human diseases. Failure to express a functional cystic fibrosis...

...David Mellis; Andrea Caporali MicroRNAs (miRNAs) are small non-coding RNAs of ∼22 nucleotides, which have increasingly been recognized as potent post-transcriptional regulators of gene expression. MiRNA targeting is defined by the complementarities between positions 2–8 of miRNA 5′-end...

... on the target gene. Correspondence: Yvonne Tay ( yvonnetay@nus.edu.sg ) 28 2 2017 31 3 2017 6 4 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 cancer microRNA noncoding RNAs The concept of ‘junk DNA’, i.e...

... or genome doublings. Correspondence: Yosef Yarden ( yosef.yarden@weizmann.ac.il ) 29 9 2016 26 11 2016 1 12 2016 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 cancer growth factor microRNA non-coding RNA signal...

...) can broadly be defined as the control of gene expression at the level of RNA transcript abundance and includes aspects of RNA biology, such as transcript stability/RNA turnover, binding of the RNAs by RNA-binding proteins (RBPs) and post-transcriptional regulation by microRNAs (miRNAs). It is known...

...Catherine L. Jopling Most metazoan miRNAs (microRNAs) bind to sites in the 3′-UTRs (untranslated regions) of mRNA targets and negatively regulate protein synthesis. The liver-specific miR - 122 , however, exerts a positive effect on HCV (hepatitis C virus) RNA levels by binding directly to a site...

...P. Laporte; F. Merchan; B.B. Amor; S. Wirth; M. Crespi npcRNA (non-protein-coding RNAs) are an emerging class of regulators, so-called riboregulators, and include a large diversity of small RNAs [miRNAs (microRNAs)/siRNAs (small interfering RNAs)] that are involved in various developmental...

... CLL chronic lymphocytic leukaemia GC germinal centre HSC haemopoietic stem cell Tcl-1 T-cell leukaemia/lymphoma-1 hTCL-1 human TCL-1 Ig immunoglobulin IgH Ig heavy-chain gene locus LPD lymphoproliferative disease M-CLL mutated CLL miRNA microRNA...

...P. Keller; N. Vollaard; J. Babraj; D. Ball; D.A. Sewell; J.A. Timmons We predict that RNA level regulation is as diverse and powerful as protein level regulation when considering physiological adaptation. Non-coding RNA molecules, such as miRNAs (microRNAs), have emerged as a powerful mechanism...