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Keywords: methylation
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Articles
Biochem Soc Trans (2024) 52 (1): 217–229.
Published: 22 February 2024
... methylation or regulating H3K27me3 levels [ 84–88 ]. DNA at bivalent regions is generally unmethylated, and so bivalent chromatin has been proposed as a mechanism to protect CpG islands from aberrant DNA methylation [ 89 ]. The ten–eleven translocation (TET) enzymes are involved in the active turnover of DNA...
Articles
Biochem Soc Trans (2022) 50 (3): 1179–1190.
Published: 06 May 2022
...Peter Sarkies DNA methylation is an epigenetic modification with a very long evolutionary history. However, DNA methylation evolves surprisingly rapidly across eukaryotes. The genome-wide distribution of methylation diversifies rapidly in different lineages, and DNA methylation is lost altogether...
Articles
Biochem Soc Trans (2022) 50 (1): 583–596.
Published: 25 February 2022
...Ulduz Vafadarshamasbi; Emma Mace; David Jordan; Peter A. Crisp DNA methylation is a chromatin modification that plays an essential role in regulating gene expression and genome stability and it is typically associated with gene silencing and heterochromatin. Owing to its heritability, alterations...
Articles
Biochem Soc Trans (2021) 49 (3): 1479–1487.
Published: 01 June 2021
... process of vegetable crops is not only regulated by environmental stimulations, but also manipulated by both genetic and epigenetic modifications. Epigenetic modifications are composed by several regulatory mechanisms, including DNA methylation, histone modification, chromatin remodeling, and non-coding...
Articles
Biochem Soc Trans (2019) 47 (3): 875–885.
Published: 17 June 2019
... of the Biochemical Society 2019 cell differentiation epigenetics epigenomics methylation model organisms pluripotency Ten-eleven translocation (TET) methylcytosine dioxygenases were first described when TET1 was identified as a fusion partner of the mixed lineage leukaemia gene ( MLL ) in acute...
Articles
Biochem Soc Trans (2019) 47 (2): 713–724.
Published: 05 April 2019
... depend on other factors such as DNA methylation, the presence of particular histone variants and post-translational modifications of histones. Collectively, factors that modify DNA or affect its packaging and accessibility contribute to a chromatin landscape that helps to control the timely expression...
Articles
Biochem Soc Trans (2008) 36 (4): 637–639.
Published: 22 July 2008
...Questa H. Karlsson; Celine Schelcher; Elizabeth Verrall; Carlo Petosa; Alison J. Sinclair EBV (Epstein–Barr virus) alternates between latency and lytic replication. During latency, the viral genome is largely silenced by host-driven methylation of CpG motifs and in the switch to the lytic cycle...
Articles
Biochem Soc Trans (2004) 32 (6): 916–917.
Published: 26 October 2004
...J.M. Teodoridis; G. Strathdee; J.A. Plumb; R. Brown Aberrant methylation of CpG islands (CpG-rich regions of DNA associated with the promoters of many genes) is associated with transcriptional inactivation of genes involved in tumour development. Genes involved in key DNA damage response pathways...