... and alter cell behaviour. Whilst peroxidasin is reported to be up-regulated in a number of different cancers, the role that it plays in disease progression and metastasis has only recently begun to be studied. This review highlights the current literature exploring the known roles of peroxidasin in normal...

... to collectively co-ordinate such polarisation between cells allows for the genesis of multicellularity, such as the formation of organs. During tumourigenesis, the rules for such tissue polarisation become dysregulated, allowing for collective polarity rearrangements that can drive metastasis. In this review, we...

...Ryan Lusby; Philip Dunne; Vijay K. Tiwari Activating invasion and metastasis are one of the primary hallmarks of cancer, the latter representing the leading cause of death in cancer patients. Whilst many advances in this area have been made in recent years, the process of cancer dissemination...

... implication in the specificity and robustness of signaling events downstream of SOCE, with a focus on the spatiotemporal SOCE signaling during cancer cell migration, invasion and metastasis. We further discuss the limitation of our current understanding of SOCE in cancer metastasis and potential approaches...

... Society under a transformative agreement with JISC. cancer Cdc42 metastasis Rho GTPases Correspondence: Darerca Owen ( do202@cam.ac.uk ) Figure 1. The structure of Cdc42. Cartoon representation of Cdc42 (PDB:1NF3) with key features highlighted (left): P-loop (orange, residues...

...-step process, called metastasis, disseminates cancer cells primarily through vascular routes. The major steps of the metastatic cascade comprise intravasation into blood vessels, circulation as single or collectives of cells, and eventual colonization of distant organs. Herein, we consider metastasis...

... ) 3 8 2020 2 11 2020 4 11 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cell invasion drug resistance long non-coding RNAs metastasis triple-negative breast cancer The mutational burden of TNBC tumors...

... different effects on the components of the ECM driving or inhibiting augmented angiogenesis and tumour progression and tumour cell proliferation and metastasis. These effects rely on the concentration of NO within the tumour tissue, the nature of the surrounding microenvironment and the sensitivity...

... Limited on behalf of the Biochemical Society 2019 cancer extracellular matrix fibrosis lysyl oxidases metastasis The amorphous material present between cells in tissues and organs was initially referred to in 1852 as ‘Grundsubstanz', translating roughly to ‘basic or fundamental substance...

... published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cholesterol cytochrome p450 Hedgehog Huntington's disease metastasis sterols Oxysterols are oxidised forms of cholesterol or of its...

... 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 extracellular matrix fibroblasts metastasis tumor microenvironments Tumor progression culminating in metastasis underlies cancer mortality and it is estimated that ∼90% of all cancer...

..., and promote carcinogenesis and metastasis formation. Importantly, the role of platelets in tumor immune escape has been described. These lines of evidence open the way to novel strategies to fight cancer based on the use of antiplatelet agents. In addition to their ability to release factors, platelets...

... shRNA was shown to inhibit the acidification and degradative activity of lysosomes, resulting in the increased production of exosomes that promoted metastasis [ 37 ]. In line with these findings, inhibiting lysosomal activity by treating cells with Chloroquine or Bafilomycin has been consistently shown...

... in neuroinflammation and carcinogenesis. In the central nervous system, Tspan2 may contribute to the early stages of the oligodendrocyte differentiation into myelin-forming glia. Furthermore, in human lung cancer, Tspan2 could be involved in the progression of the tumour metastasis by modulating cancer cell motility...

... The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 cell migration extracellular matrix growth factors metastasis stroma tumor microenvironments Carcinomas are heterogeneous tissues composed of cancer cells and stromal cells, such as fibroblasts...

... (a TRX-related protein) reduces the PRLs protecting them from oxidation and, in consequence, maintaining their activity and thus contributing to cancer progression and metastasis [ 34 ]. Correspondence: Maja Köhn ( koehn@embl.de ) 2 6 2016 4 7 2016 11 7 2016 © 2016...

... cyclooxygenase 1 (COX-1) cyclooxygenase 2 (COX-2) epithelial mesenchymal transition metastasis platelets Platelets are chief effector cells in haemostasis but they are also inflammatory cells. In fact, they play a central role in the cross-talk with stromal and immune cells leading...

... AS of key genes and the initiation of prostate cancer metastasis. 1 Correspondence may be addressed to either author (email Rachel.Hagen@uwe.ac.uk or Michael.Ladomery@uwe.ac.uk ). 31 1 2012 The treatment of localized prostate cancer largely results in excellent survival outcome...

... in cancer progression including cell transformation/oncogenesis, cell survival/apoptosis, cell migration/metastasis and tumour microenvironment neovascularization. In the present paper, we describe our research findings regarding the correlation of sphingosine kinase 1 and S1P receptor expression in tumours...

.... In the present paper, we review recent progress in understanding how the p38 MAPK (mitogen-activated protein kinase) signalling pathway participates in the different steps of metastasis. Experimental evidence suggests that tumour cells need to modulate p38 MAPK activity levels to successfully metastasize...

... 1 To whom correspondence should be addressed (email jaro.sodek@utoronto.ca ) 16 4 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 collagen degradation confocal microscopy fibroblast membrane-type 1 matrix metalloproteinase (MT1-MMP) metastasis...

... The Biochemical Society 2005 ADP-ribosylation factor-GTPase-activating protein (Arf-GAP) Arf-GAP containing Src homology domain ankyrin repeats pleckstrin homology domains 1 (ASAP1) cancer centaurin β4 development and differentiation-enhancing factor 1 (DDEF1) metastasis Mammals have six...

... November 2003 22 October 2003 © 2004 Biochemical Society 2004 basement membrane gene expression array gene silencing metastasis phosphoinositide 3-kinase PTEN (phosphatase and tensin homologue deleted on chromosome 10) Abbreviations used: GB, GeneBloc; p110...

... in the prophylactic treatment of diseases whose pathologies feature the formation of neovascular tissue, e.g. tumour growth and metastasis, rupture of atherosclerotic plaques and retinopathy secondary to diabetes. 1 To whom correspondence should be addressed (e-mail nickie@njce.fsnet.co.uk ). 20 11...

...Mingcai Li © 2000 Biochemical Society 2000 fibronectin recombinant polypeptide metastasis 18th International Congress of Biochemistry and Molecular Biology: Abstracts from the 18th International Congress of Biochemistry and Molecular Biology, 16–20 July 2000, Birmingham, UK...