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Keywords: metabolism
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Articles
Biochem Soc Trans (2022) 50 (1): 473–485.
Published: 07 February 2022
... ligase NEDD4 enzyme activity metabolism ubiquitin signaling By targeting at least one third of our proteome, ubiquitin (Ub) affects virtually all biological pathways including those regulating cell growth and death, development, differentiation, inflammation, protein trafficking...
Articles
Biochem Soc Trans (2021) 49 (1): 17–27.
Published: 18 February 2021
... of the role of CHCHD4 and the DRS in physiology and disease, with a specific focus on the emerging importance of CHCHD4 in regulating the cellular response to low oxygen (hypoxia) and metabolism in cancer. Correspondence: Margaret Ashcroft ( m.ashcroft@medschl.cam.ac.uk ) 19 11 2020 19 12...
Articles
Biochem Soc Trans (2020) 48 (5): 1889–1903.
Published: 17 September 2020
...Fernando Cruz; José P. Faria; Miguel Rocha; Isabel Rocha; Oscar Dias The current survey aims to describe the main methodologies for extending the reconstruction and analysis of genome-scale metabolic models and phenotype simulation with Flux Balance Analysis mathematical frameworks, via...
Includes: Supplementary data
Articles
Biochem Soc Trans (2020) 48 (4): 1379–1395.
Published: 24 August 2020
...Herbert M. Sauro Linear metabolic pathways are the simplest network architecture we find in metabolism and are a good starting point to gain insight into the operating principles of metabolic control. Linear pathways possess some well-known properties, such as a bias of flux control towards...
Articles
Biochem Soc Trans (2020) 48 (1): 165–177.
Published: 03 February 2020
... purpose than a simple barrier or transporter of ions. New paradigms suggest that the membrane serves as a critical bridge to connect extracellular to intracellular communication particularly to regulate energy and metabolism by forming physical and biochemical associations with intracellular organelles...
Articles
Biochem Soc Trans (2018) 46 (4): 817–827.
Published: 03 July 2018
...Dunja Aksentijevic; Brett A. O'Brien; Thomas R. Eykyn; Michael J. Shattock Alterations in excitation–contraction coupling and elevated intracellular sodium (Na i ) are hallmarks of pathological cardiac remodelling that underline contractile dysfunction. In addition, changes in cardiac metabolism...
Articles
Biochem Soc Trans (2017) 45 (4): 979–985.
Published: 14 July 2017
...Anna M. Kirwan; Yvonne M. Lenighan; Marcella E. O'Reilly; Fiona C. McGillicuddy; Helen M. Roche Metabolic inflammation is a very topical area of research, wherein aberrations in metabolic and inflammatory pathways probably contribute to atherosclerosis, insulin resistance (IR) and type 2 diabetes...
Articles
Biochem Soc Trans (2017) 45 (4): 871–884.
Published: 03 July 2017
...Minnie Fu; Xiaoyong Yang The endogenous circadian clock is a key regulator of daily metabolic processes. On the other hand, circadian clocks in a broad range of tissues can be tuned by extrinsic and intrinsic metabolic cues. The bidirectional interaction between circadian clocks and metabolism...
Articles
Biochem Soc Trans (2016) 44 (1): 253–259.
Published: 09 February 2016
..., it is no surprise that members of the inositol phosphate family also regulate cellular phosphate homoeostasis. Notably, the PP-IPs play a fundamental role in controlling the metabolism of the ancient polymeric form of phosphate, inorganic polyphosphate (polyP). Here we explore the intimate links between phosphate...
Articles
Biochem Soc Trans (2015) 43 (5): 1049–1050.
Published: 09 October 2015
...Endre Kiss-Toth; Guillermo Velasco; Warren S. Pear 1 To whom correspondence should be addressed (email e.kiss-toth@sheffield.ac.uk ) . 2 6 2015 © 2015 Authors; published by Portland Press Limited 2015 cancer lipids metabolism signalling tribbles ubiquitin...
Articles
Biochem Soc Trans (2015) 43 (4): 593–594.
Published: 03 August 2015
... and clinical applications. Mitochondrial Stress Response Pathways: Held at University of London, UK, 16–17 Dec 2014. References 1 McEwen B.S. Biomarkers for assessing population and individual health and disease related to stress and adaptation Metabolism 2015 64 3 Suppl 1 S2 S10...
Articles
Biochem Soc Trans (2015) 43 (4): 553–558.
Published: 03 August 2015
... illnesses. Many functions have been attributed to TSPO/PBR including a role in the mitochondrial permeability transition pore (MPTP), steroidogenesis and energy metabolism. In this review, we detail the recent developments in determining the physiological role of TSPO/PBR, specifically based on data...
Articles
Biochem Soc Trans (2015) 43 (4): 595–601.
Published: 03 August 2015
... proteins that control the level and activity of NRF2. In addition, NRF2 itself has been identified as a regulator of miRs, which exert some of the functions of NRF2 in metabolic regulation and also novel functions in the regulation of cell adhesion. Here, we summarize the roles and mechanisms of action...
Articles
Biochem Soc Trans (2015) 43 (4): 639–644.
Published: 03 August 2015
...Dionysios V. Chartoumpekis; Nobunao Wakabayashi; Thomas W. Kensler Cancer cells adapt their metabolism to their increased needs for energy and substrates for protein, lipid and nucleic acid synthesis. Nuclear erythroid factor 2-like 2 (Nrf2) pathway is usually activated in cancers and has been...
Articles
Biochem Soc Trans (2015) 43 (4): 740–744.
Published: 03 August 2015
... analysed the metabolic aspects associated with macrophage activation to answer the question about what changes in the regulation of energy metabolism and biosynthesis of anabolic precursors accompany the different types of polarization and to what extent they are necessary for the expression...
Articles
Biochem Soc Trans (2014) 42 (4): 939–944.
Published: 11 August 2014
...Margaret M. Briehl; Margaret E. Tome; Sarah T. Wilkinson; Melba C. Jaramillo; Kristy Lee Characteristics of cancer cells include a more oxidized redox environment, metabolic reprogramming and apoptosis resistance. Our studies with a lymphoma model have explored connections between the cellular...
Articles
Biochem Soc Trans (2014) 42 (4): 1052–1055.
Published: 11 August 2014
... control of PPAR (peroxisome-proliferator-activated receptor)-α and nutritional status, suggesting a role in energy metabolism. Recently, the specific substrates and inhibitors of VNNs were obtained as tools to study VNN biology and to investigate whether VNNs are potential drug targets. Oral...
Articles
Biochem Soc Trans (2014) 42 (4): 1037–1042.
Published: 11 August 2014
...Lei Shi; Benjamin P. Tu Protein acetylation has emerged as a prominent post-translational modification that can occur on a wide variety of proteins. The metabolite acetyl-CoA is a key intermediate in energy metabolism that also serves as the acetyl group donor in protein acetylation modifications...
Articles
Biochem Soc Trans (2014) 42 (3): 617–623.
Published: 22 May 2014
... increasingly appreciated as important regulators of various cellular processes, including cell metabolism, motility, proliferation and signalling [ 47 , 48 ]. Indeed, we found that decreasing ROS levels during tail regeneration via chemical inhibitors or gene-knockdown strategies, especially during the first...
Articles
Biochem Soc Trans (2014) 42 (1): 98–102.
Published: 23 January 2014
... have focused on its function in prokaryotes. In prokaryotes, polyP has been implicated in many unrelated processes ranging from basic metabolism to structural functions. However, polyP analysis and function in higher eukaryotes has been gaining momentum recently. In the present review, we mainly aim...
Articles
Biochem Soc Trans (2013) 41 (6): 1569–1576.
Published: 20 November 2013
...Erik Keimpema; Daniela Calvigioni; Tibor Harkany It is increasingly recognized that maternal exposure to metabolic (nutritional) stimuli, infections, illicit or prescription drugs and environmental stressors during pregnancy can predispose affected offspring to developing devastating postnatal...
Articles
Biochem Soc Trans (2013) 41 (4): 917–922.
Published: 18 July 2013
...Ivan Nemazanyy; Catherine Espeillac; Mario Pende; Ganna Panasyuk To sustain increased growth, rapidly proliferating cells, such as tumour cells, undergo metabolic adaptations. In recent years, the mechanisms of glycolysis activation as a key metabolic adaptation in proliferating cells became...
Articles
Biochem Soc Trans (2013) 41 (2): 670–673.
Published: 21 March 2013
...Lorraine Brennan Metabolomics is the study of metabolites present in biological samples such as biofluids, tissue/cellular extracts and culture media. Combining metabolomic data with multivariate data analysis tools allows us to study alterations in metabolic pathways following different...
Articles
Biochem Soc Trans (2013) 41 (2): 687–693.
Published: 21 March 2013
... and is required for the switch from glycolysis (fermentation) to oxidative metabolism when glucose runs low. In mammals, rapidly proliferating cells (including tumour cells) and immune cells involved in inflammation both tend to utilize rapid glucose uptake and glycolysis (termed the Warburg effect or aerobic...
Articles
Biochem Soc Trans (2012) 40 (6): 1249–1256.
Published: 21 November 2012
... environments, highlighting key biochemical aspects of the extracellular iron-redox metabolisms involved. Of specific interest are the coupling of iron oxidation and reduction in field and experimental systems that model redox gradients and fluctuations in the subsurface, and novel pathways and organisms...
Articles
Biochem Soc Trans (2011) 39 (2): 466–471.
Published: 22 March 2011
... mammalian target of rapamycin (mTOR) metabolism proliferation survival tuberous sclerosis Figure 3 Proposed model for the dual role of TSC1/2 in balancing proliferation and survival The ability of TSC1/2-sufficient and TSC1/2-deficient cells to sense growth factors (GF) and nutrients...
Articles
Biochem Soc Trans (2011) 39 (2): 460–465.
Published: 22 March 2011
... with a pharmacological inhibitor of the TOR pathway, rapamycin, can replicate those findings and improve aging in a variety of model organisms. The proposed underlying anti-aging mechanisms are down-regulated translation, increased autophagy, altered metabolism and increased stress resistance. 1 Correspondence...
Articles
Biochem Soc Trans (2010) 38 (5): 1286–1289.
Published: 24 September 2010
.... Important discoveries linking the metabolism of M. tuberculosis and pathogenesis has renewed interest in this area of research. Previous experimental studies were limited to the analysis of individual genes or enzymes, whereas recent advances in computational systems biology and high-throughput experimental...
Articles
Biochem Soc Trans (2009) 37 (3): 511–517.
Published: 20 May 2009
... invasion metabolism murine double minute 2 (MDM2) p53 tumour suppression Although cancer occurs fairly frequently within the population, when considering the number of cells and cell divisions that occur during a human lifespan, the development of a malignant cell is a rather rare event...
Articles
Biochem Soc Trans (2009) 37 (1): 278–283.
Published: 20 January 2009
...) metabolism sterol-regulatory-element-binding protein (SREBP) The serine/threonine kinase Akt/PKB (protein kinase B)/c-Akt is activated in response to PI3K signalling and regulates numerous downstream effectors including components of the apoptotic machinery such as Bad, the metabolic regulators GSK3...
Articles
Biochem Soc Trans (2009) 37 (1): 295–298.
Published: 20 January 2009
..., the Royal Society of Arts and Sciences in Gothenburg, the Herbert and Karin Jacobsson Foundation and the Royal Swedish Academy of Sciences. References 1 Wullschleger S. Loewith R. Hall M.N. TOR signaling in growth and metabolism Cell 2006 124 471 484 2 Sarbassov D.D...
Articles
Biochem Soc Trans (2009) 37 (1): 291–294.
Published: 20 January 2009
... and that 2-oxoglutarate levels depend on amino acid availability, it is possible that PHD activity depends not only on oxygen, but also on amino acid availability, suggesting a global metabolic sensor function for PHDs which could be signalling not only to HIF, but also to mTOR. 18 9 2008 ©...
Articles
Biochem Soc Trans (2008) 36 (5): 935–940.
Published: 19 September 2008
...Chong Yew Tan; Antonio Vidal-Puig The prevalence of obesity is increasing and with it the prevalence of associated metabolic complications. Precisely how obesity results in metabolic disturbances remains unclear. In the face of persistent positive caloric balance, it has been postulated...
Articles
Biochem Soc Trans (2006) 34 (6): 1103–1106.
Published: 25 October 2006
...M.G. Parker; M. Christian; R. White NRs (nuclear receptors) regulate the expression of specific gene networks in target cells by recruiting cofactor complexes involved in chromatin remodelling and in the assembly of transcription complexes. The importance of activating gene expression, in metabolic...
Articles
Biochem Soc Trans (2005) 33 (6): 1423–1426.
Published: 26 October 2005
...M.P. Brynildsen; W.W. Wong; J.C. Liao Understanding organisms from a systems perspective is essential for predicting cellular behaviour as well as designing gene-metabolic circuits for novel functions. The structure, dynamics and interactions of cellular networks are all vital components of systems...
Articles
Biochem Soc Trans (2005) 33 (6): 1399–1403.
Published: 26 October 2005
... regulated process may lead to disease upon excessive or inappropriate nitration. 1 Correspondence may be addressed to either of these authors (email koeckt@ccf.org or aulakk@ccf.org ). 2 8 2005 © 2005 The Biochemical Society 2005 denitration metabolism mitochondrion nitric...
Articles
Biochem Soc Trans (2005) 33 (3): 516–519.
Published: 01 June 2005
... to be changed if systems biology is to lead to an understanding of life and to provide the benefits that are expected from it. The emphasis ought to be on the needs of the system as a whole for understanding the components, not the converse. General properties of metabolic systems, such as feed-back inhibition...
Articles
Biochem Soc Trans (2003) 31 (6): 1130–1132.
Published: 01 December 2003
... development and lipid metabolism, by using two approaches. We have used C 2 C 12 myotubes in which the PPAR δ activity was altered by overexpression of either native or dominant-negative (DN) mutant forms of PPAR δ. Treatment of C 2 C 12 cells by specific PPAR δ agonists promotes expression of genes...
Articles
Biochem Soc Trans (2003) 31 (6): 1270–1273.
Published: 01 December 2003
... and training status. Changes in carbohydrate metabolism during the transition from rest to exercise and from low- to high-intensity exercise are mainly due to allosteric regulation. The factors that up-regulate fat metabolism in the transition to moderate-intensity exercise and the factors that result...
Articles
Biochem Soc Trans (2002) 30 (2): 30–38.
Published: 01 April 2002
...), structural ( in silico ) and ultrastructural (immunoelectron microscopy) data for characterization of mutant isomerase structures and for the TPI-related metabolic processes in normal and deficient cells. The relationships between mutation-induced TPI misfolding and formation of aberrant protein aggregates...
Articles
Biochem Soc Trans (2001) 29 (4): 525–529.
Published: 01 August 2001
... distinct physiological roles for the IRS proteins. Deletion of Irsl produces a mild metabolic phenotype with compensated insulin resistance but also causes marked growth retardation. In contrast, mice lacking IRS-2 display nearly normal growth but develop diabetes owing to a combination of peripheral...
Articles
Biochem Soc Trans (2001) 29 (2): 237–240.
Published: 01 May 2001
...R. D. Evans; M. Stubbs; G. F. Gibbons; E. A. Newsholme Derek Williamson's scientific career spanned the ‘Golden Age’ of research into metabolic regulation, to which he made an important and sustained contribution. Derek joined Hans Krebs' laboratory at Sheffield University in 1946 and moved...
Articles
Biochem Soc Trans (2000) 28 (6): 855–856.
Published: 01 December 2000
... © 2000 Biochemical Society 2000 expressed sequence tag gene regulation metabolism oxylipin EH, epoxide hydrolase Lipids and Signalling: Oxylipins 2 Hamberg, M. and Hamberg, G. ( 1990) Arch. Biochern. Biophys. 283,4094 I 6 Grechkin, A. N., Ilyasov, A. V. and Hamberg, M. ( I 997) Eur...
Articles
Biochem Soc Trans (2000) 28 (2): 16–22.
Published: 01 February 2000
... and metabolic route of two groups of plant phenolics, the flavonols and hydroxycinnamates. 6 8 1999 © 2000 Biochemical Society 2000 LPH, lactase phlorizin hydrolase SGLTI, sodium-dependent glucose transporter chlorogenic acid diet glycosidase metabolism phenolic Biochemical...
Articles
Biochem Soc Trans (2000) 28 (2): 126–131.
Published: 01 February 2000
... of growth hormone are described. Introduction Survival away from immediate supplies of food requires a store of energy . Poikilotherms, such as fish and reptiles, which have relatively low basal metabolic rates, store substantial amounts of lipid in their livers, but in addition they have evolved...