...Tanecia Mitchell; Balu Chacko; Scott W. Ballinger; Shannon M. Bailey; Jianhua Zhang; Victor Darley-Usmar Mitochondrial dysfunction is associated with a broad range of pathologies including diabetes, ethanol toxicity, metabolic syndrome and cardiac failure. It is now becoming clear that maintaining...

...Cécile Guichard; Richard Moreau; Dominique Pessayre; Terry Kay Epperson; Karl-Heinz Krause The incidence of obesity and non-esterified (‘free’) fatty acid-associated metabolic disorders such as the metabolic syndrome and diabetes is increasing dramatically in most countries. Although...

... insulin-sensitivity metabolic syndrome signalling cross-talk Diet-induced obesity and the subsequent development of features of the metabolic syndrome have become major worldwide health problems [ 1 , 2 ]. Almost 70% of adults in U.S.A. are overweight but, perhaps more alarmingly, 16...

... to be important in the development of diseases linked to obesity, particularly Type II diabetes and the metabolic syndrome. WAT is involved in extensive cross-talk with other organs and multiple metabolic systems through the various adipokines. The critical change in perspective on the physiological role of WAT...

... mechanisms through which DM2 may affect the brain have now been identified. First, factors related to the ‘metabolic syndrome’, a cluster of metabolic and vascular risk factors (e.g. dyslipidaemia and hypertension) that is closely linked to DM2, may be involved. A number of these risk factors are predictors...

...@imperial.ac.uk or dcarling@imperial.ac.uk ). 26 10 2004 © 2005 The Biochemical Society 2005 AMP-activated protein kinase energy homoeostasis fatty acid oxidation glucose uptake LKB1 metabolic syndrome AMPK is a heterotrimeric protein comprising a catalytic α subunit and two...

... functions such as epithelial transport and cardiac and neuronal excitability. At least partially through its effect on transport, SGK1 contributes to a number of pathophysiological conditions including metabolic syndrome and fibrosing disease. glucocorticoid hypertension metabolic syndrome obesity...

...-sensitive transcription factors. This explains the molecular basis of some of the health effects associated with altered dietary fatty acid composition. The metabolic syndrome is a very common condition, characterized by insulin resistance, abdominal obesity, dyslipidaemia and hypertension. It often...

... glucose uptake metabolic syndrome Abbreviations used: ACC, acetyl-CoA carboxylase; AICA, 5-amino-4-imidazole carboxamide; AMPK, AMP-activated protein kinase; CBS, cystathionine-β-synthase; ZMP, AICA riboside monophosphate. The Glucose/Fatty Acid Cycle 1963 2003 1157 Bypassing the glucose...