... on interprotomer cooperativity in elevator-type proteins, a class of membrane transporters characterized by large rigid-body movements perpendicular to the membrane, and highlight well-studied examples and experimental approaches. Correspondence: Eric R. Geertsma ( geertsma@em.uni-frankfurt.de...

... and the Biochemical Society under a transformative agreement with JISC. drug transport membrane transport prodrug recognition SLC15 Solute carrier (SLC) transporters are important determinants of drug pharmacokinetics and are increasingly being identified as important therapeutic targets in their own...

...Anna Mullen; Jenny Hall; Janika Diegel; Isa Hassan; Adam Fey; Fraser MacMillan During their mechanistic cycles membrane transporters often undergo extensive conformational changes, sampling a range of orientations, in order to complete their function. Such membrane transporters present somewhat...

... garnering some degree of pessimism in the field. This review highlights the progress that has been achieved in understanding this complex protein and the value of undertaking molecular studies. ATP-binding cassette (ABC) protein cancer chemotherapy membrane transport molecular mechanism multi-drug...

... pressing questions are why does TorD attach to the signal peptide and when and how is the signal peptide ‘handed-over’ to the Tat translocase? membrane protein membrane transport molecular chaperone protein–protein interaction protein targeting twin-arginine translocase The efficient...

... and esterification. Further characterization of the precise role of these genes is likely to advance our understanding of this elusive pathway in yeast and may prove to be relevant to understand sterol homoeostasis in higher eukaryotic cells. anaerobiosis cholesterol membrane transport Saccharomyces...

... in this paper. ATP-binding-cassette protein (ABC protein) lincosamide macrolide membrane transport ribosome protection streptogramin The majority of ABC ( A TP- b inding- c assette) proteins, discussed in previous contributions to this symposium, act as ATP-driven transporters. However, some...

..., including the mitochondria, which are the ultimate site of NADH reoxidation and full degradation of acetyl-CoA to CO 2 and water; and (5) the different disorders of peroxisomal α- and β-oxidation. genetic diseases membrane transport peroxisomes ACOXI/SCOX, acyl-CoA oxidase I ACOX2/BCOX, branched...